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Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations 治疗性siRNA和ASOs的转化与临床开发:当前行业实践、观点和建议 Christensen, Jesper Kammersgaard; Colletti, Nicholas; Hooshfar, Shirin; Jiang, Rongrong(Rosa); Kuo, Carol; Lindmark, Bosse; Lumen, Annie; Youssef, Amir S.; Albertolle, Matthew; Aluri, Krishna C.; Chen, Linzhi; Chen, Jingxian; Chopda, Girish; Chua, Xien Yu; Morais, Pedro; Dubois, Barent; Gibbons, Francis (Frank); Gudey, Shyam Kumar; Gupta, Swati; Hood, Steve; Humphreys, Sara; Husser, Christophe; Huth, Felix; Jani, Darshana; Jian, Wenying; Kakuda, Thomas; Kurz, Jeffrey; Linnebjerg, Helle; Liu, Jing; Lohmann, Sabine; Niu, Tao; Root, Katharina; Singla, Sumeet; Tang, Chenxiao; Veluri, Ravikanth; Zhang, Guangnong (Sunny); Zhang, Steven; Jawa, Vibha 分享 收藏
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Lepodisiran, an Extended-Duration Short Interfering RNA Targeting Lipoprotein(a): A Randomized Dose-Ascending Clinical Trial Nissen, Steven E.; Linnebjerg, Helle; Shen, Xi; Wolski, Kathy; Ma, Xiaosu; Lim, Shufen; Michael, Laura F.; Ruotolo, Giacomo; Gribble, Grace; Navar, Ann Marie; Nicholls, Stephen J. 分享 收藏
Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation A Randomized Clinical Trial Nicholls, Stephen J.; Nissen, Steven E.; Fleming, Cynthia; Urva, Shweta; Suico, Jeffrey; Berg, Paul H.; Linnebjerg, Helle; Ruotolo, Giacomo; Turner, P. Kellie; Michael, Laura F. 分享 收藏
Ultra rapid lispro showed greater reduction in postprandial glucose versus Humalog in children, adolescents and adults with type 1 diabetes mellitus Aronson, Ronnie; Biester, Torben; Leohr, Jennifer; Pollom, Robyn; Linnebjerg, Helle; LaBell, Elizabeth Smith; Zhang, Qianyi; Coutant, David E.; Danne, Thomas 分享 收藏
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Pharmacokinetics and Pharmacodynamics of Human Regular U-500 Insulin Administered via Continuous Subcutaneous Insulin Infusion Versus Subcutaneous Injection in Adults With Type 2 Diabetes and High-Dose Insulin Requirements Ma, Xiaosu; Benson, Charles T.; Prescilla, Randy; Zhang, Shuyu; Linnebjerg, Helle; LaBell, Elizabeth S.; Morrow, Linda A.; Jackson, Jeffrey A.; Nguyen, Alex; Ilag, Liza L.; Johnson, Jennal L.; Leishman, Derek 分享 收藏
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Ultrarapid lispro lowers postprandial glucose and more closely matches normal physiological glucose response compared to other rapid insulin analogues: A phase 1 randomized, crossover study Heise, Tim; Linnebjerg, Helle; Coutant, David; LaBell, Elizabeth; Zijlstra, Eric; Kapitza, Christoph; Bue-Valleskey, Juliana; Zhang, Qianyi; Dellva, Mary Anne; Leohr, Jennifer 分享 收藏
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Ultra-Rapid Lispro (URLi) Showed Greater Reduction in Postprandial Glucose (PPG) vs. Humalog in Children, Adolescents, and Adult Patients with Type 1 Diabetes (T1D) Aronson, Ronnie; Linnebjerg, Helle; Leohr, Jennifer; Labell, Elizabeth S.; Coutant, David E.; Zhang, Qianyi; Danne, Thomas; Pollom, Robyn K. 分享 收藏
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Ultra Rapid Lispro (URLi) Accelerates Insulin Lispro Absorption and Insulin Action vs. Humalog (Lispro) in Patients with T2D Leohr, Jennifer; Dellva, Mary A.; Coutant, David E.; Labell, Elizabeth S.; Reddy, Shobha; Heise, Tim; Andersen, Grit; Zijlstra, Eric; Hermanski, Lidia; Nosek, Leszek; Linnebjerg, Helle 分享 收藏
Ultra Rapid Lispro (URLi) Lowers Postprandial Glucose (PPG) and More Closely Matches Normal Physiological Glucose Response Compared with Other Rapid Insulin Analogs Heise, Tim; Linnebjerg, Helle; Cao, Dachuang; Coutant, David E.; Labell, Elizabeth S.; Reddy, Shobha; Zijlstra, Eric; Kapitza, Christoph; Bue-Valleskey, Juliana M.; Zhang, Qianyi; Leohr, Jennifer 分享 收藏
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Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion Tiffner, Katrin; Boulgaropoulos, Beate; Hoefferer, Christian; Birngruber, Thomas; Porksen, Niels; Linnebjerg, Helle; Garhyan, Parag; Lam, Eric Chen Quin; Knadler, Mary Pat; Pieber, Thomas R.; Sinner, Frank 分享 收藏