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Synthesis and new DNA targeting activity of 6-and 7-tert-butylfascaplysins Dyshlovoy, Sergey A.; Mansour, Wael Y.; Ramm, Natalia A.; Hauschild, Jessica; Zhidkov, Maxim E.; Kriegs, Malte; Zielinski, Alexandra; Hoffer, Konstantin; Busenbender, Tobias; Glumakova, Ksenia A.; Spirin, Pavel V.; Prassolov, Vladimir S.; Tilki, Derya; Graefen, Markus; Bokemeyer, Carsten; von Amsberg, Gunhild 分享 收藏
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Preclinical patient-derived modeling of castration-resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease Elsesy, Mohamed E.; Oh-Hohenhorst, Su Jung; Oing, Christoph; Eckhardt, Alicia; Burdak-Rothkamm, Susanne; Alawi, Malik; Mueller, Christian; Schueller, Ulrich; Maurer, Tobias; von Amsberg, Gunhild; Petersen, Cordula; Rothkamm, Kai; Mansour, Wael Y. 分享 收藏
A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells Koecher, Sabrina; Zech, Henrike Barbara; Krug, Leonie; Gatzemeier, Fruzsina; Christiansen, Sabrina; Meyer, Felix; Rietow, Ruth; Struve, Nina; Mansour, Wael Yassin; Kriegs, Malte; Petersen, Cordula; Betz, Christian; Rothkamm, Kai; Rieckmann, Thorsten 分享 收藏
Patient derived ex vivo tissue slice cultures demonstrate a profound DNA double-strand break repair defect in HPV-positive oropharyngeal head and neck cancer Zech, Henrike Barbara; Berger, Joanna; Mansour, Wael Yassin; Nordquist, Lena; von Bargen, Clara Marie; Bussmann, Lara; Oetting, Agnes; Christiansen, Sabrina; Moeckelmann, Nikolaus; Boettcher, Arne; Busch, Chia-Jung; Petersen, Cordula; Betz, Christian; Rothkamm, Kai; Kriegs, Malte; Koecher, Sabrina; Rieckmann, Thorsten 分享 收藏
Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities Struve, Nina; Hoffer, Konstantin; Weik, Anna-Sophie; Riepen, Britta; Krug, Leonie; Cetin, Meryem H.; Burmester, Jasmin; Ott, Leonie; Liebing, Jana; Gatzemeier, Fruzsina; Muller-Goebel, Justus; Gerbach, Mirja; Bussmann, Lara; Parplys, Ann Christin; Unger, Kristian; Mansour, Wael Y.; Schuller, Ulrich; Rieckmann, Thorsten; Petersen, Cordula; Rothkamm, Kai; Short, Susan C.; Kriegs, Malte 分享 收藏
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Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer Meyer, Felix; Becker, Saskia; Classen, Sandra; Parplys, Ann Christin; Mansour, Wael Yassin; Riepen, Britta; Timm, Sara; Ruebe, Claudia; Jasin, Maria; Wikman, Harriet; Petersen, Cordula; Rothkamm, Kai; Borgmann, Kerstin 分享 收藏
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The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness Kari, Vijayalakshmi; Raul, Sanjay Kumar; Henck, Jana Maria; Kitz, Julia; Kramer, Frank; Kosinsky, Robyn Laura; Uebelmesser, Nadine; Mansour, Wael Yassin; Eggert, Jessica; Spitzner, Melanie; Najafova, Zeynab; Bastians, Holger; Grade, Marian; Gaedcke, Jochen; Wegwitz, Florian; Johnsen, Steven A. 分享 收藏
A functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer Koecher, Sabrina; Beyer, Burkhard; Lange, Tobias; Nordquist, Lena; Volquardsen, Jennifer; Burdak-Rothkamm, Susanne; Schlomm, Thorsten; Petersen, Cordula; Rothkamm, Kai; Mansour, Wael Yassin 分享 收藏
BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy BCL2-overexpressing前列腺癌细胞依赖于PARP1-dependent末端连接，对PARP抑制剂和放射治疗联合敏感 Oing, Christoph; Tennstedt, Pierre; Simon, Ronald; Volquardsen, Jennifer; Borgmann, Kerstin; Bokemeyer, Carsten; Petersen, Cordula; Dikomey, Ekkehard; Rothkamm, Kai; Mansour, Wael Y. 分享 收藏
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