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Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling in Pulmonary Hypertension: Implications for RNA-Based Diagnostics and Therapeutics 替代多聚腺苷酸化特征可区分肺动脉高压中的不良性右心室重塑：对基于RNA的诊断和治疗的意义 Subramaniam, Janani; Jonnakuti, Venkata; Collum, Scott D.; Martineau, Sandra; Huang, Kai-Lieh; Breuils-Bonnet, Sandra; Frump, Andrea L.; Akkanti, Bindu H.; Patel, Jayeshkumar A.; Patel, Manish K.; Salas De Armas, Ismael; Lefebvre, Isabella N.; Radovancevic, Rajko; Blanco, Elvin; Wagner, Eric J.; Gregoric, Igor; Nathan, Sriram; Kar, Biswajit; Provencher, Steeve; Bonnet, Sebastien; Potus, Francois; Yalamanchili, Hari Krishna; Karmouty-Quintana, Harry 分享 收藏
Real-world Persistence on Selexipag for Pulmonary Arterial Hypertension in Canada 加拿大肺动脉高压患者使用塞来昔帕的实际持续性研究 Weatherald, Jason; Provencher, Steeve; Murray, Jillian; Badin, Matthew; Golden, Shane; Mielniczuk, Lisa; Swiston, John; Zhang, Chang; Yip, Cindy Y. Y.; Mamputu, Jean-Claude; Millson, Brad 分享 收藏
Transitioning From Parenteral Prostanoids to Oral Selexipag in Pulmonary Arterial Hypertension: A Multicenter Retrospective Cohort Study 从静脉前列腺素类药物转换为口服塞来昔帕治疗肺动脉高压：一项多中心回顾性队列研究 Budhram, Brandon; Alrasheed, Sarah K.; Rashad, Moaaz; Chandy, George; Dvorkin-Gheva, Anna; Fox, George A.; Foxall, Julia; Gardner, Andrea; Helmersen, Doug; Hirani, Naushad; Kemp, Kristina; Kularatne, Mithum; Langleben, David; Lesenko, Lyda; Provencher, Steeve; Spence, Emma; Swiston, John R.; Thakrar, Mitesh; Wadden, Daniel; Weatherald, Jason; Hambly, Nathan 分享 收藏
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Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation Epac1的药理学抑制通过阻断FoxO3a的neddylation来保护 against 肺纤维化 Jankowski, Katherine; Lemay, Sarah E.; Lozano-Ojalvo, Daniel; Perez-Rodriguez, Leticia; Sauvaget, Melanie; Breuils-Bonnet, Sandra; Formoso, Karina; Jagana, Vineeta; Ochoa, Maria T.; Zhang, Shihong; Milara, Javier; Cortijo, Julio; Turnbull, Irene C.; Provencher, Steeve; Bonnet, Sebastien; Ochando, Jordi; Lezoualch, Frank; Bisserier, Malik; Hadri, Lahouaria 分享 收藏
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Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies 通过整合转录组学分析和临床前研究，阐明AURKB作为肺动脉高压潜在治疗靶点的价值。 Lemay, Sarah-Eve; Mougin, Manon; Sauvaget, Melanie; El Kabbout, Reem; Valasarajan, Chanil; Yamamoto, Keiko; Martineau, Sandra; Pelletier, Andreanne; Bilodeau, Coralie; Grobs, Yann; Bourgeois, Alice; Romanet, Charlotte; Breuils-Bonnet, Sandra; Montesinos, Monica S.; Lu, Min; Chen, Huidong; Gilbert, Megan; Theberge, Charlie; Potus, Francois; Pullamsetti, Soni; Provencher, Steeve; Bonnet, Sebastien; Boucherat, Oliver 分享 收藏
ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes Grobs, Yann; Romanet, Charlotte; Lemay, Sarah-Eve; Bourgeois, Alice; Voisine, Pierre; Theberge, Charlie; Sauvaget, Melanie; Breuils-Bonnet, Sandra; Martineau, Sandra; El Kabbout, Reem; Valasarajan, Chanil; Chelladurai, Prakash; Pelletier, Andreanne; Mougin, Manon; Dumais, Elizabeth; Perron, Jean; Flamand, Nicolas; Potus, Francois; Provencher, Steeve; Pullamsetti, Soni Savai; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
Integrin α5β1 represents a novel therapeutic target to improve vascular remodeling in pulmonary arterial hypertension 整合素α5β1是改善肺动脉高压血管重塑的一个新型治疗靶点。 Lemay, Sarah-Eve; Montesinos, Monica; Grobs, Yann; Yokokawa, Tetsuro; Shimauchi, Tsukasa; Romanet, Charlotte; Sauvaget, Melanie; Bonnet, Sandra Breuils; Bourgeois, Alice; Theberge, Charlie; Martineau, Sandra; Lippa, Blaise; Goodwin, Bryan; Lin, Albert; Wang, Hua; Dowling, James; Lu, Min; Qiao, Qi; McTeague, T. Andrew; Moy, Terence I.; Potus, Francois; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
Development and characterization of an ex vivo human precision-cut lung slice (hPCLS) system for target validation for pulmonary arterial hypertension 人肺精密切片（hPCLS）系统的建立与表征：用于肺动脉高压靶向验证的离体模型 Kim, Haejin; Jain, Dhawal; Akram, Muzaffar; Zhou, Willa; Provencher, Steeve; Lemay, Sarah-Eve; Bonnet, Sebastien; Potus, Francois; Montesinos, Monica; Lu, Min; Goodwin, Bryan 分享 收藏
Integrin α5β1 contributes to pathological remodeling of the right ventricle in pulmonary arterial hypertension 整合素α5β1参与肺动脉高压中右心室病理性重塑。 Lemay, Sarah-Eve; Montesinos, Monica; Grobs, Yann; Bourgeois, Alice; Romanet, Charlotte; Sauvaget, Melanie; Bonnet, Sandra Breuils; Theberge, Charlie; Martineau, Sandra; Lippa, Blaise; Goodwin, Bryan; Lin, Albert; Wang, Hua; Dowling, James; Lu, Min; Qiao, Qi; McTeague, T. Andrew; Moy, Terence I.; Potus, Francois; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
Targeting ATP Citrate Lyase: A Novel Therapeutic Strategy for Vascular Remodeling in Pulmonary Hypertension 靶向乙酰辅酶A柠檬酸合酶：肺动脉高压血管重塑的一种新型治疗策略 Grobs, Yann; Romanet, Charlotte; Lemay, Sarah-Eve; Bourgeois, Alice; Voisine, Pierre; Theberge, Charlie; Sauvaget, Melanie; Bonnet, Sandra Breuils; Martineau, Sandra; Reem, EL-Kabbout; Pelletier, Andreanne; Mougin, Manon; Dumais, Elizabeth; Perron, Jean; Flamand, Nicolas; Potus, Francois; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
Targeting NEK2 to Induce Senescence and DNA Damage in Pulmonary Arterial Hypertension 靶向NEK2以诱导肺动脉高压中的衰老和DNA损伤 Martineau, Sandra; Yamamoto, Keiko; Bourgeois, Alice; Lemay, Sarah-Eve; Sauvaget, Melanie; Breuils, Sandra Bonnet; Potus, Francois; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
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