未登录Structure, substrate recognition and therapeutic targeting of the human ADAMTS-5 spacer domain人ADAMTS-5间隔结构域的结构、底物识别和治疗靶向性
Milani, Mario; Visintin, Michela; Krastanova, Ivet; Visentini, Marco; Margotti, Elisa; Ugolini, Gabriele; Bolognesi, Martino; Rovati, Lucio C.; Mastrangelo, Eloise .png)
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收藏CR10049, THE FIRST OA-TARGETED KINASE INHIBITOR, IMPROVES PAIN BEHAVIOUR, RESOLVES INFLAMMATION AND PRESERVES JOINT STRUCTURE IN SMALL AND LARGE ANIMAL MODELSPiepoli, Tiziana; Giancotti, Luigino A.; Artusi, Roberto; Ghirri, Matteo; Visintin, Michela; Caselli, Gianfranco; Rovati, Lucio 分享 收藏 Ferulated Poly(vinyl alcohol) based hydrogels发酵的聚 (乙烯醇) 基水凝胶Pepi, Simone; Paolino, Marco; Saletti, Mario; Venditti, Jacopo; Talarico, Luigi; Andreassi, Marco; Giuliani, Germano; Caselli, Gianfranco; Artusi, Roberto; Cappelli, Andrea; Leone, Gemma; Magnani, Agnese; Rovati, Lucio 分享 收藏 Phase I/II study of the EP4 antagonist CR6086 combined with the anti-PD-1 balstilimab in mismatch-repair-proficient and microsatellite stable (pMMR/MSS) chemorefractory metastatic colorectal cancer (mCRC)Pietrantonio, F.; Morano, F.; Niger, M.; Ghelardi, F.; Chiodoni, C.; Palazzo, M.; Brambilla, N.; Benincasa, E.; Giacovelli, G.; Vitalini, C.; Girolami, F.; Rovati, L. C. 分享 收藏 A first-in-human trial on the safety and immunogenicity of COVID-eVax, a cellular response-skewed DNA vaccine against COVID-19Aurisicchio, Luigi; Brambilla, Nadia; Cazzaniga, Marina E.; Bonfanti, Paolo; Milleri, Stefano; Ascierto, Paolo A.; Capici, Serena; Vitalini, Cristina; Girolami, Federica; Giacovelli, Giampaolo; Caselli, Gianfranco; Visintin, Michela; Fanti, Francesca; Ghirri, Matteo; Conforti, Antonella; Compagnone, Mirco; Lione, Lucia; Salvatori, Erika; Pinto, Eleonora; Muzi, Alessia; Marra, Emanuele; Palombo, Fabio; Roscilli, Giuseppe; Manenti, Alessandro; Montomoli, Emanuele; Cadossi, Matteo; Rovati, Lucio C. 分享 收藏 COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal modelsConforti, Antonella; Marra, Emanuele; Palombo, Fabio; Roscilli, Giuseppe; Rava, Micol; Fumagalli, Valeria; Muzi, Alessia; Maffei, Mariano; Luberto, Laura; Lione, Lucia; Salvatori, Erika; Compagnone, Mirco; Pinto, Eleonora; Pavoni, Emiliano; Bucci, Federica; Vitagliano, Grazia; Stoppoloni, Daniela; Pacello, Maria Lucrezia; Cappelletti, Manuela; Ferrara, Fabiana Fosca; D'Acunto, Emanuela; Chiarini, Valerio; Arriga, Roberto; Nyska, Abraham; Di Lucia, Pietro; Marotta, Davide; Bono, Elisa; Giustini, Leonardo; Sala, Eleonora; Perucchini, Chiara; Paterson, Jemma; Ryan, Kathryn Ann; Challis, Amy-Rose; Matusali, Giulia; Colavita, Francesca; Caselli, Gianfranco; Criscuolo, Elena; Clementi, Nicola; Mancini, Nicasio; Gross, Ruediger; Seidel, Alina; Wettstein, Lukas; Muench, Jan; Donnici, Lorena; Conti, Matteo; De Francesco, Raffaele; Kuka, Mirela; Ciliberto, Gennaro; Castilletti, Concetta; Capobianchi, Maria Rosaria; Ippolito, Giuseppe; Guidotti, Luca G.; Rovati, Lucio; Iannacone, Matteo; Aurisicchio, Luigi 分享 收藏 Efficacy of CR13626, a novel oral brain penetrant multi-kinase inhibitor, in a mouse model of glioblastomaGalimberti, Chiara; Piepoli, Tiziana; Montagna, Giuseppe M.; Zerbi, Silvia; Letari, Ornella; Artusi, Roberto; Colovic, Milena; Persiani, Stefano; Caselli, Gianfranco; Rovati, Lucio C. 分享 收藏 Combination of the EP4 antagonist CR6086 and anti-PD-1 monoclonal antibody inhibits tumor growth in a microsatellite stable colorectal cancer in miceCaselli, Gianfranco; Ferrari, Flora; Piepoli, Tiziana; Grotti, Adriana; Cavagnoli, Rosanna; Montagna, Giuseppe M.; Romanelli, Pierpaolo; Bonazzi, Albino; Lanza, Marco; Recordati, Camilla; Rovati, Lucio C. 分享 收藏 Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent modelsSala, Emanuele; Ferrari, Flora; Lanza, Marco; Milia, Chiara; Sabatini, Chiara; Bonazzi, Albino; Comi, Eleonora; Borsi Franchini, Miriam; Caselli, Gianfranco; Rovati, Lucio Claudio 分享 收藏 Efficacy and safety of the first-in-class imidazoline-2 receptor ligand CR4056 in pain from knee osteoarthritis and disease phenotypes: a randomized, double-blind, placebo-controlled phase 2 trial一流的imidazoline-2受体配体CR4056在膝骨关节炎和疾病表型引起的疼痛中的疗效和安全性: 一项随机，双盲，安慰剂对照的2期试验Rovati, L. C.; Brambilla, N.; Blicharski, T.; Connell, J.; Vitalini, C.; Bonazzi, A.; Giacovelli, G.; Girolami, F.; D'Amato, M. 分享 收藏 CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neuronsVellani, Vittorio; Sabatini, Chiara; Milia, Chiara; Caselli, Gianfranco; Lanza, Marco; Letari, Ornella; Rovati, Lucio Claudio; Giacomoni, Chiara 分享 收藏 CR13626, AN ORAL TYROSINE KINASE INHIBITOR CROSSING THE BLOOD BRAIN BARRIER, REDUCES TUMOUR GROWTH AND PROLONGS SURVIVAL IN A MOUSE MODEL OF GLIOBLASTOMAGalimberti, C.; Montagna, M.; Piepoli, T.; Letari, O.; Caselli, G.; Artusi, R.; Colovic, M.; Persiani, S.; Rovati, L. C. 分享 收藏 分享 收藏 CR4056, A FIRST-IN-CLASS IMIDAZOLINE-2 RECEPTOR LIGAND ANALGESIC, IN PAIN FROM KNEE OSTEOARTHRITIS PHENOTYPES: A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, PHASE IIA CLINICAL TRIALRovati, L.; Probert, N. J.; Blicharski, T.; Brambilla, N.; Vitalini, C.; Girolami, F. F.; Giacovelli, G.; D'Amato, M. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty我们能否确定骨关节炎进展风险高的患者对治疗有反应？关注生物标志物和脆弱性Arden, Nigel; Richette, Pascal; Cooper, Cyrus; Bruyere, Olivier; Abadie, Eric; Branco, Jaime; Brandi, Maria Luisa; Berenbaum, Francis; Clerc, Cecile; Dennison, Elaine; Devogelaer, Jean-Pierre; Hochberg, Marc; D'Hooghe, Pieter; Herrero-Beaumont, Gabriel; Kanis, John A.; Laslop, Andrea; Leblanc, Veronique; Maggi, Stefania; Mautone, Giuseppe; Pelletier, Jean-Pierre; Petit-Dop, Florence; Reiter-Niesert, Susanne; Rizzoli, Rene; Rovati, Lucio; Messi, Eleonora Tajana; Tsouderos, Yannis; Martel-Pelletier, Johanne; Reginster, Jean-Yves 分享 收藏 分享 收藏 
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