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收藏Large scale pan cancer drug combination screening to identify effective and actionable combinations and biomarker hypothesis
Bashi, Azadeh; Coker, Elizabeth A.; Bulusu, Krishna; Milo, Marta; Crafter, Claire; Lynch, James; Jenkins, David; Lightfoot, Howard; Willis, Brandon; Andersen, Courtney; Tavana, Omid; Mongeon, Kevin; Gordon, Jacob; Smith, Paul; Barry, Simon; McDermott, Ultan; Drew, Lisa; Critchlow, Susan; Garnett, Mathew J.; Mettetal, Jerome
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收藏Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal modelsDodstarlimab的临床前表征,dodstarlimab是一种治疗性anti-PD-1抗体,在体外细胞测定和体内动物模型中具有增强免疫功能的有效活性
Kumar, Sujatha; Ghosh, Srimoyee; Sharma, Geeta; Wang, Zebin; Kehry, Marilyn R.; Marino, Margaret H.; Neben, Tamlyn Y.; Lu, Sharon; Luo, Shouqi; Roberts, Simon; Ramaswamy, Sridhar; Danaee, Hadi; Jenkins, David
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收藏TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo
Ghosh, Srimoyee; Sharma, Geeta; Travers, Jon; Kumar, Sujatha; Choi, Justin; Jun, H. Toni; Kehry, Marilyn; Ramaswamy, Sridhar; Jenkins, David
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收藏Simultaneous measurement and significance of PD-1, LAG-3 and TIM-3 expression in human solid tumors
Morgado, Micaela; Datar, Ila; Wang, Jun; Sanmamed, Miguel F.; McEachern, Kristen; Jenkins, David; Chen, Lieping; Carvajal-Hausdorf, Daniel; Rimm, David L.; Herbst, Roy S.; Schalper, Kurt A.
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收藏Characterization of tumor growth and immune microenvironment in humanized NOG-EXL mice implanted with A549, MDA-MB-436 and A375 cells
Ghosh, Srimoyee; Fiore, Anne; Eberle, Christoph; Wang, Sarah; Mikule, Keith; McEachern, Kristen; Kumar, Sujatha; Jenkins, David; Sharma, Geeta
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收藏Simultaneous measurement and clinical significance of PD-1, LAG-3 and TIM-3 in non-small cell lung cancer (NSCLC)
Datar, Ila J.; Wang, Jun; Mani, Nikita; Villarroel-Espindola, Franz; Ryan, Patrick; Sanmamed, Miguel F.; McEachern, Kristen; Jenkins, David; Rimm, David L.; Chen, Leiping; Herbst, Roy; Schalper, Kurt
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收藏Discovery of TSR-022, a novel, potent anti-human TIM-3 therapeutic antibody
Murtaza, A.; Laken, H.; Correia, J. Da Silva; McNeeley, P.; Altobell, L.; Zhang, J.; Vancutsem, P.; Wilcoxen, K.; Jenkins, D.
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