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J

James M. Cleary

Dana-Farber Cancer Institute
H指数:52
被引数:1.9万

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Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: a randomized, multiarm, run-in phase trial

吉西他滨和nab-紫杉醇联合或不联合VDR激动剂帕立骨化醇治疗转移性胰腺癌: 一项随机，多臂，磨合期试验

Nature Cancer
IF28.5
2026-05-250
PRE
Kimberly J. Perez; Andressa Dias Costa; Alexander Jordan; Thomas B. Karasic; Dalia Elganainy; Suryun Kim; Chen Yuan; Dan Y. Gui; Runzi Tan; Sung Chul Hong; Xi Wang; Simona Cristea; Emma Coleman; Morgan Truitt; Tae Gyu Oh; Hui Zheng; C. Sloane Furniss; Lauren Brais; Alexandra Bird; Josh Remland; Vasilena Gocheva; Jennifer S. Thalappillil; Mark Anderson; James M. Cleary; Andrea Enzinger; Marios Giannakis; Kimmie Ng; Douglas A. Rubinson; Benjamin Schlechter; Rishi Surana; Harshabad Singh; Thomas Abrams; Ursina Teitelbaum; Natallia Izgur; Eliezer Allen; Peter S. Winter; Srivatsan Raghavan; Jen Jen Yeh; Daniel Von Hoff; Christopher Liddle; Michael Downes; Ronald M. Evans; Peter O’Dwyer; Andrew Aguirre; Jonathan A. Nowak; Brian M. Wolpin
Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer

树突状细胞冗余性使胰腺癌中抗肿瘤CD4+ T细胞的初始激活成为可能

Cancer Cell
IF44.5
2026-05-070
OAAI
Courtney T.S. Kureshi; Michael J. Walsh; Rakeeb Kureshi; Victoire Cardot-Ruffino; Dennis A. Agardy; Lestat R. Ali; James M. Dougan; Li Qiang; Jiao Shen; Chong Zuo; Patrick J. Lenehan; S. Jennifer Wang; Eugena Chang; Joshua Remland; Lauren Brais; Thomas E. Clancy; James M. Cleary; Jason L. Hornick; Brandon M. Huffman; Joseph D. Mancias
Phase 1 clinical trial of the ataxia telangiectasia and Rad3-related inhibitor berzosertib with irinotecan in patients with advanced solid tumors (ETCTN 9938)

I期临床试验：评估ataxia telangiectasia和Rad3-related抑制剂berzosertib联合伊立替康治疗晚期实体瘤患者的疗效（ETCTN 9938）

Cancer
IF5.1
2025-10-290
PRE
Liza C. Villaruz MD; Jingxiao Jin MD; Hong Wang PhD; James J. Lee MD, PhD; Jason J. Luke MD; John C. Rhee MD; Saiama N. Waqar MD; Geoffrey I. Shapiro MD, PhD; James Cleary MD, PhD; Diwakar Davar MD; Timothy F. Burns MD, PhD; Rashmi Verma MD; Manik Amin MD; Leonard Appleman MD, PhD; Kristen K. Ciombor MD; Elizabeth J. Davis MD; Jonathan W. Riess MD; E. Claire Dees MD; Edward J. Kim MD, PhD; Dana Cardin MD; Jianxia Guo PhD; Susan M. Christner BS; Joshua Deppas MS; Angelina M. Parise BS; John C. Schmitz PhD; Bella S. Guerrouahen PhD; Michael Suchko BS; Alejandro Contreras MD, PhD; Li Li PhD; Katherine V. Ferry-Galow PhD; Ting-Chia Chang MS; Shahanawaz Jiwani MD, PhD; Christopher J. Bakkenist PhD; Edward Chu MD; Steven D. Gore MD; Jan H. Beumer PharmD, PhD
Chemical perturbations impacting histone acetylation govern colorectal cancer differentiation

化学扰动影响组蛋白乙酰化，调控结直肠癌分化

Gastroenterology
IF25.1
2025-07-070
OA
Pornlada Likasitwatanakul; Zhixin Li; Paul Doan; Sandor Spisak; Akhouri Kishore Raghawan; Qi Liu; Priscilla Liow; Sunwoo Lee; David Chen; Pratyusha Bala; Pranshu Sahgal; Daulet Aitymbayev; Jennifer S. Thalappillil; Malvina Papanastasiou; William Hawkins; Steven A. Carr; Haeseong Park; James M. Cleary; Jun Qi; Nilay S. Sethi
Pancreatic cancer-restricted cryptic antigens are targets for T cell recognition

胰腺癌特异性隐蔽抗原是T细胞识别的靶点

SCIENCE
IF45.8
2025-05-080
PRE
Ely, Zackery A.; Kulstad, Zachary J.; Gunaydin, Gurcan; Addepalli, Sudarsana; Verzani, Eva K.; Casarrubios, Marta; Clauser, Karl R.; Wang, Xilin; Lippincott, Isabelle E.; Louvet, Cedric; Schmitt, Thomas; Kapner, Kevin S.; Agus, Miles P.; Hennessey, Connor J.; Cleary, James M.; Hadrup, Sine R.; Klaeger, Susan; Su, Jennifer; Jaeger, Alex M.; Wolpin, Brian M.; Raghavan, Srivatsan; Smith, Eric L.; Greenberg, Philip D.; Aguirre, Andrew J.; Abelin, Jennifer G.; Carr, Steven A.; Jacks, Tyler; Freed-Pastor, William A.
A model for decoding resistance in precision oncology: acquired resistance to FGFR inhibitors in cholangiocarcinoma

精准肿瘤学中耐药性解码模型：胆管癌对FGFR抑制剂的获得性耐药

ANNALS OF ONCOLOGY
IF65.4
2024-12-011
OAAI
Goyal, L.; DiToro, D.; Facchinetti, F.; Martin, E. E.; Peng, P.; Baiev, I.; Iyer, R.; Maurer, J.; Reyes, S.; Zhang, K.; Majeed, U.; Berchuck, J. E.; Chen, C. T.; Walmsley, C.; Pinto, C.; Vasseur, D.; Gordan, J. D.; Mody, K.; Borad, M.; Karasic, T.; Damjanov, N.; Danysh, B. P.; Wehrenberg-Klee, E.; Kambadakone, A. R.; Saha, S. K.; Hoffman, I. D.; Nelson, K. J.; Iyer, S.; Qiang, X.; Sun, C.; Wang, H.; Li, L.; Javle, M.; Lin, B.; Harris, W.; Zhu, A. X.; Cleary, J. M.; Flaherty, K. T.; Harris, T.; Shroff, R. T.; Leshchiner, I.; Parida, L.; Kelley, R. K.; Fan, J.; Stone, J. R.; Uboha, N. V.; Hirai, H.; Sootome, H.; Wu, F.; Bensen, D. C.; Hollebecque, A.; Friboulet, L.; Lennerz, J. K.; Getz, G.; Juric, D.
Discovery and therapeutic potential of novel cryptic peptides in pancreatic cancer
CANCER RESEARCH
IF16.6
2024-09-150
PRE
Ely, Zackery A.; Kulstad, Zachary J.; Gunaydin, Gurcan; Addepalli, Sudarsana; Verzani, Eva K.; Abelin, Jennifer G.; Casarrubios, Marta; Clauser, Karl R.; Wang, Xilin; Lippincott, Isabelle; Louvet, Cedric; Schmitt, Tom; Agus, Miles; Kapner, Kevin S.; Hennessey, Connor J.; Cleary, James; Hadrup, Sine R.; Klaeger, Susan; Su, Jennifer; Jaeger, Alex M.; Wolpin, Brian M.; Raghavan, Srivatsan; Smith, Eric; Greenberg, Philip D.; Aguirre, Andrew J.; Carr, Steven A.; Jacks, Tyler; Freed-Pastor, William A.
Phase 2 Trial Testing The PARP Inhibitor Niraparib In Patients With Advanced Pancreatic Cancer with Pathogenic Variants In BRCA 1, BRCA2, PALB2, ATM and CHEK2
CANCER RESEARCH
IF16.6
2024-09-150
PRE
Huffman, Brandon M.; Crowdis, Jett; Yurgelun, Matthew B.; Horick, Nora; Li, Yvonne; Huy Nguyen; Parmar, Kalindi; Kochupurakkal, Bose S.; Enzinger, Andrea; Giannakis, Marios; McCleary, Nadine; Ng, Kimmie; Patel, Anuj K.; Perez, Kimberly J.; Rubinson, Douglas A.; Schlechter, Benjamin L.; Singh, Harshabad; Lam, Helen; Ramsey, Kaitlyn; Andrews, Elizabeth; Culnane, Leigh; Bullock, Andrea; Rattani, Ahmed; Clark, Jeffrey; Peters, Mary Linton; Wolpin, Brian M.; D'Andrea, Alan D.; Shapiro, Geoffrey I.; Aguirre, Andrew J.; Cleary, James M.
Temporal stability and chemotherapy responsiveness of classical and basal transcriptional subtypes of pancreatic cancer
CANCER RESEARCH
IF16.6
2024-09-150
PRE
Singh, Harshabad; Xiu, Joanne; Kapner, Kevin; Yuan, Chen; Narayan, Raja R.; Oberley, Matthew; Farrell, Alex; Surana, Rishi; Huffmann, Brandon M.; Perez, Kimberly J.; Cleary, James M.; Jordan, Alexander C.; Costa, Andressa Dias; Williams, Hannah L.; Raghavan, Srivatsan; Weinberg, Benjamin; Pishvaian, Michael J.; Shroff, Rachna T.; Goel, Sanjay; Dougan, Stephanie K.; Nowak, Jonathan; Spetzler, David; Sledge, George; Wolpin, Brian M.; Aguirre, Andrew J.
An open label, phase II trial of ERK inhibition alone and in combination with autophagy inhibition in patients with metastatic cancreatic cancer
CANCER RESEARCH
IF16.6
2024-09-150
PRE
Surana, Rishi; Zheng, Hui; Wang, Junning; Morgado, Micaela; Brais, Lauren K.; Bryant, Kirsten L.; Somasundaram, Ashwin; Weekes, Colin D.; Bockorny, Bruno; Peters, Mary Linton B.; Bullock, Andrea J.; Zerillo, Jessica A.; Rattani, Ahmed A.; Sanoff, Hanna K.; Clark, Jeffrey W.; Parikh, Aparna R.; Yurgelun, Matthew B.; Patel, Anuj; Mayer, Robert J.; Cleary, James M.; Enzinger, Peter C.; Rubinson, Douglas A.; McCleary, Nadine J.; Enzinger, Andrea C.; Slater, Sarah E.; Ng, Kimmie; Abrams, Thomas A.; Biller, Leah; Raghavan, Srivatsan; Mancias, Joseph D.; Nowak, Jonathan O.; Aguirre, Andrew J.; Der, Channing J.; Wolpin, Brian M.; Perez, Kimberley
Clinical outcomes and ctDNA correlates for CAPOX BETR: a phase II trial of capecitabine, oxaliplatin, bevacizumab, trastuzumab in previously untreated advanced HER2+gastroesophageal adenocarcinoma
NATURE COMMUNICATIONS
IF15.7
2024-08-091
OAAI
Singh, Harshabad; Lowder, Kristen E.; Kapner, Kevin; Kelly, Ronan J.; Zheng, Hui; McCleary, Nadine Jackson; Abrams, Thomas A.; Chan, Jennifer A.; Regan, Eileen M.; Klempner, Samuel J.; Hannigan, Alison M.; Remland, Joshua; Brais, Lauren K.; Andrews, Elizabeth; Yurgelun, Matthew; Cleary, James M.; Rubinson, Douglas A.; Ritterhouse, Lauren L.; Maron, Garrett; Aguirre, Andrew J.; Meyerhardt, Jeffrey A.; Gardecki, Emma; Lennerz, Jochen K.; Wolpin, Brian M.; Enzinger, Peter C.
FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma
JOURNAL OF HEPATOLOGY
IF33
2024-08-014
PRE
Xu, Lixia; Zhang, Ying; Lin, Zhilong; Deng, Xinlang; Ren, Xiaoxue; Huang, Mingle; Li, Shangru; Zhou, Qianying; Fang, Fei; Yang, Qingxia; Zheng, Gaomin; Chen, Zebin; Wu, Zhongdao; Sun, Xi; Lin, Jie; Shen, Jingxian; Guo, Jianping; Li, Xiaoxing; Xue, Tianchen; Tan, Jing; Lin, Xiaoxuan; Tan, Li; Peng, Hong; Shen, Shunli; Peng, Sui; Li, Shaoqiang; Liang, Lijian; Cleary, James M.; Lai, Jiaming; Xie, Yubin; Kuang, Ming
Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting (vol 8, 87, 2024)
NPJ PRECISION ONCOLOGY
IF8
2024-05-060
OAAI
Prosz, Aurel; Sahgal, Pranshu; Huffman, Brandon M.; Sztupinszki, Zsofia; Morris, Clare X.; Chen, David; Borcsok, Judit; Diossy, Miklos; Tisza, Viktoria; Spisak, Sandor; Likasitwatanakul, Pornlada; Rusz, Orsolya; Csabai, Istvan; Cecchini, Michael; Baca, Yasmine; Elliott, Andrew; Enzinger, Peter; Singh, Harshabad; Ubellaker, Jessalyn; Lazaro, Jean-Bernard; Cleary, James M.; Szallasi, Zoltan; Sethi, Nilay S.
Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
NPJ PRECISION ONCOLOGY
IF8
2024-04-082
OAAI
Prosz, Aurel; Sahgal, Pranshu; Huffman, Brandon M.; Sztupinszki, Zsofia; Morris, Clare X.; Chen, David; Borcsok, Judit; Diossy, Miklos; Tisza, Viktoria; Spisak, Sandor; Likasitwatanakul, Pornlada; Rusz, Orsolya; Csabai, Istvan; Cecchini, Michael; Baca, Yasmine; Elliot, Andrew; Enzinger, Peter; Singh, Harshabad; Ubellaker, Jessalyn; Lazaro, Jean-Bernard; Cleary, James M.; Szallasi, Zoltan; Sethi, Nilay S.
The phase I/II eNRGy trial: Zenocutuzumab in patients with cancers harboring NRG1 gene fusions

I/II期eNRGy试验: Zenocutuzumab在携带NRG1基因融合的癌症患者中

FUTURE ONCOLOGY
IF2.6
2024-02-1320
OAAI
Kim, Dong-Wan; Schram, Alison M.; Hollebecque, Antoine; Nishino, Kazumi; Macarulla, Teresa; Rha, Sun Young; Duruisseaux, Michael; Liu, Stephen, V; Al Hallak, Mohammed Najeeb; Umemoto, Kumiko; Wesseler, Claas; Cleary, James M.; Springfeld, Christoph; Neuzillet, Cindy; Joe, Andrew; Jauhari, Shekeab; Ford, Jim; Goto, Koichi
A phase 1 expansion cohort study evaluating the safety and efficacy of the CHK1 inhibitor LY2880070 with low-dose gemcitabine in metastatic pancreatic adenocarcinoma
CANCER RESEARCH
IF16.6
2024-01-160
PRE
Huffman, Brandon M.; Feng, Hanrong; Parmar, Kalindi; Wang, Junning; Kapner, Kevin; Kochupurakkal, Bose; Martignetti, David; Abrams, Thomas; Biller, Leah; Giannakis, Marios; Ng, Kimmie; Patel, Anuj; Perez, Kimberly; Singh, Harshabad; Rubinson, Douglas; Schlechter, Benjamin; Andrews, Elizabeth; Hannigan, Alison; Dunwell, Stanley; Getchell, Zoe; Raghavan, Srivatsan; Wolpin, Brian; D'Andrea, Alan; Aguirre, Andrew; Shapiro, Geoffrey; Cleary, James
Cabozantinib plus atezolizumab in previously untreated advanced hepatocellular carcinoma and previously treated gastric cancer and gastroesophageal junction adenocarcinoma: results from two expansion cohorts of a multicentre, open-label, phase 1b trial (COSMIC-021)
ECLINICALMEDICINE
IF10
2024-01-011
OAAI
Li, Daneng; Loriot, Yohann; Burgoyne, Adam M.; Cleary, James M.; Santoro, Armando; Lin, Daniel; Aix, Santiago Ponce; Garrido-Laguna, Ignacio; Sudhagoni, Ramu; Guo, Xiang; Andrianova, Svetlana; Paulson, Scott
NCI10066: a Phase 1/2 study of olaparib in combination with ramucirumab in previously treated metastatic gastric and gastroesophageal junction adenocarcinoma
BRITISH JOURNAL OF CANCER
IF6.8
2023-12-224
OA
Cecchini, Michael; Cleary, James M.; Shyr, Yu; Chao, Joseph; Uboha, Nataliya; Cho, May; Shields, Anthony; Pant, Shubham; Goff, Laura; Spencer, Kristen; Kim, Edward; Stein, Stacey; Kortmansky, Jeremy S.; Canosa, Sandra; Sklar, Jeffrey; Swisher, Elizabeth M.; Radke, Marc; Ivy, Percy; Boerner, Scott; Durecki, Diane E.; Hsu, Chih-Yuan; Lorusso, Patricia; Lacy, Jill
Durable efficacy of zenocutuzumab, a HER2 x HER3 bispecific antibody, in advanced NRG1 fusion positive (NRG1+) pancreatic ductal adenocarcinoma (PDAC)

HER2 x HER3双特异性抗体zenocutuzumab在晚期NRG1融合阳性 (NRG1) 胰腺导管腺癌 (PDAC) 中的持久疗效

ANNALS OF ONCOLOGY
IF65.4
2023-10-013
PRE
Schram, A.; Macarulla, T.; Cleary, J.; Neuzillet, C.; Arnold, D.; Reiss, K. A.; Bekaii-Saab, T.; Rodon, J.; Goto, K.; Rha, S. Y.; Duruisseaux, M.; Leighl, N.; Weinberg, B. A.; Al-Hallak, M. N.; Joe, A. K.; Adeyemi, S.; Wasserman, E.; Koeman, K-J.; Drilon, A.; O'Reilly, E. M.

研究方向

暂未获取到该数据
G
Geoffrey I. Shapiro
H 指数:115论文数:2,042被引数:5.7万
B
Brian M. Wolpin
H 指数:88论文数:1,210被引数:3.0万
A
Andrew J. Aguirre
H 指数:57论文数:758被引数:2.1万
D
Douglas A. Rubinson
H 指数:37论文数:417被引数:7,686
S
Srivatsan Raghavan
H 指数:27论文数:388被引数:4,491
K
Kimmie Ng
H 指数:68论文数:793被引数:1.8万
N
Nadine J. McCleary
H 指数:25论文数:204被引数:3,586
L
Lauren K. Brais
H 指数:38论文数:520被引数:6,924
H
Harshabad Singh
H 指数:19论文数:393被引数:1,525
T
Thomas A. Abrams
H 指数:37论文数:229被引数:6,114