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Alexandre Prat

centre de recherche du chum
H指数:83
被引数:2.9万

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Periventricular gradient pathology is linked to ependymal reactivity and cell adhesion disruption in multiple sclerosis

室管膜周围梯度病理与多发性硬化症中的室管膜细胞反应性和细胞粘附破坏有关

Nature Neuroscience
IF20
2026-10-150
PRE
Adam M. R. Groh; Elia Afanasiev; Risavarshni Thevakumaran; Finn Creeggan; Liam Callahan-Martin; Maxime Bigotte; Moein Yaqubi; Joshua Gertsvolf; Junze Pei; Hayden Wu; Judith de Vos; Maurice C. G. Aalders; Stephanie Zandee; Alexandre Prat; David A. Rudko; Jo Anne Stratton
Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity

CD40和MHC-II阳性的星形胶质细胞介导的抗原呈递促进中枢神经系统自身免疫反应

Nature
IF48.5
2026-08-050
PRE
Joon-Hyuk Lee; Zhaorong Li; Joselyn S. Soto; Ah-Ram Kim; Tomer Illouz; Carolina M. Polonio; Michael Kilian; Jessica E. Kenison; Anton M. Schüle; Camilo Faust Akl; Hong-Gyun Lee; Brian M. Andersen; Jessica J. Ye; Joseph M. Rone; Gavin Piester; Lena Srun; Jazmin Martinez; Austin Danko; Jinsu Lee; Tae Hyun Heo; Elizabeth N. Chung; Landon K. Oetjen; Pere Duart-Abadia; Nakyung Koo; Norbert Perrimon; Michael A. Wheeler; Baljit S. Khakh; Stephanie E. J. Zandee; Alexandre Prat; Francisco J. Quintana
Causal effects of multiple sclerosis therapies in left-truncated registry data

多发性硬化疗法在左截断登记数据中的因果效应

Multiple Sclerosis Journal
IF5
2026-07-210
PRE
Dagmawi Chilot Haile; Ibrahima Diouf; Serkan Ozakbas; Dana Horakova; Eva Kubala Havrdova; Francesco Patti; Sara Eichau; Raed Alroughani; Alessandra Lugaresi; Valentina Tomassini; Alexandre Prat; Marc Girard; Murat Terzi; Bassem Yamout; Samia J Khoury; Pierre Grammond; Yolanda Blanco; Vahid Shaygannejad; Matteo Foschi; Andrea Surcinelli; Stefano Neri; Bianca Weinstock-Guttman; Julie Prevost; Maria Pia Amato; Michael Barnett; Oliver Gerlach; Nevin John; Allan G Kermode; Marzena Fabis-Pedrini; William M. Carroll; Anneke van der Walt; Helmut Butzkueven; Vincent van Pesch; Aysun Soysal; Riadh Gouider; Saloua Mrabet; Daniele Spitaleri; Elisabetta Cartechini; Davide Maimone; Radek Ampapa; Guy Laureys; Cristina Ramo-Tello; Maria Di Gregorio; Emmanuelle Lapointe; Mark Slee; Rana Karabudak; Justin Garber; Ayse Altintas; Suzanne Hodgkinson; Jose Luis Sanchez-Menoyo; Tamara Castillo-Triviño; Mario Habek; Abdullah Al-Asmi; Talal Al-Harbi; Tunde Csepany; Simón Cárdenas-Robledo; Bruce Taylor; Yi Chao Foong; Barbara Willekens; Nevin Shalaby; Fraser Moore; Chris McGuigan; Seyed Mohammad Baghbanian; Jennifer Massey; Todd A Hardy; Sudarshini Ramanathan; Katrin Gross-Paju; Orla Gray; Danny Decoo; Cameron Shaw; Mihaela Simu; Csilla Rozsa; Elizabeth A Stuart; Sifat Sharmin; Izanne Roos; Tomas Kalincik
Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria

2024年麦唐纳诊断标准后多发性硬化的挑战与未来方向

Nature Medicine
IF50
2026-07-090
PRE
Jiwon Oh; Frederik Barkhof; Amit Bar-Or; Olga Ciccarrelli; Timothy Coetzee; Massimo Filippi; Cristina Granziera; Yael Hacohen; Bernhard Hemmer; Orhun H. Kantarci; Ho Jin Kim; Christine Lebrun-Frenay; Xavier Montalban; Ellen Mowry; Daniel Ontaneda; Alexandre Prat; Daniel S. Reich; Àlex Rovira; Pascal Sati; Aksel Siva; Andrew J. Solomon; Maria Pia Sormani; Bruno Stankoff; Alan Thompson; Mar Tintore; Anthony Traboulsee; Anneke van der walt; Heinz Wiendl; Peter A. Calabresi
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients

广泛存在的基因-环境相互作用塑造了住院COVID-19患者对SARS-CoV-2感染的免疫反应

Nature Communications
IF15.7
2026-04-280
OAAI
Haley E. Randolph; Raúl Aguirre-Gamboa; Elsa Brunet-Ratnasingham; Tomoko Nakanishi; Zepeng Mu; Veronica Locher; Ellen Ketter; Cary Brandolino; Catherine Larochelle; Alexandre Prat; Nathalie Arbour; Anne Dumaine; Andrés Finzi; Madeleine Durand; J. Brent Richards; Daniel E. Kaufmann; Luis B. Barreiro
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling

氧化磷脂酰胆碱沉积通过IL-1β信号通路驱动渐进性多发性硬化症小鼠模型中的慢性神经退行性变

Nature Neuroscience
IF20
2025-12-010
PRE
Ruoqi Yu; Brian M. Lozinski; Ally Seifert; Khanh Ta; Stephanie Zandee; Deepak K. Kaushik; Jian Park; Wendy Klement; Sandra Larouche; Sotirios Tsimikas; Joseph L. Witztum; Dorian B. McGavern; Alexandre Prat; Yifei Dong
Bruton’s tyrosine kinase inhibitors rescue neuronal impairment caused by B cell–mediated lymphotoxin-α release

布鲁顿酪氨酸激酶抑制剂可挽救由B细胞介导的淋巴毒素-α释放引起的神经元损伤

Science Translational Medicine
IF14.6
2025-10-290
PRE
Josef Shin; Paul Götz; Nesrin Sharif; Noemi Sola-Sevilla; Camille Grasmuck; Muriel Schraad; Katrin Pape; Muthuraman Muthuraman; Vinzenz Fleischer; Stephanie EJ Zandee; Stefan Bittner; Christina Francisca Vogelaar; Alexandre Prat; Nicholas Hanuscheck; Frauke Zipp
Disease course after pregnancy in women with progressive multiple sclerosis symptoms

妊娠后进展性多发性硬化症状女性的疾病病程

Multiple Sclerosis Journal
IF5
2025-09-200
OA
Jessica Shipley; Heidi N Beadnall; Paul G Sanfilippo; Dana Horakova; Cavit Boz; Alexandre Prat; Serkan Ozakbas; Tomas Kalincik; Izanne Roos; Ayse Altintas; Sara Eichau; Olga Skibina; Raed Alroughani; Francesco Patti; Masoud Etemadifar; Alessandra Lugaresi; Valentina Tomassini; Helmut Butzkueven; Anneke van der Walt; Vilija G Jokubaitis
Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology

作者更正: 疾病相关星形胶质细胞表观遗传记忆促进CNS病理

Nature
IF48.5
2025-08-260
OA
Hong-Gyun Lee; Joseph M. Rone; Zhaorong Li; Camilo Faust Akl; Seung Won Shin; Joon-Hyuk Lee; Lucas E. Flausino; Florian Pernin; Chun-Cheih Chao; Kilian L. Kleemann; Lena Srun; Tomer Illouz; Federico Giovannoni; Marc Charabati; Liliana M. Sanmarco; Jessica E. Kenison; Gavin Piester; Stephanie E. J. Zandee; Jack P. Antel; Veit Rothhammer; Michael A. Wheeler; Alexandre Prat; Iain C. Clark; Francisco J. Quintana
Clinical and mechanistic effects of cladribine in relapsing multiple sclerosis: 2-year results from the MAGNIFY-MS Study

克拉屈滨在复发型多发性硬化中的临床和机制性作用：MAGNIFY-MS研究2年结果

Therapeutic Advances in Neurological Disorders
IF4.1
2025-07-310
OA
Klaus Schmierer; Heinz Wiendl; Frederik Barkhof; Xavier Montalban; Anat Achiron; Tobias Derfuss; Andrew Chan; Suzanne Hodgkinson; Alexandre Prat; Letizia Leocani; Finn Sellebjerg; Patrick Vermersch; Hulin Jin; Laura Sponton; Anita Chudecka; Lidia Gardner; Nicola De Stefano
Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data

基于真实世界常规临床数据的个性化联邦学习在预测多发性硬化致残进展中的应用

npj Digital Medicine
IF15.1
2025-07-240
OAAI
Ashkan Pirmani; Edward De Brouwer; Ádám Arany; Martijn Oldenhof; Antoine Passemiers; Axel Faes; Tomas Kalincik; Serkan Ozakbas; Riadh Gouider; Barbara Willekens; Dana Horakova; Eva Kubala Havrdova; Francesco Patti; Alexandre Prat; Alessandra Lugaresi; Valentina Tomassini; Pierre Grammond; Elisabetta Cartechini; Izanne Roos; Cavit Boz; Raed Alroughani; Maria Pia Amato; Katherine Buzzard; Jeannette Lechner-Scott; Joana Guimarães; Claudio Solaro; Oliver Gerlach; Aysun Soysal; Jens Kuhle; Jose Luis Sanchez-Menoyo; Daniele Spitaleri; Tunde Csepany; Bart Van Wijmeersch; Radek Ampapa; Julie Prevost; Samia J. Khoury; Vincent Van Pesch; Nevin John; Davide Maimone; Bianca Weinstock-Guttman; Guy Laureys; Pamela McCombe; Yolanda Blanco; Ayse Altintas; Abdullah Al-Asmi; Justin Garber; Anneke Van der Walt; Helmut Butzkueven; Koen de Gans; Csilla Rozsa; Bruce Taylor; Talal Al-Harbi; Attila Sas; Cecilia Rajda; Orla Gray; Danny Decoo; William M. Carroll; Allan G. Kermode; Marzena Fabis-Pedrini; Deborah Mason; Angel Perez-Sempere; Mihaela Simu; Neil Shuey; Bhim Singhal; Marija Cauchi; Todd A. Hardy; Sudarshini Ramanathan; Patrice Lalive; Carmen-Adella Sirbu; Stella Hughes; Tamara Castillo Trivino; Liesbet M. Peeters; Yves Moreau
Four years on: Pregnancy and birth outcomes reported in the MSBase pregnancy, neonatal outcomes, and Women’s Health Registry (2020–2024)

四年之后：MSBase妊娠、新生儿结局及女性健康登记册（2020–2024）中报告的妊娠与分娩结局

Multiple Sclerosis Journal
IF5
2025-07-070
PRE
Vilija G Jokubaitis; Raed Alroughani; Ayse Altintas; Sara Eichau; Stella Hughes; Barbara Willekens; Dana Horakova; Eva Kubala Havrdova; Serkan Ozakbas; Cavit Boz; Mario Habek; Tomas Kalincik; Izanne Roos; Masoud Etemadifar; Marek Peterka; Jeannette Lechner-Scott; Jose E Meca-Lallana; Zuzana Rous; Jana Houskova; Alexandre Prat; Marc Girard; Radek Ampapa; Katherine Buzzard; Olga Skibina; Nevin A John; Allan G Kermode; Marzena J Fabis-Pedrini; Matteo Foschi; Andrea Surcinelli; Yolanda Blanco; Seyed Mohammad Baghbanian; Oliver Gerlach; Richard Macdonell; Zbysek Pavelek; Pavel Stourac; Pamela McCombe; Guy Laureys; Helmut Butzkueven; Anneke van der Walt; Orla Gray; Marta Vachova; Jana Libertinova; Michael Barnett; Pavel Hradilek; Pierre Duquette; Alena Martinkova; William M Carroll; Eva Recmanova; Julie Prevost; Louise Rath; Guillermo Izquierdo; Abdorreza Naser Moghadasi; Mark Slee; Davide Maimone; Jiwon Oh; Murat Terzi; Pierre Grammond; Jose Luis Sanchez-Menoyo; Emanuele D’Amico; Beatriz Romero Ferrando; Mehmet Fatih Yetkin; Bassem Yamout; Ivana Stetkarova; Cristina Ramo-Tello; Koen de Gans; Riadh Gouider; Saloua Mrabet; Abdullah Al-Asmi; Rana Karabudak; Aysun Soysal; Samia J. Khoury; Emmanuelle Lapointe; Simón Cárdenas-Robledo; Nevin Shalaby; Daniele Spitaleri; Joana Guimarães; Gregor Brecl Jakob; Suzanne Hodgkinson; Mohammad Baghbanian; Recai Turkoglu; Vincent van Pesch; Francois Grand’Maison; Elisabetta Cartechini; Enrique Gomez-Figueroa; Jennifer Massey; Chiyoko Nohara; Kenzo Sakurai; Deborah Mason; Talal Al-Harbi; Tamara Castillo-Triviño; Fumitaka Shimizu; Bruce Taylor; Todd A. Hardy; Steve Vucic; Stephen Reddel; Sudarshini Ramanathan; Danny Decoo; Maria Cecilia Aragon de Vecino; Yuri Nakamura; Norio Chihara; Eli Skromne; Oksana Kopchak
Summary of Research: Blood Biomarker Dynamics in People with Relapsing Multiple Sclerosis Treated with Cladribine Tablets: Results of the 2-Year MAGNIFY-MS Study

研究总结：接受克拉屈滨片治疗复发型多发性硬化患者的血液生物标志物动态变化：MAGNIFY-MS研究2年结果

Neurology and Therapy
IF4.8
2025-07-040
OAAI
Heinz Wiendl; Frederik Barkhof; Xavier Montalban; Anat Achiron; Tobias Derfuss; Andrew Chan; Suzanne Hodgkinson; Alexandre Prat; Letizia Leocani; Klaus Schmierer; Finn Sellebjerg; Patrick Vermersch; Hulin Jin; Anita Chudecka; Andreas Kloetgen; Dongdong Lin; Lidia Gardner; Nicola De Stefano
Standardized Definition of Progression Independent of Relapse Activity (PIRA) in Relapsing-Remitting Multiple Sclerosis

复发缓解型多发性硬化中与复发活动无关的进展标准化定义（PIRA）

JAMA NEUROLOGY
IF21.3
2025-06-010
PRE
Muller, Jannis; Sharmin, Sifat; Lorscheider, Johannes; Ozakbas, Serkan; Karabudak, Rana; Horakova, Dana; Weinstock-Guttman, Bianca; Shaygannejad, Vahid; Etemadifar, Masoud; Alroughani, Raed; Patti, Francesco; Eichau, Sara; Prat, Alexandre; Tomassini, Valentina; Kermode, Allan G.; Amato, Maria Pia; Turkoglu, Recai; Altintas, Ayse; Buzzard, Katherine; Soysal, Aysun; van der Walt, Anneke; Butzkueven, Helmut; Blanco, Yolanda; Gerlach, Oliver; Khoury, Samia J.; Barnett, Michael; John, Nevin; Lechner-Scott, Jeannette; Surcinelli, Andrea; van Pesch, Vincent; Prevost, Julie; Sa, Maria Jose; Maimone, Davide; D'hooghe, Marie; Hughes, Stella; Hodgkinson, Suzanne; McGuigan, Chris; Cartechini, Elisabetta; Taylor, Bruce; Spitaleri, Daniele; Slee, Mark; McCombe, Pamela; Yamout, Bassem; Benkert, Pascal; Kuhle, Jens; Kappos, Ludwig; Roos, Izanne
Explainable time-to-progression predictions in multiple sclerosis

多发性硬化症可解释的进展时间预测

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
IF4.8
2025-05-010
PRE
D'hondt, Robbe; Dedja, Klest; Aerts, Sofie; Van Wijmeersch, Bart; Kalincik, Tomas; Reddel, Stephen; Havrdova, Eva Kubala; Lugaresi, Alessandra; Weinstock-Guttman, Bianca; Mrabet, Saloua; Lalive, Patrice; Kermode, Allan G.; Ozakbas, Serkan; Patti, Francesco; Prat, Alexandre; Tomassini, Valentina; Roos, Izanne; Alroughani, Raed; Gerlach, Oliver; Khoury, Samia J.; van Pesch, Vincent; Sa, Maria Jose; Prevost, Julie; Spitaleri, Daniele; Mccombe, Pamela; Solaro, Claudio; van der Walt, Anneke; Al-Asmi, Helmut Butzkueven Abdullah; Laureys, Guy; Sanchez-Menoyo, Jose Luis; de Gans, Koen; Al-Asmi, Abdullah; Deri, Norma; Csepany, Tunde; Al-Harbi, Talal; Carroll, William M.; Rozsa, Csilla; Singhal, Bhim; Hardy, Todd A.; Ramanathan, Sudarshini; Peeters, Liesbet; Vens, Celine; MSBase Study Grp, MSBase Study
Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study

克拉屈滨片治疗复发性多发性硬化症患者的血液生物标志物动态: 2年MAGNIFY-MS研究结果

FRONTIERS IN IMMUNOLOGY
IF5.9
2025-02-030
OAAI
Wiendl, Heinz; Barkhof, Frederik; Montalban, Xavier; Achiron, Anat; Derfuss, Tobias; Chan, Andrew; Hodgkinson, Suzanne; Prat, Alexandre; Leocani, Letizia; Schmierer, Klaus; Sellebjerg, Finn; Vermersch, Patrick; Jin, Hulin; Chudecka, Anita; Kloetgen, Andreas; Lin, Dongdong; Gardner, Lidia; De Stefano, Nicola
First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis

一年治疗反应预测复发缓解型多发性硬化患者后续5年的疾病进程

NEUROTHERAPEUTICS
IF6.9
2025-02-010
OAAI
Toscano, Simona; Spelman, Tim; Ozakbas, Serkan; Alroughani, Raed; Chisari, Clara G.; Lo Fermo, Salvatore; Prat, Alexandre; Girard, Marc; Duquette, Pierre; Izquierdo, Guillermo; Eichau, Sara; Grammond, Pierre; Boz, Cavit; Kalincik, Tomas; Blanco, Yolanda; Buzzard, Katherine; Skibina, Olga; Sa, Maria Jose; van der Walt, Anneke; Butzkueven, Helmut; Terzi, Murat; Gerlach, Oliver; Grand'Maison, Francois; Surcinelli, Andrea; Barnett, Michael; Onofrj, Marco; Yamout, Bassem; Khoury, Samia J.; Prevost, Julie; Lechner-Scott, Jeannette; Maimone, Davide; Amato, Maria Pia; Spitaleri, Daniele; Van Pesch, Vincent; Macdonell, Richard; Cartechini, Elisabetta; de Gans, Koen; Slee, Mark; Castillo-Trivino, Tamara; Soysal, Aysun; Sanchez-Menoyo, Jose Luis; Laureys, Guy; Van Hijfte, Liesbeth; Mccombe, Pamela; Altintas, Ayse; Weinstock-Guttman, Bianca; Aguera-Morales, Eduardo; Etemadifar, Masoud; Ramo-Tello, Cristina; John, Nevin; Turkoglu, Recai; Hodgkinson, Suzanne; Besora, Sarah; Fernandez-Bolanos, Ricardo; Patti, Francesco
Disease-modifying treatment and disability progression in subclasses of patients with primary progressive MS: results from the Big MS Data Network

原发性进行性MS患者亚类的疾病改善治疗和残疾进展: 来自大MS数据网络的结果

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
IF7.5
2024-12-060
OAAI
Lorscheider, Johannes; Signori, Alessio; Subramaniam, Suvitha; Benkert, Pascal; Vukusic, Sandra; Trojano, Maria; Hillert, Jan; Glaser, Anna; Hyde, Robert; Spelman, Tim; Magyari, Melinda; Elberling, Frederik; Pontieri, Luigi; Koch-Henriksen, Nils; Sorensen, Per Soelberg; Gerlach, Oliver; Prat, Alexandre; Girard, Marc; Eichau, Sara; Grammond, Pierre; Horakova, Dana; Ramo-Tello, Cristina; Roos, Izanne; Buzzard, Katherine; Scott, Jeanette Lechner; Sanchez-Menoyo, Jose Luis; Alroughani, Raed; Prevost, Julie; Kuhle, Jens; Gray, Orla; Mathey, Guillaume; Michel, Laure; Ciron, Jonathan; De Seze, Jerome; Maillart, Elisabeth; Ruet, Aurelie; Labauge, Pierre; Zephir, Helene; Kwiatkowski, Arnaud; van der Walt, Anneke; Kalincik, Tomas; Butzkueven, Helmut; Observatoire Francais de la Sclerose en Plaques OFSEP; MSBase Study Group; Swedish MS Registry; Big MS Data Network

研究方向

暂未获取到该数据
P
Pierre Duquette
H 指数:66论文数:341被引数:1.7万
T
Tomáš Kalinčík
H 指数:46论文数:445被引数:8,779
H
Helmut Butzkueven
H 指数:73论文数:722被引数:2.1万
J
Jack P. Antel
H 指数:122论文数:755被引数:5.8万
C
Cavit Boz
H 指数:45论文数:284被引数:8,591
P
Pierre Grammond
H 指数:39论文数:161被引数:5,744
A
Alessandra Lugaresi
H 指数:61论文数:476被引数:1.3万
D
Dana Horáková
H 指数:49论文数:390被引数:8,769
N
Nathalie Arbour
H 指数:47论文数:166被引数:8,899
M
Marc Girard
H 指数:41论文数:171被引数:7,095