Robert C. Rintoul - Publications, H-index & Citations

Robert C. Rintoul

university of cambridge

76H指数

319论文数

4.8W被引数

收录论文 99

发表时间

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing 一种可扩展的深度学习框架，用于通过游离细胞DNA浅层全基因组测序进行癌症检测

Science Advances

IF12.5

2026-07-10

OAAI

Haichao Wang; Paulius D. Mennea; Grainne McAndrew; Ozge Sonmezler; Dmitry S. Shcherbo; Emma-Jane Ditter; Sarah Østrup Jensen; Alessandra I. G. Buma; Christopher G. Smith; Zhao Cheng; Clare Harris; Rosalind. J. Cutts; Sarah Hrebien; Philip A. J. Crosbie; Pippa G. Corrie; Michel M. van den Heuvel; Amit Roshan; Frank McCaughan; Robert C. Rintoul; Florian Markowetz; Tommy Kaplan; Wendy N. Cooper; Hui Zhao; Nitzan Rosenfeld

Developing carbon assimilation methods in duckweed for insights into photosynthesis and growth mechanisms 开发浮萍碳同化方法以深入了解光合作用和生长机制

Plant Physiology

IF6.9

2026-05-26

OAAI

Robert C Rintoul; Alison R Gill; Lorna McAusland; Erik H Murchie; Matthew Gilliham; Jenny C Mortimer; null

Implementation of the NHS England Lung Cancer Screening Programme over 5 years 实施NHS英格兰肺癌筛查计划超过5年

Nature Medicine

IF50

2026-03-23

OAAI

Richard W. Lee; Arjun Nair; Haval Balata; Charlotte Graham; Craig Parylo; Jessica Abell; Michael Woodall; Michael Lawrie; Sally Mouland; Kate Brain; Michelle Clark; Philip Crosbie; Anand Devaraj; Jesme Fox; Martin Grange; Sam M. Janes; Peter Johnson; Anne Mackie; Neal Navani; Samantha L. Quaife; Amelia Randle; Janette Rawlinson; Robert C. Rintoul; Liz Rochelle; Peter Sasieni; Matthew E. J. Callister; David R. Baldwin

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome 肺癌和卵巢癌对铂类化疗的治疗耐药性是由可靶向的tgf β 衰老分泌蛋白驱动的

Nature Aging

IF19.4

2026-02-03

OAAI

Estela González-Gualda; Marika A. V. Reinius; David Macias; Samir Morsli; Jianfeng Ge; Ioana Olan; José Ezequiel Martín; Hui-Ling Ou; Muhamad Hartono; María Pilar Puerto-Camacho; Mary Denholm; Rosalind Kieran; Reuben Hoffmann; Mark Dane; Dimitris Veroutis; Guillermo Medrano; Francisca Mulero; Mercedes Jimenez-Linan; Ljiljana Fruk; Carla P. Martins; Mariano Barbacid; Vassilis Gorgoulis; James E. Korkola; Doris M. Rassl; Gary J. Doherty; Robert C. Rintoul; Masashi Narita; James D. Brenton; Daniel Muñoz-Espín

Multi-cohort analysis identifies a blood-based immune transcriptomic signature for early lung cancer detection 多队列分析识别出一种基于血液的免疫转录组学特征，用于早期肺癌检测

npj Precision Oncology

IF8

2025-07-19

OAAI

Hong Zheng; Aditya M. Rao; Ananthakrishnan Ganesan; Hyongsok Tom Soh; Bruce AJ Ponder; Robert C. Rintoul; Purvesh Khatri

Recurrence prediction using circulating tumor DNA in patients with early-stage non-small cell lung cancer after treatment with curative intent: A retrospective validation study 基于循环肿瘤DNA对接受根治性治疗后的早期非小细胞肺癌患者复发进行预测：一项回顾性验证研究

PLOS MEDICINE

IF9.9

2025-04-15

OAAI

Schuurbiers, Milou M. F.; Smith, Christopher G.; Hartemink, Koen J.; Rintoul, Robert C.; Gale, Davina; Mandos, Bas L. R.; Paterson, Anna L.; van den Broek, Dan; Rosenfeld, Nitzan; van den Heuvel, Michel M.

Predictive value of circulating tumor DNA (ctDNA) before and shortly after curative treatment in early stage non-small cell lung cancer (NSCLC), and exploration of (pre-)analytical factors 早期非小细胞肺癌（NSCLC）在根治性治疗前后循环肿瘤DNA（ctDNA）的预测价值，以及对（预）分析因素的探索

ANNALS OF ONCOLOGY

IF65.4

2024-09-01

PREAI

van den Heuvel, M.; Smith, C. G.; Schuurbiers, M.; Hartemink, K.; Rintoul, R.; Monkhorst, K.; Van Den Broek, D.; Rosenfeld, N.

Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial 胸膜间皮瘤 (MARS 2) 的扩大胸膜切除术和化学疗法与单纯化学疗法的比较: 一项3期随机对照试验

LANCET RESPIRATORY MEDICINE

IF32.8

2024-06-01

OAAI

Lim, Eric; Waller, David; Lau, Kelvin; Steele, Jeremy; Pope, Anthony; Ali, Clinton; Bilancia, Rocco; Keni, Manjusha; Popat, Sanjay; O'Brien, Mary; Tokaca, Nadza; Maskell, Nick; Stadon, Louise; Fennell, Dean; Nelson, Louise; Edwards, John; Tenconi, Sara; Socci, Laura; Rintoul, Robert C.; Wood, Kelly; Stone, Amanda; Muthukumar, Dakshinamoorthy; Ingle, Charlotte; Taylor, Paul; Cove-Smith, Laura; Califano, Raffaele; Summers, Yvonne; Tasigiannopoulos, Zacharias; Bille, Andrea; Shah, Riyaz; Fuller, Elizabeth; Macnair, Andrew; Shamash, Jonathan; Mansy, Talal; Milton, Richard; Koh, Pek; Ionescu, Andreea Alina; Treece, Sarah; Roy, Amy; Middleton, Gary; Kirk, Alan; Harris, Rosie A.; Ashton, Kate; Warnes, Barbara; Bridgeman, Emma; Joyce, Katherine; Mills, Nicola; Elliott, Daisy; Farrar, Nicola; Stokes, Elizabeth; Hughes, Vikki; Nicholson, Andrew G.; Rogers, Chris A.

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

EUROPEAN RESPIRATORY JOURNAL

IF21

2024-01-11

OAAI

Obacz, Joanna; Valer, Jose Antonio; Nibhani, Reshma; Adams, Taylor S.; Schupp, Jonas C.; Veale, Niki; Lewis-Wade, Amanah; Flint, Jasper; Hogan, John; Aresu, Giuseppe; Coonar, Aman S.; Peryt, Adam; Biffi, Giulia; Kaminski, Naftali; Francies, Hayley; Rassl, Doris M.; Garnett, Mathew J.; Rintoul, Robert C.; Marciniak, Stefan J.

An update regarding the Meso-ORIGINS study: part of the PREDICT-Meso International Accelerator

EUROPEAN RESPIRATORY JOURNAL

IF21

2023-10-27

PREAI

Neilly, Mark; Tsim, Selina; Maclay, John; Bilancia, Rocco; Bibby, Anna; Gatheral, Timothy; Ionescu, Alina; Griffiths, Andrew; Aujayeb, Avinash; Rahman, Najib; Fallon, Janet; Craig, Christopher; Macdougall, Michelle; Corcoran, John; Panchal, Rakesh; Chetty, Mahendran; Lamote, Kevin; Cowell, Gordon; Miller, Crispin; Rintoul, Robert; Van Meerbeeck, Jan; Roche, Joshua; Macpherson, Alexandrea; Alexander, Laura; Roberts, Julie; Gourlay, Jacqui; Mcgarry, Joanne; Walker, Nicola; Blyth, Kevin

What's new in pleural disease?

THORAX

IF7.7

2023-10-17

PREAI

Rintoul, Robert Campbell; Marciniak, Stefan John

Hamlet.rt Trans: Prospective single-centre translational study evaluating liquid biomarkers of radiation response

ANNALS OF ONCOLOGY

IF65.4

2023-10-01

OAAI

Denholm, M.; Martin, H. W.; Roshan, A.; Miller, S.; Harden, G.; Towns, C.; Kadyan, S.; Mennea, P.; Munoz-Espin, D.; Rosenfeld, N.; Barnett, G. C.; Rintoul, R.; Coles, C. E.; Yang, H.; Jena, R.

A tumor-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Gonzalez-Gualda, Estela; Macias, David; Morsli, Samir; Martin, Jose Ezequiel; Ou, Hui-Ling; Denholm, Mary; Olan, Ioana; Hoffmann, Reuben; Dane, Mark; Veroutis, Dimitris; Medrano, Guillermo; Mulero, Francisca; Martins, Carla P.; Barbacid, Mariano; Gorgoulis, Vassilis; Korkola, James E.; Rassl, Doris M.; Doherty, Gary J.; Rintoul, Robert C.; Narita, Masashi; Munoz-Espin, Daniel

Breath-based detection of lung cancer using exogenous volatile organic compound targeting β-glucuronidase in the tumor microenvironment

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Labuschagne, Christiaan; Smith, Rob; Kumar, Neelam; Allsworth, Max; Boyle, Billy; Janes, Sam; Crosbie, Philip; Rintoul, Robert

Diagnostic Accuracy of a Convolutional Neural Network Assessment of Solitary Pulmonary Nodules Compared With PET With CT Imaging and Dynamic Contrast-Enhanced CT Imaging Using Unenhanced and Contrast-Enhanced CT Imaging 卷积神经网络评估孤立性肺结节的诊断准确性与PET与CT成像和动态对比增强CT成像相比，使用未增强和对比增强CT成像

CHEST

IF8.6

2023-02-01

OAAI

Weir-McCall, Jonathan R.; Debruyn, Elise; Harris, Scott; Qureshi, Nagmi R.; Rintoul, Robert C.; Gleeson, Fergus, V; Gilbert, Fiona J.

SARS-CoV-2-induced senescence as a potential therapeutic target

EUROPEAN RESPIRATORY JOURNAL

IF21

2022-07-01

OAAI

Denholm, Mary; Rintoul, Robert C.; Munoz-Espin, Daniel

Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer 早期非小细胞肺癌患者治疗后残留ctDNA预测早期复发

ANNALS OF ONCOLOGY

IF65.4

2022-05-01

150

OAAI

Gale, D.; Heider, K.; Ruiz-Valdepenas, A.; Hackinger, S.; Perry, M.; Marsico, G.; Rundell, V; Wulff, J.; Sharma, G.; Knock, H.; Castedo, J.; Cooper, W.; Zhao, H.; Smith, C. G.; Garg, S.; Anand, S.; Howarth, K.; Gilligan, D.; Harden, S., V; Rassl, D. M.; Rintoul, R. C.; Rosenfeld, N.

Integrated genomics point to immune vulnerabilities in pleural mesothelioma (vol 11, 19138, 2021)综合基因组学指出胸膜间皮瘤的免疫脆弱性 (第11卷，19138，2021)

SCIENTIFIC REPORTS

IF3.9

2022-03-21

OAAI

Nastase, Anca; Mandal, Amit; Lu, Shir Kiong; Anbunathan, Hima; Morris-Rosendahl, Deborah; Zhang, Yu Zhi; Sun, Xiao-Ming; Gennatas, Spyridon; Rintoul, Robert C.; Edwards, Matthew; Bowman, Alex; Chernova, Tatyana; Benepal, Tim; Lim, Eric; Taylor, Anthony Newman; Nicholson, Andrew G.; Popat, Sanjay; Willis, Anne E.; MacFarlane, Marion; Lathrop, Mark; Bowcock, Anne M.; Moffatt, Miriam F.; Cookson, William O. C. M.

Dynamic contrast-enhanced CT compared with positron emission tomography CT to characterise solitary pulmonary nodules: the SPUtNIk diagnostic accuracy study and economic modelling 动态对比增强CT与正电子发射断层扫描/计算机断层扫描在孤立性肺结节鉴别诊断中的比较：SPUtNIk诊断准确性研究及经济模型分析

HEALTH TECHNOLOGY ASSESSMENT

IF4

2022-03-01

OAAI

Gilbert, Fiona J.; Harris, Scott; Miles, Kenneth A.; Weir-McCall, Jonathan R.; Qureshi, Nagmi R.; Rintoul, Robert C.; Dizdarevic, Sabina; Pike, Lucy; Sinclair, Donald; Shah, Andrew; Eaton, Rosemary; Clegg, Andrew; Benedetto, Valerio; Hill, James E.; Cook, Andrew; Tzelis, Dimitrios; Vale, Luke; Brindle, Lucy; Madden, Jackie; Cozens, Kelly; Little, Louisa A.; Eichhorst, Kathrin; Moate, Patricia; McClement, Chris; Peebles, Charles; Banerjee, Anindo; Han, Sai; Poon, Fat Wui; Groves, Ashley M.; Kurban, Lutfi; Frew, Anthony J.; Callister, Matthew E.; Crosbie, Philip; Gleeson, Fergus, V; Karunasaagarar, Kavitasagary; Kankam, Osei; George, Steve

Comparative accuracy and cost-effectiveness of dynamic contrast-enhanced CT and positron emission tomography in the characterisation of solitary pulmonary nodules 动态对比增强CT和正电子发射断层扫描在孤立性肺结节表征中的比较准确性和成本效益

THORAX

IF7.7

2021-12-09

OAAI

Gilbert, Fiona J.; Harris, Scott; Miles, Kenneth A.; Weir-McCall, Jonathan R.; Qureshi, Nagmi R.; Rintoul, Robert Campbell; Dizdarevic, Sabina; Pike, Lucy; Sinclair, Donald; Shah, Andrew; Eaton, Rosemary; Jones, Jeremy; Clegg, Andrew; Benedetto, Valerio; Hill, James; Cook, Andrew; Tzelis, Dimitrios; Vale, Luke; Brindle, Lucy; Madden, Jackie; Cozens, Kelly; Little, Louisa; Eichhorst, Kathrin; Moate, Patricia; McClement, Chris; Peebles, Charles; Banerjee, Anindo; Han, Sai; Poon, Fat-Wui; Groves, Ashley M.; Kurban, Lutfi; Frew, Anthony; Callister, Matthew E. J.; Crosbie, Phil A.; Gleeson, Fergus Vincent; Karunasaagarar, Kavitasagary; Kankam, Osei; George, Steve

研究方向