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R

Robert C. Rintoul

University of Cambridge
H指数:76
被引数:4.8万

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A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing

一种可扩展的深度学习框架，用于通过游离细胞DNA浅层全基因组测序进行癌症检测

Science Advances
IF12.5
2026-07-100
OA
Haichao Wang; Paulius D. Mennea; Grainne McAndrew; Ozge Sonmezler; Dmitry S. Shcherbo; Emma-Jane Ditter; Sarah Østrup Jensen; Alessandra I. G. Buma; Christopher G. Smith; Zhao Cheng; Clare Harris; Rosalind. J. Cutts; Sarah Hrebien; Philip A. J. Crosbie; Pippa G. Corrie; Michel M. van den Heuvel; Amit Roshan; Frank McCaughan; Robert C. Rintoul; Florian Markowetz; Tommy Kaplan; Wendy N. Cooper; Hui Zhao; Nitzan Rosenfeld
Implementation of the NHS England Lung Cancer Screening Programme over 5 years

实施NHS英格兰肺癌筛查计划超过5年

Nature Medicine
IF50
2026-03-230
OAAI
Richard W. Lee; Arjun Nair; Haval Balata; Charlotte Graham; Craig Parylo; Jessica Abell; Michael Woodall; Michael Lawrie; Sally Mouland; Kate Brain; Michelle Clark; Philip Crosbie; Anand Devaraj; Jesme Fox; Martin Grange; Sam M. Janes; Peter Johnson; Anne Mackie; Neal Navani; Samantha L. Quaife; Amelia Randle; Janette Rawlinson; Robert C. Rintoul; Liz Rochelle; Peter Sasieni; Matthew E. J. Callister; David R. Baldwin
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

肺癌和卵巢癌对铂类化疗的治疗耐药性是由可靶向的tgf β 衰老分泌蛋白驱动的

Nature Aging
IF19.4
2026-02-030
OAAI
Estela González-Gualda; Marika A. V. Reinius; David Macias; Samir Morsli; Jianfeng Ge; Ioana Olan; José Ezequiel Martín; Hui-Ling Ou; Muhamad Hartono; María Pilar Puerto-Camacho; Mary Denholm; Rosalind Kieran; Reuben Hoffmann; Mark Dane; Dimitris Veroutis; Guillermo Medrano; Francisca Mulero; Mercedes Jimenez-Linan; Ljiljana Fruk; Carla P. Martins; Mariano Barbacid; Vassilis Gorgoulis; James E. Korkola; Doris M. Rassl; Gary J. Doherty; Robert C. Rintoul; Masashi Narita; James D. Brenton; Daniel Muñoz-Espín
Recurrence prediction using circulating tumor DNA in patients with early-stage non-small cell lung cancer after treatment with curative intent: A retrospective validation study

基于循环肿瘤DNA对接受根治性治疗后的早期非小细胞肺癌患者复发进行预测：一项回顾性验证研究

PLOS MEDICINE
IF9.9
2025-04-150
OA
Schuurbiers, Milou M. F.; Smith, Christopher G.; Hartemink, Koen J.; Rintoul, Robert C.; Gale, Davina; Mandos, Bas L. R.; Paterson, Anna L.; van den Broek, Dan; Rosenfeld, Nitzan; van den Heuvel, Michel M.
Predictive value of circulating tumor DNA (ctDNA) before and shortly after curative treatment in early stage non-small cell lung cancer (NSCLC), and exploration of (pre-)analytical factors

早期非小细胞肺癌（NSCLC）在根治性治疗前后循环肿瘤DNA（ctDNA）的预测价值，以及对（预）分析因素的探索

ANNALS OF ONCOLOGY
IF65.4
2024-09-010
PRE
van den Heuvel, M.; Smith, C. G.; Schuurbiers, M.; Hartemink, K.; Rintoul, R.; Monkhorst, K.; Van Den Broek, D.; Rosenfeld, N.
Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial

胸膜间皮瘤 (MARS 2) 的扩大胸膜切除术和化学疗法与单纯化学疗法的比较: 一项3期随机对照试验

LANCET RESPIRATORY MEDICINE
IF32.8
2024-06-0121
OAAI
Lim, Eric; Waller, David; Lau, Kelvin; Steele, Jeremy; Pope, Anthony; Ali, Clinton; Bilancia, Rocco; Keni, Manjusha; Popat, Sanjay; O'Brien, Mary; Tokaca, Nadza; Maskell, Nick; Stadon, Louise; Fennell, Dean; Nelson, Louise; Edwards, John; Tenconi, Sara; Socci, Laura; Rintoul, Robert C.; Wood, Kelly; Stone, Amanda; Muthukumar, Dakshinamoorthy; Ingle, Charlotte; Taylor, Paul; Cove-Smith, Laura; Califano, Raffaele; Summers, Yvonne; Tasigiannopoulos, Zacharias; Bille, Andrea; Shah, Riyaz; Fuller, Elizabeth; Macnair, Andrew; Shamash, Jonathan; Mansy, Talal; Milton, Richard; Koh, Pek; Ionescu, Andreea Alina; Treece, Sarah; Roy, Amy; Middleton, Gary; Kirk, Alan; Harris, Rosie A.; Ashton, Kate; Warnes, Barbara; Bridgeman, Emma; Joyce, Katherine; Mills, Nicola; Elliott, Daisy; Farrar, Nicola; Stokes, Elizabeth; Hughes, Vikki; Nicholson, Andrew G.; Rogers, Chris A.
Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma
EUROPEAN RESPIRATORY JOURNAL
IF21
2024-01-110
OAAI
Obacz, Joanna; Valer, Jose Antonio; Nibhani, Reshma; Adams, Taylor S.; Schupp, Jonas C.; Veale, Niki; Lewis-Wade, Amanah; Flint, Jasper; Hogan, John; Aresu, Giuseppe; Coonar, Aman S.; Peryt, Adam; Biffi, Giulia; Kaminski, Naftali; Francies, Hayley; Rassl, Doris M.; Garnett, Mathew J.; Rintoul, Robert C.; Marciniak, Stefan J.
An update regarding the Meso-ORIGINS study: part of the PREDICT-Meso International Accelerator
EUROPEAN RESPIRATORY JOURNAL
IF21
2023-10-272
PRE
Neilly, Mark; Tsim, Selina; Maclay, John; Bilancia, Rocco; Bibby, Anna; Gatheral, Timothy; Ionescu, Alina; Griffiths, Andrew; Aujayeb, Avinash; Rahman, Najib; Fallon, Janet; Craig, Christopher; Macdougall, Michelle; Corcoran, John; Panchal, Rakesh; Chetty, Mahendran; Lamote, Kevin; Cowell, Gordon; Miller, Crispin; Rintoul, Robert; Van Meerbeeck, Jan; Roche, Joshua; Macpherson, Alexandrea; Alexander, Laura; Roberts, Julie; Gourlay, Jacqui; Mcgarry, Joanne; Walker, Nicola; Blyth, Kevin
A tumor-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Gonzalez-Gualda, Estela; Macias, David; Morsli, Samir; Martin, Jose Ezequiel; Ou, Hui-Ling; Denholm, Mary; Olan, Ioana; Hoffmann, Reuben; Dane, Mark; Veroutis, Dimitris; Medrano, Guillermo; Mulero, Francisca; Martins, Carla P.; Barbacid, Mariano; Gorgoulis, Vassilis; Korkola, James E.; Rassl, Doris M.; Doherty, Gary J.; Rintoul, Robert C.; Narita, Masashi; Munoz-Espin, Daniel
Diagnostic Accuracy of a Convolutional Neural Network Assessment of Solitary Pulmonary Nodules Compared With PET With CT Imaging and Dynamic Contrast-Enhanced CT Imaging Using Unenhanced and Contrast-Enhanced CT Imaging

卷积神经网络评估孤立性肺结节的诊断准确性与PET与CT成像和动态对比增强CT成像相比，使用未增强和对比增强CT成像

CHEST
IF8.6
2023-02-017
OAAI
Weir-McCall, Jonathan R.; Debruyn, Elise; Harris, Scott; Qureshi, Nagmi R.; Rintoul, Robert C.; Gleeson, Fergus, V; Gilbert, Fiona J.
Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer

早期非小细胞肺癌患者治疗后残留ctDNA预测早期复发

ANNALS OF ONCOLOGY
IF65.4
2022-05-01150
OAAI
Gale, D.; Heider, K.; Ruiz-Valdepenas, A.; Hackinger, S.; Perry, M.; Marsico, G.; Rundell, V; Wulff, J.; Sharma, G.; Knock, H.; Castedo, J.; Cooper, W.; Zhao, H.; Smith, C. G.; Garg, S.; Anand, S.; Howarth, K.; Gilligan, D.; Harden, S., V; Rassl, D. M.; Rintoul, R. C.; Rosenfeld, N.
Integrated genomics point to immune vulnerabilities in pleural mesothelioma (vol 11, 19138, 2021)

综合基因组学指出胸膜间皮瘤的免疫脆弱性 (第11卷，19138，2021)

SCIENTIFIC REPORTS
IF3.9
2022-03-210
OAAI
Nastase, Anca; Mandal, Amit; Lu, Shir Kiong; Anbunathan, Hima; Morris-Rosendahl, Deborah; Zhang, Yu Zhi; Sun, Xiao-Ming; Gennatas, Spyridon; Rintoul, Robert C.; Edwards, Matthew; Bowman, Alex; Chernova, Tatyana; Benepal, Tim; Lim, Eric; Taylor, Anthony Newman; Nicholson, Andrew G.; Popat, Sanjay; Willis, Anne E.; MacFarlane, Marion; Lathrop, Mark; Bowcock, Anne M.; Moffatt, Miriam F.; Cookson, William O. C. M.
Dynamic contrast-enhanced CT compared with positron emission tomography CT to characterise solitary pulmonary nodules: the SPUtNIk diagnostic accuracy study and economic modelling

动态对比增强CT与正电子发射断层扫描/计算机断层扫描在孤立性肺结节鉴别诊断中的比较：SPUtNIk诊断准确性研究及经济模型分析

HEALTH TECHNOLOGY ASSESSMENT
IF4
2022-03-014
OA
Gilbert, Fiona J.; Harris, Scott; Miles, Kenneth A.; Weir-McCall, Jonathan R.; Qureshi, Nagmi R.; Rintoul, Robert C.; Dizdarevic, Sabina; Pike, Lucy; Sinclair, Donald; Shah, Andrew; Eaton, Rosemary; Clegg, Andrew; Benedetto, Valerio; Hill, James E.; Cook, Andrew; Tzelis, Dimitrios; Vale, Luke; Brindle, Lucy; Madden, Jackie; Cozens, Kelly; Little, Louisa A.; Eichhorst, Kathrin; Moate, Patricia; McClement, Chris; Peebles, Charles; Banerjee, Anindo; Han, Sai; Poon, Fat Wui; Groves, Ashley M.; Kurban, Lutfi; Frew, Anthony J.; Callister, Matthew E.; Crosbie, Philip; Gleeson, Fergus, V; Karunasaagarar, Kavitasagary; Kankam, Osei; George, Steve
Comparative accuracy and cost-effectiveness of dynamic contrast-enhanced CT and positron emission tomography in the characterisation of solitary pulmonary nodules

动态对比增强CT和正电子发射断层扫描在孤立性肺结节表征中的比较准确性和成本效益

THORAX
IF7.7
2021-12-098
OA
Gilbert, Fiona J.; Harris, Scott; Miles, Kenneth A.; Weir-McCall, Jonathan R.; Qureshi, Nagmi R.; Rintoul, Robert Campbell; Dizdarevic, Sabina; Pike, Lucy; Sinclair, Donald; Shah, Andrew; Eaton, Rosemary; Jones, Jeremy; Clegg, Andrew; Benedetto, Valerio; Hill, James; Cook, Andrew; Tzelis, Dimitrios; Vale, Luke; Brindle, Lucy; Madden, Jackie; Cozens, Kelly; Little, Louisa; Eichhorst, Kathrin; Moate, Patricia; McClement, Chris; Peebles, Charles; Banerjee, Anindo; Han, Sai; Poon, Fat-Wui; Groves, Ashley M.; Kurban, Lutfi; Frew, Anthony; Callister, Matthew E. J.; Crosbie, Phil A.; Gleeson, Fergus Vincent; Karunasaagarar, Kavitasagary; Kankam, Osei; George, Steve

研究方向

暂未获取到该数据
D
Doris M. Rassl
H 指数:53论文数:220被引数:4.2万
D
David Baldwin
H 指数:56论文数:598被引数:1.5万
A
Andrew G. Nicholson
H 指数:148论文数:697被引数:12.1万
N
Nitzan Rosenfeld
H 指数:55论文数:199被引数:2.5万
D
DM Rassl
H 指数:5论文数:24被引数:813
S
Stefan J. Marciniak
H 指数:49论文数:295被引数:1.8万
L
Linda Sharples
H 指数:70论文数:397被引数:1.9万
M
Matthew Callister
H 指数:32论文数:190被引数:5,355
S
Sam M. Janes
H 指数:77论文数:643被引数:2.7万
C
Christophe Dooms
H 指数:51论文数:321被引数:1.1万