Lynn Morris

South African Medical Research Council

H指数:86

被引数:2.8万

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VRC01 Exerted Differential Pressure on HIV-1 Envelope From Subtypes B and C That Continued in the First Weeks Postdiagnosis in the Antibody Mediated Prevention Trials

VRC01 对 B 和 C 亚型 HIV-1 包膜施加的差异压力在抗体介导的预防试验中确诊后的前几周持续存在

The Journal of Infectious Diseases

IF0

2026-09-080

OAAI

Hongjun Bai; Michal Juraska; Craig A Magaret; Anna Yssel; Raabya Rossenkhan; Ben Murrell; Bethany L Dearlove; Eric Lewitus; Allan C deCamp; Elena E Giorgi; James Ludwig; Dylan H Westfall; Wenjie Deng; Lennie Chen; Hong Zhao; Alec Pankow; Tanmoy Bhattacharya; Talita York; Asanda Gwashu-Nyangiwe; Nonkululeko Ndabambi; Ruwayhida Thebus; Julie A Ake; Sandhya Vasan; April Randhawa; John A Hural; Sri Edupuganti; Nyaradzo Mgodi; Shelly T Karuna; Lynn Morris; David C Montefiori; Myron S Cohen; Lawrence Corey; Paul T Edlefsen; M Julianna McElrath; Peter B Gilbert; Carolyn Williamson; James I Mullins; Morgane Rolland; null

Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials

在抗体介导的预防试验中，广泛中和抗体VRC01对HIV突破性病毒人群的影响

Nature Communications

IF15.7

2026-04-030

OAAI

Carolyn Williamson; Chivonne Moodley; Craig A. Magaret; Elena E. Giorgi; Morgane Rolland; Dylan H. Westfall; Anna Yssel; Wenjie Deng; Raabya Rossenkhan; Nonhlanhla N. Mkhize; Lennie Chen; Hong Zhao; Tanmoy Bhattacharya; Alec Pankow; Ben Murrell; Talita York; Asanda Gwashu-Nyangiwe; Nonkululeko Ndabambi; Ruwayhida Thebus; Paula Cohen; Bronwen Lambson; Haajira Kaldine; Sinethemba Bhebhe; Michal Juraska; Hongjun Bai; Allan C. deCamp; Maurine D. Miner; James Ludwig; Cindy Molitor; Nicolas Beaume; David Matten; Yunda Huang; Lily Zhang; Daniel B. Reeves; Bryan Mayer; Shelly T. Karuna; John A. Hural; Lynn Morris; David Montefiori; Roger E. Bumgarner; Penny L. Moore; Paul T. Edlefsen; Srilatha Edupuganti; Nyaradzo Mgodi; M. Juliana McElrath; Myron S. Cohen; Lawrence Corey; Peter B. Gilbert; James I. Mullins

Extended in vivo activity of VRC01 HIV-1 prophylaxis entails initial protective efficacy and subsequent breakthrough infections

VRC01 HIV-1预防性治疗的体内持续活性涉及初始保护效果及后续突破性感染

Science Translational Medicine

IF14.6

2026-01-010

Allan C. deCamp; Michal Juraska; Li Li; Craig A. Magaret; Brian D. Williamson; Hongjun Bai; Yunda Huang; Elena E. Giorgi; Lily Zhang; Lindsay N. Carpp; Srilatha Edupuganti; Nyaradzo Mavis Mgodi; Kevin Gillespie; Beatrix Haddock; Pedro Gonzáles; Robinson L. Cabello; Catherine Orrell; Javier R. Lama; Fatima Laher; Erica Maxine Lazarus; Jorge Sánchez; Ian Frank; Juan Hinojosa; Magdalena E. Sobieszczyk; Pamela Grace Mukwekwerere; Joseph M. Makhema; Lindsey Robert Baden; Kelly E. Seaton; John Hural; M. Juliana McElrath; Simbarashe G. Takuva; April Kaur Randhawa; Nidhi K. Kochar; Estelle Piwowar‐Manning; Deborah J Donnell; Nirupama Sista; P. Andrew; Shelly Karuna; James G. Kublin; Glenda Gray; Myron S. Cohen; Dan H. Barouch; Georgia D. Tomaras; Morgane Rolland; David C. Montefiori; Lynn Morris; James I. Mullins; Carolyn E. Williamson; Lawrence Corey; Peter B. Gilbert

Population pharmacokinetics of weight-based compared with fixed dosing of CAP256V2LS, a broadly neutralizing antibody for HIV prevention in women

与固定剂量相比，基于体重的CAP256V2LS（一种用于女性HIV预防的广谱中和抗体）的群体药代动力学研究

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

IF3.6

2025-06-010

OAAI

Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance

JOURNAL OF VIROLOGY

IF3.8

2025-02-250

OAAI

Population shift in antibody immunity following the emergence of a SARS-CoV-2 variant of concern

SCIENTIFIC REPORTS

IF3.9

2025-02-140

OAAI

Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals

南非个体抗体IGH位点的全新多态性和拷贝数多样性

Immunogenetics

IF2.9

2024-12-040

OAAI

High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials ( vol 14 , 8299 , 2023)

NATURE COMMUNICATIONS

IF15.7

2024-03-220

OAAI

Reeves, Daniel B.; Mayer, Bryan T.; DeCamp, Allan C.; Huang, Yunda; Zhang, Bo; Carpp, Lindsay N.; Magaret, Craig A.; Juraska, Michal; Gilbert, Peter B.; Montefiori, David C.; Bar, Katharine J.; Cardozo-Ojeda, E. Fabian; Schiffer, Joshua T.; Rossenkhan, Raabya; Edlefsen, Paul; Morris, Lynn; Mkhize, Nonhlanhla N.; Williamson, Carolyn; Mullins, James I.; Seaton, Kelly E.; Tomaras, Georgia D.; Andrew, Philip; Mgodi, Nyaradzo; Ledgerwood, Julie E.; Cohen, Myron S.; Corey, Lawrence; Naidoo, Logashvari; Orrell, Catherine; Goepfert, Paul A.; Casapia, Martin; Sobieszczyk, Magdalena E.; Karuna, Shelly T.; Edupuganti, Srilatha

Prevention efficacy of the broadly neutralizing antibody VRC01 depends on HIV-1 envelope sequence features

广泛中和抗体VRC01的预防功效取决于HIV-1的包膜序列特征

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-01-194

OAAI

Juraska, Michal; Bai, Hongjun; deCamp, Allan C.; Magaret, Craig A.; Li, Li; Gillespie, Kevin; Carpp, Lindsay N.; Giorgi, Elena E.; Ludwig, James; Molitor, Cindy; Hudson, Aaron; Williamson, Brian D.; Espy, Nicole; Simpkins, Brian; Rudnicki, Erika; Shao, Danica; Rossenkhan, Raabya; Edlefsen, Paul T.; Westfall, Dylan H.; Deng, Wenjie; Chen, Lennie; Zhao, Hong; Bhattacharya, Tanmoy; Pankow, Alec; Murrell, Ben; Yssel, Anna; Matten, David; York, Talita; Beaume, Nicolas; Gwashu-Nyangiwe, Asanda; Ndabambi, Nonkululeko; Thebus, Ruwayhida; Karuna, Shelly T.; Morris, Lynn; Montefiori, David C.; Hural, John A.; Cohen, Myron S.; Corey, Lawrence; Rolland, Morgane; Gilbert, Peter B.; Williamson, Carolyn; Mullins, James I.

High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials

NATURE COMMUNICATIONS

IF15.7

2023-12-144

OAAI

Reeves, Daniel B.; Mayer, Bryan T.; Decamp, Allan C.; Huang, Yunda; Zhang, Bo; Carpp, Lindsay N.; Magaret, Craig A.; Juraska, Michal; Gilbert, Peter B.; Montefiori, David C.; Bar, Katharine J.; Cardozo-Ojeda, E. Fabian; Schiffer, Joshua T.; Rossenkhan, Raabya; Edlefsen, Paul; Morris, Lynn; Mkhize, Nonhlanhla N.; Williamson, Carolyn; Mullins, James I.; Seaton, Kelly E.; Tomaras, Georgia D.; Andrew, Philip; Mgodi, Nyaradzo; Ledgerwood, Julie E.; Cohen, Myron S.; Corey, Lawrence; Naidoo, Logashvari; Orrell, Catherine; Goepfert, Paul A.; Casapia, Martin; Sobieszczyk, Magdalena E.; Karuna, Shelly T.; Edupuganti, Srilatha

Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition

EBIOMEDICINE

IF10.8

2023-07-0110

OAAI

Seaton, Kelly E.; Huang, Yund; Karuna, Shelly; Heptinstall, Jack R.; Brackett, Caroline; Chiong, Kelvin; Zhang, Lily; Yates, Nicole L.; Sampson, Mark; Rudnicki, Erika; Juraska, Michal; deCamp, Allan C.; Edlefsen, Paul T.; Mullins, James I.; Williamson, Carolyn; Rossenkhan, Raabya; Giorgi, Elena E.; Kenny, Avi; Angier, Heather; Randhawa, April; Weiner, Joshua A.; Rojas, Michelle; Sarzotti-Kelsoe, Marcella; Zhang, Lu; Sawant, Sheetal; Ackerman, Margaret E.; McDermott, Adrian B.; Mascola, John R.; Hural, John; McElrath, M. Julianna; Andrew, Philip; Hidalgo, Jose A.; Clark, Jesse; Laher, Fatima; Orrell, Catherine; Frank, Ian; Gonzales, Pedro; Edupuganti, Srilatha; Mgodi, Nyaradzo; Corey, Lawrence; Morris, Lynn; Monte, David; Cohen, Myron S.; Gilbert, Peter B.; Tomaras, Georgia D.

Neutralization profiles of HIV-1 viruses from the VRC01 Antibody Mediated Prevention (AMP) trials

PLOS PATHOGENS

IF4.9

2023-06-2920

OAAI

Mkhize, Nonhlanhla N.; Yssel, Anna; Kaldine, Haajira; van Dorsten, Rebecca T.; Davis, Amanda S.; Beaume, Nicolas; Matten, David; Lambson, Bronwen; Modise, Tandile; Kgagudi, Prudence; York, Talita; Westfall, Dylan H.; Giorgi, Elena E.; Korber, Bette; Anthony, Colin; Mapengo, Rutendo E.; Bekker, Valerie; Domin, Elizabeth; Eaton, Amanda; Deng, Wenjie; DeCamp, Allan; Huang, Yunda; Gilbert, Peter B.; Gwashu-Nyangiwe, Asanda; Thebus, Ruwayhida; Ndabambi, Nonkululeko; Mielke, Dieter; Mgodi, Nyaradzo; Karuna, Shelly; Edupuganti, Srilatha; Seaman, Michael S.; Corey, Lawrence; Cohen, Myron S.; Hural, John; McElrath, M. Juliana; Mullins, James I.; Montefiori, David; Moore, Penny L.; Williamson, Carolyn; Morris, Lynn

Safety and pharmacokinetics of escalating doses of neutralising monoclonal antibody CAP256V2LS administered with and without VRC07-523LS in HIV-negative women in South Africa (CAPRISA 012B) : a phase 1, dose-escalation, randomised controlled trial

LANCET HIV

IF13

2023-04-0111

PRE

Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor

CELL REPORTS

IF6.9

2023-02-017

OAAI

Pilewski, Kelsey A.; Wall, Steven; Richardson, Simone I.; Manamela, Nelia P.; Clark, Kaitlyn; Hermanus, Tandile; Binshtein, Elad; Venkat, Rohit; Sautto, Giuseppe A.; Kramer, Kevin J.; Shiakolas, Andrea R.; Setliff, Ian; Salas, Jordan; Mapengo, Rutendo E.; Suryadevara, Naveen; Brannon, John R.; Beebout, Connor J.; Parks, Rob; Raju, Nagarajan; Frumento, Nicole; Walker, Lauren M.; Fechter, Emilee Friedman; Qin, Juliana S.; Murji, Amyn A.; Janowska, Katarzyna; Thakur, Bhishem; Lindenberger, Jared; May, Aaron J.; Huang, Xiao; Sammour, Salam; Acharya, Priyamvada; Carnahan, Robert H.; Ross, Ted M.; Haynes, Barton F.; Hadjifrangiskou, Maria; Crowe Jr, James E.; Bailey, Justin R.; Kalams, Spyros; Morris, Lynn; Georgiev, Ivelin S.

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

SCIENTIFIC REPORTS

IF3.9

2022-10-018

OAAI

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

PLOS PATHOGENS

IF4.9

2022-09-020

OAAI

Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition

NATURE MEDICINE

IF50

2022-08-2254

OAAI

Gilbert, Peter B.; Huang, Yunda; deCamp, Allan C.; Karuna, Shelly; Zhang, Yuanyuan; Magaret, Craig A.; Giorgi, Elena E.; Korber, Bette; Edlefsen, Paul T.; Rossenkhan, Raabya; Juraska, Michal; Rudnicki, Erika; Kochar, Nidhi; Huang, Ying; Carpp, Lindsay N.; Barouch, Dan H.; Mkhize, Nonhlanhla N.; Hermanus, Tandile; Kgagudi, Prudence; Bekker, Valerie; Kaldine, Haajira; Mapengo, Rutendo E.; Eaton, Amanda; Domin, Elize; West, Carley; Feng, Wenhong; Tang, Haili; Seaton, Kelly E.; Heptinstall, Jack; Brackett, Caroline; Chiong, Kelvin; Tomaras, Georgia D.; Andrew, Philip; Mayer, Bryan T.; Reeves, Daniel B.; Sobieszczyk, Magdalena E.; Garrett, Nigel; Sanchez, Jorge; Gay, Cynthia; Makhema, Joseph; Williamson, Carolyn; Mullins, James I.; Hural, John; Cohen, Myron S.; Corey, Lawrence; Montefiori, David C.; Morris, Lynn

HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies

HIV共感染为疫苗鸡尾酒的设计提供了见解，以引发广泛的中和抗体

JOURNAL OF VIROLOGY

IF3.8

2022-07-271

OAAI

Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb Lineage

JOURNAL OF VIROLOGY

IF3.8

2022-05-251