logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
Guo-li Ming 封面图

Guo-li Ming

University of Pennsylvania教授邮箱:gming@pennmedicine.upenn.edu
H指数:113
被引数:5.2万

个人简介

Research in the laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. The lab uses a combination of experimental approaches that include molecular biology, biochemistry, mouse genetics, imaging, electrophysiology, electron microscopy, optogenetic manipulations, next generation sequencing, and behavioral tests to study neural development. The scholar has been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. The scholar is interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons, and functional regeneration of mature neurons.

教育背景

  • 1994.12

    Tongji Medical University, P. R. China M.D. Medicine (OBGYN)

  • 2002.12

    University of California at San Diego, California Ph.D. Biology

工作经历

暂无内容

荣誉奖项

暂无内容

The need for a global effort to attend to human neural organoid and assembloid research

全球共同致力于人类神经类器官和类集合体研究的必要性

Science
IF45.8
2025-11-060
PRE
Sergiu P. Pașca; Paola Arlotta; Philip Campbell; Alta Charo; John H. Evans; Nita Farahany; Fred H. Gage; Peter Godfrey-Smith; Insoo Hyun; Arnold R. Kriegstein; Lucia Melloni; Guo-Li Ming; Jonathan D. Moreno; Jeremy Sugarman; Sally Temple; Giuseppe Testa; Henry T. Greely
A CHOLINERGIC NEURON-TO-TUMOR CIRCUIT ENHANCES HUMAN GLIOBLASTOMA PROGRESSION VIA SYNAPTIC AND PARACRINE MECHANISMS

一个胆碱能神经元-肿瘤回路通过突触和旁分泌机制促进人类胶质母细胞瘤进展

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Sun, Yusha; Wang, Xin; Zhang, Zhijian; Park, Kristen; Wu, Yicheng; Dong, Weifan; Zhang, Daniel; Fu, Yao; Zhang, Feng; Binder, Zev; Pai, Emily; Nasrallah, Maclean; Christian, Kimberly; O'rourke, Donald; Toni, Nicolas; Ming, Guo-li; Song, Hongjun
Growth rates of patient-derived tumor organoids reflect glioblastoma patients' heterogeneity in survival

患者来源的肿瘤类器官的生长速率反映了胶质母细胞瘤患者生存的异质性

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Scheer, Kaitlin; Yeo, Erica; Shard, Chloe; Lenin, Sakthi; Ormsby, Rebecca; Skarne, Niclas; To, Minh-Son; Toubia, John; Mittal, Parul; Young, Clifford; Patrick, Conor; Palethorpe, Helen; Mascarenhas, Annika; Tomatis, Vanesa; Brown, Anna; Tea, Melinda; Klingler-Hoffmann, Manuela; Hoffmann, Peter; Sun, Yusha; Jacob, Fadi; Wang, Xin; Nasrallah, Maclean; Binder, Zev; O'rourke, Donald; Ming, Guo-Li; Song, Hongjun; Day, Bryan; Pitson, Stuart; Brown, Michael; Poonnoose, Santosh; Gargett, Tessa; Patil, Ashwini; Ebert, Lisa; Gomez, Guillermo
Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes

跨物种分析成年海马神经发生揭示了人类特异性的基因表达，但生物学过程趋同。

Nature Neuroscience
IF20
2025-08-110
PRE
Yi Zhou; Yijing Su; Qian Yang; Jiaqi Li; Yan Hong; Taosha Gao; Yanqing Zhong; Xueting Ma; Mengmeng Jin; Xinglan Liu; Nini Yuan; Benjamin C. Kennedy; Lizhou Wang; Longying Yan; Angela N. Viaene; Ingo Helbig; Sudha K. Kessler; Joel E. Kleinman; Thomas M. Hyde; David W. Nauen; Cirong Liu; Zhen Liu; Zhiming Shen; Chao Li; Shengjin Xu; Jie He; Daniel R. Weinberger; Guo-li Ming; Hongjun Song
MONOSYNAPTIC TRACING DEFINES BRAIN-WIDE CIRCUIT CONNECTIVITY OF HUMAN GLIOBLASTOMA

单突触追踪定义了人类胶质母细胞瘤的全脑电路连接

NEURO-ONCOLOGY
IF13.4
2024-11-110
PRE
Sun, Yusha; Wang, Xin; Zhang, Daniel; Zhang, Zhijian; Bhattarai, Janardhan; Wang, Yingqi; Park, Kristen; Dong, Weifan; Yang, Qian; Zhang, Feng; Rajamani, Keerthi; Mu, Shang; Kennedy, Benjamin; Hong, Yan; Galanaugh, Jamie; Sambangi, Abhijeet; Kim, Sang Hoon; Wheeler, Garrett; Goncalves, Tiago; Wang, Qing; Geschwind, Daniel; Kawaguchi, Riki; Viaene, Angela; Helbig, Ingo; Kessler, Sudha; Hoke, Ahmet; Wang, Huadong; Xu, Fuqiang; Binder, Zev; Chen, Isaac; Pai, Emily Ling-Lin; Stone, Sara; Nasrallah, Maclean; Christian, Kimberly; Fuccillo, Marc; Toni, Nicolas; Wu, Zhuhao; O'Rourke, Donald; Ma, Minghong; Ming, Guo-li; Song, Hongjun
PATIENT-DERIVED GLIOBLASTOMA ORGANOIDS AS REAL-TIME AVATARS FOR ASSESSING RESPONSES TO CLINICAL CAR-T CELL THERAPY

患者来源的胶质母细胞瘤类器官作为实时化身，用于评估对临床car-t细胞治疗的反应

NEURO-ONCOLOGY
IF13.4
2024-11-110
PRE
Wang, Xin; Logun, Meghan; Sun, Yusha; Bagley, Stephen J.; Li, Nannan; Desai, Arati; Zhang, Daniel Y.; Nasrallah, MacLean P.; Pai, Emily Ling-Lin; Oner, Bike Su; Plesa, Gabriela; Siegel, Donald; Binder, Zev A.; Ming, Guo-li; Song, Hongjun; O'Rourke, Donald M.
Exposure to the antiretroviral drug dolutegravir impairs structure and neurogenesis in a forebrain organoid model of human embryonic cortical development

在人类胚胎皮质发育的前脑类器官模型中，暴露于抗逆转录病毒药物dolutegavir会损害结构和神经发生

FRONTIERS IN MOLECULAR NEUROSCIENCE
IF3.8
2024-11-060
OAAI
LaNoce, Emma; Zhang, Daniel Y.; Garcia-Epelboim, Alan; Su, Yijing; Sun, Yusha; Alepa, Giana; Angelucci, Angelina R.; Akay-Espinoza, Cagla; Jordan-Sciutto, Kelly L.; Song, Hongjun; Ming, Guo-li; Christian, Kimberly M.
Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation

利用深度单核RNA测序探索人类躯体感觉的神经基础

Nature Neuroscience
IF20
2024-11-040
OAAI
Huasheng Yu; Saad S. Nagi; Dmitry Usoskin; Yizhou Hu; Jussi Kupari; Otmane Bouchatta; Hanying Yan; Suna Li Cranfill; Mayank Gautam; Yijing Su; You Lu; James Wymer; Max Glanz; Phillip Albrecht; Hongjun Song; Guo-Li Ming; Stephen Prouty; John Seykora; Hao Wu; Minghong Ma; Andrew Marshall; Frank L. Rice; Mingyao Li; Håkan Olausson; Patrik Ernfors; Wenqin Luo

研究方向

Neurobiology of mental disordersNeural developmenthuman induced pluripotent stem cellscell signallingcell and molecular biology
Hongjun Song 封面图
Hongjun Song
H 指数:109论文数:544被引数:5.0万
K
Kimberly M. Christian
H 指数:36论文数:97被引数:1.2万
K
Ki‐Jun Yoon
H 指数:28论文数:99被引数:6,059
Z
Zhexing Wen
H 指数:43论文数:137被引数:1.0万
Y
Yijing Su
H 指数:28论文数:67被引数:7,908
F
Fadi Jacob
H 指数:19论文数:45被引数:7,880
T
Tang, Hengli
H 指数:0论文数:1被引数:22
X
Xuyu Qian
H 指数:20论文数:37被引数:8,353
Y
Yusha Sun
H 指数:14论文数:55被引数:1,180
W
Wei Zheng
H 指数:71论文数:772被引数:2.0万