Mario L. Suvà - Publications, H-index & Citations

Mario L. Suvà

massachusetts general hospital

57H指数

267论文数

2.5W被引数

收录论文 80

发表时间

Spatial analysis reveals the evolving organization of IDH-mutant glioma 空间分析揭示了IDH突变型胶质瘤的演变组织

Cancer Cell

IF44.5

2026-09-01

PREAI

Hoefflin, Rouven; Greenwald, Alissa C.; Darnell, Noam Galili; Mount, Christopher W.; Tiomkin, Yali; Castro, L. Nicolas Gonzalez; Wen, Zebin; Simkin, Dor; Patterson, Angelica B.; Goliand, Inna; Golani, Ofra; Fellus-Alyagor, Liat; Cohen, Marina; Joseph, Kevin; Beck, Jurgen; Ravi, Vidhya M.; Kedmi, Merav; Keren-Shaul, Hadas; Weller, Michael; Addadi, Yoseph; Neidert, Marian C.; Suva, Mario L.; Tirosh, Itay

Vorasidenib improves response to subsequent chemoradiation in a genetically engineered mouse model of IDH-mutant glioma Vorasanib在IDH突变胶质瘤的基因工程小鼠模型中改善了对后续放化疗的反应

Science Translational Medicine

IF14.6

2026-08-05

PREAI

Diana D. Shi; Ester Calvo Fernández; Vinesh T. Puliyappadamba; Tyler A. Lanman; Yi Xiao; Zebin Wen; Maria Minor; Diego Prost; Aleksandra B. Lasica; Feng Cai; Ethan Neumann; Sriram Gudipelly; Louise M. Clark; Quang-De Nguyen; Salvador Peña; Janaka Wansapura; Pranita Kaphle; Tracey Shipman; Michael M. Levitt; Mathew D. Lin; Alexander C.-Y. Tsai; Joyce H. Lee; Daniel P. Cahill; Rifaquat Rahman; Daphne A. Haas-Kogan; Timothy E. Richardson; Itay Tirosh; Payal Jain; Adriana E. Tron; Vihang Nakhate; Gilbert Youssef; Caroline Dehais; Julian Jacob; David A. Reardon; Julie J. Miller; Kalil G. Abdullah; Patrick Y. Wen; Ralph J. DeBerardinis; Lin Xu; Mehdi Touat; Katherine B. Peters; L. Nicolas Gonzalez Castro; William G. Kaelin; Mario L. Suvà; Samuel K. McBrayer

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation IDH突变型神经胶质瘤中DNA甲基化的纵向变化通过改变细胞状态分化促进疾病进展

Nature Genetics

IF29

2026-06-22

OAAI

Masashi Nomura; Ramya Raviram; Joshua S. Schiffman; Lillian Bussema; Vivian Lu; Noelle Wheeler; John J. Y. Lee; Yilin Fan; Mian Hua Zheng; Florian Ruiz; Husain Danish; Sorcha Kellett; Labeeba Nusrat; Ronan Chaligne; Jason T. Huse; W. K. Alfred Yung; Shota Tanaka; Nobuhito Saito; Sunit Das; Catherine Potenski; Dan A. Landau; Mario L. Suvà

Acquired genetic and cell-state changes in IDH-mutant glioma progression IDH突变型胶质瘤进展中的获得性遗传和细胞状态变化

Nature

IF48.5

2026-06-03

OAAI

Kevin C. Johnson; Avishay Spitzer; Frederick S. Varn; Masashi Nomura; Luciano Garofano; Tamrin Chowdhury; Anuja Lipsa; Linbin Zhang; Ester Calvo Fernández; Tanyeri Barak; A. Gulhan Ercan-Sencicek; Ayse Buket Peksen; Kevin J. Anderson; C. Mircea S. Tesileanu; Samirkumar B. Amin; Emre Kocakavuk; Dacheng Zhao; Fulvio D’Angelo; Simona Migliozzi; Lillian Bussema; Simon Gritsch; Hyo-Eun Moon; Sun Ha Paek; Franck Bielle; Alice Laurenge; Anna Luisa Di Stefano; Bertrand Mathon; Alberto Picca; Marc Sanson; Ann-Christin Hau; Frank Hertel; Kamil Grzyb; Zheng Zhao; Qianghu Wang; Tao Jiang; Julie J. Miller; Hiroaki Wakimoto; Daniel P. Cahill; Jennifer Moliterno; Murat Günel; Beth Hermes; Nader Sanai; Anna Golebiewska; Simone P. Niclou; Jason Huse; W. K. Alfred Yung; Anna Lasorella; Mario L. Suvà; Antonio Iavarone; Itay Tirosh; Roel G. W. Verhaak

A cellular epigenetic classification system for glioblastoma 胶质母细胞瘤的细胞表观遗传分类系统

Neuro-Oncology

IF13.4

2026-04-01

PREAI

Silverbush, Dana; Jurgensen, Liv; Freeburg, Nelson F.; Pooley, Channing S.; Boniolo, Fabio; Gaiti, Federico; Suva, Mario L.; Hovestadt, Volker

Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial 临床试验中单次溶瘤病毒治疗后对胶质母细胞瘤的持续性T细胞激活和细胞毒性

Cell

IF42.5

2026-02-11

PREAI

Maxime Meylan; Ye Tian; Lijian Wu; Alexander L. Ling; Daniel Kovarsky; Graham L. Barlow; Linh D. Nguyen; Jason Pyrdol; Sascha Marx; Lucas Westphal; Julius Michel; L. Nicolas Gonzalez Castro; Sydney Dumont; Andres Santos; Itay Tirosh; Mario L. Suvà; E. Antonio Chiocca; Kai W. Wucherpfennig

Deciphering the spatial architecture of transcriptional heterogeneity in glioblastoma at single cell resolution 解析胶质母细胞瘤转录异质性的空间架构：单细胞分辨率研究

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Mount, Christopher; Wen, Zebin; Greenwald, Alissa; Kovatsis, Sophia; Lu, Jack; Gerovasilis, Demi; Tirosh, Itay; Suva, Mario

Preclinical and clinical assessment of chemoradiation after mutant IDH inhibitor treatment in IDH-mutant glioma IDH突变抑制剂治疗后IDH突变胶质瘤的化学放射治疗预临床与临床评估

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Shi, Diana; Calvo-Fernandez, Ester; Puliyappadamba, Vinesh; Lanman, Tyler; Cruickshank, Aiden; Prost, Diego; Xiao, Yi; Neumann, Ethan; Gudipelly, Sriram; Clark, Louise; Kaphle, Pranita; Shipman, Tracey; Levitt, Michael; Lin, Mathew; Tsai, Alexander; Lee, Joyce; Simons, Donald; Tyagi, Ethika; Rahman, Rifaquat; De Nguyen, Quang-; Wen, Patrick; Haas-Kogan, Daphne; Yates, Kathleen; Manguso, Robert; Bardeesy, Nabeel; Bernstein, Bradley; Wu, Jingyi; Abdullah, Kalil; Jain, Payal; Tron, Adriana; Touat, Mehdi; Castro, L. Nicolas Gonzalez; Suva, Mario; Kaelin, William; Mcbrayer, Samuel

Evaluating cell state-targeting CAR-T cells in glioblastoma 评估靶向细胞状态 CAR-T 细胞在胶质母细胞瘤中的应用

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Kovatsis, Sophia; Mount, Christopher; Boxer, Emily; Zhong, Jun; Dumont, Sydney; Gerovasilis, Demi; Lu, Jack; Tirosh, Itay; Suva, Mario

Developing cell-state guided chimeric antigen receptor (CAR)-T cell therapies for IDH-mutant glioma 开发基于细胞状态指导的嵌合抗原受体（CAR）-T细胞疗法用于IDH突变型胶质瘤

NEURO-ONCOLOGY

IF13.4

2025-11-01

PREAI

Dumont, Sydney; Mount, Christopher; Gerovasilis, Demi; Kovatsis, Sophia; Lu, Jack; Zhong, Jun; Boxer, Emily; Cahill, Daniel; Tirosh, Itay; Suva, Mario

LONGITUDINAL DNA METHYLATION CHANGE FUELS DISEASE PROGRESSION THROUGH ALTERED CELL STATE DIFFERENTIATION IN IDH-MUTANT GLIOMA 纵向DNA甲基化变化通过改变细胞状态分化推动IDH突变型胶质瘤的疾病进展

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Nomura, Masashi; Ravirum, Ramya; Schiffman, Joshua S.; Bussema, Lillian; Lu, Vivian; Wheeler, Noelle; Lee, John; Fan, Yilin; Zheng, Mian Hua; Ruiz, Florian; Danish, Husain; Kellet, Sorcha; Nusrat, Labeeba; Chaligne, Ronan; Huse, Jason T.; Yung, W. K. Alfred; Tanaka, Shota; Saito, Nobuhito; Potenski, Catherine; Das, Sunit; Landau, Dan A.; Suva, Mario L.

The impact of ASC expression and NLRP1 inflammasome signaling in glioblastoma ASC表达和NLRP1炎症小体信号在胶质母细胞瘤中的影响

NEURO-ONCOLOGY

IF13.4

2025-11-01

PREAI

Hammes, Lara C.; Gohr, Florian N.; Zeyen, Thomas; Potthoff, Anna-Laura; Jenster, Lea-Marie; Klein, Rebecca; Kempchen, Tim N.; Effern, Maike; Pregler, Barbara E. F.; Weller, Johannes; Layer, Julian P.; Yong, Michelle; Broske, Bianca; Melhem, Ahmad; Goschzik, Tobias; Dorner, Evelyn; Dreschmann, Verena; Wichtmann, Barbara D.; Foltyn-Dumitru, Martha; Herms, Stefan; Gielen, Gerrit H.; Suva, Mario L.; Schneider, Matthias; Waha, Andreas; Pietsch, Torsten; Herrlinger, Ulrich; Schmidt, Florian, I; Holzel, Michael; Friker, Lea L.

Single-cell RNA sequencing of cerebrospinal fluid in CARv3-TEAM-E treated glioblastoma 脑脊液的单细胞RNA测序在CARv3-TEAM-E治疗的胶质母细胞瘤中

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Gerovasilis, Demi; Mount, Christopher; Kovatsis, Sophia K.; Zhong, Jun; Chowdhury, Md Raihan; King, Maxx; Curry, William T.; Gerstner, Elizabeth R.; Gallagher, Kathleen; Choi, Bryan D.; Suva, Mario; Maus, Marcela, V

Uncovering the metabolic programs underlying malignant cell state heterogeneity in glioblastoma 揭示胶质母细胞瘤中恶性细胞状态异质性背后的代谢程序

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Jucht, Alexander; Ge, Maolin; Chanoch-Myers, Rony; Ruiz, Florian; Baquer, Gerard; Greenwald, Alissa; Yang, Min; Hara, Toshiro; Fan, Yilin; Pooley, Channing; Gerovasilis, Demi; Couturier, Charles; Agar, Nathalie; Tirosh, Itay; Bar-Peled, Liron; Suva, Mario

Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis 突变IDH沉默GSX2以重编程神经祖细胞命运并促进胶质瘤发生

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Xiao, Yi; Shi, Diana; Guo, Lei; Neumann, Ethan; Levitt, Michael; Kaphle, Pranita; Shipman, Tracey; Li, Haocheng; Cai, Feng; Ramirez, Denise; Zacharias, Lauren; Chen, Zhenkang; Lin, Mathew; Thidil, Vinesh; Mathews, Thomas; Mishra, Prashant; Kim, Yoon Jung; Xu, Jian; Mack, Stephen; Deberardinis, Ralph; Tirosh, Itay; Suva, Mario; Xu, Lin; Abdullah, Kalil; Mcbrayer, Samuel

CELL STATE TARGETING CAR T CELL THERAPIES FOR IDH MUTANT GLIOMAS 靶向细胞状态 CAR T 细胞疗法治疗 IDH 突变型胶质瘤

NEURO-ONCOLOGY

IF13.4

2025-10-01

OAAI

Mount, C.; Dumont, S.; Gerovasilis, D.; Boxer, E.; Kovatsis, S.; Lu, J.; Zhong, J.; Cahill, D.; Tirosh, I; Suva, M.

DECIPHERING THE LONGITUDINAL TRAJECTORIES OF GLIOBLASTOMA ECOSYSTEMS BY INTEGRATIVE SINGLE-CELL GENOMICS 通过整合单细胞基因组学解析胶质母细胞瘤生态系统的纵向轨迹

NEURO-ONCOLOGY

IF13.4

2025-10-01

OAAI

Spitzer, A.; Johnson, K.; Nomura, M.; Garofano, L.; Nehar-Belaid, D.; Galili Darnell, N.; Greenwald, A.; Bussema, L.; Oh, Y.; Varn, F. S.; D'Angelo, F.; Gritsch, S.; Anderson, K. J.; Migliozzi, S.; Gonzalez Castro, L.; Chowdhury, T.; Robine, N.; Reeves, C.; Park, J.; Lipsa, A.; Hertel, F.; Golebiewska, A.; Niclou, S.; Nusrat, L.; Kellett, S.; Das, S.; Moon, H.; Paek, S.; Bielle, F.; Laurenge, A.; Di Stefano, A.; Mathon, B.; Picca, A.; Sanson, M.; Tanaka, S.; Saito, N.; Ashley, D. M.; Keir, S. T.; Ligon, K. L.; Huse, J. T.; Yung, W.; Lasorella, A.; Iavarone, A.; Verhaak, R.; Tirosh, I; Suva, M. L.

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma 癌症细胞与免疫细胞之间的相互作用驱动胶质母细胞瘤向类间质状态转变

Cancer Cell

IF44.5

2025-05-27

PREAI

Toshiro Hara; Rony Chanoch-Myers; Nathan D. Mathewson; Chad Myskiw; Lyla Atta; Lillian Bussema; Stephen W. Eichhorn; Alissa C. Greenwald; Gabriela S. Kinker; Christopher Rodman; L. Nicolas Gonzalez Castro; Hiroaki Wakimoto; Orit Rozenblatt-Rosen; Xiaowei Zhuang; Jean Fan; Tony Hunter; Inder M. Verma; Kai W. Wucherpfennig; Aviv Regev; Mario L. Suvà; Itay Tirosh

Like, share, and spike: Glioblastoma progenitors influence neuronal excitability at the glioma-neural interface 点赞、分享与激增：胶质母细胞瘤前体细胞影响肿瘤-神经界面处的神经元兴奋性

NEURON

IF15

2025-01-01

PREAI

Mount, Christopher W.; Suva, Mario L.

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas IDH突变型神经胶质瘤进展过程中细胞状态的演变和致癌驱动因素

NATURE CANCER

IF28.5

2024-11-21

PREAI

Wu, Jingyi; Castro, L. Nicolas Gonzalez; Battaglia, Sofia; El Farran, Chadi A.; D'Antonio, Joshua P.; Miller, Tyler E.; Suva, Mario L.; Bernstein, Bradley E.

研究方向