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Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health 肝脏X受体-α 的破坏性突变具有肝毒性，并暗示肝脏健康中的胆固醇感应 Lockhart, Sam M.; Muso, Milan; Zvetkova, Ilona; Lam, Brian Y. H.; Ferrari, Alessandra; Schoenmakers, Erik; Duckett, Katie; Leslie, Jack; Collins, Amy; Romartinez-Alonso, Beatriz; Tadross, John A.; Jia, Raina; Gardner, Eugene J.; Kentistou, Katherine; Zhao, Yajie; Day, Felix; Moerseburg, Alexander; Rainbow, Kara; Rimmington, Debra; Mastantuoni, Matteo; Harrison, James; Nus, Meritxell; Guma'a, Khalid; Sherratt-Mayhew, Sam; Jiang, Xiao; Smith, Katherine R.; Paul, Dirk S.; Jenkins, Benjamin; Koulman, Albert; Pietzner, Maik; Langenberg, Claudia; Wareham, Nicholas; Yeo, Giles S.; Chatterjee, Krishna; Schwabe, John; Oakley, Fiona; Mann, Derek A.; Tontonoz, Peter; Coll, Anthony P.; Ong, Ken; Perry, John R. B.; O'Rahilly, Stephen 分享 收藏
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Proteomic signatures improve risk prediction for common and rare diseases 蛋白质组学特征改善了常见和罕见疾病的风险预测 Carrasco-Zanini, Julia; Pietzner, Maik; Davitte, Jonathan; Surendran, Praveen; Croteau-Chonka, Damien C.; Robins, Chloe; Torralbo, Ana; Tomlinson, Christopher; Gruenschlaeger, Florian; Fitzpatrick, Natalie; Ytsma, Cai; Kanno, Tokuwa; Gade, Stephan; Freitag, Daniel; Ziebell, Frederik; Haas, Simon; Denaxas, Spiros; Betts, Joanna C.; Wareham, Nicholas J.; Hemingway, Harry; Scott, Robert A.; Langenberg, Claudia 分享 收藏
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Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics 使用孟德尔随机化和肿瘤空间转录组学确定总体，侵袭性和早发性前列腺癌的蛋白质组学危险因素 Desai, Trishna A.; Hedman, Asa K.; Dimitriou, Marios; Koprulu, Mine; Figiel, Sandy; Yin, Wencheng; Johansson, Mattias; Watts, Eleanor L.; Atkins, Joshua R.; Sokolov, Aleksandr, V; Schioeth, Helgi B.; Gunter, Marc J.; Tsilidis, Konstantinos K.; Martin, Richard M.; Pietzner, Maik; Langenberg, Claudia; Mills, Ian G.; Lamb, Alastair D.; Maelarstig, Anders; Key, Tim J.; Travis, Ruth C.; Smith-Byrne, Karl 分享 收藏
Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats 病史可预测整个表型组的疾病发作，并能够对新出现的健康威胁做出快速反应 Steinfeldt, Jakob; Wild, Benjamin; Buergel, Thore; Pietzner, Maik; Upmeier zu Belzen, Julius; Vauvelle, Andre; Hegselmann, Stefan; Denaxas, Spiros; Hemingway, Harry; Langenberg, Claudia; Landmesser, Ulf; Deanfield, John; Eils, Roland 分享 收藏
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers 在2074循环蛋白质中确定癌症治疗靶点和9种癌症的风险 Smith-Byrne, Karl; Hedman, Asa; Dimitriou, Marios; Desai, Trishna; Sokolov, Alexandr V.; Schioth, Helgi B.; Koprulu, Mine; Pietzner, Maik; Langenberg, Claudia; Atkins, Joshua; Penha, Ricardo Cortez; Mckay, James; Brennan, Paul; Zhou, Sirui; Richards, Brent J.; Yarmolinsky, James; Martin, Richard M.; Borlido, Joana; Mu, Xinmeng J.; Butterworth, Adam; Shen, Xia; Wilson, Jim; Assimes, Themistocles L.; Hung, Rayjean J.; Amos, Christopher; Purdue, Mark; Rothman, Nathaniel; Chanock, Stephen; Travis, Ruth C.; Johansson, Mattias; Maelarstig, Anders 分享 收藏
Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using mendelian randomization and tumor spatial transcriptomics Desai, Trishna A.; Hedman, Asa K.; Dimitriou, Marios; Koprulu, Mine; Figiel, Sandy; Yin, Wencheng; Johansson, Matthias; Watts, Eleanor L.; Atkins, Joshua R.; Sokolov, Aleksandr V.; Schioth, Helgi B.; Gunter, Marc J.; Tsilidis, Konstantinos K.; Martin, Richard M.; Pietzner, Maik; Langenberg, Claudia; Mills, Ian G.; Lamb, Alastair D.; Malarstig, Anders; The, Tim J. Key; Travis, Ruth C.; Smith-Byrne, Karl 分享 收藏
Systemic proteome adaptions to 7-day complete caloric restriction in humans 人类对7天完全热量限制的系统蛋白质组适应 Pietzner, Maik; Uluvar, Burulca; Kolnes, Kristoffer J.; Jeppesen, Per B.; Frivold, S. Victoria; Skattebo, Oyvind; Johansen, Egil I.; Skalhegg, Bjorn S.; Wojtaszewski, Jorgen F. P.; Kolnes, Anders J.; Yeo, Giles S. H.; O'Rahilly, Stephen; Jensen, Jorgen; Langenberg, Claudia 分享 收藏
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications 多性状分析表征甲状腺功能的遗传学，并确定与临床意义的因果关系 Sterenborg, Rosalie B. T. M.; Steinbrenner, Inga; Li, Yong; Bujnis, Melissa N.; Naito, Tatsuhiko; Marouli, Eirini; Galesloot, Tessel E.; Babajide, Oladapo; Andreasen, Laura; Astrup, Arne; Asvold, Bjorn Olav; Bandinelli, Stefania; Beekman, Marian; Beilby, John P.; Bork-Jensen, Jette; Boutin, Thibaud; Brody, Jennifer A.; Brown, Suzanne J.; Brumpton, Ben; Campbell, Purdey J.; Cappola, Anne R.; Ceresini, Graziano; Chaker, Layal; Chasman, Daniel, I; Concas, Maria Pina; de Almeida, Rodrigo Coutinho; Cross, Simone M.; Cucca, Francesco; Deary, Ian J.; Kjaergaard, Alisa Devedzic; Tcheugui, Justin B. Echouffo; Ellervik, Christina; Eriksson, Johan G.; Ferrucci, Luigi; Freudenberg, Jan; Fuchsberger, Christian; Gieger, Christian; Giulianini, Franco; Gogele, Martin; Graham, Sarah E.; Grarup, Niels; Gunjaca, Ivana; Hansen, Torben; Harding, Barbara N.; Harris, Sarah E.; Haunso, Stig; Hayward, Caroline; Hui, Jennie; Ittermann, Till; Jukema, J. Wouter; Kajantie, Eero; Kanters, Jurgen K.; Karhus, Line L.; Kiemeney, Lambertus A. L. M.; Kloppenburg, Margreet; Kuhnel, Brigitte; Lahti, Jari; Langenberg, Claudia; Lapauw, Bruno; Leese, Graham; Li, Shuo; Liewald, David C. M.; Linneberg, Allan; Lominchar, Jesus V. T.; Luan, Jian'an; Martin, Nicholas G.; Matana, Antonela; Meima, Marcel E.; Meitinger, Thomas; Meulenbelt, Ingrid; Mitchell, Braxton D.; Mollehave, Line T.; Mora, Samia; Naitza, Silvia; Nauck, Matthias; Netea-Maier, Romana T.; Noordam, Raymond; Nursyifa, Casia; Okada, Yukinori; Onano, Stefano; Papadopoulou, Areti; Palmer, Colin N. A.; Pattaro, Cristian; Pedersen, Oluf; Peters, Annette; Pietzner, Maik; Polasek, Ozren; Pramstaller, Peter P.; Psaty, Bruce M.; Punda, Ante; Ray, Debashree; Redmond, Paul; Richards, J. Brent; Ridker, Paul M.; Russ, Tom C.; Ryan, Kathleen A.; Olesen, Morten Salling; Schultheiss, Ulla T.; Selvin, Elizabeth; Siddiqui, Moneeza K.; Sidore, Carlo; Slagboom, P. Eline; Sorensen, Thorkild I. A.; Soto-Pedre, Enrique; Spector, Tim D.; Spedicati, Beatrice; Srinivasan, Sundararajan; Starr, John M.; Stott, David J.; Tanaka, Toshiko; Torlak, Vesela; Trompet, Stella; Tuhkanen, Johanna; Uitterlinden, Andre G.; van den Akker, Erik B.; van den Eynde, Tibbert; van der Klauw, Melanie M.; van Heemst, Diana; Verroken, Charlotte; Visser, W. Edward; Vojinovic, Dina; Volzke, Henry; Waldenberger, Melanie; Walsh, John P.; Wareham, Nicholas J.; Weiss, Stefan; Willer, Cristen J.; Wilson, Scott G.; Wolffenbuttel, Bruce H. R.; Wouters, Hanneke J. C. M.; Wright, Margaret J.; Yang, Qiong; Zemunik, Tatijana; Zhou, Wei; Zhu, Gu; Zollner, Sebastian; Smit, Johannes W. A.; Peeters, Robin P.; Kottgen, Anna; Teumer, Alexander; Medici, Marco 分享 收藏
Genetic determinants of complement activation in the general population Noce, Damia; Foco, Luisa; Orth-Holler, Dorothea; Konig, Eva; Barbieri, Giulia; Pietzner, Maik; Ghasemi-Semeskandeh, Dariush; Coassin, Stefan; Fuchsberger, Christian; Gogele, Martin; Del Greco, M. Fabiola; De Grandi, Alessandro; Summerer, Monika; Wheeler, Eleanor; Langenberg, Claudia; Lass-Florl, Cornelia; Pramstaller, Peter Paul; Kronenberg, Florian; Wurzner, Reinhard; Pattaro, Cristian 分享 收藏
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism (vol 14, 3280, 2023) Iglesias, Maria Jesus; Sanchez-Rivera, Laura; Ibrahim-Kosta, Manal; Naudin, Clement; Munsch, Gaelle; Goumidi, Louisa; Farm, Maria; Smith, Philip M.; Thibord, Florian; Kral-Pointner, Julia Barbara; Hong, Mun-Gwan; Suchon, Pierre; Germain, Marine; Schrottmaier, Waltraud; Dusart, Philip; Boland, Anne; Kotol, David; Edfors, Fredrik; Koprulu, Mine; Pietzner, Maik; Langenberg, Claudia; Damrauer, Scott M.; Johnson, Andrew D.; Klarin, Derek M.; Smith, Nicholas L.; Smadja, David M.; Holmstroem, Margareta; Magnusson, Maria; Silveira, Angela; Uhlen, Mathias; Renne, Thomas; Martinez-Perez, Angel; Emmerich, Joseph; Deleuze, Jean-Francois; Antovic, Jovan; Soria Fernandez, Jose Manuel; Assinger, Alice; Schwenk, Jochen M.; Souto Andres, Joan Carles; Morange, Pierre-Emmanuel; Butler, Lynn Marie; Tregouet, David-Alexandre; Odeberg, Jacob 分享 收藏
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