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Sex-Specific Subcutaneous Adipose Tissue Transcriptome in Obesity: Insights From Monozygotic Twin Pairs Discordant for BMI 肥胖症中性别特异的皮下脂肪组织转录组：来自BMI不一致的单卵双胞胎对的见解 Haltia, Hanna; Muniandy, Maheswary; Heinonen, Sini; Saari, Sina; Alvarez, Marcus; Hakkarainen, Antti; Lundbom, Jesper; Kuula, Juho; Groop, Per-Henrik; Kaprio, Jaakko; Pajukanta, Paivi; Pietilainen, Kirsi H.; van der Kolk, Birgitta W. 分享 收藏
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Indole-3-propionic acid promotes hepatic stellate cells inactivation Ilha, Mariana; Sehgal, Ratika; Matilainen, Johanna; Rilla, Kirsi; Kaminska, Dorota; Gandhi, Shrey; Mannisto, Ville; Ling, Charlotte; Romeo, Stefano; Pajukanta, Paeivi; Pirinen, Eija; Virtanen, Kirsi A.; Pietilainen, Kirsi H.; Vaittinen, Maija; Pihlajamaki, Jussi 分享 收藏
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease 划分的多基因风险评分可识别代谢功能障碍相关的脂肪性肝病的不同类型 Jamialahmadi, Oveis; De Vincentis, Antonio; Tavaglione, Federica; Malvestiti, Francesco; Li-Gao, Ruifang; Mancina, Rosellina M.; Alvarez, Marcus; Gelev, Kyla; Maurotti, Samantha; Vespasiani-Gentilucci, Umberto; Rosendaal, Frits Richard; Kozlitina, Julia; Pajukanta, Paeivi; Pattou, Francois; Valenti, Luca; Romeo, Stefano 分享 收藏
A novel long non-coding RNA connects obesity to impaired adipocyte function 一种新的长链非编码RNA将肥胖与受损的脂肪细胞功能联系起来 Lluch, Aina; Latorre, Jessica; Oliveras-Canellas, Nuria; Fernandez-Sanchez, Ana; Moreno-Navarrete, Jose M.; Castells-Nobau, Anna; Comas, Ferran; Buxo, Maria; Rodriguez-Hermosa, Jose I.; Ballester, Maria; Espadas, Isabel; Martin-Montalvo, Alejandro; Zhang, Birong; Zhou, You; Burkhardt, Ralph; Hoering, Marcus; Liebisch, Gerhard; Castellanos-Rubio, Ainara; Santin, Izortze; Kar, Asha; Laakso, Markku; Pajukanta, Paeivi; Olkkonen, Vesa M.; Fernandez-Real, Jose M.; Ortega, Francisco J. 分享 收藏
An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns Deal, Milena; Kar, Asha; Lee, Seung Hyuk T.; Alvarez, Marcus; Rajkumar, Sandhya; Arasu, Uma Thanigai; Kaminska, Dorota; Mannisto, Ville; Heinonen, Sini; van der Kolk, Birgitta W.; Sailakivi, Ulla; Saarinen, Tuure; Juuti, Anne; Pihlajamaki, Jussi; Kaikkonen, Minna U.; Laakso, Markku; Pietilainen, Kirsi H.; Pajukanta, Paivi 分享 收藏
Single nucleus RNA-sequencing integrated into risk variant Lee, Seung Hyuk T.; Garske, Kristina M.; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N.; Pan, David Z.; Ord, Tiit; Kaminska, Dorota; Mannisto, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G.; Pisegna, Joseph R.; Pietilainen, Kirsi H.; Pihlajamaki, Jussi; Kaikkonen, Minna U.; Pajukanta, Paeivi 分享 收藏
Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries An, Ulzee; Pazokitoroudi, Ali; Alvarez, Marcus; Huang, Lianyun; Bacanu, Silviu; Schork, Andrew J.; Kendler, Kenneth; Pajukanta, Paeivi; Flint, Jonathan; Zaitlen, Noah; Cai, Na; Dahl, Andy; Sankararaman, Sriram 分享 收藏
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Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits Brotman, Sarah M.; Oravilahti, Anniina; Rosen, Jonathan D.; Alvarez, Marcus; Heinonen, Sini; van der Kolk, Birgitta W.; Silva, Lilian Fernandes; Perrin, Hannah J.; Vadlamudi, Swarooparani; Pylant, Cortney; Deochand, Sonia; Basta, Patricia V.; Valone, Jordan M.; Narain, Morgan N.; Stringham, Heather M.; Boehnke, Michael; Kuusisto, Johanna; Love, Michael I.; Pietilainen, Kirsi H.; Pajukanta, Paivi; Laakso, Markku; Mohlke, Karen L. 分享 收藏
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T.; Pan, David Z.; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Ord, Tiit; Benhammou, Jihane N.; Wabitsch, Martin; Pisegna, Joseph R.; Mannisto, Ville; Pietilainen, Kirsi H.; Laakso, Markku; Sinsheimer, Janet S.; Kaikkonen, Minna U.; Pihlajamaki, Jussi; Pajukanta, Paivi 分享 收藏
Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism Jersin, Regine A.; Tallapragada, Divya Sri Priyanka; Skartveit, Linn; Bjune, Mona S.; Muniandy, Maheswary; Lee-Odegard, Sindre; Heinonen, Sini; Alvarez, Marcus; Birkeland, Kare Inge; Drevon, Christian Andre; Pajukanta, Paeivi; McCann, Adrian; Pietilainen, Kirsi H.; Claussnitzer, Melina; Mellgren, Gunnar; Dankel, Simon N. 分享 收藏
Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice Hui, Simon T.; Gong, Lili; Swichkow, Chantle; Blencowe, Montgomery; Kaminska, Dorota; Diamante, Graciel; Pan, Calvin; Dalsania, Meet; French, Samuel W.; Magyar, Clara E.; Pajukanta, Paivi; Pihlajamaki, Jussi; Bostrom, Kristina I.; Yang, Xia; Lusis, Aldons J. 分享 收藏
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells Yang, Jiekun; Vamvini, Maria; Nigro, Pasquale; Ho, Li-Lun; Galani, Kyriakitsa; Alvarez, Marcus; Tanigawa, Yosuke; Renfro, Ashley; Carbone, Nicholas P.; Laakso, Markku; Agudelo, Leandro Z.; Pajukanta, Paivi; Hirshman, Michael F.; Middelbeek, Roeland J. W.; Grove, Kevin; Goodyear, Laurie J.; Kellis, Manolis 分享 收藏
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids 了解脂质非编码遗传变异的多层功能基因组分析 Ramdas, Shweta; Judd, Jonathan; Graham, Sarah E.; Kanoni, Stavroula; Wang, Yuxuan; Surakka, Ida; Wenz, Brandon; Clarke, Shoa L.; Chesi, Alessandra; Wells, Andrew; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J. M.; Wu, Kuan-Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben M.; Rasheed, Humaira; Havulinna, Aki S.; Veturi, Yogasudha; Pacheco, Jennifer Allen; Rosenthal, Elisabeth A.; Lingren, Todd; Feng, QiPing; Kullo, Iftikhar J.; Narita, Akira; Takayama, Jun; Martin, Hilary C.; Hunt, Karen A.; Trivedi, Bhavi; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E.; Campbell, Archie; Lin, Kuang; Millwood, Iona Y.; Rasheed, Asif; Hindy, George; Faul, Jessica D.; Zhao, Wei; Weir, David R.; Turman, Constance; Huang, Hongyan; Graff, Mariaelisa; Choudhury, Ananyo; Sengupta, Dhriti; Mahajan, Anubha; Brown, Michael R.; Zhang, Weihua; Yu, Ketian; Schmidt, Ellen M.; Pandit, Anita; Gustafsson, Stefan; Yin, Xianyong; Luan, Jian'an; Zhao, Jing-Hua; Matsuda, Fumihiko; Jang, Hye-Mi; Yoon, Kyungheon; Medina-Gomez, Carolina; Pitsillides, Achilleas; Hottenga, Jouke Jan; Wood, Andrew R.; Ji, Yingji; Gao, Zishan; Haworth, Simon; Mitchell, Ruth E.; Chai, Jin Fang; Aadahl, Mette; Bjerregaard, Anne A.; Yao, Jie; Manichaikul, Ani; Lee, Wen-Jane; Hsiung, Chao Agnes; Warren, Helen R.; Ramirez, Julia; Bork-Jensen, Jette; Karhus, Line L.; Goel, Anuj; Sabater-Lleal, Maria; Noordam, Raymond; Mauro, Pala; Matteo, Floris; McDaid, Aaron F.; Marques-Vidal, Pedro; Wielscher, Matthias; Trompet, Stella; Sattar, Naveed; Mollehave, Line T.; Munz, Matthias; Zeng, Lingyao; Huang, Jianfeng; Yang, Bin; Poveda, Alaitz; Kurbasic, Azra; Schonherr, Sebastian; Forer, Lukas; Scholz, Markus; Galesloot, Tessel E.; Bradfield, Jonathan P.; Ruotsalainen, Sanni E.; Daw, E. Warwick; Zmuda, Joseph M.; Mitchell, Jonathan S.; Fuchsberger, Christian; Christensen, Henry; Brody, Jennifer A.; Le, Phuong; Feitosa, Mary F.; Wojczynski, Mary K.; Hemerich, Daiane; Preuss, Michael; Mangino, Massimo; Christofidou, Paraskevi; Verweij, Niek; Benjamins, Jan W.; Engmann, Jorgen; Noah, Tsao L.; Verma, Anurag; Slieker, Roderick C.; Lo, Ken Sin; Zilhao, Nuno R.; Kleber, Marcus E.; Delgado, Graciela E.; Huo, Shaofeng; Ikeda, Daisuke D.; Iha, Hiroyuki; Yang, Jian; Liu, Jun; Demirkan, Ayse; Leonard, Hampton L.; Marten, Jonathan; Emmel, Carina; Schmidt, Borge; Smyth, Laura J.; Canadas-Garre, Marisa; Wang, Chaolong; Nakatochi, Masahiro; Wong, Andrew; Hutri-Kahonen, Nina; Sim, Xueling; Xia, Rui; Huerta-Chagoya, Alicia; Fernandez-Lopez, Juan Carlos; Lyssenko, Valeriya; Nongmaithem, Suraj S.; Sankareswaran, Alagu; Irvin, Marguerite R.; Oldmeadow, Christopher; Kim, Han-Na; Ryu, Seungho; Timmers, Paul R. H. J.; Arbeeva, Liubov; Dorajoo, Rajkumar; Lange, Leslie A.; Prasad, Gauri; Lores-Motta, Laura; Pauper, Marc; Long, Jirong; Li, Xiaohui; Theusch, Elizabeth; Takeuchi, Fumihiko; Spracklen, Cassandra N.; Loukola, Anu; Bollepalli, Sailalitha; Warner, Sophie C.; Wang, Ya Xing; Wei, Wen B.; Nutile, Teresa; Ruggiero, Daniela; Sung, Yun Ju; Chen, Shufeng; Liu, Fangchao; Yang, Jingyun; Kentistou, Katherine A.; Banas, Bernhard; Morgan, Anna; Meidtner, Karina; Bielak, Lawrence F.; Smith, Jennifer A.; Hebbar, Prashantha; Farmaki, Aliki-Eleni; Hofer, Edith; Lin, Maoxuan; Concas, Maria Pina; Vaccargiu, Simona; van der Most, Peter J.; Pitkanen, Niina; Cade, Brian E.; van der Laan, Sander W.; Chitrala, Kumaraswamy Naidu; Weiss, Stefan; Bentley, Amy R.; Doumatey, Ayo P.; Adeyemo, Adebowale A.; Lee, Jong Young; Petersen, Eva R. B.; Nielsen, Aneta A.; Choi, Hyeok Sun; Nethander, Maria; Freitag-Wolf, Sandra; Southam, Lorraine; Rayner, Nigel W.; Wang, Carol A.; Lin, Shih-Yi; Wang, Jun-Sing; Couture, Christian; Lyytikainen, Leo-Pekka; Nikus, Kjell; Cuellar-Partida, Gabriel; Vestergaard, Henrik; Hidalgo, Bertha; Giannakopoulou, Olga; Cai, Qiuyin; Obura, Morgan O.; van Setten, Jessica; He, Karen Y.; Tang, Hua; Terzikhan, Natalie; Shin, Jae Hun; Jackson, Rebecca D.; Reiner, Alexander P.; Martin, Lisa Warsinger; Chen, Zhengming; Li, Liming; Kawaguchi, Takahisa; Thiery, Joachim; Bis, Joshua C.; Launer, Lenore J.; Li, Huaixing; Nalls, Mike A.; Raitakari, Olli T.; Ichihara, Sahoko; Wild, Sarah H.; Nelson, Christopher P.; Campbell, Harry; Jager, Susanne; Nabika, Toru; Al-Mulla, Fahd; Niinikoski, Harri; Braund, Peter S.; Kolcic, Ivana; Kovacs, Peter; Giardoglou, Tota; Katsuya, Tomohiro; de Kleijn, Dominique; de Borst, Gert J.; Kim, Eung Kweon; Adams, Hieab H. H.; Ikram, M. Arfan; Zhu, Xiaofeng; Asselbergs, Folkert W.; Kraaijeveld, Adriaan O.; Beulens, Joline W. J.; Shu, Xiao-Ou; Rallidis, Loukianos S.; Pedersen, Oluf; Hansen, Torben; Mitchell, Paul; Hewitt, Alex W.; Kahonen, Mika; Perusse, Louis; Bouchard, Claude; Tonjes, Anke; Chen, Yii-Der Ida; Pennell, Craig E.; Mori, Trevor A.; Lieb, Wolfgang; Franke, Andre; Ohlsson, Claes; Mellstrom, Dan; Cho, Yoon Shin; Lee, Hyejin; Yuan, Jian-Min; Koh, Woon-Puay; Rhee, Sang Youl; Woo, Jeong-Taek; Heid, Iris M.; Stark, Klaus J.; Zimmermann, Martina E.; Volzke, Henry; Homuth, Georg; Evans, Michele K.; Zonderman, Alan B.; Polasek, Ozren; Pasterkamp, Gerard; Hoefer, Imo E.; Redline, Susan; Pahkala, Katja; Oldehinkel, Albertine J.; Snieder, Harold; Biino, Ginevra; Schmidt, Reinhold; Schmidt, Helena; Bandinelli, Stefania; Dedoussis, George; Thanaraj, Thangavel Alphonse; Peyser, Patricia A.; Kato, Norihiro; Schulze, Matthias B.; Girotto, Giorgia; Boger, Carsten A.; Jung, Bettina; Joshi, Peter K.; Bennett, David A.; De Jager, Philip L.; Lu, Xiangfeng; Mamakou, Vasiliki; Brown, Morris; Caulfield, Mark J.; Munroe, Patricia B.; Guo, Xiuqing; Ciullo, Marina; Jonas, Jost B.; Samani, Nilesh J.; Kaprio, Jaakko; Pajukanta, Paivi; Tusie-Luna, Teresa; Aguilar-Salinas, Carlos A.; Adair, Linda S.; Bechayda, Sonny Augustin; de Silva, H. Janaka; Wickremasinghe, Ananda R.; Krauss, Ronald M.; Wu, Jer-Yuarn; Zheng, Wei; den Hollander, Anneke, I; Bharadwaj, Dwaipayan; Correa, Adolfo; Wilson, James G.; Lind, Lars; Heng, Chew-Kiat; Nelson, Amanda E.; Golightly, Yvonne M.; Wilson, James F.; Penninx, Brenda; Kim, Hyung-Lae; Attia, John; Scott, Rodney J.; Rao, D. C.; Arnett, Donna K.; Walker, Mark; Scott, Laura J.; Koistinen, Heikki A.; Chandak, Giriraj R.; Mercader, Josep M.; Villalpando, Clicerio Gonzalez; Orozco, Lorena; Fornage, Myriam; Tai, E. Shyong; van Dam, Rob M.; Lehtimaki, Terho; Chaturvedi, Nish; Yokota, Mitsuhiro; Liu, Jianjun; Reilly, Dermot F.; McKnight, Amy Jayne; Kee, Frank; Jockel, Karl-Heinz; McCarthy, Mark, I; Palmer, Colin N. A.; Vitart, Veronique; Hayward, Caroline; Simonsick, Eleanor; van Duijn, Cornelia M.; Jin, Zi-Bing; Lu, Fan; Hishigaki, Haretsugu; Lin, Xu; Marz, Winfried; Gudnason, Vilmundur; Tardif, Jean-Claude; Lettre, Guillaume; Hart, Leen M. T.; Elders, Petra J. M.; Rader, Daniel J.; Damrauer, Scott M.; Kumari, Meena; Kivimaki, Mika; van der Harst, Pim; Spector, Tim D.; Loos, Ruth J. F.; Province, Michael A.; Parra, Esteban J.; Cruz, Miguel; Psaty, Bruce M.; Brandslund, Ivan; Pramstaller, Peter P.; Rotimi, Charles N.; Christensen, Kaare; Ripatti, Samuli; Widen, Elisabeth; Hakonarson, Hakon; Grant, Struan F. A.; Kiemeney, Lambertus; de Graaf, Jacqueline; Loeffler, Markus; Kronenberg, Florian; Gu, Dongfeng; Erdmann, Jeanette; Schunkert, Heribert; Franks, Paul W.; Linneberg, Allan; Jukema, J. Wouter; Khera, Amit, V; Mannikko, Minna; Jarvelin, Marjo-Riitta; Kutalik, Zoltan; Francesco, Cucca; Mook-Kanamori, Dennis O.; van Dijk, Ko Willems; Watkins, Hugh; Strachan, David P.; Grarup, Niels; Sever, Peter; Poulter, Neil; Sheu, Wayne Huey-Herng; Rotter, Jerome, I; Dantoft, Thomas M.; Karpe, Fredrik; Neville, Matt J.; Timpson, Nicholas J.; Cheng, Ching-Yu; Wong, Tien-Yin; Khor, Chiea Chuen; Li, Hengtong; Sabanayagam, Charumathi; Peters, Annette; Gieger, Christian; Hattersley, Andrew T.; Pedersen, Nancy L.; Magnusson, Patrik K. E.; Boomsma, Dorret, I; de Geus, Eco J. C.; Cupples, L. Adrienne; van Meurs, Joyce B. J.; Ikram, Arfan; Ghanbari, Mohsen; Gordon-Larsen, Penny; Huang, Wei; Kim, Young Jin; Tabara, Yasuharu; Wareham, Nicholas J.; Langenberg, Claudia; Zeggini, Eleftheria; Tuomilehto, Jaakko; Kuusisto, Johanna; Laakso, Markku; Ingelsson, Erik; Abecasis, Goncalo; Chambers, John C.; Kooner, Jaspal S.; de Vries, Paul S.; Morrison, Alanna C.; Hazelhurst, Scott; Ramsay, Michele; North, Kari E.; Daviglus, Martha; Kraft, Peter; Martin, Nicholas G.; Whitfield, John B.; Abbas, Shahid; Saleheen, Danish; Walters, Robin G.; Holmes, Michael, V; Black, Corri; Smith, Blair H.; Baras, Aris; Justice, Anne E.; Buring, Julie E.; Ridker, Paul M.; Chasman, Daniel, I; Kooperberg, Charles; Tamiya, Gen; Yamamoto, Masayuki; van Heel, David A.; Trembath, Richard C.; Wei, Wei-Qi; Jarvik, Gail P.; Namjou, Bahram; Hayes, M. Geoffrey; Ritchie, Marylyn D.; Jousilahti, Pekka; Salomaa, Veikko; Hveem, Kristian; Asvold, Bjorn Olav; Kubo, Michiaki; Kamatani, Yoichiro; Okada, Yukinori; Murakami, Yoshinori; Kim, Bong-Jo; Thorsteinsdottir, Unnur; Stefansson, Kari; Zhang, Jifeng; Chen, Y. Eugene; Ho, Yuk-Lam; Lynch, Julie A.; Tsao, Philip S.; Chang, Kyong-Mi; Cho, Kelly; O'Donnell, Christopher J.; Gaziano, John M.; Wilson, Peter; Mohlke, Karen L.; Frayling, Timothy M.; Hirschhorn, Joel N.; Kathiresan, Sekar; Boehnke, Michael; Grant, Struan; Natarajan, Pradeep; Sun, Yan, V; Morris, Andrew P.; Deloukas, Panos; Peloso, Gina; Assimes, Themistocles L.; Willer, Cristen J.; Zhu, Xiang; Brown, Christopher D. 分享 收藏
Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts 在两个独立的队列中，高胰岛素血症与肝细胞衰老的标志物高度相关 Meijnikman, Abraham S.; van Olden, Casper C.; Aydin, Omrum; Herrema, Hilde; Kaminska, Dorota; Lappa, Dimitra; Mannisto, Ville; Tremaroli, Valentina; Olofsson, Louise E.; de Brauw, Maurits; van de Laar, Arnold; Verheij, Joanne; Gerdes, Victor E. A.; Schwartz, Thue W.; Nielsen, Jens; Backhed, Fredrik; Pajukanta, Paivi; Pihlajamaki, Jussi; Tchkonia, Tamar; Kirkland, James L.; Kuipers, Folkert; Nieuwdorp, Max; Groen, Albert K. 分享 收藏
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