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Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease PILRA的缺失促进小胶质细胞免疫代谢，以减少阿尔茨海默病细胞和动物模型中的淀粉样蛋白病理。 Weerakkody, Tanya N.; Sabelstrom, Hanna; Andrews, Shan V.; Chadarevian, Jean Paul; Chin, Marcus Y.; Tatarakis, David; Propson, Nicholas E.; Kim, Do Jin; Theolis, Richard; Parico, Gian Carlo G.; Misker, Hiwot; Kung, Jennifer E.; Bandyopadhyay, Abira; Robles Colmenares, Yaneth; Jackson, Taggra-Nicole; Qerqez, Ahlam N.; Balasundar, Srijana; Davis, Sonnet S.; Ha, Connie; Ghosh, Rajarshi; Ravi, Ritesh; Rana, Anil; Germain, Kyla; Tao, Arnold; Xiong, Ken; Braun, Dylan; Raju, Karthik; Huang, Kang-Chieh; Zhan, Lihong; Guo, Jing L.; Safari Yazd, Hoda; Sarrafha, Lily; Capocchi, Joia Kai; Hasselmann, Jonathan; Chadarevian, Alina L.; Tu, Christina; Mansour, Kimiya; Eskandari-Sedighi, Ghazaleh; Tesi, Niccolo; Van Der Lee, Sven; Hulsman, Marc; Oshegov, Georgii; Pijnenburg, Yolande; Calvert, Meredith; Holstege, Henne; Suh, Jung H.; Di Paolo, Gilbert; Davtyan, Hayk; Lewcock, Joseph W.; Blurton-Jones, Mathew; Monroe, Kathryn M. 分享 收藏
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo 人源小胶质细胞在体内对β-淀粉样蛋白、tau蛋白以及联合阿尔茨海默病病理的不同反应 Coburn, Morgan A.; Eskandari-sedighi, Ghazaleh; Hasselmann, Jonathan; England, Whitney; Shabestari, Sepideh Kiani; Mansour, Kimiya; McQuade, Amanda; Mgerian, Michael Armen; Chadarevian, Jean Paul; Tu, Christina; Silva, Jorge; Beck, Jaclyn; Keulen, Zahara; Spitale, Robert C.; Davtyan, Hayk; Blurton-jones, Mathew 分享 收藏
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RETRACTION: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies 撤稿：基于MultiTEP的针对人α-突触核蛋白的DNA疫苗的疗效和免疫原性：用于支持IND的启始研究 Kim, Changyoun; Hovakimyan, Armine; Zagorski, Karen; Antonyan, Tatevik; Petrushina, Irina; Davtyan, Hayk; Chailyan, Gor; Hasselmann, Jonathan; Iba, Michiyo; Adame, Anthony; Rockenstein, Edward; Szabo, Marcell; Blurton-Jones, Mathew; Cribbs, David H.; Ghochikyan, Anahit; Masliah, Eliezer; Agadjanyan, Michael G. 分享 收藏
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Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism Profaci, Caterina P.; Harvey, Sean S.; Bajc, Kaja; Zhang, Tony Z.; Jeffrey, Danielle A.; Zhang, Alexander Z.; Nemec, Kelsey M.; Davtyan, Hayk; O'Brien, Carleigh A.; Mckinsey, Gabriel L.; Longworth, Aaron; Mcmullen, Timothy P.; Capocchi, Joia K.; Gonzalez, Jessica G.; Lawson, Devon A.; Arnold, Thomas D.; Davalos, Dimitrios; Blurton-Jones, Mathew; Dabertrand, Fabrice; Bennett, F. Chris; Daneman, Richard 分享 收藏
Microglia protect against age-associated brain pathologies Munro, David A. D.; Bestard-Cuche, Nadine; McQuaid, Conor; Chagnot, Audrey; Shabestari, Sepideh Kiani; Chadarevian, Jean Paul; Maheshwari, Upasana; Szymkowiak, Stefan; Morris, Kim; Mohammad, Mehreen; Corsinotti, Andrea; Bradford, Barry; Mabbott, Neil; Lennen, Ross J.; Jansen, Maurits A.; Pridans, Clare; McColl, Barry W.; Keller, Annika; Blurton-Jones, Mathew; Montagne, Axel; Williams, Anna; Priller, Josef 分享 收藏
Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy Chadarevian, Jean Paul; Hasselmann, Jonathan; Lahian, Alina; Capocchi, Joia K.; Escobar, Adrian; Lim, Tau En; Le, Lauren; Tu, Christina; Nguyen, Jasmine; Shabestari, Sepideh Kiani; Carlen-Jones, William; Gandhi, Sunil; Bu, Guojun; Hume, David A.; Pridans, Clare; Wszolek, Zbigniew K.; Spitale, Robert C.; Davtyan, Hayk; Blurton-Jones, Mathew 分享 收藏
Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease 性别依赖的APOE4中性粒细胞-小胶质细胞相互作用驱动阿尔茨海默病的认知障碍 Rosenzweig, Neta; Kleemann, Kilian L.; Rust, Thomas; Carpenter, Madison; Grucci, Madeline; Aronchik, Michael; Brouwer, Nieske; Valenbreder, Isabel; Cooper-Hohn, Joya; Iyer, Malvika; Krishnan, Rajesh K.; Sivanathan, Kisha N.; Brandao, Wesley; Yahya, Taha; Durao, Ana; Yin, Zhuoran; Chadarevian, Jean Paul; Properzi, Michael J.; Nowarski, Roni; Davtyan, Hayk; Weiner, Howard L.; Blurton-Jones, Mathew; Yang, Hyun-Sik; Eggen, Bart J. L.; Sperling, Reisa A.; Butovsky, Oleg 分享 收藏
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models (vol 5, 46, 2014) Blurton-Jones, Mathew; Spencer, Brian; Michael, Sara; Castello, Nicholas A.; Agazaryan, Andranik A.; Davis, Joy L.; Mueller, Franz-Josef; Loring, Jeanne F.; Masliah, Eliezer; Laferla, Frank M. 分享 收藏
Genetic contribution to microglial activation in schizophrenia 精神分裂症小胶质细胞激活的遗传贡献 Koskuvi, Marja; Poersti, Elina; Hewitt, Tristen; Raesaenen, Noora; Wu, Ying-Chieh; Trontti, Kalevi; Mcquade, Amanda; Kalyanaraman, Shringaa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D.; Loennqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Blurton-Jones, Mathew; Hovatta, Iiris; Laehteenvuo, Markku; Rolova, Taisia; Lehtonen, Sarka; Tiihonen, Jari; Koistinaho, Jari 分享 收藏
Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease 通过ifn γ 诱导的Nrf2减少的神经毒性小胶质细胞激活加剧了阿尔茨海默氏病 Kang, You Jung; Hyeon, Seung Jae; Mcquade, Amanda; Lim, Jiwoon; Baek, Seung Hyun; Diep, Yen N.; Do, Khanh V.; Jeon, Yeji; Jo, Dong-Gyu; Lee, C. Justin; Blurton-Jones, Mathew; Ryu, Hoon; Cho, Hansang 分享 收藏
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Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis Evans, Katrina T.; Blake, Kerrigan; Longworth, Aaron; Coburn, Morgan A.; Insua-Rodriguez, Jacob; Mcmullen, Timothy P.; Nguyen, Quy H.; Ma, Dennis; Lev, Tatyana; Hernandez, Grace A.; Oganyan, Armani K.; Orujyan, Davit; Edwards, Robert A.; Pridans, Clare; Green, Kim N.; Villalta, S. Armando; Blurton-Jones, Mathew; Lawson, Devon A. 分享 收藏
Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3 在hiPSC衍生的额颞叶痴呆小胶质细胞模型中，小胶质细胞代谢和炎症特征的改变有助于神经毒性3 Haukedal, Henriette; Lorenzen, Signe Syshoj; Westi, Emil Winther; Corsi, Giulia I.; Gadekar, Veerendra P.; McQuade, Amanda; Davtyan, Hayk; Doncheva, Nadezhda T.; Schmid, Benjamin; Chandrasekaran, Abinaya; Seemann, Stefan E.; Cirera, Susanna; Blurton-Jones, Mathew; Meyer, Morten; Gorodkin, Jan; Aldana, Blanca I.; Freude, Kristine 分享 收藏
Human microglia maturation is underpinned by specific gene regulatory networks Han, Claudia Z.; Li, Rick Z.; Hansen, Emily; Trescott, Samantha; Fixsen, Bethany R.; Nguyen, Celina T.; Mora, Cristina M.; Spann, Nathanael J.; Bennett, Hunter R.; Poirion, Olivier; Buchanan, Justin; Warden, Anna S.; Xia, Bing; Schlachetzki, Johannes C. M.; Pasillas, Martina P.; Preissl, Sebastian; Wang, Allen; O'Connor, Carolyn; Shriram, Shreya; Kim, Roy; Schafer, Danielle; Ramirez, Gabriela; Challacombe, Jean; Anavim, Samuel A.; Johnson, Avalon; Gupta, Mihir; Glass, Ian A.; Birth Defects Res Lab, Birth Defects Research; Levy, Michael L.; Ben Haim, Sharona; Gonda, David D.; Laurent, Louise; Hughes, Jennifer F.; Page, David C.; Blurton-Jones, Mathew; Glass, Christopher K.; Coufal, Nicole G. 分享 收藏
Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model Liaudanskaya, Volha; Fiore, Nicholas J.; Zhang, Yang; Milton, Yuka; Kelly, Marilyn F.; Coe, Marly; Barreiro, Ariana; Rose, Victoria K.; Shapiro, Matthew R.; Mullis, Adam S.; Shevzov-Zebrun, Anna; Blurton-Jones, Mathew; Whalen, Michael J.; Symes, Aviva J.; Georgakoudi, Irene; Nieland, Thomas J. F.; Kaplan, David L. 分享 收藏
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