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A

Adrian G. Sacher

Princess Margaret Cancer Centre
H指数:39
被引数:9,168

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Pan-tumor activity of olomorasib, a next-generation KRAS G12C inhibitor in KRAS G12C-mutant advanced solid tumors: a first-in-human study

奥罗玛西布（olomorasib）对KRAS G12C突变型晚期实体瘤的泛瘤活性：一项首次人体研究

Nature Communications
IF15.7
2026-03-120
OAAI
Yonina R. Murciano-Goroff; Antoine Hollebecque; Rebecca S. Heist; Philippe A. Cassier; Ji-Youn Han; So Yeon Kim; Joshua K. Sabari; Diego Tosi; Adrian Sacher; Timothy F. Burns; Toshio Shimizu; Natraj Reddy Ammakkanavar; Alexander Spira; Carlos Gomez-Roca; Amita Patnaik; Rasha Cosman; J. Nicholas Bodor; Misako Nagasaka; Arthur Xintian You; Samuel C. McNeely; Raimund Peter; Aaron Fink; Aaron Chen; Geoffrey R. Oxnard; Melinda D. Willard; Yasutoshi Kuboki; Takafumi Koyama
Efficacy and Safety of Olomorasib in Combination with Pembrolizumab in Treatment of Patients with KRAS G12C-Mutant Advanced NSCLC

奥罗莫西布与帕博利珠单抗联合治疗KRAS G12C突变型晚期非小细胞肺癌的疗效与安全性

Journal of Thoracic Oncology
IF20.8
2025-11-290
PRE
Timothy F. Burns; Natraj Reddy Ammakkanavar; Antoine Hollebecque; Dae Ho Lee; Takafumi Koyama; Philippe A. Cassier; Antoine Italiano; Ji-Youn Han; Nimit Singhal; Shinji Takeuchi; Rebecca S. Heist; Dustin Deming; Alexander Spira; Quincy Chu; Adrian Sacher; Yutaka Fujiwara; Michael J. Chisamore; Arthur Xintian You; Samuel C. McNeely; Aaron Fink
A retrospective analysis exploring the association of pretreatment neutrophil-to-lymphocyte ratio and immune checkpoint inhibitor outcomes in patients with advanced NSCLC and liver metastases

一项回顾性分析，探讨治疗前中性粒细胞与淋巴细胞比值与晚期非小细胞肺癌伴肝转移患者免疫检查点抑制剂疗效的关联。

Therapeutic Advances in Medical Oncology
IF4.2
2025-10-220
OA
Maisam Makarem; Tuan Hoang; Mitchell J. Elliott; Andrew Rabinovitch; Katrina Hueniken; Shelley Kuang; Sabine Schmid; Ming Sound Tsao; Tracy McGaha; Pamela S. Ohashi; Frances A. Shepherd; Penelope A. Bradbury; Geoffrey Liu; Natasha B. Leighl; Adrian Sacher; Sally C. M. Lau
Modeling response to the KRAS-G12C inhibitor AZD4625 in KRASG12C NSCLC patient-derived xenografts reveals insights into primary resistance mechanisms

对KRAS-G12C抑制剂AZD4625在KRASG12C NSCLC患者来源的异种移植模型中的反应进行建模，揭示了原发性耐药机制方面的见解。

British Journal of Cancer
IF6.8
2025-10-110
OA
Joshua C. Rosen; Pinjiang Cao; Nhu-An Pham; Matthew Waas; Quan Li; Katrina Hueniken; Mutian Wang; Roya Navab; Leanne Wybenga-Groot; Nikolina Radulovich; Michael Niedbala; Alex Koers; Sarah Ross; Michael F. Moran; Adrian Sacher; Ming-Sound Tsao
Lung Cancer and Cardiovascular Disease

肺癌和心血管疾病

JACC: CardioOncology
IF12.8
2025-06-170
OAAI
Malak El-Rayes; Inbar Nardi Agmon; Christopher Yu; Nichanan Osataphan; Helena A. Yu; Andrew Hope; Adrian Sacher; Anthony F. Yu; Husam Abdel-Qadir; Paaladinesh Thavendiranathan
Savolitinib plus osimertinib in epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer with MET overexpression and/or amplification following disease progression on osimertinib: primary results from the phase II SAVANNAH study

赛沃替尼联合奥希替尼治疗表皮生长因子受体（EGFR）突变型晚期非小细胞肺癌，该患者伴有MET过表达和/或扩增，且在奥希替尼治疗进展后：SAVANNAH II期研究的主要结果

Annals of Oncology
IF65.4
2025-06-020
OAAI
F. de Marinis; T.M. Kim; L. Bonanno; S. Cheng; S.-W. Kim; M. Tiseo; Q. Chu; C. Proto; A. Sacher; Y.-H. Luo; S. Novello; D. Hao; C. Baik; L. Bazhenova; J.S. Lee; B.C. Cho; J. Cadranel; T.B. Diep; G. Metro; P. Narayanan; M.-J. Ahn
Molecular determinants of sotorasib clinical efficacy in KRASG12C-mutated non-small-cell lung cancer

Skoulidis, F.; Li, B.T.; de Langen, A.J.; Hong, D.S.; Lena, H.; Wolf, J.; Dy, G.K.; Curioni Fontecedro, A.; Tomasini, P.; Velcheti, V.; et al. Sotorasib在KRASG12C突变非小细胞肺癌中的临床疗效分子决定因素。Nat. Med. 2025, 31, 2755–2767. [Google Scholar] [CrossRef] [PubMed]

Nature Medicine
IF50
2025-05-280
OAAI
Ferdinandos Skoulidis; Bob T. Li; Adrianus Johannes de Langen; David S. Hong; Herve Lena; Juergen Wolf; Grace K. Dy; Alessandra Curioni Fontecedro; Pascale Tomasini; Vamsidhar Velcheti; Anthonie J. van der Wekken; Christophe Dooms; Luis Paz-Ares Rodriguez; Giannis Mountzios; Adrian Sacher; Ernest Nadal; Sebastien Couraud; Sang-We Kim; Kenneth O’Byrne; Danilo Rocco; Ryo Toyozawa; Izabela Chmielewska; Colin R. Lindsay; Antreas Hindoyan; Lata Mukundan; Tomasz Wilmanski; Abraham Anderson; Christine Ardito-Abraham; Amrita Pati; Anita Reddy; Bhakti Mehta; Martin Schuler
Real-World Creatinine-Based Estimates of Acute and Chronic Kidney Dysfunction in Patients with Advanced ALK-Rearranged Non-Small-Cell Lung Cancer Receiving Tyrosine Kinase Inhibitors

基于真实世界肌酐测量的ALK重排晚期非小细胞肺癌患者接受酪氨酸激酶抑制剂治疗时的急性与慢性肾功能障碍评估

Clinical Lung Cancer
IF3.3
2025-04-080
PRE
Louis Pinard; Avinash Rao Ullur; Louis Everest; Luna Jia Zhan; Rajeevan Selvaratnam; Karmugi Balaratnam; Khaleeq Khan; Sabine Schmid; Simren Chotai; Devalben Patel; Faisal Al-Agha; Benjamin Grant; M. Catherine Brown; Roula Raptis; Wei Xu; Patrick Moriarty; Frances A. Shepherd; Adrian G. Sacher; Natasha B. Leighl; Penelope A. Bradbury; Geoffrey Liu; Abhijat Kitchlu
Prognostic and predictive effects of TP53 co-mutation in patients with non-small cell lung cancer with rare treatable driver mutations

TP53共突变在具有罕见可治疗驱动基因突变非小细胞肺癌患者中的预后和预测效果

LUNG CANCER
IF4.4
2025-02-010
PRE
Feng, Jamie; Hueniken, Katrina; Fan, Zhen Jason; Zhan, Luna Jia; Faour, Elizabeth; Corke, Lucy; Alghabban, Abdulrahman; Leighl, Natasha B.; Liu, Geoffrey; Bradbury, Penelope A.; Sacher, Adrian; Eng, Lawson; Stockley, Tracy L.; Tsao, Ming Sound; Shepherd, Frances A.
Health Utility and Symptom Scores in Patients With Advanced Malignant Pleural Mesothelioma Treated in a Real-World Setting

晚期恶性胸膜间皮瘤患者在真实世界治疗中的健康效用和症状评分

JTO CLINICAL AND RESEARCH REPORTS
IF3.5
2025-02-010
OAAI
Mittal, Abhenil; Everest, Louis; Patel, Devalben; Zhan, Luna J.; Brown, M. Catherine; Zaeimi, Fatemah; Schmid, Sabine; Khan, Khaleeq; Dietrich, Kristen; Balaratnam, Karmugi; Santayana, Miguel Garcia Pardo de; Eng, Lawson; Sacher, Adrian G.; Shepherd, Frances A.; Leighl, Natasha B.; Cho, John; De Perrot, Marc; Liu, Geoffrey; Bradbury, Penelope
Assessing the feasibility and external validity of natural language processing-extracted data for advanced lung cancer patients

评估自然语言处理提取数据在晚期肺癌患者中的可行性与外部有效性

LUNG CANCER
IF4.4
2025-01-010
OAAI
Li, Yuchen; Law, Jennifer; Le, Lisa W.; Li, Janice J. N.; Pettengell, Christopher; Demarco, Patricia; Duong, Michael; Merritt, David; Davidson, Sean; Sung, Mike; Li, Qixuan; Lau, Sally C. M.; Zahir, Sajda; Chu, Ryan; Ryan, Malcom; Karim, Khizar; Morganstein, Josh; Sacher, Adrian; Eng, Lawson; Shepherd, Frances A.; Bradbury, Penelope; Liu, Geoffrey; Leighl, Natasha B.
Analysis of outcomes in resected early-stage NSCLC with rare targetable driver mutations
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
IF4.2
2024-12-230
OAAI
Ghazali, Nadia; Feng, Jamie; Hueniken, Katrina; Khan, Khaleeq; Balaratnam, Karmugi; Waddell, Thomas K.; Yasufuku, Kazuhiro; Pierre, Andrew; Donahoe, Laura; Wakeam, Elliot; Cypel, Marcelo; Yeung, Jonathan; Keshavjee, Shaf; de Perrot, Marc; Leighl, Natasha B.; Liu, Geoffrey; Bradbury, Penelope A.; Sacher, Adrian; Eng, Lawson; Stockley, Tracy; Tsao, Ming Sound; Shepherd, Frances A.
First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase I dose exploration5

MTAP缺失的实体瘤患者中MTA合作PRMT5抑制剂AMG 193的首次人体研究: I期剂量探索的结果5

ANNALS OF ONCOLOGY
IF65.4
2024-12-014
PRE
Rodon, J.; Prenen, H.; Sacher, A.; Villalona-Calero, M.; Penel, N.; El Helali, A.; Rottey, S.; Yamamoto, N.; Ghiringhelli, F.; Goebeler, M. E.; Doi, T.; Postel-Vinay, S.; Lin, C. -c.; Liu, C.; Chuang, C. -h.; Keyvanjah, K.; Eggert, T.; Neil, B. h. o '

研究方向

暂未获取到该数据
N
Natasha B. Leighl
H 指数:87论文数:963被引数:4.4万
P
Penelope A. Bradbury
H 指数:37论文数:306被引数:4,319
F
Frances A. Shepherd
H 指数:127论文数:1,119被引数:8.1万
G
Geoffrey Liu
H 指数:88论文数:1,484被引数:3.6万
M
Ming‐Sound Tsao
H 指数:151论文数:1,571被引数:11.3万
S
Sabine Schmid
H 指数:25论文数:125被引数:3,450
L
Luna Jia Zhan
H 指数:7论文数:84被引数:184
M
M. Catherine Brown
H 指数:23论文数:176被引数:1,337
S
Sally C. M. Lau
H 指数:19论文数:90被引数:1,395
K
Khaleeq Khan
H 指数:7论文数:56被引数:143