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邓宏魁 封面图

邓宏魁 (Hongkui Deng)

peking university

76H指数
264论文数
2.6W被引数
收录论文 132
发表时间
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Scalable generation of T lymphocytes from human pluripotent stem cells in suspended organoids从悬浮类器官中规模化生成人诱导多能干细胞来源的T淋巴细胞
errStem Cell Reports
IF5.1
err2026-09-03
err0
errOAAI
errQi Lei; Yudi Miao; Feng Zheng; Ruoqi Cheng; Yating Mo; Weifeng Lai; Zhengyang Zhou; Lejun Lv; Yuanyuan He; Huangfan Xie; Chenyi Dai; Yingfeng Zhang; Zixin Zhao; Mengxin Liu; Lemei Jia; Jun Xu; Cheng Li; Hongkui Deng; Chengyan Wang
err分享
err收藏
The evolution of iPSC-based cell therapy across autologous and allogeneic pathwaysiPSC基细胞疗法在自体和异体途径中的发展
errCell Reports Medicine
IF10.6
err2026-08-18
err0
errOAAI
errAnmin Wang; Yunpei Zhang; Hongkui Deng; Mingxia Gu
err分享
err收藏
p53 safeguards chemical reprogramming of human somatic cells toward pluripotencyp53保护化学重编程使人类体细胞向多能性转变
errCell
IF42.5
err2026-04-17
err0
PREAI
errLin Cheng; Yanglu Wang; Zhihan Yang; Jingxiao Cao; Fangqi Peng; Tianlong Lan; Ruoqi Cheng; Tianxing Liu; Ziqing Xia; Jingyang Guan; Cheng Li; Shicheng Sun; Hongkui Deng
err分享
err收藏
Efficient chemical reprogramming of human T cells to pluripotent stem cells人类T细胞向多能干细胞的有效化学重编程
errCell Research
IF25.9
err2026-01-16
err0
PREAI
errYanglu Wang; Fangqi Peng; Ruoqi Cheng; Jingran Zeng; Weizhen Zeng; Jingping Mao; Xiaodi Fu; Guanxian Chen; Tianxing Liu; Zhihan Yang; Cheng Li; Bei Liu; Jingyang Guan; Lin Cheng; Hongkui Deng
err分享
err收藏
Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming通过化学重编程从外周血中稳健生成临床适用性人 pluripotent stem cells
errCell Discovery
IF12.5
err2025-12-23
err0
errOAAI
errXiaodi Fu; Fangqi Peng; Ruyi Cai; Jingping Mao; Tianxing Liu; Yingshuai Dong; Ruoqi Cheng; Zhihan Yang; Guanxian Chen; Cheng Li; Rong Mu; Lin Cheng; Yanglu Wang; Jingyang Guan; Hongkui Deng
err分享
err收藏
IL-12 and GM-CSF engineered dendritic cells enhance the enrichment and selection of tumor-reactive T cells for cancer immunotherapyIL-12和GM-CSF工程化树突状细胞可增强肿瘤反应性T细胞的富集与筛选，用于癌症免疫治疗。
errFrontiers in Immunology
IF5.9
err2025-11-18
err0
errOAAI
errZhen Liu†; Haoyun Li†; Zhaoya Gao; Ruoqi Cheng; Jiahua Lu; Xuan Che; Jiebin Dong; Zilong Wang; Zejia Cui; Jin Gu; Yun Bai; Cheng Li; Yinan Liu; Chengyan Wang; Hongkui Deng
err分享
err收藏
β-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritisβ-半乳糖苷酶靶向性抗衰老前药改善了创伤后骨关节炎的预临床模型
erreBioMedicine
IF10.8
err2025-11-06
err0
errOAAI
errQi Li; Tong Wu; Yifei Fan; Jin Cheng; Junyan Wang; Boyang Xu; Mengze Sun; Xi Gong; Hongkui Deng; Yingfang Ao; Xiaoqing Hu
err分享
err收藏
A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation一种连续的全能性样细胞胚胎模型重现了从合子基因组激活到原肠胚形成的鼠胚发育过程
errNature Cell Biology
IF19.1
err2025-10-15
err0
errOAAI
errYixuan Ren; Xuyang Wang; Haiyin Liu; Yaxing Xu; Ruoqi Cheng; Shengnan Ren; Zining Li; Yunfei Huo; Bo Li; Jingyang Guan; Cheng Li; Hongkui Deng; Jun Xu
err分享
err收藏
Improved identification of tumor-specific TCRs from circulating lymphocytes using autologous colorectal tumor organoids通过自体结直肠癌类器官改善从循环淋巴细胞中鉴定肿瘤特异性TCRs
errCancer Letters
IF10.1
err2025-09-10
err0
PREAI
errLisha Ma; Xiya Wang; Qianjing Zhang; Zhaoya Gao; Xiangwen Ji; Zhilang Li; Yixian Li; Pengchong Zhang; Xuan Che; Yun Sun; Yun Bai; Hongkui Deng
err分享
err收藏
Trophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulationEPS细胞来源的拟滋养层外胚层样细胞能够生成完成原肠形成的EPS细胞来源的植入后胚胎样结构。
errProtein and Cell
IF12.8
err2025-08-11
err0
errOAAI
errXuyang Wang; Ruoqi Cheng; Chenyang Wu; Haiyin Liu; Zining Li; Yunfei Huo; Bo Li; Dongyu Zhao; Cheng Li; Hongkui Deng; Jun Xu; null
err分享
err收藏
Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo重建具有体内低血糖保护能力的内分泌亚型完整的人多能干细胞来源的胰岛
errCell Stem Cell
IF20.4
err2025-08-08
err0
PREAI
errGaofan Meng; Jiabin Gu; Soon Yi Liew; Jingxiao Cao; Zhihui Wang; Chunyu Ma; Zhenzhen Fu; Hongwen Zhou; Jinlin Wang; Shusen Wang; Sijia Jing; Yiqi Wu; Zhengjun Lei; Shuli Zhi; Yuanyuan He; Cheng Li; Hongkui Deng
err分享
err收藏
Chemical reprogramming of human blood cells to pluripotent stem cells将人血细胞化学重编程为多能干细胞
errCell Stem Cell
IF20.4
err2025-07-30
err0
PREAI
errFangqi Peng; Yanglu Wang; Lin Cheng; Ruyi Cai; Xiaodi Fu; Zhihan Yang; Ruoqi Cheng; Weizhen Zeng; Yingshuai Dong; Jingxiao Cao; Jingping Mao; Jingran Zeng; Tianxing Liu; Guanxian Chen; Qi Lei; Lipeng Wang; Lulu Liu; Shicheng Sun; Cheng Li; Rong Mu; Jingyang Guan; Hongkui Deng
err分享
err收藏
CRISPR-based screening identifies the role of KRAB-containing transcription factors ZIM3 and ZNF394 in human major zygotic genome activationCRISPR技术筛选确定了KRAB结构域转录因子ZIM3和ZNF394在人类主要合子基因组激活中的作用
errCell Reports
IF6.9
err2025-07-15
err0
errOAAI
errJiayu Li; Liangfu Xie; Cheng Shi; Tiantian Zhang; Xiwen Lin; Haokun Da; Kongqianqian Sun; Chunsheng Han; Bing Zhu; Xi Chen; Hongkui Deng; Jun Xu
err分享
err收藏
A patient-derived organoid model captures fetal-like plasticity in colorectal cancer患者来源的类器官模型捕获了结直肠癌中的胎源性可塑性
errCell Research
IF25.9
err2025-07-04
err0
PREAI
errLiang Xiong; Ying Xu; Zhaoya Gao; Jingyi Shi; Yunfan Wang; Xiaodong Wang; Wensheng Huang; Ming Li; Longteng Wang; Jun Xu; Cheng Li; Jin Gu; Hongkui Deng; Molong Qu
err分享
err收藏
Human embryo research: how to move towards a 28-day limit人类胚胎研究：如何迈向28天限制
errNature
IF48.5
err2025-07-01
err0
PREAI
errAlejandro De Los Angeles; Nissim Benvenisty; Hongkui Deng; Jacob H. Hanna; Julian Koplin; Tianqing Li; Pentao Liu; Yuin-Han Loh; Duanqing Pei; Ryohichi Sugimura; Timothy Theodore Ka Ki Tam; Tan Tao; Alan Trounson; Shao Xu; Leqian Yu; Elias Zambidis; Magdalena Zernicka-Goetz; Robin Lovell-Badge
err分享
err收藏
Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells单细胞转录组学揭示了人诱导性肝细胞样细胞谱系重编程过程中的肝脏发育轨迹
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2025-04-06
err0
errOAAI
errJiang, Nan; Li, Guangya; Luo, Sen; Kong, Xi; Yin, Shigang; Peng, Jianhua; Jiang, Yong; Tao, Wei; Li, Cheng; Xie, Huangfan; Deng, Hongkui; Xie, Bingqing
err分享
err收藏
Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure利用化学诱导的人源多能干细胞来源的功能性肝细胞类器官进行生物打印以治疗肝衰竭
errGUT
IF25.8
err2025-03-03
err1
PREAI
errLi, Guangya; He, Jianyu; Shi, Jihang; Li, Xinyi; Liu, Lulu; Ge, Xinlan; Chen, Wenhan; Jia, Jun; Wang, Jinlin; Yin, Ming; Sakai, Yasuyuki; Sun, Wei; Deng, Hongkui; Pang, Yuan
err分享
err收藏
TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumorsTLR7/8信号激活增强了人 pluripotent stem cell 衍生的 eosinophils 在实体瘤癌症免疫治疗中的效力
errhematology oncology
IF13.5
err2025-03-01
err1
errOAAI
errZhu, Sheng; Zhou, Zhengyang; Gu, Ruixin; Zhao, Zixin; Zhang, Yingfeng; Miao, Yudi; Lei, Qi; Liu, Tianxing; Wang, Guokai; Dai, Chenyi; Huo, Yi; You, Jinghao; Lv, Lejun; Li, Cheng; Yin, Ming; Wang, Chengyan; Deng, Hongkui
err分享
err收藏
Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal通过逆转TGF-β信号，在免疫抑制性肿瘤微环境中增强CAR-T细胞功能
errMOLECULAR THERAPY
IF12
err2025-02-01
err1
PREAI
errZheng, Shen; Che, Xuan; Zhang, Kai; Bai, Yun; Deng, Hongkui
err分享
err收藏
A two-step strategy to expand primary human hepatocytes in vitro with efficient metabolic and regenerative capacities
errSTEM CELL RESEARCH & THERAPY
IF7.3
err2024-09-04
err0
errOAAI
errXie, Huangfan; Li, Guangya; Fu, Yunxi; Jiang, Nan; Yi, Simeng; Kong, Xi; Shi, Jihang; Yin, Shigang; Peng, Jianhua; Jiang, Yong; Lu, Shichun; Deng, Hongkui; Xie, Bingqing
err分享
err收藏

研究方向

体细胞重编程，细胞命运调控的分子机制再生医学，组织器官再生，清除衰老细胞肿瘤的免疫治疗
合作学者
合作期刊
王
王军 (Jun Wang)
H 指数: 222 · 论文数: 3.2K
I
Irving L. Weissman
H 指数: 215 · 论文数: 1.3K
G
George M. Church
H 指数: 190 · 论文数: 1.3K
H
Huanming Yang
H 指数: 171 · 论文数: 1.1K
J
Janet Rossant
H 指数: 149 · 论文数: 1.1K
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