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G

Guofeng Zhang

department of neurosurgery
H指数:38
被引数:5,442

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Discovery of a Selective and Potent Inhibitor of Cyclin-Dependent Kinase 12/13 Employing a Noncovalent Mechanism

使用非共价机制发现细胞周期蛋白依赖性激酶12/13的选择性和有效抑制剂

ACS Medicinal Chemistry Letters
IF4
2026-02-050
PRE
Robert A. Swyka; Evan D. Styduhar; Anlai Wang; Xin Li; Ke Zhang; Michael R. Witten; Peng Zhao; Michael Z. Liang; Onur Atasoylu; Peng He; Ryan Soderquist; Mike Hansbury; Lu Huo; Haiying Chen; Derek Zimmer; Wenliang Zhang; Kathy Wang; Alla Volgina; Leslie B. Epling; Erin Crowgey; Ekta Kumari; Angela Abdollahi; Guofeng Zhang; Mark Rupar; Michael Schaffer; Patrick A. Mayes; Sunkyu Kim; Oleg Vechorkin; Xiaozhao Wang
Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor

发现INCB159020，一种口服生物利用的KRAS G12D抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-01-080
PRE
Ye, Qinda; Shvartsbart, Artem; Li, Zhenwu; Gan, Pei; Policarpo, Rocco L.; Qi, Chao; Roach, Jeremy J.; Zhu, Wenyu; Mccammant, Matthew S.; Hu, Bin; Li, Gencheng; Yin, Haolin; Carlsen, Peter; Hoang, Gia; Zhao, Le; Susick, Robert; Zhang, Fenglei; Lai, Cheng-Tsung; Hassani, Abdellah Allali; Epling, Leslie B.; Gallion, Alexandra; Kurzeja-Lipinski, Kerri; Gallagher, Karen; Roman, Valerie; Farren, Matthew R.; Kong, Weixi; Deller, Marc C.; Zhang, Guofeng; Covington, Maryanne; Diamond, Sharon; Kim, Sunkyu; Yao, Wenqing; Sokolsky, Alexander; Wang, Xiaozhao
INCB161734: A novel, potent, and orally bioavailable KRAS G12D selective inhibitor demonstrates antitumor activity in KRAS G12D mutant tumors
CANCER RESEARCH
IF16.6
2024-03-221
PRE
Farren, Matthew R.; Roman, Valerie; Gallion, Alexandra; Allali-Hassani, Abdellah; Sokolsky, Alexander; Kong, Weixi; Smith, Amanda; Wang, Hui; Correa, Gina; Deller, Marc; Epling, Leslie B.; Procak, Jessica; Zhang, Guofeng; Pecko, Katherine; Kennedy, Keith; Boer, Jason; Kurzeja-Lipinski, Kerri; Covington, Maryanne; Chen, Kwang-Jong; Wallower, Renee; Rocha, Jennifer; Pan, Rina; Perry, Anthony; Yuska, Brad; Wang, Xiaozhao; Macarron, Ricardo; Kim, Sunkyu
Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-02-072
PRE
Hummel, Joshua R.; Xiao, Kai-Jiong; Yang, Jeffrey C.; Epling, Leslie B.; Mukai Ken; Ye, Qinda; Xu, Meizhong; Qian, Dingquan; Huo, Lu; Weber, Michael; Roman, Valerie; Lo, Yvonne; Drake, Katherine; Stump, Kristine; Covington, Maryanne; Kapilashrami, Kanishk; Zhang, Guofeng; Ye, Min; Diamond, Sharon; Yeleswaram, Swamy; Macarron, Ricardo; Deller, Marc C.; Wee, Susan; Kim, Sunkyu; Wang, Xiaozhao; Wu, Liangxing; Yao, Wenqing
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-02-285
OA
Nguyen, Minh H.; Ye, Hai -Fen; Xu, Yao; Truong, Lisa; Horsey, April; Zhao, Peng; Styduhar, Evan D.; Frascella, Michelle; Leffet, Lynn; Federowicz, Kelly; Behshad, Elham; Wang, Anlai; Zhang, Ke; Witten, Michael R.; Qi, Chao; Jalluri, Ravi; Lai, Cheng-Tsung; Atasoylu, Onur; Harris, Jennifer J.; Hess, Rodrigo; Lin, Luping; Zhang, Guofeng; Covington, Maryanne; Diamond, Sharon; Yao, Wenqing; Vechorkin, Oleg

研究方向

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J
Jon A. Wolff
H 指数:70论文数:258被引数:2.2万
S
So C. Wong
H 指数:19论文数:125被引数:2,060
M
Maryanne Covington
H 指数:39论文数:199被引数:6,161
M
Magdolna G. Sebestyén
H 指数:15论文数:31被引数:1,117
S
Sunkyu Kim
H 指数:41论文数:196被引数:1.3万
X
Xiaozhao Wang
H 指数:26论文数:110被引数:2,091
D
David L. Lewis
H 指数:53论文数:306被引数:1.0万
J
Julia Hegge
H 指数:22论文数:100被引数:1,742
H
Hans Herweijer
H 指数:28论文数:68被引数:3,418
L
L.B. Epling
H 指数:8论文数:24被引数:367