Diego Pérez–Tilve - Publications, H-index & Citations

Diego Pérez–Tilve

university of cincinnati

56H指数

153论文数

1.4W被引数

收录论文 100

发表时间

GIPR:GCGR co-agonism restores normal weight in obese rodents GIPR:GCGR协同激动作用恢复肥胖啮齿动物的正常体重

Molecular Metabolism

IF6.6

2026-04-15

OAAI

Diego Perez-Tilve; Fa Zhang; Yujin Zhang; Kaitlyn Lohman; Joyce Sorrell; Andrew Vick; Timo D. Müller; Matthias H. Tschöp; Richard D. DiMarchi

Discovery and Characterization of Canvuparatide, a Once-Weekly Parathyroid Hormone Analog for the Treatment of Hypoparathyroidism 发现和表征Canvuparatide，一种每周一次的甲状旁腺激素类似物，用于治疗甲状旁腺功能减退症

Molecular Metabolism

IF6.6

2026-03-02

OAAI

Fa Zhang; Diego Perez-Tilve; Matthew R. Allen; Corinne E. Metzger; Michael A. Dorato; Mary Jane Geiger; Richard D. DiMarchi

A once-daily GLP-1/GIP/glucagon receptor triagonist (NN1706) lowers body weight in rodents, monkeys and humans 一种每日一次的GLP-1/GIP/胰高血糖素受体三激动剂（NN1706）可降低啮齿动物、猴和人体的体重。

MOLECULAR METABOLISM

IF6.6

2025-06-01

OAAI

Finan, Brian; Douros, Jonathan D.; Goldwater, Ronald; Hansen, Ann Maria Kruse; Hjerpsted, Julie B.; Hjollund, Karina Rahr; Kankam, Martin K.; Knerr, Patrick J.; Konkar, Anish; Mowery, Stephanie A.; Mueller, Timo D.; Nielsen, John Romer; Nygard, Sune Boris; Perez-Tilve, Diego; Raun, Kirsten; Yang, Bin; Tschop, Matthias H.; DiMarchi, Richard D.

Overexpression of the short isoform of the dopamine D2 receptor causes diet-induced obesity and hyperglycemia in mice 多巴胺D2受体短异构体的过表达会导致小鼠出现饮食诱导的肥胖和高血压。

JOURNAL OF NEUROENDOCRINOLOGY

IF4.1

2025-05-04

OAAI

Hanna Gonzalez; Lei Cheng; Qing Chang; Paul E. Gold; Diego Perez-Tilve; YanYan Wang

A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice.一种针对cAMP偏倚信号进行优化的GLP-1类似物可改善肥胖小鼠的体重减轻。

Molecular Metabolism

IF6.6

2025-03-27

OAAI

Jonathan D. Douros; Aaron Novikoff; Barent DuBois; Rebecca Rohlfs; Jacek Mokrosinski; Wouter F.J. Hogendorf; Robert Augustin; Myrte Merkestein; Lene Brandt Egaa Martini; Lars Linderoth; Elliot Gerrard; Janos Tibor Kodra; Jenny Norlin; Nikolaj Kulahin Roed; Anouk Oldenburger; Stephanie A. Mowery; Maria Waldhoer; Diego Perez-Tilve; Brian Finan; Steffen Reedtz-Runge; Timo D. Müller; Patrick J. Knerr

Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons 不同GPCR信号通路的化学发生作用使AGRP神经元从全身葡萄糖代谢的控制中分离出来

MOLECULAR METABOLISM

IF6.6

2025-01-01

OAAI

Abreu, Valerie Espinal; Barnes, Rachel; Borra, Vishnupriya; Schurdak, Jennifer; Perez-Tilve, Diego

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes GIPR遗传变异的表征揭示了 β-arrestin对代谢表型的贡献

NATURE METABOLISM

IF20.8

2024-06-13

OAAI

Kizilkaya, Husun S.; Sorensen, Kimmie V.; Madsen, Jakob S.; Lindquist, Peter; Douros, Jonathan D.; Bork-Jensen, Jette; Berghella, Alessandro; Gerlach, Peter A.; Gasbjerg, Laerke S.; Mokrosinski, Jacek; Mowery, Stephanie A.; Knerr, Patrick J.; Finan, Brian; Campbell, Jonathan E.; D'Alessio, David A.; Perez-Tilve, Diego; Faas, Felix; Mathiasen, Signe; Rungby, Jorgen; Sorensen, Henrik T.; Vaag, Allan; Nielsen, Jens S.; Holm, Jens-Christian; Lauenborg, Jeannet; Damm, Peter; Pedersen, Oluf; Linneberg, Allan; Hartmann, Bolette; Holst, Jens J.; Hansen, Torben; Wright, Shane C.; Lauschke, Volker M.; Grarup, Niels; Hauser, Alexander S.; Rosenkilde, Mette M.

A long-acting LEAP2 analog reduces hepatic steatosis and inflammation and causes marked weight loss in mice

MOLECULAR METABOLISM

IF6.6

2024-06-01

OAAI

Shankar, Kripa; Metzger, Nathan P.; Lawrence, Connor; Gupta, Deepali; Osborne-Lawrence, Sherri; Varshney, Salil; Singh, Omprakash; Richard, Corine P.; Zaykov, Alexander N.; Rolfts, Rebecca; Dubois, Barent N.; Perez-Tilve, Diego; Mani, Bharath K.; Hammer, Suntrea T. G.; Zigman, Jeffrey M.

Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

RSC CHEMICAL BIOLOGY

IF3.1

2024-01-01

OAAI

Zaykov, Alexander N.; Gelfanov, Vasily M.; Tagmose, Tina M.; Demozay, Damien; Manfe, Valentina; Rohlfs, Rebecca; Rivir, Marita; Perez-Tilve, Diego; Finan, Brian; DiMarchi, Richard D.

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

NATURE METABOLISM

IF20.8

2023-06-05

OAAI

El, Kimberley; Douros, Jonathan D.; Willard, Francis S.; Novikoff, Aaron; Sargsyan, Ashot; Perez-Tilve, Diego; Wainscott, David B.; Yang, Bin; Chen, Alex; Wothe, Donald; Coupland, Callum; Tschoep, Mattias H.; Finan, Brian; D'Alessio, David A.; Sloop, Kyle W.; Mueller, Timo D.; Campbell, Jonathan E.

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

MOLECULAR METABOLISM

IF6.6

2022-12-01

OAAI

Yang, Bin; Gelfanov, Vasily M.; El, Kimberley; Chen, Alex; Rohlfs, Rebecca; DuBois, Barent; Hansen, Ann Maria Kruse; Perez-Tilve, Diego; Knerr, Patrick J.; 'Alessio, David; Campbell, Jonathan E.; Douros, Jonathan D.; Finan, Brian

Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice 下一代GLP-1/GIP/胰高血糖素三重激动剂使肥胖小鼠体重正常化

MOLECULAR METABOLISM

IF6.6

2022-09-01

OAAI

Knerr, Patrick J.; Mowery, Stephanie A.; Douros, Jonathan D.; Premdjee, Bhavesh; Hjollund, Karina Rahr; He, Yantao; Hansen, Ann Maria Kruse; Olsen, Anette K.; Perez-Tilve, Diego; DiMarchi, Richard D.; Finan, Brian

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice GLP-1-mediated递送tesaglitazar改善雄性小鼠的肥胖和葡萄糖代谢

NATURE METABOLISM

IF20.8

2022-08-22

OAAI

Quarta, Carmelo; Stemmer, Kerstin; Novikoff, Aaron; Yang, Bin; Klingelhuber, Felix; Harger, Alex; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Bauge, Eric; Campbell, Jonathan E.; Capozzi, Megan; Clemmensen, Christoffer; Collden, Gustav; Cota, Perla; Douros, Jon; Drucker, Daniel J.; DuBois, Barent; Feuchtinger, Annette; Garcia-Caceres, Cristina; Grandl, Gerald; Hennuyer, Nathalie; Herzig, Stephan; Hofmann, Susanna M.; Knerr, Patrick J.; Kulaj, Konxhe; Lalloyer, Fanny; Lickert, Heiko; Liskiewicz, Arek; Liskiewicz, Daniela; Maity, Gandhari; Perez-Tilve, Diego; Prakash, Sneha; Sanchez-Garrido, Miguel A.; Zhang, Qian; Staels, Bart; Krahmer, Natalie; DiMarchi, Richard D.; Tschoep, Matthias H.; Finan, Brian; Mueller, Timo D.

Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons

NEUROENDOCRINOLOGY

IF2.8

2021-04-27

PREAI

Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S.; Perez-Tilve, Diego

Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-04-06

OAAI

Yang, Bin; Gelfanov, Vasily M.; Perez-Tilve, Diego; DuBois, Barent; Rohlfs, Rebecca; Levy, Jay; Douros, Jonathan D.; Finan, Brian; Mayer, John P.; DiMarchi, Richard D.

CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity

DIABETES

IF7.5

2020-11-03

OAAI

Zizzari, Philippe; He, Rongjun; Falk, Sarah; Bellocchio, Luigi; Allard, Camille; Clark, Samantha; Leste-Lasserre, Thierry; Marsicano, Giovanni; Clemmensen, Christoffer; Perez-Tilve, Diego; Finan, Brian; Cota, Daniela; Quarta, Carmelo

Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-05-14

PREAI

Kabotso, Daniel E. K.; Smiley, David; Mayer, John P.; Gelfanov, Vasily M.; Perez-Tilve, Diego; DiMarchi, Richard D.; Pohl, Nicola L. B.; Liu, Fa

Glucagon Peptide Family and Adipose Tissue: Not that Intimate, just Acquaintances

ENDOCRINOLOGY

IF3.3

2020-01-17

OAAI

Perez-Tilve, Diego

Glucagon-like peptide 1 (GLP-1)胰高血糖素样肽1 (GLP-1)

MOLECULAR METABOLISM

IF6.6

2019-12-01

1.1K

OAAI

Mueller, T. D.; Finan, B.; Bloom, S. R.; D'Alessio, D.; Drucker, D. J.; Flatt, P. R.; Fritsche, A.; Gribble, F.; Grill, H. J.; Habener, J. F.; Holst, J. J.; Langhans, W.; Meier, J. J.; Nauck, M. A.; Perez-Tilve, D.; Pocai, A.; Reimann, F.; Sandoval, D. A.; Schwartz, T. W.; Seeley, R. J.; Stemmer, K.; Tang-Christensen, M.; Woods, S. C.; DiMarchi, R. D.; Tschoep, M. H.

A Disulfide Scan of Insulin by [3+1] Methodology Exhibits Site-Specific Influence on Bioactivity

ACS CHEMICAL BIOLOGY

IF3.8

2019-07-25

PREAI

Brunel, Florence M.; Mayer, John P.; Gelfanov, Vasily M.; Zaykov, Alexander N.; Finan, Brian; Perez-Tilve, Diego; DiMarchi, Richard D.

研究方向