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T

Takehisa Kitazawa

Chugai Pharmaceutical Co., Ltd.
H指数:22
被引数:3,078

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SAIL66, a next generation CLDN6-targeting T-cell engager, demonstrates potent antitumor efficacy through dual binding to CD3/CD137
JOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
2024-10-140
OAAI
Kamikawa, Takayuki; Kimura, Naoki; Ishii, Shinya; Muraoka, Masaru; Kodama, Tatsushi; Taniguchi, Kenji; Yoshimoto, Moe; Miura-Okuda, Momoko; Uchikawa, Ryo; Kato, Chie; Shinozuka, Junko; Akai, Sho; Naoi, Sotaro; Tomioka, Nanami; Nagaya, Nishiki; Pang, Chai Ling; Garvita, Gupta; Feng, Shu; Shimada, Mei; Kamata-Sakurai, Mika; Aburatani, Hiroyuki; Kitazawa, Takehisa; Igawa, Tomoyuki
Anti-tumor activity of orally-available cyclic peptide LUNA18 through direct RAS inhibition in RAS-altered tumors

口服可利用的环肽LUNA18在RAS改变的肿瘤中通过直接RAS抑制的抗肿瘤活性

CANCER RESEARCH
IF16.6
2024-03-220
PRE
Sase, Hitoshi; Michisaka, Saki; Tachibana, Yukako; Hasegawa, Masami; Fujii, Toshihiko; Takei, Kana; Kanei, Tomoko; Murao, Naoaki; Kuramoto, Shino; Shibahara, Norihito; Ohta, Atsushi; Tanada, Mikimasa; Shiraishi, Takuya; Iikura, Hitoshi; Kitazawa, Takehisa; Tanaka, Hiroshi
1664: Combination of LUNA18, a novel RAS inhibitor, with KRAS G12C inhibitors augments anti-tumor activity via inhibition of MAPK pathway reactivation

1664: 新型RAS抑制剂LUNA18与KRAS G12C抑制剂联合应用可通过抑制MAPK通路再激活增强抗肿瘤活性

CANCER RESEARCH
IF16.6
2024-03-220
PRE
Michisaka, Saki; Sase, Hitoshi; Tachibana, Yukako; Hasegawa, Masami; Fujii, Toshihiko; Kuramoto, Shino; Shibahara, Norihito; Ohta, Atsushi; Tanada, Mikihisa; Shiraishi, Takuya; Iikura, Hitoshi; Kitazawa, Takehisa; Tanaka, Hiroshi
A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state

双特异性抗体NXT007在血友病A猴中发挥止血活性，足以保持非血友病状态

JOURNAL OF THROMBOSIS AND HAEMOSTASIS
IF5
2024-02-0112
OAAI
Teranishi-Ikawa, Yuri; Soeda, Tetsuhiro; Koga, Hikaru; Yamaguchi, Kazuki; Kato, Kazuki; Esaki, Keiko; Asanuma, Kentaro; Funaki, Miho; Ichiki, Mina; Ikuta, Yuri; Ito, Shunsuke; Joyashiki, Eri; Komatsu, Shun-Ichiro; Muto, Atsushi; Nishimura, Kei; Okuda, Momoko; Sanada, Hisakazu; Sato, Motohiko; Shibahara, Norihito; Wakabayashi, Tetsuya; Yamaguchi, Koji; Matsusaki, Akiko; Sampei, Zenjiro; Shiraiwa, Hirotake; Konishi, Hiroko; Kawabe, Yoshiki; Hattori, Kunihiro; Kitazawa, Takehisa; Igawa, Tomoyuki
Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease
NATURE COMMUNICATIONS
IF15.7
2023-12-224
OAAI
Okura, Yuu; Ikawa-Teranishi, Yuri; Mizoroki, Akihiko; Takahashi, Noriyuki; Tsushima, Takashi; Irie, Machiko; Harfuddin, Zulkarnain; Miura-Okuda, Momoko; Ito, Shunsuke; Nakamura, Genki; Takesue, Hiroaki; Ozono, Yui; Nishihara, Masamichi; Yamada, Kenta; Gan, Siok Wan; Hayasaka, Akira; Ishii, Shinya; Wakabayashi, Tetsuya; Muraoka, Masaru; Nagaya, Nishiki; Hino, Hiroshi; Nemoto, Takayuki; Kuramochi, Taichi; Torizawa, Takuya; Shimada, Hideaki; Kitazawa, Takehisa; Okazaki, Makoto; Nezu, Junichi; Sollid, Ludvig M.; Igawa, Tomoyuki
A DLL3/CD3/CD137 trispecific T cell engager shows potent antitumor activity in small cell lung cancer models
CANCER RESEARCH
IF16.6
2023-04-043
PRE
Mikami, Hirofumi; Feng, Shu; Naoi, Sotaro; Azuma, Yumiko; Kayukawa, Yoko; Tsunenari, Toshiaki; Asanuma, Kentaro; Iwabuchi, Ryutaro; Nagano, Hiroaki; Shinozuka, Junko; Yamazaki, Masaki; Kuroi, Haruka; Gan, Siok Wan; Chichili, Priyanka; Shimizu, Shun; Matsuda, Yutaka; Ishii, Shinya; Kamikawaji, Shogo; Kinoshita, Yasuko; Shimizu, Yuichiro; Sakamoto, Akihisa; Muraoka, Masaru; Takahashi, Noriyuki; Kawa, Tatsuya; Shiraiwa, Hirotake; Kashima, Kenji; Mimoto, Futa; Kamata-Sakurai, Mika; Kitazawa, Takehisa; Igawa, Tomoyuki
Combination of T cell-redirecting bispecific antibody ERY974 and chemotherapy reciprocally enhances efficacy against non-inflamed tumours
NATURE COMMUNICATIONS
IF15.7
2022-09-0712
OAAI
Sano, Yuji; Azuma, Yumiko; Tsunenari, Toshiaki; Kayukawa, Yoko; Shinozuka, Junko; Fujii, Etsuko; Amano, Jun; Nishito, Yukari; Maruyama, Toru; Kinoshita, Yasuko; Sakamoto, Yuichiro; Yoshida, Ayae; Miyazaki, Yoko; Sato, Yuta; Teramoto-Seida, Chifumi; Ishiguro, Takahiro; Tanaka, Takayoshi; Kitazawa, Takehisa; Endo, Mika

研究方向

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K
Keiji Nogami
H 指数:37论文数:479被引数:5,480
T
Tomoyuki Igawa
H 指数:29论文数:106被引数:3,731
M
Midori Shima
H 指数:56论文数:578被引数:1.4万
T
Tetsuhiro Soeda
H 指数:19论文数:92被引数:2,089
K
Kunihiro Hattori
H 指数:35论文数:142被引数:5,040
Y
Yoshiki Kawabe
H 指数:44论文数:154被引数:7,912
S
Shinya Ishii
H 指数:39论文数:162被引数:6,295
K
Kenichi Ogiwara
H 指数:24论文数:155被引数:1,585
M
Masaru Muraoka
H 指数:17论文数:106被引数:1,223
K
Kenta Haraya
H 指数:19论文数:54被引数:2,438