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M

Michael Ohh

University of Toronto

53H指数
221论文数
1.5W被引数
收录论文 79
发表时间
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Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
errELIFE
IF0
err2025-10-20
err0
PREAI
errTaber, Cassandra C.; He, Wenguang; Gasmi-Seabrook, Genevieve M. C.; Hubert, Mia; Ferens, Fraser G.; Ikura, Mitsuhiko; Lee, Jeffrey E.; Ohh, Michael
err分享
err收藏
Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer患者来源肾癌细胞在细胞和动物模型中的比较单细胞转录组学分析
errFEBS OPEN BIO
IF2.3
err2025-04-16
err0
errOAAI
errRichard Huang; Lynn Kee; Alexander Gont; Jalna Meens; Fraser G. Ferens; Meredith S. Irwin; Laurie Ailles; Scott A. Yuzwa; Claire M. Robinson; Michael Ohh
err分享
err收藏
Time- resolved NMR detection of prolyl- hydroxylation in intrinsically disordered region of HIF-1α
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-09-04
err0
errOAAI
errHe, Wenguang; Seabrook, Genevieve M. C. Gasmi; Ikura, Mitsuhiko; Lee, Jeffrey E.; Ohh, Michael
err分享
err收藏
Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage
errSCIENTIFIC REPORTS
IF3.9
err2024-06-26
err0
errOAAI
errStuart, Sarah; Tarade, Daniel; Ohh, Michael
err分享
err收藏
Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-02-28
err1
errOAAI
errFerens, Fraser G.; Taber, Cassandra C.; Stuart, Sarah; Hubert, Mia; Tarade, Daniel; Lee, Jeffrey E.; Ohh, Michael
err分享
err收藏
Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway氧化低密度脂蛋白积累通过将转录从HIF-1α 转移到Nrf2途径来抑制糖酵解并减弱巨噬细胞炎症反应
errJOURNAL OF IMMUNOLOGY
IF3.4
err2023-09-27
err13
errOAAI
errTing, Kenneth K. Y.; Yu, Pei; Dow, Riley; Floro, Eric; Ibrahim, Hisham; Scipione, Corey A.; Hyduk, Sharon J.; Polenz, Chanele K.; Zaslaver, Olga; Karmaus, Peer W. F.; Fessler, Michael B.; Rost, Hannes L.; Ohh, Michael; Tsai, Sue; Winer, Daniel A.; Woo, Minna; Rocheleau, Jonathan; Jongstra-Bilen, Jenny; Cybulsky, Myron I.
err分享
err收藏
Diverse effects of mutations in Exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err74
errOAAI
errHansen, WJ; Ohh, M; Moslehi, J; Kondo, K; Kaelin, WG; Welch, WJ
err分享
err收藏
Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err376
errOAAI
errLonergan, KM; Iliopoulos, O; Ohh, M; Kamura, T; Conaway, RC; Conaway, JW; Kaelin, WG
err分享
err收藏
PVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err186
errOAAI
errStickle, NH; Chung, J; Klco, JM; Hill, RP; Kaelin, WG; Ohh, M
err分享
err收藏
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err254
errOAAI
errEvans, Andrew J.; Russell, Ryan C.; Roche, Olga; Burry, T. Nadine; Fish, Jason E.; Chow, Vinca W. K.; Kim, William Y.; Saravanan, Arthy; Maynard, Mindy A.; Gervais, Michelle L.; Sufan, Roxana I.; Roberts, Andrew M.; Wilson, Leigh A.; Betten, Mark; Vandewalle, Cindy; Berx, Geert; Marsden, Philip A.; Irwin, Meredith S.; Teh, Bin T.; Jewett, Michael A. S.; Ohh, Michael
err分享
err收藏
DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-21
err19
errOAAI
errHeir, Pardeep; Sufan, Roxana I.; Greer, Samantha N.; Poon, Betty P.; Lee, Jeffrey E.; Ohh, Michael
err分享
err收藏
Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata
errELIFE
IF0
err2022-08-30
err19
errOAAI
errOhh, Michael; Taber, Cassandra C.; Ferens, Fraser G.; Tarade, Daniel
err分享
err收藏
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
errNATURE COMMUNICATIONS
IF15.7
err2021-11-01
err30
errOAAI
errGebregiworgis, Teklab; Kano, Yoshihito; St-Germain, Jonathan; Radulovich, Nikolina; Udaskin, Molly L.; Mentes, Ahmet; Huang, Richard; Poon, Betty P. K.; He, Wenguang; Valencia-Sama, Ivette; Robinson, Claire M.; Huestis, Melissa; Miao, Jinmin; Yeh, Jen Jen; Zhang, Zhong-Yin; Irwin, Meredith S.; Lee, Jeffrey E.; Tsao, Ming-Sound; Raught, Brian; Marshall, Christopher B.; Ohh, Michael; Ikura, Mitsuhiko
err分享
err收藏
KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor
errANNALS OF ONCOLOGY
IF65.4
err2021-07-01
err0
errOAAI
errKano, Yoshihito; Gebregiworgis, Teklab; Marshall, Christopher; Ikura, Mitsuhiko; Miyake, Satoshi; Ohh, Michael
err分享
err收藏
Hypoxia and viral infectious diseases
errJCI INSIGHT
IF6.1
err2021-04-08
err17
errOAAI
errHuang, Richard; Huestis, Melissa; Gan, Esther Shuyi; Ooi, Eng Eong; Ohh, Michael
err分享
err收藏
PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
errJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
err2021-01-07
err51
errOAAI
errLiotti, Federica; Kumar, Narender; Prevete, Nella; Marotta, Maria; Sorriento, Daniela; Ierano, Caterina; Ronchi, Andrea; Marino, Federica Zito; Moretti, Sonia; Colella, Renato; Puxeddu, Efiso; Paladino, Simona; Kano, Yoshihito; Ohh, Michael; Scala, Stefania; Melillo, Rosa Marina
err分享
err收藏
NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma
errCANCER RESEARCH
IF16.6
err2020-08-14
err51
errOAAI
errValencia-Sama, Ivette; Ladumor, Yagnesh; Kee, Lynn; Adderley, Teresa; Christopher, Gabriella; Robinson, Claire M.; Kano, Yoshihito; Ohh, Michael; Irwin, Meredith S.
err分享
err收藏
AHypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding
errMOLECULAR CANCER RESEARCH
IF4.7
err2019-11-01
err22
PREAI
errRobinson, Claire M.; Poon, Betty P. K.; Kano, Yoshihito; Pluthero, Fred G.; Kahr, Walter H. A.; Ohh, Michael
err分享
err收藏
Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
errNATURE COMMUNICATIONS
IF15.7
err2019-07-23
err20
errOAAI
errTarade, Daniel; Lee, Jeffrey E.; Ohh, Michael
err分享
err收藏
Targeting SHP2 and RAS MAPK pathway in neuroblastoma
errCANCER RESEARCH
IF16.6
err2019-07-01
err0
PREAI
errValencia-Sama, Ivette; Adderley, Teresa; Kee, Lynn; Christopher, Gabriella; Kano, Yoshihito; Ohh, Michael; Irwin, Meredith
err分享
err收藏

研究方向

暂无研究方向
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