未登录 Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers Cyclin E1/CDK2的激活定义了妇科癌症中WEE1激酶抑制的关键易损性。 Kim, Daehwan; Chung, Heekyung; Liu, Wen; Jeong, Kangjin; Ozmen, Tugba Y.; Ozmen, Furkan; Rames, Matthew J.; Kim, Sangyub; Guo, Xiao; Jameson, Nathan; de Jong, Petrus R.; Yea, Steven; Harford, Laurie; Li, Jiali; Mathews, Cara A.; Doroshow, Deborah B.; Charles, Vincent J.; Kim, Doris; Fischer, Kimberlee; Samatar, Ahmed A.; Jubb, Adrian; Bunker, Kevin D.; Blackwell, Kimberly; Simpkins, Fiona; Meric-Bernstam, Funda; Mills, Gordon B.; Harismendy, Olivier; Ma, Jianhui; Lackner, Mark R. 分享 收藏
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The selective WEE1 inhibitor azenosertib shows synergistic anti-tumor activity with KRASG12C inhibitors in multiple KRASG12C models Jameson, Nathan M.; Kim, Gabriel; Lee, Catherine; Skrable, Blake; Shea, Alexandra; Abed, Monah; Harismendy, Olivier; Ma, Jianhui; Kim, Doris; Lackner, Mark R. 分享 收藏
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IDE161, a potential first-in-class clinical candidate PARG inhibitor, selectively targets homologous-recombination-deficient and PARP inhibitor resistant breast and ovarian tumors Abed, Monah; Munoz, Diana; Seshadri, Vidya; Federowicz, Steve; Rao, Arjun A.; Bhupathi, Deepthi; Liimatta, Marya; Ousterhout, Rita; Jaipuri, Firoz; Neilan, Claire; Lackner, Mark; White, Mike; Mounir, Zineb 分享 收藏
Dual inhibition of MAT2A and PRMT5 delivers synergistic anti-tumor responses in preclinical models of MTAP-deleted cancer Fischer, Marcus M.; Gerrick, Kimberline; Belmontes, Brian; Slemmons, Katherine; Freyman, Yevgeniy; Jain, Jay; Federowicz, Steve; Bishof, Isaac; Rao, Arjun A.; Fleury, Melissa; Mounir, Zineb; Lackner, Mark R.; Hughes, Paul E.; White, Mike; Neilan, Claire L. 分享 收藏
Cyclin E1 protein overexpression sensitizes ovarian cancer cells to ZN-c3, a novel, selective and oral bioavailable inhibitor of Wee1 Ma, Jianhui; Liu, Wen; Chung, Heekyung; Izadi, Hooman; DeJong, Petrus; Harismendy, Olivier; Li, Jia; Donate, Fernando; Samatar, Ahmed; Lackner, Mark; Escoubet, Laure; Bunker, Kevin; Kim, Daehwan; Jameson, Nathan; Ozmen, Tugba Yildiran; Jeong, Kangjin; Zhang, Dong; Pan, Wen-An; Mills, Gordon 分享 收藏
A small-molecule inhibitor of WRN selectively kills MSI-H cancer cells and phenocopies WRN genetic defects Rao, Yanhua; Srivatsan, Anjana; Liimatta, Marya; Munoz, Diana; Quirit, Jeanne; Shi, Jianxia; Nguyen, An; Xin Linghu; Federowicz, Federowicz; Jones, Brian; Fleury, Melissa; Newby, Zach; Dillon, Michael P.; Barsanti, Paul A.; Lackner, Mark R.; White, Michael A.; Lee, Yang; Landis, Phil; Peng, Yang; Cicchini, Michelle; Cottom, Josh; Nickels, Leng; Brnardic, Ed; DeMartino, Michael; Taygerly, Josh 分享 收藏
MAT2A inhibition in MTAP-/- tumors confers mechanistic vulnerabilities to multiple clinically actionable synthetic lethal drug combinations Gerrick, Kimberline Y.; Laraio, Jenny; Annen, Kelsey; Tran, Hoang; Fischer, Marcus M.; Freyman, Yevgeniy; Sharma, Geeta; Bishof, Isaac; Federowicz, Stephen; Pankajakshan, Divya; Neilan, Claire L.; Mangatt, Biju; Mazurek, Anthony; Lackner, Mark R.; White, Michael; Mounir, Zineb 分享 收藏
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In vitro and in vivo characterization of novel MAT2A allosteric inhibitors Pei, Zhonghua; Alam, Muzaffar; Bhola, Neil; Cleary, Leah; Drummond, Jake; Fisher, Marcus; Fleury, Melissa; Garcia, Candy; Givmanesh, Atieh; Xin Linghu; McSpadden, Ethan; Mounir, Zineb; Neilan, Claire; Newby, Zach; Perumal, Senthil; Steel, Richard; Sutton, James; Vaidya, Kedar; Wagle, Marie-Claire; Wang, Jianhong; Yao, Bing; Lackner, Mark; Dillon, Michael P. 分享 收藏
Mat2A Inhibitors decrease growth, increase senescence and p53 stability in MTAP-deleted cancer cells Bhola, Neil; Givmanesh, Atieh; Wagle, Marie-Claire; Garcia, Candy; Vaidya, Kedar; Cleary, Leah; Pei, Zhonghua; Lackner, Mark; Mounir, Zineb 分享 收藏
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Genomic Analysis of Circulating Tumor Cells at the Single-Cell Level Lu, Shan; Chang, Chia-Jung; Guan, Yinghui; Szafer-Glusman, Edith; Punnoose, Elizabeth; Do, An; Suttmann, Becky; Gagnon, Ross; Rodriguez, Angel; Landers, Mark; Spoerke, Jill; Lackner, Mark R.; Xiao, Wenzhong; Wang, Yulei 分享 收藏
Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models Moore, Heather M.; Savage, Heidi M.; O'Brien, Carol; Zhou, Wei; Sokol, Ethan S.; Goldberg, Michael E.; Metcalfe, Ciara; Friedman, Lori S.; Lackner, Mark R.; Wilson, Timothy R. 分享 收藏
CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms Castillo, Joseph; Wu, Esther; Lowe, Christopher; Srinivasan, Shrividhya; McCord, Ron; Wagle, Marie-Claire; Jayakar, Sangeeta; Edick, Melissa Gonzalez; Eastham-Anderson, Jeffrey; Liu, Bonnie; Hutchinson, Katherine E.; Jones, Wendell; Stokes, Matthew P.; Tarighat, Somayeh S.; Holcomb, Thomas; Glibicky, Andrew; Romero, F. Anthony; Magnuson, Steven; Huang, Shih-Min A.; Plaks, Vicki; Giltnane, Jennifer M.; Lackner, Mark R.; Mounir, Zineb 分享 收藏
Genomic Alterations Associated with Recurrence and TNBC Subtype in High-Risk Early Breast Cancers Wilson, Timothy R.; Udyavar, Akshata R.; Chang, Ching-Wei; Spoerke, Jill M.; Aimi, Junko; Savage, Heidi M.; Daemen, Anneleen; O'Shaughnessy, Joyce A.; Bourgon, Richard; Lackner, Mark R. 分享 收藏
Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology Okrah, K.; Tarighat, S.; Liu, B.; Koeppen, H.; Wagle, M. C.; Cheng, G.; Sun, C.; Dey, A.; Chang, M. T.; Sumiyoshi, T.; Mounir, Z.; Cummings, C.; Hampton, G.; Amler, L.; Fridlyand, J.; Hegde, P. S.; Turley, S. J.; Lackner, M. R.; Huang, S. M. 分享 收藏
Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA Clark, Travis A.; Chung, Jon H.; Kennedy, Mark; Hughes, Jason D.; Chennagiri, Niru; Lieber, Daniel S.; Fendler, Bernard; Young, Lauren; Zhao, Mandy; Coyne, Michael; Breese, Virginia; Young, Geneva; Donahue, Amy; Pavlick, Dean; Tsiros, Alyssa; Brennan, Timothy; Zhong, Shan; Mughal, Tariq; Bailey, Mark; He, Jie; Roels, Steven; Frampton, Garrett M.; Spoerke, Jill M.; Gendreau, Steven; Lackner, Mark; Schleifman, Erica; Peters, Eric; Ross, Jeffrey S.; Ali, Siraj M.; Miller, Vincent A.; Gregg, Jeffrey P.; Stephens, Philip J.; Welsh, Allison; Otto, Geoff A.; Lipson, Doron 分享 收藏
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