Wolfgang A. Linke - Publications, H-index & Citations

Wolfgang A. Linke

university of munster

81H指数

326论文数

2.2W被引数

收录论文 174

发表时间

Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis 选择性肌联蛋白切割破坏心脏机械稳态，驱动心力衰竭和纤维化

Nature Cardiovascular Research

IF10.8

2026-06-16

OAAI

Johanna K. Freundt; Paulina Hartmann; Christine M. Loescher; Andreas Unger; Franziska Koser; Annika J. Klotz; Lena Wildschütz; Lydia Wachsmuth; Susanne Hille; Michaela M. Door; Anne Helfen; Richard Holtmeier; Cornelius Faber; Jonathan A. Kirk; Verena Hoerr; Oliver J. Müller; Wolfgang A. Linke

Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6 自噬阻滞导致肌原纤维肌病6型小鼠模型中骨骼肌严重破坏

Nature Communications

IF15.7

2026-04-11

OAAI

Kerstin Filippi; Kathrin Graf-Riesen; Maithreyan Kuppusamy; Andreas Unger; Kenichi Kimura; Martin Matijass; Henrique Baeta; Magdalena Podlacha; Daniel Haertter; Alexei P. Kudin; Martin Wiemann; Grzegorz Węgrzyn; Cornelia Kornblum; Jens Reimann; Wolfgang A. Linke; Pitter F. Huesgen; Wolfram S. Kunz; Bernd K. Fleischmann; Michael Hesse

Highlights from the cellular biology and function of the Heart Biennial Meeting 2025 2025年心脏细胞生物学与功能双年会的重点内容

European Heart Journal

IF35.6

2026-04-01

PREAI

Linke, Wolfgang A.; Pesce, Maurizio

PO29 Quantification of titin protein isoforms in patients with dilated cardiomyopathy PO29 肌联蛋白异形体在扩张型心肌病患者的量化

European Journal of Preventive Cardiology

IF7.5

2026-03-19

PREAI

Marketa Adamova; Franziska Koser; Mate Andrik; Milos Kubanek; Alice Krebsova; Vojtech Melenovsky; Wolfgang Linke

Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities: A scientific statement of the ESC Council on Basic Cardiovascular Science, the ESC Working Group on Atherosclerosis and Vascular Biology, the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Myocardial Function, and the ESC Working Group on Cardiac Cellular Electrophysiology 新型心血管代谢危险因素机制与治疗机遇：欧洲心脏病学会基础心血管科学委员会、欧洲心脏病学会动脉粥样硬化和血管生物学工作组、欧洲心脏病学会心脏细胞生物学工作组、欧洲心脏病学会心肌功能工作组以及欧洲心脏病学会心脏细胞电生理工作组科学声明

European Heart Journal

IF35.6

2026-03-06

OAAI

Paul C Evans; Gemma Vilahur; Petra Kleinbongard; Elena Osto; Carol Ann Remme; Rosalinda Madonna; Dunja Aksentijevic; Harald Sourij; Sean M Davidson; Donato Santovito; Jürgen Gindlhuber; Christian Weber; Wolfgang A Linke; Esther Lutgens; Luc Bertrand; Dana Dawson; Magnus Bäck; G Danilo Norata; Johann Wojta; Cinzia Perrino

Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed mouse skeletal muscle

PHYSIOLOGICAL REPORTS

IF1.9

2025-10-27

OAAI

Kuehn, Michel N.; Engels, Nichlas M.; Nissen, Devin L.; Freundt, Johanna K.; Ma, Weikang; Harris, Samantha P.; Irving, Thomas C.; Linke, Wolfgang A.; Hessel, Anthony L.

Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy 预防收缩力下降诱导的成纤维细胞增殖可缓解扩张型心肌病

Science

IF45.8

2025-09-11

PREAI

Ross C. Bretherton; Isabella M. Reichardt; Kristin A. Zabrecky; Abigail Nagle; Logan R. J. Bailey; Darrian Bugg; Sasha Smolgovsky; Amy L. Gifford; Timothy S. McMillen; Alex J. Goldstein; Kristina B. Kooiker; Galina V. Flint; Amy Martinson; Jagdambika Gunaje; Franziska Koser; Elizabeth Plaster; Wolfgang A. Linke; Michael Regnier; Farid Moussavi-Harami; Nathan J. Sniadecki; Cole A. DeForest; Jennifer Davis

NAD+ repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling NAD+补充通过抑制过度的营养信号，恢复肥胖相关心力衰竭中的心脏保护性自噬和线粒体自噬。

Autophagy

IF14.3

2025-07-04

PREAI

Mahmoud Abdellatif; Francisco Vasques-Nóvoa; João Pedro Ferreira; Junichi Sadoshima; Abhinav Diwan; Wolfgang A. Linke; Guido Kroemer; Simon Sedej

Direction-dependent contributions of cardiac myofilament networks to myocardial passive stiffness reveal a major disparity for titin 心肌肌丝网络对心肌被动刚度的方向依赖性贡献揭示了titin的重大差异。

Basic Research in Cardiology

IF8

2025-06-13

OAAI

Felix A. Wagner; Christine M. Loescher; Andreas Unger; Michel Kühn; Annika J. Klotz; Ivan Liashkovich; Dominika Ciechanska; Hermann Schillers; Franziska Koser; Johanna K. Freundt; Anthony L. Hessel; Wolfgang A. Linke

Obesity and Comorbidities in HFpEF: A Retrospective Cohort Analysis in a University Hospital Setting HFpEF中的肥胖和合并症: 大学医院环境中的回顾性队列分析

JOURNAL OF CLINICAL MEDICINE

IF2.9

2025-05-12

OAAI

Hobbach, Anastasia Janina; Brix, Tobias Johannes; Weyer-Elberich, Veronika; Varghese, Julian; Reinecke, Holger; Linke, Wolfgang Albrecht

Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation

CIRCULATION

IF38.6

2024-08-13

OAAI

Fakuade, Funsho E.; Hubricht, Dominik; Moeller, Vanessa; Sobitov, Izzatullo; Liutkute, Aiste; Doering, Yannic; Seibertz, Fitzwilliam; Gerloff, Marcus; Pronto, Julius Ryan D.; Haghighi, Fereshteh; Brandenburg, Soeren; Alhussini, Khaled; Ignatyeva, Nadezda; Bonhoff, Yara; Kestel, Stefanie; El-Essawi, Aschraf; Jebran, Ahmad Fawad; Grossmann, Marius; Danner, Bernhard C.; Baraki, Hassina; Schmidt, Constanze; Sossalla, Samuel; Kutschka, Ingo; Bening, Constanze; Maack, Christoph; Linke, Wolfgang A.; Heijman, Jordi; Lehnart, Stephan E.; Kensah, George; Ebert, Antje; Mason, Fleur E.; Voigt, Niels

Imaging of Existing and Newly Translated Proteins Elucidates Mechanisms of Sarcomere Turnover

CIRCULATION RESEARCH

IF16.2

2024-08-02

OAAI

Douvdevany, Guy; Erlich, Itai; Haimovich-Caspi, Lilac; Mashiah, Tomer; Prondzynski, Maksymilian; Pricolo, Maria Rosaria; Alegre-Cebollada, Jorge; Linke, Wolfgang A.; Carrier, Lucie; Kehat, Izhak

Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function

EUROPEAN JOURNAL OF HEART FAILURE

IF10.8

2024-06-04

OAAI

Falcao-Pires, Ines; Ferreira, Ana Filipa; Trindade, Fabio; Bertrand, Luc; Ciccarelli, Michele; Visco, Valeria; Dawson, Dana; Hamdani, Nazha; Van Laake, Linda W.; Lezoualc'h, Frank; Linke, Wolfgang A.; Lunde, Ida G.; Rainer, Peter P.; Abdellatif, Mahmoud; van der Velden, Jolanda; Cosentino, Nicola; Paldino, Alessia; Pompilio, Giulio; Zacchigna, Serena; Heymans, Stephane; Thum, Thomas; Tocchetti, Carlo Gabriele

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure

COMMUNICATIONS BIOLOGY

IF5.1

2024-05-27

OAAI

Hessel, Anthony L.; Kuehn, Michel N.; Han, Seong-Won; Ma, Weikang; Irving, Thomas C.; Momb, Brent A.; Song, Taejeong; Sadayappan, Sakthivel; Linke, Wolfgang A.; Palmer, Bradley M.

Titin-Based Force Modulates Cardiac Thick and Thin Filaments

CIRCULATION RESEARCH

IF16.2

2024-04-12

PREAI

Hessel, Anthony L.; Kuehn, Michel N.; Engels, Nichlas M.; Nissen, Devin L.; Freundt, Johanna K.; Ma, Weikang; Irving, Thomas C.; Linke, Wolfgang A.

Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis

ANGIOGENESIS

IF9.2

2024-04-10

OAAI

Drost, Carolin Christina; Rovas, Alexandros; Osiaevi, Irina; Schughart, Klaus; Lukasz, Alexander; Linke, Wolfgang A.; Pavenstaedt, Hermann; Kuempers, Philipp

BMI-Stratified Exploration of the 'Obesity Paradox': Heart Failure Perspectives from a Large German Insurance Database

JOURNAL OF CLINICAL MEDICINE

IF2.9

2024-04-03

OAAI

Hobbach, Anastasia J.; Feld, Jannik; Linke, Wolfgang A.; Sindermann, Jurgen R.; Droege, Patrik; Ruhnke, Thomas; Guenster, Christian; Reinecke, Holger

Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads

NATURE COMMUNICATIONS

IF15.7

2024-03-23

OAAI

Hessel, Anthony L.; Engels, Nichlas M.; Kuehn, Michel N.; Nissen, Devin; Sadler, Rachel L.; Ma, Weikang; Irving, Thomas C.; Linke, Wolfgang A.; Harris, Samantha P.

Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix

cardiovascular research

IF10.8

2023-10-26

OAAI

Loescher, Christine M.; Freundt, Johanna K.; Unger, Andreas; Hessel, Anthony L.; Kuehn, Michel; Koser, Franziska; Linke, Wolfgang A.

Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte

CIRCULATION RESEARCH

IF16.2

2023-07-21

OAAI

Li, Jia; Sundnes, Joakim; Hou, Yufeng; Laasmaa, Martin; Ruud, Marianne; Unger, Andreas; Kolstad, Terje R.; Frisk, Michael; Norseng, Per Andreas; Yang, Limin; Setterberg, Ingunn E.; Alves, Estela S.; Kalakoutis, Michaeljohn; Sejersted, Ole M.; Lanner, Johanna T.; Linke, Wolfgang A.; Lunde, Ida G.; de Tombe, Pieter P.; Louch, William E.

研究方向