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Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts Bhagat, Tushar D.; Von Ahrens, Dagny; Dawlaty, Meelad; Zou, Yiyu; Baddour, Joelle; Achreja, Abhinav; Zhao, Hongyun; Yang, Lifeng; Patel, Brijesh; Kwak, Changsoo; Choudhary, Gaurav S.; Gordon-Mitchell, Shanisha; Aluri, Srinivas; Bhattacharyya, Sanchari; Sahu, Srabani; Bhagat, Prafulla; Yu, Yiting; Bartenstein, Matthias; Giricz, Orsi; Suzuki, Masako; Sohal, Davendra; Gupta, Sonal; Guerrero, Paola A.; Batra, Surinder; Goggins, Michael; Steidl, Ulrich; Greally, John; Agarwal, Beamon; Pradhan, Kith; Banerjee, Debabrata; Nagrath, Deepak; Maitra, Anirban; Verma, Amit 分享 收藏
The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma Giricz, Orsi; Mo, Yongkai; Dahlman, Kimberly B.; Cotto-Rios, Xiomaris M.; Vardabasso, Chiara; Hoa Nguyen; Matusow, Bernice; Bartenstein, Matthias; Polishchuk, Veronika; Johnson, Douglas B.; Bhagat, Tushar D.; Shellooe, Rafe; Burton, Elizabeth; Tsai, James; Zhang, Chao; Habets, Gaston; Greally, John M.; Yu, Yiting; Kenny, Paraic A.; Fields, Gregg B.; Pradhan, Kith; Stanley, E. Richard; Bernstein, Emily; Bollag, Gideon; Gavathiotis, Evripidis; West, Brian L.; Sosman, Jeffrey A.; Verma, Amit K. 分享 收藏
Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways Bhattacharyya, Sanchari; Pradhan, Kith; Campbell, Nathaniel; Mazdo, Jozef; Vasantkumar, Aparna; Maqbool, Shahina; Bhagat, Tushar D.; Gupta, Sonal; Suzuki, Masako; Yu, Yiting; Greally, John M.; Steidl, Ulrich; Bradner, James; Dawlaty, Meelad; Godley, Lucy; Maitra, Anirban; Verma, Amit 分享 收藏
Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation Bhagat, Tushar D.; Chen, Si; Bartenstein, Matthias; Barlowe, A. Trevor; Von Ahrens, Dagny; Choudhary, Gaurav S.; Tivnan, Patrick; Amin, Elianna; Marcondes, A. Mario; Sanders, Mathijs A.; Hoogenboezem, Remco M.; Kambhampati, Suman; Ramachandra, Nandini; Mantzaris, Iaonnis; Sukrithan, Vineeth; Laurence, Remi; Lopez, Robert; Bhagat, Prafullla; Giricz, Orsi; Sohal, Davendra; Wickrema, Amittha; Yeung, Cecilia; Gritsman, Kira; Aplan, Peter; Hochedlinger, Konrad; Yu, Yiting; Pradhan, Kith; Zhang, Jinghang; Greally, John M.; Mukherjee, Siddhartha; Pellagatti, Andrea; Boultwood, Jacqueline; Will, Britta; Steidl, Ulrich; Raaijmakers, Marc H. G. P.; Deeg, H. Joachim; Kharas, Michael G.; Verma, Amit 分享 收藏
Aberrant expression of CSF1R in melanoma is driven through an endogenous viral promoter and it contributes to malignant growth and the acquisition of resistance against BRAF inhibition Giricz, Orsolya; Mo, Yongkai; Hu, Caroline Y.; Yu, Yiting; Pradhan, Kith; Bartenstein, Matthias; Ramachandra, Nandini; Polishchuck, Veronika; Dahlman, Kimberly B.; Bhagat, Tushar; Hoa Nguyen; Matusow, Bernice; Shellooe, Rafe; Burton, Elizabeth; Kenny, Paraic; Greally, John; Sosman, Jeffrey; Bollag, Gideon; West, Brian; Verma, Amit 分享 收藏
In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice Seki, Yoshinori; Suzuki, Masako; Guo, Xingyi; Glenn, Alan Scott; Vuguin, Patricia M.; Fiallo, Ariana; Du, Quan; Ko, Yi-An; Yu, Yiting; Susztak, Katalin; Zheng, Deyou; Greally, John M.; Katz, Ellen B.; Charron, Maureen J. 分享 收藏
Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer Bhagat, Tushar D.; Zou, Yiyu; Huang, Shizheng; Park, Jihwan; Palmer, Matthew B.; Hu, Caroline; Li, Weijuan; Shenoy, Niraj; Giricz, Orsolya; Choudhary, Gaurav; Yu, Yiting; Ko, Yi-An; Izquierdo, Maria C.; Park, Ae Seo Deok; Vallumsetla, Nishanth; Laurence, Remi; Lopez, Robert; Suzuki, Masako; Pullman, James; Kaner, Justin; Gartrell, Benjamin; Hakimi, A. Ari; Greally, John M.; Patel, Bharvin; Benhadji, Karim; Pradhan, Kith; Verma, Amit; Susztak, Katalin 分享 收藏
Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia Bachegowda, Lohith; Morrone, Kerry; Winski, Shannon L.; Mantzaris, Ioannis; Bartenstein, Matthias; Ramachandra, Nandini; Giricz, Orsi; Sukrithan, Vineeth; Nwankwo, George; Shahnaz, Samira; Bhagat, Tushar D.; Bhattacharyya, Sanchari; Assal, Amer; Shastri, Aditi; Gordon-Mitchell, Shanisha; Pellagatti, Andrea; Boultwood, Jacqueline; Schinke, Carolina; Yu, Yiting; Guha, Chandan; Rizzi, James; Garrus, Jennifer; Brown, Suzy; Wollenberg, Lance; Hogeland, Grant; Wright, Dale; Munson, Mark; Rodriguez, Mareli; Gross, Stefan; Chantry, David; Zou, Yiyu; Platanias, Leonidas C.; Burgess, Laurence E.; Pradhan, Kith; Steidl, Ulrich; Verma, Amit 分享 收藏
Integrated epigenomic profiling reveals widespread demethylation in melanoma and points to the role of CSF1R-RUNX1 axis in resistance against BRAF inhibition Giricz, Orsolya; Mo, Yongkai; Hu, Caroline H.; Dahlman, Kimberly; Ramachandra, Nandini; Bartenstein, Matthias; Pradhan, Kith; Bhagat, Tushar; Yu, Yiting; Nguyen, Hoa; Burton, Elizabeth; Matusow, Bernice; Habets, Gaston; Shellooe, Rafe; Bollag, Gideon; West, Brian; Greally, John; Sosman, Jeffrey; Kenny, Paraic; Verma, Amit 分享 收藏
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RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors Cheng, Haiying; Zou, Yiyu; Ross, Jeffrey S.; Wang, Kai; Liu, Xuewen; Halmos, Balazs; Ali, Siraj M.; Liu, Huijie; Verma, Amit; Montagna, Cristina; Chachoua, Abraham; Goel, Sanjay; Schwartz, Edward L.; Zhu, Changcheng; Shan, Jidong; Yu, Yiting; Gritsman, Kira; Yelensky, Roman; Lipson, Doron; Otto, Geoff; Hawryluk, Matthew; Stephens, Philip J.; Miller, Vincent A.; Piperdi, Bilal; Perez-Soler, Roman 分享 收藏
Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes Sundaravel, Sriram; Duggan, Ryan; Bhagat, Tushar; Ebenezer, David L.; Liu, Hui; Yu, Yiting; Bartenstein, Matthias; Unnikrishnan, Madhu; Karmakar, Subhradip; Liu, Ting-Chun; Torregroza, Ingrid; Quenon, Thomas; Anastasi, John; McGraw, Kathy L.; Pellagatti, Andrea; Boultwood, Jacqueline; Yajnik, Vijay; Artz, Andrew; Le Beau, Michelle M.; Steidl, Ulrich; List, Alan F.; Evans, Todd; Verma, Amit; Wickrema, Amittha 分享 收藏
Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia Will, Britta; Vogler, Thomas O.; Narayanagari, Swathi; Bartholdy, Boris; Todorova, Tihomira I.; Ferreira, Mariana da Silva; Chen, Jiahao; Yu, Yiting; Mayer, Jillian; Barreyro, Laura; Carvajal, Luis; Ben Neriah, Daniela; Roth, Michael; van Oers, Johanna; Schaetzlein, Sonja; McMahon, Christine; Edelmann, Winfried; Verma, Amit; Steidl, Ulrich 分享 收藏
TET1 is a tumor suppressor of hematopoietic malignancy (vol 16, pg 653, 2015) Cimmino, Luisa; Dawlaty, Meelad M.; Ndiaye-Lobry, Delphine; Yap, Yoon Sing; Bakogianni, Sofia; Yu, Yiting; Bhattacharyya, Sanchari; Shaknovich, Rita; Geng, Huimin; Lobry, Camille; Mullenders, Jasper; King, Bryan; Trimarchi, Thomas; Aranda-Orgilles, Beatriz; Liu, Cynthia; Shen, Steven; Verma, Amit K.; Jaenisch, Rudolf; Aifantis, Iannis 分享 收藏
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