Leonard J. Appleman - Publications, H-index & Citations

Leonard J. Appleman

UPMC Hillman Cancer Center

41H指数

339论文数

6.2K被引数

收录论文 60

发表时间

Phase 1 clinical trial of the ataxia telangiectasia and Rad3-related inhibitor berzosertib with irinotecan in patients with advanced solid tumors (ETCTN 9938)I期临床试验：评估ataxia telangiectasia和Rad3-related抑制剂berzosertib联合伊立替康治疗晚期实体瘤患者的疗效（ETCTN 9938）

Cancer

IF5.1

2025-10-29

PREAI

Liza C. Villaruz MD; Jingxiao Jin MD; Hong Wang PhD; James J. Lee MD, PhD; Jason J. Luke MD; John C. Rhee MD; Saiama N. Waqar MD; Geoffrey I. Shapiro MD, PhD; James Cleary MD, PhD; Diwakar Davar MD; Timothy F. Burns MD, PhD; Rashmi Verma MD; Manik Amin MD; Leonard Appleman MD, PhD; Kristen K. Ciombor MD; Elizabeth J. Davis MD; Jonathan W. Riess MD; E. Claire Dees MD; Edward J. Kim MD, PhD; Dana Cardin MD; Jianxia Guo PhD; Susan M. Christner BS; Joshua Deppas MS; Angelina M. Parise BS; John C. Schmitz PhD; Bella S. Guerrouahen PhD; Michael Suchko BS; Alejandro Contreras MD, PhD; Li Li PhD; Katherine V. Ferry-Galow PhD; Ting-Chia Chang MS; Shahanawaz Jiwani MD, PhD; Christopher J. Bakkenist PhD; Edward Chu MD; Steven D. Gore MD; Jan H. Beumer PharmD, PhD

Seminoma Resulting in Rapidly Progressive Cerebellar Syndrome with Associated Dual Positive Kelch-like Protein 11 (KLHL11) and Leucine Zipper 4 (LUZP4)-immunoglobulin G (IgG) Antibodies 精原细胞瘤导致快速进展的小脑综合征，伴有双重阳性的Kelch-like蛋白11（KLHL11）和亮氨酸拉链4（LUZP4）-免疫球蛋白G（IgG）抗体。

NEUROLOGY

IF8.5

2024-10-08

PREAI

Orie, Ryan; Appleman, Leonard; Maranchie, Jodi; Suski, Valerie; Drappatz, Jan; Linnoila, Jenny

Xaluritamig, a STEAP1 x CD3 XmAb 2+1 immune therapy, in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Initial results from dose expansion cohorts in a phase I study Xaluritamig，一种STEAP1 x CD3 XmAb 2+1免疫疗法，在转移性去势抵抗性前列腺癌（mCRPC）患者（pts）中的初步研究结果：来自一项I期研究剂量扩展队列的数据

ANNALS OF ONCOLOGY

IF65.4

2024-09-01

PREAI

Kelly, W. K.; Appleman, L. J.; Lin, C-C.; Armstrong, A. J.; Fischer, S. C.; Pook, D. W.; Perez Gracia, J. L.; Lee, J. L.; Berthold, D. R.; Ward, P. J.; Castellano Gauna, D. E.; Horvath, L. G.; Kim, M.; Matsubara, N.; Sumey, C.; Shabooti, M.; Yang, Z.; Connarn, J.; Stieglmaier, J.; Danila, D. C.

Phase II randomized double-blind trial of axitinib (Axi) +/- PF 04518600, an OX40 antibody (PFOX) after PD1/PDL1 antibody (IO) therapy (Tx) in metastatic renal cell carcinoma (mRCC): Final analysis II期随机双盲试验，评估阿昔替尼（Axi）联合或不含PF 04518600（一种OX40抗体，PFOX）在PD1/PDL1抗体（IO）疗法（Tx）后用于转移性肾细胞癌（mRCC）的最终分析。

ANNALS OF ONCOLOGY

IF65.4

2024-09-01

PREAI

Sadeghi, S.; Parikh, R.; Appleman, L. J.; Tsao-Wei, D.; Groshen, S.; Li, M.; Tagawa, S. T.; Nanus, D. M.; Molina, A. M.; Ornstein, M. C.; Rini, B. I.; Dreicer, R.; Quinn, D. I.; Lara, P. N.

A phase I/ II trial of pazopanib (Paz) alternating (alt) with bevacizumab (Bev) in treatment-naive metastatic clear cell renal cell carcinoma (mccRCC) patients (pts): Phase II results 一项 pazopanib (Paz) 与 bevacizumab (Bev) 交替给药的 I/II 期临床试验，用于治疗初治性转移性透明细胞肾细胞癌 (mccRCC) 患者 (pts)：II 期结果

ANNALS OF ONCOLOGY

IF65.4

2024-09-01

PREAI

George, S.; Vaishampayan, U. N.; Hutson, A.; Groman, A.; Roche, C. L.; Herbst, L.; Kallicharsn-Smith, R.; DiRaddo, A-M.; Farrell, E.; Kilari, D.; Gopalakrishnan, D.; Heath, E.; Wulff-Burchfield, E.; Appleman, L. J.; Parikh, R.

Pembrolizumab and Enzalutamide in Patients with Abiraterone Acetate-Pretreated Metastatic Castration-Resistant Prostate Cancer: Cohort C of the Phase 1b/2 KEYNOTE-365 Study Pembrolizumab和恩扎鲁他胺治疗经醋酸阿比曲酮预处理的转移性去势抵抗性前列腺癌患者: 1b/2期KEYNOTE-365研究的队列C

EUROPEAN UROLOGY ONCOLOGY

IF9.3

2024-06-01

OAAI

Yu, Evan Y.; Berry, William R.; Gurney, Howard; Retz, Margitta; Conter, Henry J.; Laguerre, Brigitte; Fong, Peter C. C.; Ferrario, Cristiano; Todenhofer, Tilman; Gravis, Gwenaelle; Piulats, Josep M.; Emmenegger, Urban; Shore, Neal D.; Romano, Emanuela; Mourey, Loic; Li, Xin Tong; Poehlein, Christian H.; Schloss, Charles; Appleman, Leonard J.; Bono, Johann S. de

Pembrolizumab plus Abiraterone Acetate and Prednisone in Patients with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer: Results from KEYNOTE-365 Cohort D 帕博利珠单抗联合阿比特龙醋酸盐和泼尼松用于化疗初治转移性去势抵抗性前列腺癌患者：KEYNOTE-365研究D队列的结果

European Urology Oncology

IF9.3

2024-06-01

OAAI

Evan Y. Yu; Cristiano Ferrario; Mark D. Linch; Michael Stoeckle; Brigitte Laguerre; Jose A. Arranz; Tilman Todenhöfer; Peter C. Fong; Josep M. Piulats; William Berry; Urban Emmenegger; Loic Mourey; Anthony M. Joshua; Nataliya Mar; Leonard J. Appleman; Henry J. Conter; Gwenaelle Gravis; Xin Tong Li; Charles Schloss; Christian Poehlein; Johann S. de Bono

ARV-766, A PROTAC ANDROGEN RECEPTOR (AR) DEGRADER, COMBINED WITH ABIRATERONE IN NOVEL HORMONAL AGENT (NHA)-NAïVE METASTATIC PROSTATE CANCER: PHASE 1 COHORT (PART C) OF A PHASE 1/2 STUDY

JOURNAL OF UROLOGY

IF6.8

2024-05-01

PREAI

Shore, Neal; Lang, Joshua M.; Geynisman, Daniel M.; Stewart, Tyler F.; Gao, Xin; Appleman, Leonard J.; Dreicer, Robert; Dorff, Tanya; Berghorn, Elmer; Duperret, Elizabeth; Lu, Haolan; Chan, Edward; Garmezy, Benjamin; Petrylak, Daniel P.

Disease-free Survival Analysis for Patients with High-risk Muscle-invasive Urothelial Carcinoma from the Randomized CheckMate 274 Trial by PD-L1 Combined Positive Score and Tumor Cell Score (vol 83, pg 432, 2024)

EUROPEAN UROLOGY

IF25.2

2024-03-01

OAAI

Galsky, Matthew D.; Bajorin, Dean F.; Witjes, Johannes Alfred; Gschwend, Juergen E.; Tomita, Yoshihiko; Nasroulah, Federico; Li, Jun; Collette, Sandra; Valderrama, Begona P.; Grimm, Marc-Oliver; Appleman, Leonard; Gravis, Gwenaelle; Necchi, Andrea; Ye, Dingwei; Stenner, Frank; Wind-Rotolo, Megan; Zhang, Joshua; uensal-Kacmaz, Keziban

Phase I LITESPARK-001 study of belzutifan for advanced solid tumors: Extended 41-month follow-up in the clear cell renal cell carcinoma cohort Beztifan治疗晚期实体瘤的I期LITESPARK-001研究: 在透明细胞肾细胞癌队列中延长41个月的随访

EUROPEAN JOURNAL OF CANCER

IF7.1

2024-01-01

PREAI

Jonasch, Eric; Bauer, Todd M.; Papadopoulos, Kyriakos P.; Plimack, Elizabeth R.; Merchan, Jaime R.; Mcdermott, David F.; Michaelson, M. Dror; Appleman, Leonard J.; Roy, Ananya; Perini, Rodolfo F.; Liu, Yanfang; Choueiri, Toni K.

Interim results from a phase I study of AMG 509 (xaluritamig), a STEAP1 x CD3 XmAb 2+1 immune therapy in patients with metastatic castration-resistant prostate cancer (mCRPC)

ANNALS OF ONCOLOGY

IF65.4

2023-11-01

PREAI

Kelly, W. K.; Danila, D. C.; Lin, C-C.; Lee, J-L.; Matsubara, N.; Ward, P. J.; Armstrong, A. J.; Pook, D. W.; Kim, M.; Dorff, T.; Fischer, S.; Lin, Y-C.; Horvath, L. G.; Sumey, C.; Yang, Z.; Jurida, G.; Connarn, J.; Penny, H.; Stieglmaier, J.; Appleman, L. J.

Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma

CLINICAL CANCER RESEARCH

IF10.2

2023-10-20

OAAI

Petrylak, Daniel P.; Eigl, Bernhard J.; George, Saby; Heath, Elisabeth I.; Hotte, Sebastien J.; Chism, David D.; Nabell, Lisle M.; Picus, Joel; Cheng, Susanna Y.; Appleman, Leonard J.; Sonpavde, Guru P.; Morgans, Alicia K.; Pourhosseini, Pourya; Wu, Ruishan; Standley, Laura; Croitoru, Ruslan; Yu, Evan Y.

Xaluritamig, a STEAP1 x CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study Xaluritamig，用于转移性去势抵抗性前列腺癌的STEAP1 x CD3 XmAb 2 1免疫疗法: 首次人体研究中剂量探索的结果

CANCER DISCOVERY

IF33.3

2023-10-20

OAAI

Kelly, William K.; Danila, Daniel C.; Lin, Chia-Chi; Lee, Jae-Lyun; Matsubara, Nobuaki; Ward, Patrick J.; Armstrong, Andrew J.; Pook, David; Kim, Miso; Dorff, Tanya B.; Fischer, Stefanie; Lin, Yung-Chang; Horvath, Lisa G.; Sumey, Christopher; Yang, Zhao; Jurida, Gabor; Smith, Kristen M.; Connarn, Jamie N.; Penny, Hweixian L.; Stieglmaier, Julia; Appleman, Leonard J.

Interim results from a phase I study of AMG 509 (xaluritamig), a STEAP1 x CD3 XmAb 2+1 immune therapy, in patients with metastatic castration-resistant prostate cancer (mCRPC)

ANNALS OF ONCOLOGY

IF65.4

2023-10-01

PREAI

Kelly, W.; Danila, D.; Lin, C-C.; Lee, J-L.; Matsubara, N.; Ward, P.; Armstrong, A. J.; Pook, D.; Kim, M.; Dorff, T.; Fischer, S.; Lin, Y-C.; Horvath, L. G.; Sumey, C.; Yang, Z.; Jurida, G.; Connarn, J.; Penny, H.; Stieglmaier, J.; Appleman, L. J.

Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

IF7.2

2023-08-11

PREAI

El Zarif, Talal; Nassar, Amin H.; Pond, Gregory R.; Zhuang, Tony Zibo; Master, Viraj; Nazha, Bassel; Niglio, Scot; Simon, Nicholas; Hahn, Andrew W.; Pettaway, Curtis A.; Tu, Shi-Ming; Abdel-Wahab, Noha; Velev, Maud; Flippot, Ronan; Buti, Sebastiano; Maruzzo, Marco; Mittra, Arjun; Gheeya, Jinesh; Yang, Yuanquan; Rodriguez, Pablo Alvarez; Castellano, Daniel; de Velasco, Guillermo; Roviello, Giandomenico; Antonuzzo, Lorenzo; McKay, Rana R.; Vincenzi, Bruno; Cortellini, Alessio; Hui, Gavin; Drakaki, Alexandra; Glover, Michael; Khaki, Ali Raza; El-Am, Edward; Adra, Nabil; Mouhieddine, Tarek H.; Patel, Vaibhav; Piedra, Aida; Gernone, Angela; Davis, Nancy B.; Matthews, Harrison; Harrison, Michael R.; Kanesvaran, Ravindran; Giudice, Giulia Claire; Barata, Pedro; Farolfi, Alberto; Lee, Jae Lyun; Milowsky, Matthew, I; Stahlfeld, Charlotte; Appleman, Leonard; Kim, Joseph W.; Freeman, Dory; Choueiri, Toni K.; Spiess, Philippe E.; Necchi, Andrea; Apolo, Andrea B.; Sonpavde, Guru P.

Disease-free Survival Analysis for Patients with High-risk Muscle-invasive Urothelial Carcinoma from the Randomized CheckMate 274 Trial by PD-L1 Combined Positive Score and Tumor Cell Score

EUROPEAN UROLOGY

IF25.2

2023-05-01

OAAI

A phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) SWOG S1609: the non-epithelial ovarian tumor cohort

CANCER RESEARCH

IF16.6

2023-04-14

PREAI

Chae, Young Kwang; Othus, Megan; Patel, Sandip Pravin; Wilkinson, Kelly J.; Whitman-Purves, Emily M.; Lea, Jayanthi; Schallenkamp, John M.; Adra, Nabil; Appleman, Leonard J.; Alden, Mitchell; Pepin, Jessica Thomes; Ellerton, John A.; Poklepovic, Andrew; Walter, Adam; Rampurwala, Murtuza M.; Robinson, William R.; Chung, Liam Il-Young; McLeod, Christine M.; Chen, Helen X.; Sharon, Elad; Streicher, Howard; Ryan, Christopher W.; Blanke, Charles D.; Kurzrock, Razelle

First-in-human, phase 1 study of PF-06753512, a vaccine-based immunotherapy regimen (VBIR), in non-metastatic hormone-sensitive biochemical recurrence and metastatic castration-resistant prostate cancer (mCRPC)

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2023-03-22

OAAI

Autio, Karen A.; Higano, Celestia S.; Nordquist, Luke; Appleman, Leonard J.; Zhang, Tian; Zhu, Xin-Hua; Babiker, Hani; Vogelzang, Nicholas J.; Prasad, Sandip M.; Schweizer, Michael T.; Madan, Ravi A.; Billotte, Stephane; Cavazos, Nora; Bogg, Orlaith; Li, Ray; Chan, Kam; Cho, Helen; Kaneda, Megan; Wang, I-Ming; Zheng, Jenny; Tang, Szu-Yu; Hollingsworth, Robert; Kern, Kenneth A.; Petrylak, Daniel P.

A phase 1 study of veliparib (ABT-888) plus weekly carboplatin and paclitaxel in advanced solid malignancies, with an expansion cohort in triple negative breast cancer (TNBC) (ETCTN 8620)

BREAST CANCER RESEARCH AND TREATMENT

IF3

2023-02-28

OAAI

Malhotra, Monica K.; Pahuja, Shalu; Kiesel, Brian F.; Appleman, Leonard J.; Ding, Fei; Lin, Yan; Tawbi, Hussein A.; Stoller, Ronald G.; Lee, James J.; Belani, Chandra P.; Chen, Alice P.; Giranda, Vincent L.; Shepherd, Stacie Peacock; Emens, Leisha A.; Ivy, S. Percy; Chu, Edward; Beumer, Jan H.; Puhalla, Shannon

Pembrolizumab Plus Docetaxel and Prednisone in Patients with Metastatic Castration-resistant Prostate Cancer: Long-term Results from the Phase 1b/2 KEYNOTE-365 Cohort B Study Pembrolizumab联合多西他赛和泼尼松治疗转移性去势抵抗性前列腺癌患者: 1b/2期主题365队列B研究的长期结果

EUROPEAN UROLOGY

IF25.2

2022-07-01

OAAI

Yu, Evan Y.; Kolinsky, Michael P.; Berry, William R.; Retz, Margitta; Mourey, Loic; Piulats, Josep M.; Appleman, Leonard J.; Romano, Emanuela; Gravis, Gwenaelle; Gurney, Howard; Bogemann, Martin; Emmenegger, Urban; Joshua, Anthony M.; Linch, Mark; Sridhar, Srikala; Conter, Henry J.; Laguerre, Brigitte; Massard, Christophe; Li, Xin Tong; Schloss, Charles; Poehlein, Christian H.; de Bono, Johann S.

研究方向