未登录 A plain language summary of the TROPHY-U-01 study (Cohort 2): use of sacituzumab govitecan after immunotherapy in people with metastatic urothelial cancer who cannot take cisplatin-based chemotherapy TROPHY-U-01研究（队列2）的通俗总结：在无法接受顺铂为基础化疗的转移性尿路上皮癌患者中，免疫疗法后使用sacituzumab govitecan的疗效。 Grivas, Petros; Tagawa, Gurdeep; Jain, Rohit K.; Bupathi, Manojkumar; Balar, Arjun; Rezazadeh Kalebasty, Arash; George, Saby; Palmbos, Phillip; Nordquist, Luke; Petrylak, Daniel P.; Davis, Nancy; Sternberg, Cora N.; Agarwal, Neeraj; Park, Chandler; Tonelli, Julia; Zhou, Huafeng; Bangs, Rick; Loriot, Yohann 分享 收藏
Pembrolizumab plus either epacadostat or placebo for cisplatin-ineligible urothelial carcinoma: results from the ECHO-307/KEYNOTE-672 study Necchi, Andrea; van der Heijden, Michiel S.; Trukhin, Dmytro; Peer, Avivit; Gurney, Howard; Alekseev, Boris Y.; Parnis, Francis X.; Leibowitz, Raya; De Santis, Maria; Grivas, Petros; Clark, Jason; Munteanu, Mihaela; Kataria, Ritesh; Jia, Calvin; Balar, Arjun V.; de Wit, Ronald 分享 收藏
A plain language summary of the TROPHY-U-01 study: sacituzumab govitecan use in people with locally advanced or metastatic urothelial cancer Loriot, Yohann; Kalebasty, Arash Rezazadeh; Flechon, Aude; Jain, Rohit K.; Gupta, Sumati; Bupathi, Manojkumar; Beuzeboc, Philippe; Palmbos, Phillip; Balar, Arjun, V; Kyriakopoulos, Christos E.; Pouessel, Damien; Sternberg, Cora N.; Tonelli, Julia; Sierecki, Mitch; Zhou, Huafeng; Grivas, Petros; Barthelemy, Philippe; Bangs, Rick; Tagawa, Scott T. 分享 收藏
A phase 1 study of LY4101174 (ETx-22), an antibody-drug conjugate targeting nectin-4, in patients with advanced or metastatic urothelial cancer and other solid tumors (trial in progress) Rosenberg, Jonathan; Sabatier, Renaud; Viceneux, Armelle; Rouge, Thibault De la Motte; Champiat, Stephane; Lebellec, Loic; Barthelemy, Philippe; Sonpavde, Guru; Gao, Xin; Niglio, Scot; Zhang, Tian; Gedye, Craig; Galsky, Matthew; Milowsky, Matthew; Reimers, Melissa; Weickhardt, Andrew; Grande, Enrique; Castellano, Daniel E.; Bilen, Mehmet; Patnaik, Amita; Zerbib, Robert; Balbas, Minna; Xu, Xiaojian; Aptaker, Kaitlyn; Balar, Arjun V.; Awada, Ahmad H. 分享 收藏
TROPHY-U-01, a phase II open-label study of sacituzumab govitecan in patients with metastatic urothelial carcinoma progressing after platinumbased chemotherapy and checkpoint inhibitors: updated safety and efficacy outcomes TROPHY-U-01，sacituzumab govitecan用于铂化疗和检查点抑制剂后进展的转移性尿路上皮癌患者的II期开放标签研究: 更新的安全性和有效性结果 Loriot, Y.; Petrylak, D. P.; Kalebasty, A. Rezazadeh; Flechon, A.; Jain, R. K.; Gupta, S.; Bupathi, M.; Beuzeboc, P.; Palmbos, P.; V. Balar, A.; Kyriakopoulos, C. E.; Pouessel, D.; Sternberg, C. N.; Tonelli, J.; Sierecki, M.; Zhou, H.; Grivas, P.; Barthelemy, P.; Tagawa, S. T. 分享 收藏
Pembrolizumab with or Without Lenvatinib as First-line Therapy for Patients with Advanced Urothelial Carcinoma (LEAP-011): A Phase 3, Randomized, Double-Blind Trial Matsubara, Nobuaki; de Wit, Ronald; Balar, Arjun Vasant; Siefker-Radtke, Arlene O.; Zolnierek, Jakub; Csoszi, Tibor; Shin, Sang Joon; Park, Se Hoon; Atduev, Vagif; Gumus, Mahmut; Su, Yu -Li; Karaca, Saziye Burcak; Cutuli, Hernan Javier; Sendur, Mehmet A. N.; Shen, Liji; O'Hara, Karen; Okpara, Chinyere E.; Franco, Sonia; Moreno, Blanca Homet; Grivas, Petros; Loriot, Yohann 分享 收藏
A Phase 1/2 multicenter trial of DKN-01 as monotherapy or in combination with docetaxel for the treatment of metastatic castration-resistant prostate cancer (mCRPC) Wise, David R.; Pachynski, Russell K.; Denmeade, Samuel R.; Aggarwal, Rahul R.; Deng, Jiehui; Febles, Victor Adorno; Balar, Arjun V.; Economides, Minas P.; Loomis, Cynthia; Selvaraj, Shanmugapriya; Haas, Michael; Kagey, Michael H.; Newman, Walter; Baum, Jason; Troxel, Andrea B.; Griglun, Sarah; Leis, Dayna; Yang, Nina; Aranchiy, Viktoriya; Machado, Sabrina; Waalkes, Erika; Gargano, Gabrielle; Soamchand, Nadia; Puranik, Amrutesh; Chattopadhyay, Pratip; Fedal, Ezeddin; Deng, Fang-Ming; Ren, Qinghu; Chiriboga, Luis; Melamed, Jonathan; Sirard, Cynthia A.; Wong, Kwok-Kin 分享 收藏
CYCLONE 1: abemaciclib in men with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) Agarwal, Neeraj; Guana, Daniel Castellano; Gordoa, Teresa A.; Arija, Jose A.; Colomba, Emeline; Gravis, Gwenaelle; Mourey, Loic; Oudard, Stephanie; Flechon, Aude; Gonzalez, Macarena; Maroto-Rey, Pablo; Schweizer, Michael; Gallardo, Enrique; Nacerddine, Karim; Appiach, Adams K.; Balar, Arjun; Johnston, Erica; Piulats, Jose M. 分享 收藏
A first-in-human phase 1 study of LOXO-435, a potent, highly isoform-selective FGFR3 inhibitor in advanced solid tumors with FGFR3 alterations (trial in progress) Iyer, Gopa; Siefker-Radtke, Arlene; Milowsky, Matthew; Shore, Neal; Gao, Xin; Reimers, Melissa A.; Hahn, Noah; Cosman, Rasha; Matsubara, Nobuaki; Necchi, Andrea; Robbrecht, Debbie; Vinceneux, Armelle; Grande, Enrique; Lee, Jae-Lyun; Zhang, Tian; Guren, Tormod; Lauer, Ulrich M.; Sarfaty, Michal; Eigl, Bernhard; Hussain, Syed; Zhao, Xiang; Balar, Arjun V.; Francese, Kaitlyn; Widau, Ryan; Garmezy, Benjamin 分享 收藏
A first-in-human phase 1 study of LY3537982, a highly selective and potent KRAS G12C inhibitor in patients with KRAS G12C-mutant advanced solid tumors Murciano-Goroff, Yonina R.; Heist, Rebecca S.; Kuboki, Yasutoshi; Koyama, Takafumi; Ammakkanavar, Natraj Reddy; Hollebecque, Antoine; Patnaik, Amita; Shimizu, Toshio; Spira, Alexander I.; Nagasaka, Misako; Han, Ji-Youn; Iams, Wade Thomas; Deming, Dustin; Call, Justin; Cassier, Philippe; Han, Sae-Won; Chu, Quincy Siu-Chung; Cosman, Rasha; Durm, Gregory; Burns, Timothy; Willard, Melinda D.; Liu, Shiyao; Callies, Sophie; Balar, Arjun V.; Sabari, Joshua K. 分享 收藏
Efficacy and safety of pembrolizumab in metastatic urothelial carcinoma: results from KEYNOTE-045 and KEYNOTE-052 after up to 5 years of follow-up Balar, A. V.; Castellano, D. E.; Grivas, P.; Vaughn, D. J.; Powles, T.; Vuky, J.; Fradet, Y.; Lee, J. -L.; Fong, L.; Vogelzang, N. J.; Climent, M. A.; Necchi, A.; Petrylak, D. P.; Plimack, E. R.; Xu, J. Z.; Imai, K.; Moreno, B. H.; Bellmunt, J.; de Wit, R.; O'Donnell, P. H. 分享 收藏
Bempegaldesleukin plus Nivolumab in First-line Metastatic Urothelial Carcinoma: Results from PIVOT-02 Siefker-Radtke, Arlene O.; Cho, Daniel C.; Diab, Adi; Sznol, Mario; Bilen, Mehmet A.; Balar, Arjun, V; Grignani, Giovanni; Puente, Erika; Tang, Lily; Chien, David; Hoch, Ute; Choudhury, Arkopal; Yu, Danni; Currie, Sue L.; Tagliaferri, Mary A.; Zalevsky, Jonathan; Hurwitz, Michael E.; Tannir, Nizar M. 分享 收藏
Bempegaldesleukin plus nivolumab in first-line renal cell carcinoma: results from the PIVOT-02 study Tannir, Nizar M.; Cho, Daniel C.; Diab, Adi; Sznol, Mario; Bilen, Mehmet A.; Balar, Arjun, V; Grignani, Giovanni; Puente, Erika; Tang, Lily; Chien, David; Hoch, Ute; Choudhury, Arkopal; Yu, Danni; Currie, Sue L.; Tagliaferri, Mary A.; Zalevsky, Jonathan; Siefker-Radtke, Arlene O.; Hurwitz, Michael E. 分享 收藏
Randomized Phase 2 Trial of Abiraterone Acetate Plus Prednisone, Degarelix, or the Combination in Men with Biochemically Recurrent Prostate Cancer After Radical Prostatectomy Autio, Karen A.; Antonarakis, Emmanuel S.; Mayer, Tina M.; Shevrin, Daniel H.; Stein, Mark N.; Vaishampayan, Ulka N.; Morris, Michael J.; Slovin, Susan F.; Heath, Elisabeth, I; Tagawa, Scott T.; Rathkopf, Dana E.; Milowsky, Matthew, I; Harrison, Michael R.; Beer, Tomasz M.; Balar, Arjun, V; Armstrong, Andrew J.; George, Daniel J.; Paller, Channing J.; Apollo, Arlyn; Danila, Daniel C.; Graff, Julie N.; Nordquist, Luke; Cohn, Erica S. Dayan; Tse, Kin; Schreiber, Nicole A.; Heller, Glenn; Scher, Howard, I 分享 收藏
LUMINOS-103: A basket trial evaluating the safety and efficacy of PVSRIPO and PVSRIPO in combination with anti-PD-1/L1 checkpoint inhibitors in patients with advanced solid tumors Inman, Brant A.; Milowsky, Matthew I.; Pruthi, Raj S.; Posner, Marshall; Polasek, Melissa J.; Morris, Shannon R.; Mixson, Lori; Orr, Kristin; Woodson, Elizabeth M. H.; Kelly, Andrea T.; Nichols, W. Garrett; Balar, Arjun V. 分享 收藏
Atezolizumab monotherapy in cisplatin-ineligible patients with previously untreated metastatic urothelial carcinoma: 5-year response and survival analysis from the phase II IMvigor210 study (cohort 1) Rosenberg, J. E.; Galsky, M. D.; Balar, A. V.; Loriot, Y.; Necchi, A.; Hoffman-Censits, J.; Srinivas, S.; Drakaki, A.; Javery, A.; Nelson, B.; Huang, H. X.; Shen, X.; Van der Heijden, M. S. 分享 收藏
Efficacy of sacituzumab govitecan (SG) by trophoblast cell surface antigen 2 (Trop-2) expression in patients (Pts) with metastatic urothelial cancer (mUC) Loriot, Y.; Balar, A. V.; Petrylak, D. P.; Rezazadeh, A.; Grivas, P.; Flechon, A.; Jain, R. K.; Agarwal, N.; Bupathi, M.; Barthelemy, P.; Beuzeboc, P.; Palmbos, P.; Kyriakopoulos, C.; Pouessel, D.; Sternberg, C. N.; Pan, Y.; Jurgensmeier, J. M.; Goswami, T.; Tagawa, S. T. 分享 收藏
Evaluation of concordance between PD-L1 immunohistochemistry 28-8 and 22C3 pharmDx assays in metastatic urothelial carcinoma (mUC) in PIVOT-10 Siefker-Radtke, A. O.; Hoch, U.; Loriot, Y.; Balar, A. V.; Bilen, M. A.; Tannir, N. M.; Cho, D. C.; Choudhury, A.; Chien, D.; Yu, D.; Currie, S. L.; Novotny, J.; Santiago, L.; Tagliaferri, M. A.; Zalevsky, J.; Huddart, R. A. 分享 收藏
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of urothelial cancer Galsky, Matthew D.; Balar, Arjun, V; Black, Peter C.; Campbell, Matthew T.; Dykstra, Gail S.; Grivas, Petros; Gupta, Shilpa; Hoimes, Christoper J.; Lopez, Lidia P.; Meeks, Joshua J.; Plimack, Elizabeth R.; Rosenberg, Jonathan E.; Shore, Neal; Steinberg, Gary D.; Kamat, Ashish M. 分享 收藏
Multi-step screening of neoantigens' HLA- and TCR-interfaces improves prediction of survival Richard, Guilhem; De Groot, Anne S.; Steinberg, Gary D.; Garcia, Tzintzuni, I; Kacew, Alec; Ardito, Matthew; Martin, William D.; Berdugo, Gad; Princiotta, Michael F.; Balar, Arjun, V; Sweis, Randy F. 分享 收藏
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