Mathew, Nimitha R.; Baumgartner, Francis; Braun, Lukas; O'Sullivan, David; Thomas, Simone; Waterhouse, Miguel; Mueller, Tony A.; Hanke, Kathrin; Taromi, Sanaz; Apostolova, Petya; Illert, Anna L.; Melchinger, Wolfgang; Duquesne, Sandra; Schmitt-Graeff, Annette; Osswald, Lena; Yan, Kai-Li; Weber, Arnim; Tugues, Sonia; Spath, Sabine; Pfeifer, Dietmar; Follo, Marie; Claus, Rainer; Luebbert, Michael; Rummelt, Christoph; Bertz, Hartmut; Waesch, Ralph; Haag, Johanna; Schmidts, Andrea; Schultheiss, Michael; Bettinger, Dominik; Thimme, Robert; Ullrich, Evelyn; Tanriver, Yakup; Giang Lam Vuong; Arnold, Renate; Hemmati, Philipp; Wolf, Dominik; Ditschkowski, Markus; Jilg, Cordula; Wilhelm, Konrad; Leiber, Christian; Gerull, Sabine; Halter, Joerg; Lengerke, Claudia; Pabst, Thomas; Schroeder, Thomas; Kobbe, Guido; Roesler, Wolf; Doostkam, Soroush; Meckel, Stephan; Stabla, Kathleen; Metzelder, Stephan K.; Halbach, Sebastian; Brummer, Tilman; Hu, Zehan; Dengjel, Joern; Hackanson, Bjoern; Schmid, Christoph; Holtick, Udo; Scheid, Christof; Spyridonidis, Alexandros; Stoelzel, Friedrich; Ordemann, Rainer; Mueller, Lutz P.; Sicre-de-Fontbrune, Flore; Ihorst, Gabriele; Kuball, Juergen; Ehlert, Jan E.; Feger, Daniel; Wagner, Eva-Maria; Cahn, Jean-Yves; Schnell, Jacqueline; Kuchenbauer, Florian; Bunjes, Donald; Chakraverty, Ronjon; Richardson, Simon; Gill, Saar; Kroeger, Nicolaus; Ayuk, Francis; Vago, Luca; Ciceri, Fabio; Mueller, Antonia M.; Kondo, Takeshi; Teshima, Takanori; Klaeger, Susan; Kuster, Bernhard; Kim, Dennis (Dong Hwan); Weisdorf, Daniel; van der Velden, Walter; Doerfel, Daniela; Bethge, Wolfgang; Hilgendorf, Inken; Hochhaus, Andreas; Andrieux, Geoffroy; Boerries, Melanie; Busch, Hauke; Magenau, John; Reddy, Pavan; Labopin, Myriam; Antin, Joseph H.; Henden, Andrea S.; Hill, Geoffrey R.; Kennedy, Glen A.; Bar, Merav; Sarma, Anita; McLornan, Donal; Mufti, Ghulam; Oran, Betul; Rezvani, Katayoun; Shah, Omid; Negrin, Robert S.; Nagler, Arnon; Prinz, Marco; Burchert, Andreas; Neubauer, Andreas; Beelen, Dietrich; Mackensen, Andreas; von Bubnoff, Nikolas; Herr, Wolfgang; Becher, Burkhard; Socie, Gerard; Caligiuri, Michael A.; Ruggiero, Eliana; Bonini, Chiara; Haecker, Georg; Duyster, Justus; Finke, Juergen; Pearce, Erika; Blazar, Bruce R.; Zeiser, Robert

D-2-hydroxyglutarate interferes with HIF-1 stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

D-2-hydroxyglutarate干扰HIF-1稳定性，使T细胞代谢偏向氧化磷酸化并损害Th17极化

ONCOIMMUNOLOGY

IF6.3

2018-03-26100

OAAI

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

索拉非尼通过在FLT3-ITD-mutant白血病细胞中产生IL-15促进小鼠和人类的移植物抗白血病活性

NATURE MEDICINE

IF50

2018-02-12236

OAAI

Mathew, Nimitha R.; Baumgartner, Francis; Braun, Lukas; O'Sullivan, David; Thomas, Simone; Waterhouse, Miguel; Mueller, Tony A.; Hanke, Kathrin; Taromi, Sanaz; Apostolova, Petya; Illert, Anna L.; Melchinger, Wolfgang; Duquesne, Sandra; Schmitt-Graeff, Annette; Osswald, Lena; Yan, Kai-Li; Weber, Arnim; Tugues, Sonia; Spath, Sabine; Pfeifer, Dietmar; Follo, Marie; Claus, Rainer; Luebbert, Michael; Rummelt, Christoph; Bertz, Hartmut; Waesch, Ralph; Haag, Johanna; Schmidts, Andrea; Schultheiss, Michael; Bettinger, Dominik; Thimme, Robert; Ullrich, Evelyn; Tanriver, Yakup; Vuong, Giang Lam; Arnold, Renate; Hemmati, Philipp; Wolf, Dominik; Ditschkowski, Markus; Jilg, Cordula; Wilhelm, Konrad; Leiber, Christian; Gerull, Sabine; Halter, Joerg; Lengerke, Claudia; Pabst, Thomas; Schroeder, Thomas; Kobbe, Guido; Roesler, Wolf; Doostkam, Soroush; Meckel, Stephan; Stabla, Kathleen; Metzelder, Stephan K.; Halbach, Sebastian; Brummer, Tilman; Hu, Zehan; Dengjel, Joern; Hackanson, Bjoern; Schmid, Christoph; Holtick, Udo; Scheid, Christof; Spyridonidis, Alexandros; Stoelzel, Friedrich; Ordemann, Rainer; Mueller, Lutz P.; Sicre-de-Fontbrune, Flore; Ihorst, Gabriele; Kuball, Juergen; Ehlert, Jan E.; Feger, Daniel; Wagner, Eva-Maria; Cahn, Jean-Yves; Schnell, Jacqueline; Kuchenbauer, Florian; Bunjes, Donald; Chakraverty, Ronjon; Richardson, Simon; Gill, Saar; Kroeger, Nicolaus; Ayuk, Francis; Vago, Luca; Ciceri, Fabio; Mueller, Antonia M.; Kondo, Takeshi; Teshima, Takanori; Klaeger, Susan; Kuster, Bernhard; Kim, Dennis (Dong Hwan); Weisdorf, Daniel; van der Velden, Walter; Doerfel, Daniela; Bethge, Wolfgang; Hilgendorf, Inken; Hochhaus, Andreas; Andrieux, Geoffroy; Boerries, Melanie; Busch, Hauke; Magenau, John; Reddy, Pavan; Labopin, Myriam; Antin, Joseph H.; Henden, Andrea S.; Hill, Geoffrey R.; Kennedy, Glen A.; Bar, Merav; Sarma, Anita; McLornan, Donal; Mufti, Ghulam; Oran, Betul; Rezvani, Katayoun; Shah, Omid; Negrin, Robert S.; Nagler, Arnon; Prinz, Marco; Burchert, Andreas; Neubauer, Andreas; Beelen, Dietrich; Mackensen, Andreas; von Bubnoff, Nikolas; Herr, Wolfgang; Becher, Burkhard; Socie, Gerard; Caligiuri, Michael A.; Ruggiero, Eliana; Bonini, Chiara; Haecker, Georg; Duyster, Justus; Finke, Juergen; Pearce, Erika; Blazar, Bruce R.; Zeiser, Robert

CAR T-cells targeting FLT3 have potent activity against FLT3-ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib

LEUKEMIA

IF13.4

2018-02-05152

PREAI

Simone Thomas

个人简介

教育背景

工作经历

荣誉奖项

研究方向