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A second-generation polygenic risk score (PRS) based on genetic ancestry improves breast cancer (BC) risk prediction for all ancestries Simmons, Timothy; Hughes, Elisha; Pruss, Dmitry; Kucera, Matthew; Roa, Benjamin; Judkins, Thaddeus; Slavin, Thomas; Abkevich, Victor; Hoff, Ryan; Jammulapati, Srikanth; Wagner, Susanne; Muzzey, Dale; Lanchbury, Jerry; Gutin, Alexander 分享 收藏
Identifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes 确定乳腺癌中的同源重组缺陷: 基因组不稳定性得分在乳腺癌亚型之间的分布不同 Lenz, Lauren; Neff, Chris; Solimeno, Cara; Cogan, Elizabeth S.; Abramson, Vandana G.; Boughey, Judy C.; Falkson, Carla; Goetz, Matthew P.; Ford, James M.; Gradishar, William J.; Jankowitz, Rachel C.; Kaklamani, Virginia G.; Marcom, P. Kelly; Richardson, Andrea L.; Storniolo, Anna Maria; Tung, Nadine M. M.; Vinayak, Shaveta; Hodgson, Darren R.; Lai, Zhongwu; Dearden, Simon; Hennessy, Bryan T.; Mayer, Erica L.; Mills, Gordon B.; Slavin, Thomas P.; Gutin, Alexander; Connolly, Roisin M.; Telli, Melinda L.; Stearns, Vered; Lanchbury, Jerry S.; Timms, Kirsten M. 分享 收藏
Prospective longitudinal validation of a breast cancer risk prediction model in a cohort of 130,058 women Mabey, Brent; Hughes, Elisha; Probst, Braden; Pederson, Holly J.; Simmons, Timothy; Morris, Brian; Hullinger, Brooke; Domchek, Susan; Eng, Charis; Gary, Monique; Klemp, Jennifer; Mukherjee, Semanti; Joseph, Vijai; Offit, Kenneth; Olopade, Olufunmilayo I.; Pruthi, Sandhya; Kurian, Allison W.; Robson, Mark E.; Whitworth, Pat; Wagner, Susanne; Lanchbury, Jerry; Slavin, Thomas; Gutin, Alexander 分享 收藏
Integration of an ancestrally unbiased polygenic risk score with the Tyrer-Cuzick breast cancer risk model Hughes, Elisha; Bernhisel, Ryan; Pederson, Holly; Probst, Braden; Simmons, Timothy; Wagner, Susanne; Judkins, Thaddeus; Rosenthal, Eric; Roa, Benjamin; Domchek, Susan M.; Eng, Charis; Garber, Judy; Gary, Monique; Gordon, Ora K.; Klemp, Jennifer; Mukherjee, Semanti; Offit, Kenneth; Olopade, Funmi; Vijai, Joseph; Weitzel, Jeffrey N.; Whitworth, Pat; Yehia, Lamis; Kurian, Allison; Robson, Mark; Slavin, Thomas P.; Gutin, Alexander; Lanchbury, Jerry S. 分享 收藏
Identifying homologous recombination deficiency in breast cancer: Genomic instability score thresholds differ in breast cancer subtypes Timms, Kirsten M.; Lenz, Lauren; Neff, Chris; Solimeno, Cara; Flake, Darl; Boughey, Judy C.; Goetz, Matthew P.; Richardson, Andrea; Storniolo, Anna Maria; Gutin, Alexander; Connolly, Roisin M.; Stearns, Vered; Lanchbury, Jerry S. 分享 收藏
Analysis of mutation status and homologous recombination deficiency in tumors of patients with germline BRCA1 or BRCA2 mutations and metastatic breast cancer: OlympiAD Hodgson, D.; Lai, Z.; Dearden, S.; Barrett, J. C.; Harrington, E. A.; Timms, K.; Lanchbury, J.; Wu, W.; Allen, A.; Senkus, E.; Domchek, S. M.; Robson, M. 分享 收藏
Performance of the IBIS/Tyrer-Cuzick model of breast cancer risk by race and ethnicity in the Women's Health Initiative 在妇女健康倡议中，按种族和种族划分的IBIS/tyrer-cuzick乳腺癌风险模型的性能 Kurian, Allison W.; Hughes, Elisha; Simmons, Timothy; Bernhisel, Ryan; Probst, Braden; Meek, Stephanie; Caswell-Jin, Jennifer L.; John, Esther M.; Lanchbury, Jerry S.; Slavin, Thomas P.; Wagner, Susanne; Gutin, Alexander; Rohan, Thomas E.; Shadyab, Aladdin H.; Manson, JoAnn E.; Lane, Dorothy; Chlebowski, Rowan T.; Stefanick, Marcia L. 分享 收藏
Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer Lotan, Tamara L.; Kaur, Harsimar B.; Salles, Daniela C.; Murali, Sanjana; Schaeffer, Edward M.; Lanchbury, Jerry S.; Isaacs, William B.; Brown, Robert; Richardson, Andrea L.; Cussenot, Olivier; Cancel-Tassin, Geraldine; Timms, Kirsten M.; Antonarakis, Emmanuel S. 分享 收藏
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Polygenic breast cancer risk modification in carriers of high and intermediate risk gene mutations Gallagher, Shannon; Hughes, Elisha; Wagner, Susanne; Tshiaba, Placede; Rosenthal, Eric; Roa, Benjamin B.; Kurian, Allison; Domchek, Susan; Garber, Judy; Lancaster, Johnathan M.; Weitzel, Jeffrey; Gutin, Alexander; Lanchbury, Jerry S.; Robson, Mark 分享 收藏
Evaluation of the 12-Gene Molecular Score and the 21-Gene Recurrence Score as Predictors of Response to Neo-adjuvant Chemotherapy in Estrogen Receptor-Positive, HER2-Negative Breast Cancer Soliman, Hatem; Wagner, Susanne; Flake, Darl D., II; Robson, Mark; Schwartzberg, Lee; Sharma, Priyanka; Magliocco, Anthony; Kronenwett, Ralf; Lancaster, Johnathan M.; Lanchbury, Jerry S.; Gutin, Alexander; Gradishar, William 分享 收藏
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes Hodgson, Darren R.; Dougherty, Brian A.; Lai, Zhongwu; Fielding, Anitra; Grinsted, Lynda; Spencer, Stuart; O'Connor, Mark J.; Ho, Tony W.; Robertson, Jane D.; Lanchbury, Jerry S.; Timms, Kirsten M.; Gutin, Alexander; Orr, Maria; Jones, Helen; Gilks, Blake; Womack, Chris; Gourley, Charlie; Ledermann, Jonathan; Barrett, J. Carl 分享 收藏
Characterisation of homologous recombination deficiency in paired primary and recurrent high-grade serous ovarian cancer Patel, Jai N.; Braicu, Ioana; Timms, Kirsten M.; Solimeno, Cara; Tshiaba, Placede; Reid, Julia; Lanchbury, Jerry S.; Darb-Esfahani, Silvia; Ganapathi, Mahrukh K.; Sehouli, Jalid; Ganapathi, Ram N. 分享 收藏
Biomarker Assessment of HR Deficiency, Tumor BRCA1/2 Mutations, and CCNE1 Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum Monotherapy Stronach, Euan A.; Paul, James; Timms, Kirsten M.; Hughes, Elisha; Brown, Krystal; Neff, Christopher; Perry, Michael; Gutin, Alexander; El-Bahrawy, Mona; Steel, Jennifer H.; Liu, Xinxue; Lewsley, Liz-Anne; Siddiqui, Nadeem; Gabra, Hani; Lanchbury, Jerry S.; Brown, Robert 分享 收藏
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial 卡铂在BRCA1/2突变和三阴性乳腺癌BRCAness亚组中的应用: TNT试验 Tutt, Andrew; Tovey, Holly; Cheang, Maggie Chon U.; Kernaghan, Sarah; Kilburn, Lucy; Gazinska, Patrycja; Owen, Julie; Abraham, Jacinta; Barrett, Sophie; Barrett-Lee, Peter; Brown, Robert; Chan, Stephen; Dowsett, Mitchell; Flanagan, James M.; Fox, Lisa; Grigoriadis, Anita; Gutin, Alexander; Harper-Wynne, Catherine; Hatton, Matthew Q.; Hoadley, Katherine A.; Parikh, Jyoti; Parker, Peter; Perou, Charles M.; Roylance, Rebecca; Shah, Vandna; Shaw, Adam; Smith, Ian E.; Timms, Kirsten M.; Wardley, Andrew M.; Wilson, Gregory; Gillett, Cheryl; Lanchbury, Jerry S.; Ashworth, Alan; Rahman, Nazneen; Harries, Mark; Ellis, Paul; Pinder, Sarah E.; Bliss, Judith M. 分享 收藏
BRCA1 methylation status, silencing and treatment effect in the TNT trial: A randomized phase III trial of carboplatin compared with docetaxel for patients with metastatic or recurrent locally advanced triple negative or BRCA1/2 breast cancer (CRUK/07/012) Tutt, A.; Cheang, M. C. U.; Kilburn, L.; Tovey, H.; Gillett, C.; Pinder, S.; Lanchbury, J.; Abraham, J.; Barrett, S.; Barrett-Lee, P.; Chan, S.; Gazinska, P.; Grigoriadis, A.; Kernaghan, S.; Hoadley, K.; Gutin, A.; Harper-Wynne, C.; Hatton, M.; Owen, J.; Parker, P.; Roylance, R.; Shaw, A.; Smith, I.; Thompson, R.; Timms, K.; Wardley, A.; Wilson, G.; Harries, M.; Ellis, P.; Ashworth, A.; Perou, C.; Bliss, J.; Rahman, N.; Brown, R. 分享 收藏
3-biomarker HRD score versus individual biomarker (LOH, TAI, LST) scores in platinum treated serous ovarian cancer (SOC) Lanchbury, J.; Timms, K.; Reid, J.; Stronach, E.; Gutin, A.; Krivak, T.; Hennessy, B.; Paul, J.; Brown, R.; Nix, R.; Sangale, Z.; Hughes, E.; Abkevich, V.; Mills, G. B. 分享 收藏
Characteristics of homologous recombination deficiency (HRD) in paired primary and recurrent high-grade serous ovarian cancer (HGSOC) Patel, J.; Sehouli, J.; Timms, K.; Solimeno, C.; Reid, J.; Lanchbury, J.; Braicu, I.; Darb-Esfahani, S.; Ganapathi, M.; Ganapathi, R. 分享 收藏
The molecular landscape of genome instability in prostate cancer (PC) Timms, K.; Cuzick, J.; Neff, C.; Reid, J.; Solimeno, C.; Sangale, Z.; Pruss, D.; Gutin, A.; Lanchbury, J.; Stone, S. 分享 收藏
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