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Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention 蛋白质组学和观察性研究证据表明，ANGPTL4可能是结直肠癌预防的潜在治疗靶点。 Yarmolinsky, James; Lee, Matthew A.; Lau, Evelyn; Moratalla-Navarro, Ferran; Vincent, Emma E.; Li-Gao, Ruifang; Rensen, Patrick C. N.; van Dijk, Ko Willems; Tsilidis, Kostas K.; Sangphukieo, Apiwat; Ebrahimi, Elmira; Hampe, Jochen; Le Marchand, Loic; van Duijnhoven, Franzel J. B.; Visvanathan, Kala; Woods, Michael O.; Guevara, Marcela; Sieri, Sabina; Masala, Giovanna; Papier, Keren; Virani, Shama; Dudding, Tom; Dehghan, Abbas; Smith, Alexander G.; Wang, Dennis; Moreno, Victor; Gunter, Marc J.; Tzoulaki, Ioanna 分享 收藏
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A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations 一项大规模的全基因组研究，探讨了811,405名来自不同人群的个体中基因与睡眠时长对血压的交互作用。 Nagarajan, Pavithra; Winkler, Thomas W.; Bentley, Amy R.; Miller, Clint L.; Kraja, Aldi T.; Schwander, Karen; Lee, Songmi; Wang, Wenyi; Brown, Michael R.; Morrison, John L.; Giri, Ayush; O'Connell, Jeffrey R.; Bartz, Traci M.; de las Fuentes, Lisa; Gudmundsdottir, Valborg; Guo, Xiuqing; Harris, Sarah E.; Huang, Zhijie; Kals, Mart; Kho, Minjung; Lefevre, Christophe; Luan, Jian'an; Lyytikainen, Leo-Pekka; Mangino, Massimo; Milaneschi, Yuri; Palmer, Nicholette D.; Rao, Varun; Rauramaa, Rainer; Shen, Botong; Stadler, Stefan; Sun, Quan; Tang, Jingxian; Theriault, Sebastien; van der Graaf, Adriaan; van der Most, Peter J.; Wang, Yujie; Weiss, Stefan; Westerman, Kenneth E.; Yang, Qian; Yasuharu, Tabara; Zhao, Wei; Zhu, Wanying; Altschul, Drew; Ansari, Md Abu Yusuf; Anugu, Pramod; Argoty-Pantoja, Anna D.; Arzt, Michael; Aschard, Hugues; Attia, John R.; Bazzanno, Lydia; Breyer, Max A.; Brody, Jennifer A.; Cade, Brian E.; Chen, Hung-hsin; Chen, Yii-Der Ida; Chen, Zekai; de Vries, Paul S.; Dimitrov, Latchezar M.; Do, Anh; Du, Jiawen; Dupont, Charles T.; Edwards, Todd L.; Evans, Michele K.; Faquih, Tariq; Felix, Stephan B.; Fisher-Hoch, Susan P.; Floyd, James S.; Graff, Mariaelisa; Gu, Charles; Gu, Dongfeng; Hairston, Kristen G.; Hanley, Anthony J.; Heid, Iris M.; Heikkinen, Sami; Highland, Heather M.; Hood, Michelle M.; Kaehoenen, Mika; Karvonen-Gutierrez, Carrie A.; Kawaguchi, Takahisa; Kazuya, Setoh; Kelly, Tanika N.; Komulainen, Pirjo; Levy, Daniel; Lin, Henry J.; Liu, Peter Y.; Marques-Vidal, Pedro; McCormick, Joseph B.; Mei, Hao; Meigs, James B.; Menni, Cristina; Nam, Kisung; Nolte, Ilja M.; Pacheco, Natasha L.; Petty, Lauren E.; Polikowsky, Hannah G.; Province, Michael A.; Psaty, Bruce M.; Raffield, Laura M.; Raitakari, Olli T.; Rich, Stephen S.; Riha, Renata L.; Risch, Lorenz; Risch, Martin; Ruiz-Narvaez, Edward A.; Scott, Rodney J.; Sitlani, Colleen M.; Smith, Jennifer A.; Sofer, Tamar; Teder-Laving, Maris; Voelker, Uwe; Vollenweider, Peter; Wang, Guanchao; Willems van Dijk, Ko; Wilson, Otis D.; Xia, Rui; Yao, Jie; Young, Kristin L.; Zhang, Ruiyuan; Zhu, Xiaofeng; Below, Jennifer E.; Boeger, Carsten A.; Conen, David; Cox, Simon R.; Doerr, Marcus; Feitosa, Mary F.; Fox, Ervin R.; Franceschini, Nora; Gharib, Sina A.; Gudnason, Vilmundur; Harlow, Sioban D.; He, Jiang; Holliday, Elizabeth G.; Kutalik, Zoltan; Lakka, Timo A.; Lawlor, Deborah A.; Lee, Seunggeun; Lehtimaki, Terho; Li, Changwei; Liu, Ching-Ti; Magi, Reedik; Matsuda, Fumihiko; Morrison, Alanna C.; Penninx, Brenda W. J. H.; Peyser, Patricia A.; Rotter, Jerome I.; Snieder, Harold; Spector, Tim D.; Wagenknecht, Lynne E.; Wareham, Nicholas J.; Zonderman, Alan B.; North, Kari E.; Fornage, Myriam; Hung, Adriana M.; Manning, Alisa K.; Gauderman, James; Chen, Han; Munroe, Patricia B.; Rao, Dabeeru C.; van Heemst, Diana; Redline, Susan; Noordam, Raymond; Wang, Heming; Muralidhar, Sumitra; Moser, Jennifer; Deen, Jennifer E.; Tsao, Philip S.; Gaziano, J. Michael; Hauser, Elizabeth; Kilbourne, Amy; Matheny, Michael; Oslin, Dave; Churby, Lori; Whitbourne, Stacey B.; Brewer, Jessica, V; Shayan, Shahpoor Alex; Selva, Luis E.; Pyarajan, Saiju; Cho, Kelly; Duvall, Scott L.; Brophy, Mary T.; Stephens, Brady; Connor, Todd; Argyres, Dean P.; Assimes, Themistocles L.; Hung, Adriana; Kranzler, Henry; Aguayo, Samuel; Ahuja, Sunil; Alexander, Kathrina; Androulakis, Xiao M.; Balasubramanian, Prakash; Ballas, Zuhair; Bast, Elizabeth S.; Beckham, Jean; Bhushan, Sujata; Boyko, Edward; Cohen, David; Dellitalia, Louis; Dryden, Jr Gerald Wayne; Faulk, L. Christine; Fayad, Joseph; Fujii, Daryl; Gappy, Saib; Gesek, Frank; Greco, Jennifer; Godschalk, Michael; Gress, Todd W.; Gupta, Samir; Gutierrez, Salvador; Harley, John; Hamner, Mark; Hogan, Daniel J.; Hurley, Robin; Iruvanti, Pran; Jacono, Frank; Jhala, Darshana; Kinlay, Scott; Landry, Michael; Liang, Peter; Liangpunsakul, Suthat; Lichy, Jack; Lo, Tze Shien; Mahan, C. Scott; Marrache, Ronnie; Mastorides, Stephen; Mattocks, Kristin; Meyer, Paul; Moorman, Jonathan; Morales, Providencia; Morgan, Timothy; Murdoch, Maureen; Naik, Eknath; Norton, James; Okusaga, Olaoluwa; Ong, Michael K.; Oursler, Kris Ann; Petrakis, Ismene; Poon, Samuel; Potter, Emily; Rauchman, Michael; Rai, Amneet S.; Servatius, Richard; Sharma, Satish; Smith, River; Sriram, Peruvemba; Strollo, Jr Patrick; Tandon, Neeraj; Villareal, Gerardo; Walsh, Jessica; Wells, John; Whittle, Jeffrey; Whooley, Mary; Wilson, Peter; Xu, Junzhe; Yeh, Shing Shing; Yen, Andrew W. 分享 收藏
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Glycoprotein acetyls response to a mixed meal is associated with increased insulin resistance and risk of type 2 diabetes in a middle-aged population 糖蛋白乙酰化对混合餐的反应与中年人群胰岛素抵抗增加和2型糖尿病风险相关。 Monahan, Rory C.; Li-Gao, Ruifang; Noordam, Raymond; van der Velde, Jeroen H. P. M.; Dijk, Ko Willems van; de Koning, Eelco; Mook-Kanamori, Dennis O.; le Cessie, Saskia; Rosendaal, Frits R.; Mutsert, De 分享 收藏
Robust Metabolomic Age Prediction Based on a Wide Selection of Metabolites Faquih, Tariq O.; Vlieg, Astrid van Hylckama; Surendran, Praveen; Butterworth, Adam S.; Li-Gao, Ruifang; de Mutsert, Renee; Rosendaal, Frits R.; Noordam, Raymond; van Heemst, Diana; van Dijk, Ko Willems; Mook-Kanamori, Dennis O. 分享 收藏
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Understanding the genetic complexity of puberty timing across the allele frequency spectrum 了解等位基因频谱中青春期时间的遗传复杂性 Kentistou, Katherine A.; Kaisinger, Lena R.; Stankovic, Stasa; Vaudel, Marc; de Oliveira, Edson Mendes; Messina, Andrea; Walters, Robin G.; Liu, Xiaoxi; Busch, Alexander S.; Helgason, Hannes; Thompson, Deborah J.; Santoni, Federico; Petricek, Konstantin M.; Zouaghi, Yassine; Huang-Doran, Isabel; Gudbjartsson, Daniel F.; Bratland, Eirik; Lin, Kuang; Gardner, Eugene J.; Zhao, Yajie; Jia, Raina Y.; Terao, Chikashi; Riggan, Marjorie J.; Bolla, Manjeet K.; Yazdanpanah, Mojgan; Yazdanpanah, Nahid; Bradfield, Jonathan P.; Broer, Linda; Campbell, Archie; Chasman, Daniel I.; Cousminer, Diana L.; Franceschini, Nora; Franke, Lude H.; Girotto, Giorgia; He, Chunyan; Jarvelin, Marjo-Riitta; Joshi, Peter K.; Kamatani, Yoichiro; Karlsson, Robert; Luan, Jian'an; Lunetta, Kathryn L.; Magi, Reedik; Mangino, Massimo; Medland, Sarah E.; Meisinger, Christa; Noordam, Raymond; Nutile, Teresa; Concas, Maria Pina; Polasek, Ozren; Porcu, Eleonora; Ring, Susan M.; Sala, Cinzia; Smith, Albert V.; Tanaka, Toshiko; Van der Most, Peter J.; Vitart, Veronique; Wang, Carol A.; Willemsen, Gonneke; Zygmunt, Marek; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antoniou, Antonis C.; Auer, Paul L.; Barnes, Catriona L. K.; Beckmann, Matthias W.; de Gonzalez, Amy Berrington; Bogdanova, Natalia V.; Bojesen, Stig E.; Brenner, Hermann; Buring, Julie E.; Canzian, Federico; Chang-Claude, Jenny; Couch, Fergus J.; Cox, Angela; Crisponi, Laura; Czene, Kamila; Daly, Mary B.; Demerath, Ellen W.; Dennis, Joe; Devilee, Peter; De Vivo, Immaculata; Doerk, Thilo; Dunning, Alison M.; Dwek, Miriam; Eriksson, Johan G.; Fasching, Peter A.; Fernandez-Rhodes, Lindsay; Ferreli, Liana; Fletcher, Olivia; Gago-Dominguez, Manuela; Garcia-Closas, Montserrat; Garcia-Saenz, Jose A.; Gonzalez-Neira, Anna; Grallert, Harald; Guenel, Pascal; Haiman, Christopher A.; Hall, Per; Hamann, Ute; Hakonarson, Hakon; Hart, Roger J.; Hickey, Martha; Hooning, Maartje J.; Hoppe, Reiner; Hopper, John L.; Hottenga, Jouke-Jan; Hu, Frank B.; Huebner, Hanna; Hunter, David J.; Jernstrom, Helena; John, Esther M.; Karasik, David; Khusnutdinova, Elza K.; Kristensen, Vessela N.; Lacey, James V.; Lambrechts, Diether; Launer, Lenore J.; Lind, Penelope A.; Lindblom, Annika; Magnusson, Patrik K. E.; Mannermaa, Arto; McCarthy, Mark I.; Meitinger, Thomas; Menni, Cristina; Michailidou, Kyriaki; Millwood, Iona Y.; Milne, Roger L.; Montgomery, Grant W.; Nevanlinna, Heli; Nolte, Ilja M.; Nyholt, Dale R.; Obi, Nadia; O'Brien, Katie M.; Offit, Kenneth; Oldehinkel, Albertine J.; Ostrowski, Sisse R.; Palotie, Aarno; Pedersen, Ole B.; Peters, Annette; Pianigiani, Giulia; Plaseska-Karanfilska, Dijana; Pouta, Anneli; Pozarickij, Alfred; Radice, Paolo; Rennert, Gad; Rosendaal, Frits R.; Ruggiero, Daniela; Saloustros, Emmanouil; Sandler, Dale P.; Schipf, Sabine; Schmidt, Carsten O.; Schmidt, Marjanka K.; Small, Kerrin; Spedicati, Beatrice; Stampfer, Meir; Stone, Jennifer; Tamimi, Rulla M.; Teras, Lauren R.; Tikkanen, Emmi; Turman, Constance; Vachon, Celine M.; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Zemel, Babette S.; Zheng, Wei; van Dijk, Ko W.; Alizadeh, Behrooz Z.; Bandinelli, Stefania; Boerwinkle, Eric; Boomsma, Dorret I.; Ciullo, Marina; Chenevix-Trench, Georgia; Cucca, Francesco; Esko, Tonu; Gieger, Christian; Grant, Struan F. A.; Gudnason, Vilmundur; Hayward, Caroline; Kolcic, Ivana; Kraft, Peter; Lawlor, Deborah A.; Martin, Nicholas G.; Nohr, Ellen A.; Pedersen, Nancy L.; Pennell, Craig E.; Ridker, Paul M.; Robino, Antonietta; Snieder, Harold; Sovio, Ulla; Spector, Tim D.; Stockl, Doris; Sudlow, Cathie; Timpson, Nic J.; Toniolo, Daniela; Uitterlinden, Andre; Ulivi, Sheila; Volzke, Henry; Wareham, Nicholas J.; Widen, Elisabeth; Wilson, James F.; Pharoah, Paul D. P.; Li, Liming; Easton, Douglas F.; Njolstad, Pal R.; Sulem, Patrick; Murabito, Joanne M.; Murray, Anna; Manousaki, Despoina; Juul, Anders; Erikstrup, Christian; Stefansson, Kari; Horikoshi, Momoko; Chen, Zhengming; Farooqi, I. Sadaf; Pitteloud, Nelly; Johansson, Stefan; Day, Felix R.; Perry, John R. B.; Ong, Ken K. 分享 收藏
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Hypertension and diabetes, but not leptin and adiponectin, mediate the relationship between body fat and chronic kidney disease 高血压和糖尿病，但不是瘦素和脂联素，介导体脂和慢性肾脏病之间的关系 Lengton, Robin; Dekker, Friedo W.; van Rossum, Elisabeth F. C.; de Fijter, Johan W.; Rosendaal, Frits R.; van Dijk, Ko Willems; Rabelink, Ton J.; Le Cessie, Saskia; de Mutsert, Renee; Hoogeveen, Ellen K. 分享 收藏
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