logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
J

Jim Zheng

drug metabolism, gilead sciences, inc., 333 lakeside dr., foster city, california 94404, united states
H指数:15
被引数:1,794

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis

Lenacapavir的发现：首个每半年给药一次的衣壳抑制剂，用于HIV-1治疗和暴露前预防

Journal of Medicinal Chemistry
IF6.8
2025-10-010
OAAI
Eda Canales; Winston Tse; Scott D. Schroeder; Chien-Hung Chou; Qi Liu; Jennifer Zhang; Scott E. Lazerwith; Philip Morganelli; Roland D. Saito; Gediminas Brizgys; Jiayao Li; Qiaoyin Wu; Michael Graupe; Randall L. Halcomb; Manoj Desai; Carina Cannizzaro; Eric Hu; Jason K. Perry; Armando G. Villaseñor; John R. Somoza; Ryan D. Ferrao; S. Swaminathan; Jim Zheng; Bing Lu; Judy Mwangi; Kelly Wang; Raju Subramanian; Bill J. Smith; Gerry Rhodes; William Rowe; Dorothea Sauer; Latesh Lad; Giuseppe A. Papalia; Sheila Clancy; George J. Stepan; Helen Yu; Roman Sakowicz; Bing Shi; Gavin Carr; Rujuta A. Bam; Luong K. Tsai; Eric Singer; Derek Hansen; Andrew Mulato; Stephen R. Yant; Tomas Cihlar; John O. Link
Lenacapavir Exhibits Atropisomerism-Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance PathwayS
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2024-10-010
OAAI
Zheng, Jim; Lu, Bing; Carr, Gavin; Mwangi, Judy; Wang, Kelly; Hao, Jia; Staiger, Kelly McLennan; Kozon, Nathan; Murray, Bernard P.; Bashir, Mohammad; Gohdes, Mark A.; Tse, Winston C.; Schroeder, Scott; Graupe, Michael; Link, John O.; Yoon, Jungjoo; Chiu, Anna; Rowe, William; Smith, Bill J.; Subramanian, Raju
Long-acting lenacapavir protects macaques against intravenous challenge with simian-tropic HIV
EBIOMEDICINE
IF10.8
2023-09-013
OAAI
Swanstrom, Adrienne E.; Gorelick, Robert J.; Welker, Jorden L.; Schmidt, Fabian; Lu, Bing; Wang, Kelly; Rowe, William; Breed, Matthew W.; Killoran, Kristin E.; Kramer, Joshua A.; Donohue, Duncan; Roser, James D.; Bieniasz, Paul D.; Hatziioannou, Theodora; Pyle, Cathi; Thomas, James A.; Trubey, Charles M.; Zheng, Jim; Blair, Wade; Yant, Stephen R.; Lifson, Jeffrey D.; Del Prete, Gregory Q.
Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B
HEPATOLOGY
IF15.8
2020-11-2761
OAAI
Daffis, Stephane; Balsitis, Scott; Chamberlain, Jason; Zheng, Jim; Santos, Rex; Rowe, William; Ramakrishnan, Dhivya; Pattabiraman, Divya; Spurlock, Sandra; Chu, Ruth; Kang, Don; Mish, Michael; Ramirez, Ricardo; Li, Li; Li, Bei; Ma, Sarina; Hung, Magdeleine; Voitenleitner, Christian; Yon, Changsuek; Suresh, Manasa; Menne, Stephan; Cote, Paul; Delaney, William E.; Mackman, Richard; Fletcher, Simon P.
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-05-1458
PREAI
Mackman, Richard L.; Mish, Michael; Chin, Gregory; Perry, Jason K.; Appleby, Todd; Aktoudianakis, Vangelis; Metobo, Sammy; Pyun, Peter; Niu, Congrong; Daffis, Stephane; Yu, Helen; Zheng, Jim; Villasenor, Armando G.; Zablocki, Jeff; Chamberlain, Jason; Jin, Haolun; Lee, Gary; Suekawa-Pirrone, Kimberley; Santos, Rex; Delaney, William E.; Fletcher, Simon P.
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model
NATURE MEDICINE
IF50
2019-09-09105
OAAI
Yant, Stephen R.; Mulato, Andrew; Hansen, Derek; Tse, Winston C.; Niedziela-Majka, Anita; Zhang, Jennifer R.; Stepan, George J.; Jin, Debi; Wong, Melanie H.; Perreira, Jill M.; Singer, Eric; Papalia, Giuseppe A.; Hu, Eric Y.; Zheng, Jim; Lu, Bing; Schroeder, Scott D.; Chou, Kevin; Ahmadyar, Shekeba; Liclican, Albert; Yu, Helen; Novikov, Nikolai; Paoli, Eric; Gonik, Daniel; Ram, Renee R.; Hung, Magdeleine; McDougall, William M.; Brass, Abraham L.; Sundquist, Wesley I.; Cihlar, Tomas; Link, John O.
An advanced BLT-humanized mouse model for extended HIV-1 cure studies
AIDS
IF3.1
2018-01-0248
OAAI
Lavender, Kerry J.; Pace, Craig; Sutter, Kathrin; Messer, Ronald J.; Pouncey, Dakota L.; Cummins, Nathan W.; Natesampillai, Sekar; Zheng, Jim; Goldsmith, Joshua; Widera, Marek; Van Dis, Erik S.; Phillips, Katie; Race, Brent; Dittmer, Ulf; Kukolj, George; Hasenkrug, Kim J.
Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2016-03-0130
OAAI
Del Prete, Gregory Q.; Oswald, Kelli; Lara, Abigail; Shoemaker, Rebecca; Smedley, Jeremy; Macallister, Rhonda; Coalter, Vicky; Wiles, Adam; Wiles, Rodney; Li, Yuan; Fast, Randy; Kiser, Rebecca; Lu, Bing; Zheng, Jim; Alvord, W. Gregory; Trubey, Charles M.; Piatak, Michael, Jr.; Deleage, Claire; Keele, Brandon F.; Estes, Jacob D.; Hesselgesser, Joseph; Geleziunas, Romas; Lifson, Jeffrey D.
BASIC AND TRANSLATIONAL-LIVER

基础和翻译-肝脏

GASTROENTEROLOGY
IF25.1
2013-06-01329
OA
Lanford, Robert E.; Guerra, Bernadette; Chavez, Deborah; Giavedoni, Luis; Hodara, Vida L.; Brasky, Kathleen M.; Fosdick, Abigail; Frey, Christian R.; Zheng, Jim; Wolfgang, Grushenka; Halcomb, Randall L.; Tumas, Daniel B.

研究方向

暂未获取到该数据
R
Randall L. Halcomb
H 指数:32论文数:115被引数:4,237
W
William Rowe
H 指数:8论文数:19被引数:607
鲁冰 封面图
鲁冰
H 指数:21论文数:56被引数:1,626
W
Winston C. Tse
H 指数:14论文数:38被引数:2,016
S
Scott D. Schroeder
H 指数:8论文数:23被引数:713
D
Daniel B. Tumas
H 指数:28论文数:85被引数:4,638
H
Helen Yu
H 指数:25论文数:57被引数:3,828
S
Simon P. Fletcher
H 指数:35论文数:99被引数:4,510
R
Raju Subramanian
H 指数:30论文数:108被引数:3,068
S
Stephane Daffis
H 指数:2论文数:2被引数:17