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AXL promotes inflammatory breast cancer progression by regulating immunosuppressive macrophage polarization AXL通过调控免疫抑制性巨噬细胞极化促进炎性乳腺癌进展 Phi, Lan T. H.; Cheng, Yating; Funakoshi, Yohei; Bertucci, Francois; Finetti, Pascal; Van Laere, Steven J.; Zou, Fang; Long, James P.; Ogata, Suguru; Krishnamurthy, Savitri; Reuben, James M.; Foulks, Jason M.; Warner, Steven L.; Rosenbluth, Jennifer M.; Sood, Anil K.; Tripathy, Debu; Ueno, Naoto T.; Wang, Xiaoping 分享 收藏
PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma PPARα介导的脂质代谢重编程支持头颈部鳞状细胞癌中抗EGFR疗法的耐药性。 van den Bossche, Valentin; Vignau, Julie; Vigneron, Engy; Rizzi, Isabella; Zaryouh, Hannah; Wouters, An; Ambroise, Jerome; Van Laere, Steven; Beyaert, Simon; Helaers, Raphael; van Marcke, Cedric; Mignion, Lionel; Lepicard, Elise Y.; Jordan, Benedicte F.; Guilbaud, Celine; Lowyck, Olivier; Dahou, Hajar; Mendola, Antonella; Desgres, Manon; Aubert, Leo; Gerin, Isabelle; Bommer, Guido T.; Boidot, Romain; Vermonden, Perrine; Warnant, Aurelien; Larondelle, Yvan; Machiels, Jean-Pascal; Feron, Olivier; Schmitz, Sandra 分享 收藏
Molecular characterization of the histopathological growth patterns of colorectal cancer liver metastases by RNA sequencing of targeted samples at the tumor-liver interface 通过在肿瘤-肝界面处对靶向样品进行RNA测序，对结直肠癌肝转移的组织病理学生长模式进行分子表征 Latacz, Emily; Verheul, Sanne M. L.; Sillis, Yasmine; van Dam, Pieter-Jan; Doukas, Michail; Grunhagen, Dirk J.; Nystrom, Hanna; Dirix, Piet; Dirix, Luc; Van Laere, Steven; Verhoef, Cornelis; Vermeulen, Peter 分享 收藏
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Mutational landscape of inflammatory breast cancer 炎性乳腺癌的突变景观 Bertucci, Francois; Lerebours, Florence; Ceccarelli, Michele; Guille, Arnaud; Syed, Najeeb; Finetti, Pascal; Adelaide, Jose; Van Laere, Steven; Goncalves, Anthony; Viens, Patrice; Birnbaum, Daniel; Mamessier, Emilie; Callens, Celine; Bedognetti, Davide 分享 收藏
Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models 几丁质介导的几丁质酶样蛋白阻断可减少肿瘤免疫抑制，抑制淋巴转移并增强互补TNBC模型中的anti-PD-1功效 Salembier, Robbe; De Haes, Caro; Bellemans, Julie; Demeyere, Kristel; van den Broeck, Wim; Sanders, Niek N.; Van Laere, Steven; Lyons, Traci R.; Meyer, Evelyne; Steenbrugge, Jonas 分享 收藏
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XIAP overexpressing Inflammatory Breast Cancer Patients have high Infiltration of immunosuppressive subsets and increased TNFR1 signaling targetable with Birinapant, a pan- IAP antagonist Devi, G.; Van Berckelaer, C.; Van Laere, S.; Geradts, J.; Lee, S.; Morse, M.; Dirix, L.; Kockx, M.; Bertucci, F.; Van Dam, P. 分享 收藏
IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts IL-15-secreting针对泛癌症靶标CD70的CAR自然杀伤细胞可消除癌细胞和癌症相关的成纤维细胞 van den Eynde, Astrid; Gehrcken, Laura; Verhezen, Tias; Lau, Ho Wa; Hermans, Christophe; Lambrechts, Hilde; Flieswasser, Tal; Quatannens, Delphine; Roex, Gils; Zwaenepoel, Karen; Marcq, Elly; Joye, Philippe; De La Hoz, Edgar Cardenas; Deben, Christophe; Gasparini, Alessia; Montay-Gruel, Pierre; Le Compte, Maxim; Lion, Eva; Lardon, Filip; Van Laere, Steven; Siozopoulou, Vasiliki; Campillo-Davo, Diana; De Waele, Jorrit; Pauwels, Patrick; Jacobs, Julie; Smits, Evelien; Van Audenaerde, Jonas R. M. 分享 收藏
Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer 单类器官分析揭示了胰腺癌中临床相关的治疗抗性和侵袭性亚克隆 Le Compte, Maxim; De La Hoz, Edgar Cardenas; Peeters, Sofia; Fortes, Felicia Rodrigues; Hermans, Christophe; Domen, Andreas; Smits, Evelien; Lardon, Filip; Vandamme, Timon; Lin, Abraham; Vanlanduit, Steve; Roeyen, Geert; Van Laere, Steven; Prenen, Hans; Peeters, Marc; Deben, Christophe 分享 收藏
Obesity-associated changes in molecular biology of primary breast cancer 原发性乳腺癌与肥胖相关的分子生物学改变 Nguyen, Ha-Linh; Geukens, Tatjana; Maetens, Marion; Aparicio, Samuel; Bassez, Ayse; Borg, Ake; Brock, Jane; Broeks, Annegien; Caldas, Carlos; Cardoso, Fatima; De Schepper, Maxim; Delorenzi, Mauro; Drukker, Caroline A.; Glas, Annuska M.; Green, Andrew R.; Isnaldi, Edoardo; Eyfjoro, Jorunn; Khout, Hazem; Knappskog, Stian; Krishnamurthy, Savitri; Lakhani, Sunil R.; Langerod, Anita; Martens, John W. M.; Reed, Amy E. McCart; Murphy, Leigh; Naulaerts, Stefan; Nik-Zainal, Serena; Nevelsteen, Ines; Neven, Patrick; Piccart, Martine; Poncet, Coralie; Punie, Kevin; Purdie, Colin; Rakha, Emad A.; Richardson, Andrea; Rutgers, Emiel; Vincent-Salomon, Anne; Simpson, Peter T.; Schmidt, Marjanka K.; Sotiriou, Christos; Span, Paul N.; Tan, Kiat Tee Benita; Thompson, Alastair; Tommasi, Stefania; Van Baelen, Karen; Van de Vijver, Marc; Van Laere, Steven; van't Veer, Laura; Viale, Giuseppe; Viari, Alain; Vos, Hanne; Witteveen, Anke T.; Wildiers, Hans; Floris, Giuseppe; Garg, Abhishek D.; Smeets, Ann; Lambrechts, Diether; Biganzoli, Elia; Richard, Francois; Desmedt, Christine 分享 收藏
Immunohistochemical characterisation of the immune landscape in primary uveal melanoma and liver metastases Mariani, Pascale; Torossian, Nouritza; van Laere, Steven; Vermeulen, Peter; de Koning, Leanne; Roman-Roman, Sergio; Lantz, Olivier; Rodrigues, Manuel; Stern, Marc-Henri; Gardrat, Sophie; Lesage, Laetitia; Champenois, Gabriel; Nicolas, Andre; Matet, Alexandre; Cassoux, Nathalie; Servois, Vincent; Romano, Emanuela; Piperno-Neumann, Sophie; Lugassy, Claire; Barnhill, Raymond 分享 收藏
Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target 转移性炎性与非炎性乳腺癌患者肿瘤样本中存在的基因组改变的比较揭示了AURKA作为潜在的治疗靶点 Richard, Francois; De Schepper, Maxim; Maetens, Marion; Leduc, Sophia; Isnaldi, Edoardo; Geukens, Tatjana; Van Baelen, Karen; Nguyen, Ha-Linh; Vermeulen, Peter; Van Laere, Steven; Bertucci, Francois; Ueno, Naoto; Dirix, Luc; Floris, Giuseppe; Biganzoli, Elia; Desmedt, Christine 分享 收藏
Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner Molostvov, Guerman; Gachechiladze, Mariam; Shaaban, Abeer M.; Hayward, Steven; Dean, Isaac; Dias, Irundika H. K.; Badr, Nahla; Danial, Irini; Mohammed, Fiyaz; Novitskaya, Vera; Paniushkina, Liliia; Speirs, Valerie; Hanby, Andrew; Nazarenko, Irina; Withers, David R.; van Laere, Steven; Long, Heather M.; Berditchevski, Fedor 分享 收藏
EGFR is a master switch between immunosuppressive and immunoactive tumor microenvironment in inflammatory breast cancer Wang, Xiaoping; Semba, Takashi; Manyam, Ganiraju C.; Wang, Jing; Shao, Shan; Bertucci, Francois; Finetti, Pascal; Krishnamurthy, Savitri; Lan Thi Hanh Phi; Pearson, Troy; Van Laere, Steven J.; Burks, Jared K.; Cohen, Evan N.; Reuben, James M.; Yang, Fei; Min, Hu; Navin, Nicholas; Van Ngu Trinh; Iwase, Toshiaki; Batra, Harsh; Shen, Yichao; Zhang, Xiang; Tripathy, Debu; Ueno, Naoto T. 分享 收藏
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