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Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold 癌基因非-V600突变逃避了RAF的调控机制，包括Cdc37/Hsp90分子伴侣和14-3-3支架蛋白。 Wan, Xiaoyu; Yap, Jiajun; Chen, Junjun; Li, Yifan; Faruk, Regina; Tan, Nazereth Chor Boon; Ma, Yiying; Lim, Yiting; Jubri, Karlina Bte; Hu, Jingyi; Yuan, Jimin; Zhang, Ge; Li, Quan; Yap, Yoon Sim; Lam, Paula; Wang, Mei; Fu, Nai Yang; Hu, Jiancheng 分享 收藏
Acquired gene alterations in patients treated with ribociclib plus endocrine therapy or endocrine therapy alone using baseline and end-of-treatment circulating tumor DNA samples in the MONALEESA-2,-3, and-7 trials MONALEESA-2、-3和-7试验中，使用基线和治疗结束时的循环肿瘤DNA样本，评估接受ribociclib联合内分泌治疗或仅接受内分泌治疗患者的获得性基因改变。 Andre, F.; Solovieff, N.; Su, F.; Bardia, A.; Neven, P.; Yap, Y. S.; Tripathy, D.; Lu, Y. -S.; Slamon, D.; Chia, S.; Joshi, M.; Chakravartty, A.; Lteif, A.; Taran, T.; Arteaga, C. L. 分享 收藏
Survival outcomes of young-age female patients with early breast cancer: an international multicenter cohort study Kim, J.; Kim, J.; Seo, K. H.; Lee, K. -H.; Park, Y. H.; Lin, C. -H.; Lu, Y. -S.; Ueno, T.; Yap, Y. -S.; Wong, F. -Y.; Tan, V. K. M.; Lim, G. -H.; Tan, S. -M.; Yeo, W.; Liu, Q.; Leung, R.; Naito, Y.; Li, H.; Lee, H. -B.; Han, W.; Im, S. -A. 分享 收藏
A phase 3 study (PATHWAY) of palbociclib plus tamoxifen in patients with HR-positive/HER2-negative advanced breast cancer Noguchi, Emi; Yamanaka, Takashi; Mukai, Hirofumi; Yamamoto, Naohito; Chung, Chi-Feng; Lu, Yen-Shen; Chang, Dwan-Ying; Sohn, Joohyuk; Kim, Gun Min; Lee, Kyung-Hun; Lee, Soo-Chin; Iwasa, Tsutomu; Iwata, Hiroji; Watanabe, Kenichi; Jung, Kyung Hae; Tanabe, Yuko; Kang, Seok Yun; Yasojima, Hiroyuki; Aogi, Kenjiro; Tokunaga, Eriko; Sim, Sung Hoon; Yap, Yoon Sim; Matsumoto, Koji; Tseng, Ling-Ming; Umeyama, Yoshiko; Sudo, Kazuki; Kojima, Yuki; Hata, Tomomi; Kuchiba, Aya; Shibata, Taro; Nakamura, Kenichi; Fujiwara, Yasuhiro; Tamura, Kenji; Yonemori, Kan 分享 收藏
Outcomes in Nonmetastatic Hormone Receptor-Positive HER2-Negative Pure Mucinous Breast Cancer: A Multicenter Cohort Study Tan, Ryan Ying Cong; Ong, Whee Sze; Lee, Kyung-Hun; Park, Seri; Iqbal, Jabed; Park, Yeon Hee; Lee, Jeong Eon; Yu, Jong Han; Lin, Ching-Hung; Lu, Yen-Shen; Ono, Makiko; Ueno, Takayuki; Naito, Yoichi; Onishi, Tatsuya; Lim, Geok-Hoon; Tan, Su-Ming; Lee, Han-Byoel; Koh, Jiwon; Han, Wonshik; Im, Seock-Ah; Tan, Veronique Kiak Mien; Phyu, Nitar; Wong, Fuh-Yong; Tan, Puay Hoon; Yap, Yoon-Sim 分享 收藏
Clonal Architecture of circulating tumor DNA predicts Early Progression on Tamoxifen With or Without Palbociclib in Hormone Receptor-Positive Advanced Breast Cancer: NCCH1607/PATHWAY trial Yap, Yoon-Sim; Kojima, Yuki; Hamada, Akinobu; Mukai, Hirofumi; Lu, Yen-Shen; Sohn, Joo Hyuk; Umeyama, Yoshiko; Noguchi, Emi; Sudo, Kazuki; Hata, Tomomi; Kuchiba, Aya; Shibata, Taro; Yagishita, Shigehiro; Yoshida, Masayuki; Kohsaka, Shinji; Shiraishi, Kouya; Nakamura, Kenichi; Tamura, Kenji; Yonemori, Kan 分享 收藏
Comprehensive Benchmark of Somatic Mutation Callers on Cell-Free DNA Next-Generation Sequencing Data in Cancer Liquid Biopsy Carrie, Hanae; Sim, Ngak Leng; Wong, Pui Mun; Gan, Anna; Lau, Yi Ting; Poon, Polly; Thangaraju, Saranya; Tan, Iain; Yap, Yoon Sim; Wong, Limsoon; Skanderup, Anders 分享 收藏
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Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2- Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2,-3,-7 Prat, Aleix; Solovieff, Nadia; Andre, Fabrice; O'Shaughnessy, Joyce; Cameron, David A.; Janni, Wolfgang; Sonke, Gabe S.; Yap, Yoon-Sim; Yardley, Denise A.; Partridge, Ann H.; Thuerigen, Astrid; Zarate, Juan Pablo; Lteif, Agnes; Su, Fei; Carey, Lisa A. 分享 收藏
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First-line ribociclib (RIB) plus endocrine therapy (ET) vs combination chemotherapy (combo CT) in aggressive HR+/HER2-advanced breast cancer (ABC): A subgroup analysis of patients (pts) with or without visceral crisis from the phase II RIGHT choice study Azim, H. A.; El Saghir, N. S.; Yap, Y. S.; Eralp, Y.; Im, S-A.; Sandhu, M. S.; Abdel-Razeq, H.; Gupta, S.; Artamonova, E.; Rihani, J.; Alfaro, T. Delgar; Wu, J.; Hu, H.; Gao, M.; Lu, Y-S. 分享 收藏
Quality of life (QOL) analysis from the phase II RIGHT choice study of first-line ribociclib (RIB) plus endocrine therapy (ET) vs combination chemotherapy (combo CT) in aggressive HR+/HER2-advanced breast cancer (ABC) Eralp, Y.; Abdel-Razeq, H.; Im, S-A.; Rihani, J.; Lu, Y-S.; Yap, Y. S.; Azim, H. A.; Prasongsook, N.; Zhukova, L.; Hu, H.; Alfaro, T. Delgar; Wu, J.; Gao, M.; El Saghir, N. S. 分享 收藏
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Potential value of ctDNA monitoring in metastatic HR + /HER2-breast cancer: longitudinal ctDNA analysis in the phase Ib MONALEESASIA trial Chiu, Joanne; Su, Fei; Joshi, Mukta; Masuda, Norikazu; Ishikawa, Takashi; Aruga, Tomoyuki; Zarate, Juan Pablo; Babbar, Naveen; Balbin, O. Alejandro; Yap, Yoon-Sim 分享 收藏
Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer (vol 17, 66, 2023) Lee, Ning-Yuan; Hum, Melissa; Zihara, Sabna; Wang, Lanying; Myint, Matthew K.; Lim, Darren Wan-Teck; Toh, Chee-Keong; Skanderup, Anders; Samol, Jens; Tan, Min-Han; Ang, Peter; Lee, Soo-Chin; Tan, Eng-Huat; Lai, Gillianne G. Y.; Tan, Daniel S. W.; Yap, Yoon-Sim; Lee, Ann S. G. 分享 收藏
Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer 双原发乳腺癌和肺癌患者的种系致病变异景观 Lee, Ning-Yuan; Hum, Melissa; Zihara, Sabna; Wang, Lanying; Myint, Matthew K.; Lim, Darren Wan-Teck; Toh, Chee-Keong; Skanderup, Anders; Samol, Jens; Tan, Min-Han; Ang, Peter; Lee, Soo-Chin; Tan, Eng-Huat; Lai, Gillianne G. Y.; Tan, Daniel S. W.; Yap, Yoon-Sim; Lee, Ann S. G. 分享 收藏
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Identification of mechanisms of acquired resistance to ribociclib plus endocrine therapy using baseline and end-of-treatment circulating tumor DNA samples in the MONALEESA-2,-3, and-7 trials Andre, Fabrice; Solovieff, Nadia; Su, Faye; Bardia, Aditya; Neven, Patrick; Yap, Yoon-Sim; Tripathy, Debu; Lu, Yen-Shen; Slamon, Dennis; Chia, Stephen K.; Joshi, Mukta; Chakravartty, Arunava; Lteif, Agnes; Taran, Tetiana; Arteaga, Carlos 分享 收藏
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