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TSC2 loss in neural progenitor cells suppresses mRNA translation of neurodevelopmental genes TSC2在神经祖细胞中的缺失抑制了神经发育基因的mRNA翻译 Martin, Pauline; Szkop, Krzysztof J.; Robert, Francis; Bhattacharyya, Srirupa; Beauchamp, Roberta L.; Brenner, Jacob; Redmond, Nicholas E.; Huang, Sidong; Erdin, Serkan; Larsson, Ola; Ramesh, Vijaya 分享 收藏
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Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations Aksoylu, Inci S.; Martin, Pauline; Robert, Francis; Szkop, Krzysztof J.; Redmond, Nicholas E.; Bhattacharyya, Srirupa; Wang, Jennifer; Chen, Shan; Beauchamp, Roberta L.; Nobeli, Irene; Pelletier, Jerry; Larsson, Ola; Ramesh, Vijaya 分享 收藏
Comparison of Therapeutic Efficacy of Gene Therapy for Tuberous Sclerosis Type 2 with Standard of Care Everolimus in Preclinical Model Abou Haidar, Edwina; Prabhakar, Shilpa; Cheah, Pike See; Lule, Sevda; Beauchamp, Roberta L.; Yoshinaga, Akiko; Geffrey, Alexandra L.; Stemmer-Rachamimov, Anat; Ramesh, Vijaya; Maguire, Casey A.; Breakefield, Xandra O. 分享 收藏
Prospective phase II trial of the dual mTORC1/2 inhibitor vistusertib for progressive or symptomatic meningiomas in persons with neurofibromatosis 2 Jordan, Justin T.; Orr, Christina C.; Thalheimer, Raquel D.; Cambillo, Josephine, V; Beauchamp, Roberta L.; Shaikh, Ghalib; Muzikansky, Alona; Stemmer-Rachamimov, Anat; Giovannini, Marco; Kalamarides, Michel; Barker, Fred G.; Ramesh, Vijaya; Plotkin, Scott R. 分享 收藏
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Proteasomal pathway inhibition as a potential therapy for NF2-associated meningioma and schwannoma Bhattacharyya, Srirupa; Oblinger, Janet L.; Beauchamp, Roberta L.; Yin, Zhenzhen; Erdin, Serkan; Koundinya, Priya; Ware, Anna D.; Ferrer, Marc; Jordan, Justin T.; Plotkin, Scott R.; Xu, Lei; Chang, Long-Sheng; Ramesh, Vijaya 分享 收藏
SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma St Pierre, Roodolph; Collings, Clayton K.; Guerra, Daniel D. Same; Widmer, Christian J.; Bolonduro, Olubusayo; Mashtalir, Nazar; Sankar, Akshay; Liang, Yu; Bi, Wenya Linda; Gerkes, Erica H.; Ramesh, Vijaya; Qi, Jun; Smith, Miriam J.; Meredith, David M.; Kadoch, Cigall 分享 收藏
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy 基于高含量图像的分析和蛋白质组学分析在人iPSC衍生的Tau蛋白病谷氨酸能神经元模型中鉴定Tau蛋白磷酸化抑制剂 Cheng, Chialin; Reis, Surya A.; Adams, Emily T.; Fass, Daniel M.; Angus, Steven P.; Stuhlmiller, Timothy J.; Richardson, Jared; Olafson, Hailey; Wang, Eric T.; Patnaik, Debasis; Beauchamp, Roberta L.; Feldman, Danielle A.; Silva, M. Catarina; Sur, Mriganka; Johnson, Gary L.; Ramesh, Vijaya; Miller, Bruce L.; Temple, Sally; Kosik, Kenneth S.; Dickerson, Bradford C.; Haggarty, Stephen J. 分享 收藏
Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin Cheah, Pike-See; Prabhakar, Shilpa; Yellen, David; Beauchamp, Roberta L.; Zhang, Xuan; Kasamatsu, Shingo; Bronson, Roderick T.; Thiele, Elizabeth A.; Kwiatkowski, David J.; Stemmer-Rachamimov, Anat; Gyorgy, Bence; Lin, King-Hwa; Kaneki, Masao; Tannous, Bakhos A.; Ramesh, Vijaya; Maguire, Casey A.; Breakefield, Xandra O. 分享 收藏
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Combination therapy with mTOR kinase inhibitor and dasatinib as a novel therapeutic strategy for vestibular schwannoma Sagers, Jessica E.; Beauchamp, Roberta L.; Zhang, Yanling; Vasilijic, Sasa; Wu, Limeng; DeSouza, Patrick; Seist, Richard; Zhou, Wenjianlong; Xu, Lei; Ramesh, Vijaya; Stankovic, Konstantina M. 分享 收藏
TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling Martin, Pauline; Wagh, Vilas; Reis, Surya A.; Erdin, Serkan; Beauchamp, Roberta L.; Shaikh, Ghalib; Talkowski, Michael; Thiele, Elizabeth; Sheridan, Steven D.; Haggarty, Stephen J.; Ramesh, Vijaya 分享 收藏
EPH receptor signaling as a novel therapeutic target in NF2-deficient meningioma Angus, Steven P.; Oblinger, Janet L.; Stuhlmiller, Timothy J.; DeSouza, Patrick A.; Beauchamp, Roberta L.; Witt, Luke; Chen, Xin; Jordan, Justin T.; Gilbert, Thomas S. K.; Stemmer-Rachamimov, Anat; Gusella, James F.; Plotkin, Scott R.; Haggarty, Stephen J.; Chang, Long-Sheng; Johnson, Gary L.; Ramesh, Vijaya 分享 收藏
A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus 溶瘤性单纯疱疹病毒治疗的新型患者原位恶性脑膜瘤模型 Nigim, Fares; Esaki, Shin-ichi; Hood, Michael; Lelic, Nina; James, Marianne F.; Ramesh, Vijaya; Stemmer-Rachamimov, Anat; Cahill, Daniel P.; Brastianos, Priscilla K.; Rabkin, Samuel D.; Martuza, Robert L.; Wakimoto, Hiroaki 分享 收藏
Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model Prabhakar, Shilpa; Zhang, Xuan; Goto, June; Han, Sangyeul; Lai, Charles; Bronson, Roderick; Sena-Esteves, Miguel; Ramesh, Vijaya; Stemmer-Rachamimov, Anat; Kwiatkowski, David J.; Breakefield, Xandra O. 分享 收藏
AAV-Mediated Gene Replacement Therapy in Mouse Model of Tuberous Sclerosis Prabhakar, Shilpa; Zhang, Xuan; Goto, June; Sena-Esteves, Miguel; Ramesh, Vijaya; Bronson, Roderick; Chen, John W.; Stemmer-Rachamimov, Anat O.; Kwiatkowski, David J.; Breakefield, Xandra O. 分享 收藏
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