Karl S. Lang - Publications, H-index & Citations

Karl S. Lang

university hospital essen

66H指数

701论文数

1.5W被引数

收录论文 155

发表时间

Mutations at Positions 181 and 185 Within the LCMV GP Protein Increase Tumor Cell Infectivity, Limit Induction of Type I Interferon, and Accelerate T Cell Activation LCMV GP蛋白中181和185位点的突变增加肿瘤细胞感染性，限制I型干扰素的诱导，并加速T细胞激活

Viruses-Basel

IF3.5

2026-09-12

OAAI

Michael Bergerhausen; Lisa Holnsteiner; Sarah-Kim Friedrich-Becker; Zhongwen Hu; Rosa Schmitz; Dethardt Müller; Marcus Kostka; Tim Brandenburg; Haifeng C. Xu; Cornelia Hardt; Jörg Vollmer; Philipp A. Lang; Karl Sebastian Lang

Lymphocytic Choriomeningitis Virus Bearing GPC Mutations for Enhanced Tumor Tropism and Strong Anti-Tumor Activity 携带GPC突变的淋巴脉络丛脑膜炎病毒，用于增强肿瘤嗜性及强效抗肿瘤活性

Viruses-Basel

IF3.5

2026-09-12

OAAI

Sarah-Kim Friedrich-Becker; Michael Bergerhausen; Arshia Berry; Hilal Bhat; Fanghui Li; Rosa Schmitz; Lisa Holnsteiner; Dethardt Müller; Haifeng Xu; Philipp A. Lang; Karl Sebastian Lang; Jörg Vollmer

Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinoma 基于靶向和表观遗传的联合治疗通过稳定胰腺导管腺癌GATA6-dependent MHCI表达来增强抗肿瘤免疫力

Nature Communications

IF15.7

2026-02-06

OAAI

JuanFei Peng; JiaJin Yang; Georgia Antonopoulou; Rui Fang; Bikash Adhikari; Markus Vogt; Elmar Wolf; Chong Sun; Shangce Du; Laura Godfrey; Aayush Gupta; Marija Trajkovic-Arsic; Nicole Teichmann; Barbara T. Grünwald; Niklas Krebs; Katja Steiger; Carolin Mogler; Kristina Althoff; Xin Wang; Giovanni Giglio; Sven-Thorsten Liffers; Konstantinos Savvatakis; Rickmer Braren; Rita T. Lawlor; Aldo Scarpa; Diana Behrens; Karl S. Lang; Phyllis F. Cheung; Jens T. Siveke

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1 酸神经酰胺酶通过I型干扰素介导的PD-L1上调来调节CD8+ T细胞耗竭

Frontiers in Immunology

IF5.9

2025-12-09

OAAI

Zhongwen Hu†‡; Hossam Abdelrahman‡; Abdelrahman Elwy‡; Fei Kuang†‡; Swati Dhiman; Shafaqat Ali†; Marcel Marson†‡; Lisa Holnsteiner; Thamer A. Hamdan†; Justa Friebus-Kardash; Elisa Wiebeck; Wiebke Hansen; Stefanie Scheu†; Erich Gulbins; Philipp Alexander Lang; Karl Sebastian Lang; Judith Lang

Redefining the concept of erythrocyte senescence: is eryptosis fundamentally different from erythrocyte senescence 重新定义红细胞衰老的概念：红细胞程序性死亡（eryptosis）与红细胞衰老在本质上是否不同

GeroScience

IF5.4

2025-11-19

PREAI

Anton Tkachenko; Ondrej Havranek; Florian Lang; Karl S. Lang; Thomas Wieder

Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties 经过优化的具有肿瘤趋向性突变的沙粒病毒通过可持续的免疫调节特性促进安全的抗肿瘤效果。

Cell Reports Medicine

IF10.6

2025-10-13

OAAI

Philipp A. Lang; Lisa Holnsteiner; Yara M. Machlah; Sarah-Kim Friedrich-Becker; Michael Bergerhausen; Rosa Schmitz; Maximilian Schiller; Tim Brandenburg; Julia Zöller; Julia Werner; Marla Keizers; Michal Gorzkiewicz; Arshia Berry; Lara Jelic; Piyush Pandey; Ruifeng Wang; Dethardt Müller; Marcus Kostka; Cornelia Hardt; Jörg Vollmer; Haifeng C. Xu; Karl S. Lang

Nanoscale characterization of space weathering in lunar samples 月球样品空间风化的纳米尺度表征

SCIENTIFIC REPORTS

IF3.9

2025-01-02

OAAI

Grice, A. M.; Stancil, P. C.; Ghafariasl, M.; Singh, S.; Gamage, S.; Schaible, M. J.; Abate, Y.; Lang, K.; Orlando, T. M.

Increased Risk for Infections and Allergic Disease in Hereditary Hemorrhagic Telangiectasia

JOURNAL OF CLINICAL MEDICINE

IF2.9

2024-06-27

OAAI

Droege, Freya; Koenig, Jochem; Lang, Karl S.; Jablonska, Jadwiga; Pylaeva, Ekaterina; Huckenbeck, Carolin; Wrobeln, Anna; Duerig, Inga; Thangavelu, Kruthika; Lang, Stephan; Geisthoff, Urban

Natural IgG protects against early dissemination of vesicular stomatitis virus

JOURNAL OF AUTOIMMUNITY

IF7

2024-06-01

OAAI

Elwy, Abdelrahman; Abdelrahman, Hossam; Specht, Julia; Dhiman, Swati; Christ, Theresa Charlotte; Lang, Judith; Friebus-Kardash, Justa; Recher, Mike; Lang, Karl Sebastian

High-Affinity fi nity- Mediated Viral Entry Triggers Innate Affinity fi nity Escape Resulting in Type I IFN Resistance and Impaired T Cell

JOURNAL OF IMMUNOLOGY

IF3.4

2024-03-18

OAAI

Xu, Haifeng C.; Pandey, Piyush; Ward, Harry; Gorzkiewicz, Michal; Abromaviciu, Dziuljeta; Tinz, Constanze; Muller, Lisa; Meyer, Caroline; Pandyra, Aleksandra A.; Yavas, Aslihan; Borkhardt, Arndt; Esposito, Irene; Lang, Karl S.; Lang, Philipp A.

Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections

PLOS PATHOGENS

IF4.9

2023-11-29

OAAI

Abberger, Hanna; Hose, Matthias; Ninnemann, Anne; Menne, Christopher; Eilbrecht, Mareike; Lang, Karl S.; Matuschewski, Kai; Geffers, Robert; Herz, Josephine; Buer, Jan; Westendorf, Astrid M.; Hansen, Wiebke

Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8+ T Cells and Causes Immunopathology in Response to Acute LCMV Infection Usp22缺陷导致CD8 T细胞的PD-L1和病理性活化下调，并引起对急性LCMV感染的免疫病理学反应

VACCINES

IF3.4

2023-10-05

OAAI

Friebus-Kardash, Justa; Christ, Theresa Charlotte; Dietlein, Nikolaus; Elwy, Abdelrahman; Abdelrahman, Hossam; Holnsteiner, Lisa; Hu, Zhongwen; Rodewald, Hans-Reimer; Lang, Karl Sebastian

Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors

MOLECULAR CANCER

IF33.9

2023-08-15

OAAI

Stachura, Pawel; Liu, Wei; Xu, Haifeng C.; Wlodarczyk, Agnes; Stencel, Olivia; Pandey, Piyush; Vogt, Melina; Bhatia, Sanil; Picard, Daniel; Remke, Marc; Lang, Karl S.; Haeussinger, Dieter; Homey, Bernhard; Lang, Philipp A.; Borkhardt, Arndt; Pandyra, Aleksandra A.

Expression of Interferon Regulatory Factor 8 (IRF8) and Its Association with Infections in Dialysis Patients 透析患者干扰素调节因子8 (IRF8) 的表达及其与感染的关系

CELLS

IF5.2

2023-07-19

OAAI

Friebus-Kardash, Justa; Kuang, Fei; Peitz, Tobias; Hamdan, Thamer A.; Eisenberger, Ute; Boss, Kristina; Kribben, Andreas; Lang, Karl Sebastian; Jahn, Michael

Immune suppression of vaccine-induced CD8+ T-cell responses by gamma retrovirus envelope is mediated by interleukin-10-producing CD4+ T cells

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-12-20

OAAI

Podschwadt, Philip; Malyshkina, Anna; Windmann, Sonja; Papadamakis, Athanasios; Kerkmann, Leonie; Lapuente, Dennis; Tenbusch, Matthias; Lu, Mengji; Schindler, Michael; Lang, Karl Sebastian; Hansen, Wiebke; Bayer, Wibke

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis 酸性神经酰胺酶/神经酰胺轴通过调节红细胞生成来控制约氏疟原虫感染小鼠的寄生虫血症

ELIFE

IF0

2022-09-12

OAAI

Gunther, Anne; Hose, Matthias; Abberger, Hanna; Schumacher, Fabian; Veith, Ylva; Kleuser, Burkhard; Matuschewski, Kai; Lang, Karl Sebastian; Gulbins, Erich; Buer, Jan; Westendorf, Astrid M.; Hansen, Wiebke

During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor nodes 在癌症的早期阶段，中性粒细胞在肿瘤淋巴结中启动抗肿瘤免疫反应

CELL REPORTS

IF6.9

2022-08-01

OAAI

Pylaeva, Ekaterina; Korschunow, Georg; Spyra, Ilona; Bordbari, Sharareh; Siakaeva, Elena; Ozel, Irem; Domnich, Maksim; Squire, Anthony; Hasenberg, Anja; Thangavelu, Kruthika; Hussain, Timon; Goetz, Moritz; Lang, Karl S.; Gunzer, Matthias; Hansen, Wiebke; Buer, Jan; Bankfalvi, Agnes; Lang, Stephan; Jablonska, Jadwiga

Single MHC-I Expression Promotes Virus-Induced Liver Immunopathology

HEPATOLOGY COMMUNICATIONS

IF4.6

2022-02-14

OAAI

Xu, Haifeng C.; Huang, Jun; Pandyra, Aleksandra A.; Pandey, Piyush; Wang, Ruifeng; Zhang, Zeli; Zhuang, Yuan; Gertzen, Christoph G. W.; Munk, Carsten; Herebian, Diran; Borkhardt, Arndt; Recher, Mike; Gohlke, Holger; Esposito, Irene; Oberbarnscheidt, Martin; Haussinger, Dieter; Lang, Karl S.; Lang, Philipp A.

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression 颗粒蛋白前体通过调节MHCI表达介导胰腺导管腺癌的免疫逃避

NATURE COMMUNICATIONS

IF15.7

2022-01-10

OAAI

Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel R.; Soun, Camille; Cima, Igor; Scheffler, Bjoern; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens T.

SIRT1-mediated deacetylation of FOXO3a transcription factor supports pro-angiogenic activity of interferon-deficient tumor-associated neutrophils FOXO3a转录因子的SIRT1-mediated去乙酰化支持干扰素缺陷的肿瘤相关中性粒细胞的促血管生成活性

INTERNATIONAL JOURNAL OF CANCER

IF4.7

2021-11-24

OAAI

Bordbari, Sharareh; Morchen, Britta; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Domnich, Maksim; Droege, Freya; Kanaan, Oliver; Lang, Karl Sebastian; Schadendorf, Dirk; Lang, Stephan; Helfrich, Iris; Jablonska, Jadwiga

研究方向