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Deep Learning Models Capture Histological Disease Activity in Crohn's Disease and Ulcerative Colitis with High Fidelity Rymarczyk, Dawid; Schultz, Weiwei; Borowa, Adriana; Friedman, Joshua R.; Danel, Tomasz; Branigan, Patrick; Chalupczak, Michal; Bracha, Anna; Krawiec, Tomasz; Warchol, Michal; Li, Katherine; De Hertogh, Gert; Zielinski, Bartosz; Ghanem, Louis R.; Stojmirovic, Aleksandar 分享 收藏
A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients Peters, Lauren A.; Friedman, Joshua R.; Stojmirovic, Aleksandar; Hagen, Jacob; Houten, Sander; Dodatko, Tetyana; Amaro, Mariana P.; Restrepo, Paula; Chai, Zhi; Rodrigo Mora, J.; Raymond, Holly A.; Curran, Mark; Dobrin, Radu; Das, Anuk; Xiong, Huabao; Schadt, Eric E.; Argmann, Carmen; Losic, Bojan 分享 收藏
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy Interleukin-22调节溃疡性结肠炎中性粒细胞募集并与乌司他单抗治疗耐药相关 Pavlidis, Polychronis; Tsakmaki, Anastasia; Pantazi, Eirini; Li, Katherine; Cozzetto, Domenico; Digby-Bell, Jonathan; Yang, Feifei; Lo, Jonathan W.; Alberts, Elena; Sa, Ana Caroline Costa; Niazi, Umar; Friedman, Joshua; Long, Anna K.; Ding, Yuchun; Carey, Christopher D.; Lamb, Christopher; Saqi, Mansoor; Madgwick, Matthew; Gul, Leila; Treveil, Agatha; Korcsmaros, Tamas; Macdonald, Thomas T.; Lord, Graham M.; Bewick, Gavin; Powell, Nick 分享 收藏
Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease Pavlidis, Polychronis; Tsakmaki, Anastasia; Treveil, Agatha; Li, Katherine; Cozzetto, Domenico; Yang, Feifei; Niazi, Umar; Hayee, Bu Hussain; Saqi, Mansoor; Friedman, Joshua; Korcsmaros, Tamas; Bewick, Gavin; Powell, Nick 分享 收藏
Integrative Analysis of the Inflammatory Bowel Disease Serum Metabolome Improves Our Understanding of Genetic Etiology and Points to Novel Putative Therapeutic Targets Di'Narzo, Antonio F.; Houten, Sander M.; Kosoy, Roman; Huang, Ruiqi; Vaz, Frederic M.; Hou, Ruixue; Wei, Gabrielle; Wang, Wenhui; Comella, Phillip H.; Dodatko, Tetyana; Rogatsky, Eduard; Stojmirovic, Aleksandar; Brodmerkel, Carrie; Perrigoue, Jacqueline; Hart, Amy; Curran, Mark; Friedman, Joshua R.; Zhu, Jun; Agrawal, Manasi; Cho, Judy; Ungaro, Ryan; Dubinsky, Marla C.; Sands, Bruce E.; Suarez-Farinas, Mayte; Schadt, Eric E.; Colombel, Jean-Frederic; Kasarskis, Andrew; Hao, Ke; Argmann, Carmen 分享 收藏
Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension Argmann, Carmen; Tokuyama, Minami; Ungaro, Ryan C.; Huang, Ruiqi; Hou, Ruixue; Gurunathan, Sakteesh; Kosoy, Roman; Di'Narzo, Antonio; Wang, Wenhui; Losic, Bojan; Irizar, Haritz; Peters, Lauren; Stojmirovic, Aleksandar; Wei, Gabrielle; Comella, Phillip H.; Curran, Mark; Brodmerkel, Carrie; Friedman, Joshua R.; Hao, Ke; Schadt, Eric E.; Zhu, Jun; Cho, Judy; Harpaz, Noam; Dubinsky, Marla C.; Sands, Bruce E.; Kasarskis, Andrew; Mehandru, Saurabh; Colombel, Jean-Frederic; Suarez-Farinas, Mayte 分享 收藏
Deep Analysis of the Peripheral Immune System in IBD Reveals New Insight in Disease Subtyping and Response to Monotherapy or Combination Therapy Kosoy, Roman; Kim-Schulze, Seunghee; Rahman, Adeeb; Friedman, Joshua R.; Huang, Ruiqi; Peters, Lauren A.; Amir, El-ad; Perrigoue, Jacqueline; Stojmirovic, Aleksandar; Song, Won-min; Ke, Hao; Ungaro, Ryan; Mehandru, Saurabh; Cho, Judy; Dubinsky, Marla; Curran, Mark; Brodmerkel, Carrie; Schadt, Eric E.; Sands, Bruce E.; Colombel, Jean-Frederic; Kasarskis, Andrew; Argmann, Carmen A.; Suarez-Farinas, Mayte 分享 收藏
Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease Suarez-Farinas, Mayte; Tokuyama, Minami; Wei, Gabrielle; Huang, Ruiqi; Livanos, Alexandra; Jha, Divya; Levescot, Anais; Irizar, Haritz; Kosoy, Roman; Cording, Sascha; Wang, Wenhui; Losic, Bojan; Ungaro, Ryan C.; Di'Narzo, Antonio; Martinez-Delgado, Gustavo; Suprun, Maria; Corley, Michael J.; Stojmirovic, Aleksandar; Houten, Sander M.; Peters, Lauren; Curran, Mark; Brodmerkel, Carrie; Perrigoue, Jacqueline; Friedman, Joshua R.; Hao, Ke; Schadt, Eric E.; Zhu, Jun; Ko, Huaibin M.; Cho, Judy; Dubinsky, Marla C.; Sands, Bruce E.; Ndhlovu, Lishomwa; Cerf-Bensusan, Nadine; Kasarskis, Andrew; Colombel, Jean-Frederic; Harpaz, Noam; Argmann, Carmen; Mehandru, Saurabh 分享 收藏
Relationship Between Combined Histologic and Endoscopic Endpoints and Eff i cacy of Ustekinumab Treatment in Patients With Ulcerative Colitis Li, Katherine; Marano, Colleen; Zhang, Hongyan; Yang, Feifei; Sandborn, William J.; Sands, Bruce E.; Feagan, Brian G.; Rubin, David T.; Peyrin-Biroulet, Laurent; Friedman, Joshua R.; De Hertogh, Gert 分享 收藏
Effects of Ustekinumab Maintenance Therapy on Endoscopic Improvement and Histologic Improvement in the UNIFI Phase 3 Study in Ulcerative Colitis Li, Katherine; Friedman, Joshua R.; Marano, Colleen; Zhang, Hongyan; Yang, Feifei; Sandborn, William J.; Sands, Bruce E.; Feagan, Brian G.; Peyrin-Biroulet, Laurent; De Hertogh, Gert 分享 收藏
Effects of Ustekinumab on Histologic Disease Activity in Patients With Crohn's Disease Li, Katherine; Friedman, Joshua R.; Chan, Daphne; Pollack, Paul; Yang, Feifei; Jacobstein, Douglas; Brodmerkel, Carrie; Gasink, Christopher; Feagan, Brian G.; Sandborn, William J.; Rutgeerts, Paul; De Hertogh, Gert 分享 收藏
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A molecular measure of inflammation in IBD patients based on transcriptional profiles from 2495 intestinal biopsies Huang, R.; Irizar, H.; Kosoy, R.; Song, W. -M.; Dinarzo, A.; Hao, K.; Rogers, J.; Atreja, A.; Mahajan, M.; Stojmirovic, A.; Perrigoue, J.; Brodmerkel, C.; Plevy, S.; Friedman, J.; Colombel, J. -F.; Dubinsky, M.; Sands, B.; Schadt, E.; Kasarskis, A.; Losic, B.; Argmann, C.; Suarez-Farinas, M. 分享 收藏
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Gut microbiota density influences host physiology and is shaped by host and microbial factors Contijoch, Eduardo J.; Britton, Graham J.; Yang, Chao; Mogno, Ilaria; Li, Zhihua; Ng, Ruby; Llewellyn, Sean R.; Hira, Sheela; Johnson, Crystal; Rabinowitz, Keren M.; Barkan, Revital; Dotan, Iris; Hirten, Robert P.; Fu, Shih-Chen; Luo, Yuying; Yang, Nancy; Luong, Tramy; Labrias, Philippe R.; Lira, Sergio; Peter, Inga; Grinspan, Ari; Clemente, Jose C.; Kosoy, Roman; Kim-Schulze, Seunghee; Qin, Xiaochen; Castillo, Anabella; Hurley, Amanda; Atreja, Ashish; Rogers, Jason; Fasihuddin, Farah; Saliaj, Merjona; Nolan, Amy; Reyes-Mercedes, Pamela; Rodriguez, Carina; Aly, Sarah; Santa-Cruz, Kenneth; Peters, Lauren; Suarez-Farinas, Mayte; Huang, Ruiqi; Hao, Ke; Zhu, Jun; Zhang, Bin; Losic, Bojan; Irizar, Haritz; Song, Won-Min; Di Narzo, Antonio; Wang, Wenhui; Cohen, Benjamin L.; DiMaio, Christopher; Greenwald, David; Itzkowitz, Steven; Lucas, Aimee; Marion, James; Maser, Elana; Ungaro, Ryan; Naymagon, Steven; Novak, Joshua; Shah, Brijen; Ullman, Thomas; Rubin, Peter; George, James; Legnani, Peter; Telesco, Shannon E.; Friedman, Joshua R.; Brodmerkel, Carrie; Plevy, Scott; Cho, Judy H.; Colombel, Jean-Frederic; Schadt, Eric E.; Argmann, Carmen; Dubinsky, Marla; Kasarskis, Andrew; Sands, Bruce; Faith, Jeremiah J. 分享 收藏
Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model Goettel, Jeremy A.; Kotlarz, Daniel; Emani, Rohini; Canavan, James B.; Konnikova, Liza; Illig, David; Frei, Sandra M.; Field, Michael; Kowalik, Matthew; Peng, Kaiyue; Gringauz, Jordan; Mitsialis, Vanessa; Wall, Sarah M.; Tsou, Amy; Griffith, Alexandra E.; Huang, Ying; Friedman, Joshua R.; Towne, Jennifer E.; Plevy, Scott E.; Hall, Aisling O'Hara; Snapper, Scott B. 分享 收藏
Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease VanDussen, Kelli L.; Stojmirovic, Aleksandar; Li, Katherine; Liu, Ta-Chiang; Kimes, Patrick K.; Muegge, Brian D.; Simpson, Katherine F.; Ciorba, Matthew A.; Perrigoue, Jacqueline G.; Friedman, Joshua R.; Towne, Jennifer E.; Head, Richard D.; Stappenbeck, Thaddeus S. 分享 收藏
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