Francis Castellino - Publications, H-index & Citations

Francis Castellino

university of notre dame

67H指数

490论文数

1.9W被引数

收录论文 76

发表时间

Fibrin-rich environment drives catheter-associated UTIs by suppressing macrophage defenses 富纤维蛋白环境通过抑制巨噬细胞防御机制驱动导管相关尿路感染

Nature Communications

IF15.7

2026-08-25

OAAI

Armando M. Marrufo; Christopher Gager; Jonathan J. Molina; Marissa J. Andersen; Alyssa A. La Bella; Jessica J. Kean; Katelyn C. Fealy; Elizabeth R. Lucas; Ellsa Wongso; Tamanna Urmi; Kassandra Arias-Parbul; Railyn Webster; Peter V. Stuckey; Kurt N. Kohler; Deborah Donahue; Victoria A. Ploplis; Matthew J. Flick; Francis J. Castellino; Felipe H. Santiago-Tirado; Ana L. Flores-Mireles

Interactions between membrane-bound streptococcal alpha-enolase and human plasminogen captured through cryogenic-electron microscopy 通过冷冻电子显微镜捕获的膜结合链球菌烯醇化酶α与人类纤溶酶原之间的相互作用

Frontiers in Molecular Biosciences

IF4

2025-09-27

OAAI

Sheiny Tjia-Fleck; Bradley M. Readnour; Zhong Liang; Yetunde A. Ayinuola; Francis J. Castellino

Hydrophobic residues in the D-domain of a plasminogen-binding M-protein modulate α-helicity, oligomerization, and surface anchoring in Streptococcus pyogenes plasminogen-binding M蛋白中D结构域的疏水性残基调控α-螺旋度、寡聚化和表面锚定功能在Streptococcus pyogenes中。

Protein Science

IF5.2

2025-09-13

OAAI

Olawole Ayinuola; Yetunde A. Ayinuola; Zhong Liang; Francis J. Castellino

Group a Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination

MICROBIOLOGY SPECTRUM

IF3.8

2025-02-04

OAAI

Vu, Henry M.; Moran, Thomas E.; Liang, Zhong; Bao, Yun-Juan; Carles, Paulina G.; Keane, Jessica C.; Cerney, Madelyn G.; Dahnke, Caitlyn N.; Flores-Mireles, Ana L.; Ploplis, Victoria A.; Castellino, Francis J.; Lee, Shaun W.

Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI

NATURE COMMUNICATIONS

IF15.7

2024-03-27

OAAI

Molina, Jonathan J.; Kohler, Kurt N.; Gager, Christopher; Andersen, Marissa J.; Wongso, Ellsa; Lucas, Elizabeth R.; Paik, Andrew; Xu, Wei; Donahue, Deborah L.; Bergeron, Karla; Klim, Aleksandra; Caparon, Michael G.; Hultgren, Scott J.; Desai, Alana; Ploplis, Victoria A.; Flick, Matthew J.; Castellino, Francis J.; Flores-Mireles, Ana L.

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

CIRCULATION RESEARCH

IF16.2

2023-09-29

OAAI

Ranasinghe, A. Dushani C. U.; Holohan, Maggie; Borger, Kalyn M.; Donahue, Deborah L.; Kuc, Rafael D.; Gerig, Martin; Kim, Andrew; Ploplis, Victoria A.; Castellino, Francis J.; Schwarz, Margaret A.

Generation and characterization of a plasminogen-binding group A streptococcal M-protein/streptokinase-sensitive mouse line

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IF5

2023-06-01

OAAI

Ayinuola, Yetunde A.; Donahue, Deborah L.; Charles, Jermilia; Liang, Zhong; Castellino, Francis J.; Ploplis, Victoria A.

Inactivation of the lysine binding sites of human plasminogen (hPg) reveals novel structural requirements for the tight hPg conformation, M-protein binding, and rapid activation

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2023-04-04

OAAI

Ayinuola, Yetunde A. A.; Castellino, Francis J. J.

Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-06-01

OAAI

Readnour, Bradley M.; Ayinuola, Yetunde A.; Russo, Brady T.; Liang, Zhong; Lee, Shaun W.; Ploplis, Victoria A.; Fischetti, Vincent A.; Castellino, Francis J.

Relationships Between Plasminogen-Binding M-Protein and Surface Enolase for Human Plasminogen Acquisition and Activation in Streptococcus pyogenes

FRONTIERS IN MICROBIOLOGY

IF4.5

2022-05-24

OAAI

Ayinuola, Yetunde A.; Tjia-Fleck, Sheiny; Readnour, Bradley M.; Liang, Zhong; Ayinuola, Olawole; Paul, Lake N.; Lee, Shaun W.; Fischetti, Vincent A.; Ploplis, Victoria A.; Castellino, Francis J.

Plasminogen Deficiency Significantly Reduces Vascular Wall Disease in a Murine Model of Type IIa Hypercholesterolemia

BIOMEDICINES

IF3.9

2021-12-04

OAAI

Iwaki, Takayuki; Arakawa, Tomohiro; Sandoval-Cooper, Mayra J.; Smith, Denise L.; Donahue, Deborah; Ploplis, Victoria A.; Umemura, Kazuo; Castellino, Francis J.

Binding of the kringle-2 domain of human plasminogen to streptococcal PAM-type M-protein causes dissociation of PAM dimers

MICROBIOLOGYOPEN

IF4.6

2021-11-30

OAAI

Ayinuola, Olawole; Ayinuola, Yetunde A.; Qiu, Cunjia; Lee, Shaun W.; Ploplis, Victoria A.; Castellino, Francis J.

Demonstration of Three Distinct High-Molecular-Weight Complexes between Plasminogen Activator Inhibitor Type 1 and Tissue-Type Plasminogen Activator 纤溶酶原激活物抑制剂1型和组织型纤溶酶原激活物之间三种不同的高分子量复合物的证明

THROMBOSIS AND HAEMOSTASIS

IF4.3

2021-06-18

PREAI

Ito, Tae; Suzuki, Yuko; Sano, Hideto; Honkura, Naoki; Castellino, Francis J.; Urano, Tetsumei

Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Ayinuola, Yetunde A.; Brito-Robinson, Teresa; Ayinuola, Olawole; Beck, Julia E.; Cruz-Topete, Diana; Lee, Shaun W.; Ploplis, Victoria A.; Castellino, Francis J.

A unique combination of glycoside hydrolases in Streptococcus suis specifically and sequentially acts on host-derived αGal-epitope glycans

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-07-01

OAAI

Chen, Ping; Liu, Ran; Huang, Mengmeng; Zhu, Jinlu; Wei, Dong; Castellino, Francis J.; Dang, Guanghui; Xie, Fang; Li, Gang; Cui, Ziyin; Liu, Siguo; Zhang, Yueling

A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen

BIOCHEMICAL JOURNAL

IF4.3

2020-05-05

OAAI

Qiu, Cunjia; Yuan, Yue; Lee, Shaun W.; Ploplis, Victoria A.; Castellino, Francis J.

In situ metabolite and lipid analysis of GluN2D-/- and wild-type mice after ischemic stroke using MALDI MSI

ANALYTICAL AND BIOANALYTICAL CHEMISTRY

IF3.8

2020-02-28

OAAI

Andrews, William T.; Donahue, Deborah; Holmes, Adam; Balsara, Rashna; Castellino, Francis J.; Hummon, Amanda B.

Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes 人纤溶酶原与其化脓性链球菌M蛋白受体结合区复合物的溶液结构模型

JOURNAL OF STRUCTURAL BIOLOGY

IF5.1

2019-10-01

OAAI

Yuan, Yue; Ayinuola, Yetunde A.; Singh, Damini; Ayinuola, Olawole; Mayfield, Jeffrey A.; Quek, Adam; Whisstock, James C.; Law, Ruby H. P.; Lee, Shaun W.; Ploplis, Victoria A.; Castellino, Francis J.

Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review

SEMINARS IN THROMBOSIS AND HEMOSTASIS

IF4.1

2019-05-20

OAAI

Walsh, Mark; Moore, Ernest E.; Moore, Hunter; Thomas, Scott; Lune, Stefani Vande; Zimmer, David; Dynako, Joseph; Hake, Daniel; Crowell, Zachary; McCauley, Ross; Larson, Emilee E.; Miller, Michael; Pohlman, Tim; Achneck, Hardean E.; Martin, Peter; Nielsen, Nathan; Shariff, Faisal; Ploplis, Victoria A.; Castellino, Francis J.

Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen

JOURNAL OF STRUCTURAL BIOLOGY

IF5.1

2019-05-01

OAAI

Qiu, Cunjia; Yuan, Yue; Liang, Zhong; Lee, Shaun W.; Ploplis, Victoria A.; Castellino, Francis J.

研究方向