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L

Lokesh Gakhar

University of Iowa

H指数:29

被引数:2,998

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Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy

SCIENTIFIC REPORTS

IF3.9

2025-01-020

OAAI

GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production

SCIENTIFIC REPORTS

IF3.9

2023-03-028

OAAI

Structural basis for APE1 processing DNA damage in the nucleosome

NATURE COMMUNICATIONS

IF15.7

2022-09-1424

OAAI

An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking

COMMUNICATIONS BIOLOGY

IF5.1

2022-02-0817

OAAI

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

IF0

2021-11-256

PRE

Benzothiourea Derivatives Target the Secretory Pathway of the Human Fungal Pathogen Cryptococcus neoformans

ACS INFECTIOUS DISEASES

IF3.8

2020-02-186

OAAI

Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants

IF6.9

2020-01-0119

OAAI

Oscillatory Active-Site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase

IF13.1

2019-10-2533

OAAI

Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

NATURE COMMUNICATIONS

IF15.7

2019-09-1115

OAAI

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

NATURE COMMUNICATIONS

IF15.7

2019-07-1222

OAAI

Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2017-10-0912

OAAI

The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-10-0118

OAAI

Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2017-07-2415

OAAI

Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains

JOURNAL OF STRUCTURAL BIOLOGY

IF5.1

2016-12-0114

OAAI

Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

NATURE COMMUNICATIONS

IF15.7

2016-10-2567

OAAI

Structural Differences in Calmodulin Bound to Voltagate-Gated Sodium Channel IQ Motifs

BIOPHYSICAL JOURNAL

IF3.1

2016-02-010

OAAI

Insights into the Autoinhibition Mechanism of the Tiam1 Guanine Nucleotide Exchange Factor

BIOPHYSICAL JOURNAL

IF3.1

2016-02-010

OAAI

Conformational Dynamics and Structure Underlie the Novel Ligand Binding Specificity of a Tiam1 PDZ Domain Mutant

BIOPHYSICAL JOURNAL

IF3.1

2016-02-010

OAAI

CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

HUMAN MOLECULAR GENETICS

IF3.2

2015-05-2037

OAAI

Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2015-03-259

OAAI