Hiroshi Ohmoto - Publications, H-index & Citations

Hiroshi Ohmoto

carna biosciences, inc.

61H指数

259论文数

1.8W被引数

收录论文 29

发表时间

Docirbrutinib is a pan-mutant BTK inhibitor and inhibits B-cell receptor signaling in chronic lymphocytic leukemia cells in preclinical and early clinical investigations 多西布替尼是一种泛突变BTK抑制剂，并在临床前和早期临床研究中抑制慢性淋巴细胞白血病细胞的B细胞受体信号传导

Blood Cancer Journal

IF11.6

2026-05-07

OAAI

Natalia Timofeeva; Breana Herrera; Hitomi Fujiwara; Tokiko Asami; Hiroko Endo; Mariko Hatakeyama; Fumio Nakajima; Hiroshi Ohmoto; Yu Nishioka; Kyoko Miyamoto; Akinori Arimura; Shady I. Tantawy; Javier Pinilla-Ibarz; Catherine C. Coombs; Nitin Jain; Masaaki Sawa; Varsha Gandhi

Discovery of HM-279, a Potent Inhibitor of ALK5 for Improving Therapeutic Efficacy of Cancer Immunotherapy HM-279的发现，一种提高癌症免疫治疗效果的强效ALK5抑制剂

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-03-20

PREAI

Arai, Mai; Hanada, Mitsuharu; Taniguchi, Haruka; Nakajima, Fumio; Ohmoto, Hiroshi; Naka, Kazuhito; Sawa, Masaaki

Discovery of HM-279, a novel, potent and orally active inhibitor of ALK5 for cancer immunotherapy

EUROPEAN JOURNAL OF CANCER

IF7.1

2024-10-01

PREAI

Arai, M.; Hanada, M.; Moriyama, H.; Ohmoto, H.; Naka, K.; Sawa, M.

Discovery of a novel activin receptor-like kinases (ALKs) inhibitor targeting TGF-β signaling pathways

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Arai, Mai; Hanada, Mitsuharu; Moriyama, Hideki; Ohmoto, Hiroshi; Naka, Kazuhito; Sawa, Masaaki

A seawater-sulfate origin for early Earth's volcanic sulfur

NATURE GEOSCIENCE

IF16.1

2020-07-20

PREAI

Ohmoto, Hiroshi

Primary haematite formation in an oxygenated sea 3.46 billion years ago

NATURE GEOSCIENCE

IF16.1

2009-03-15

PREAI

Hoashi, Masamichi; Bevacqua, David C.; Otake, Tsubasa; Watanabe, Yumiko; Hickman, Arthur H.; Utsunomiya, Satoshi; Ohmoto, Hiroshi

Therapeutic potential of a novel synthetic selectin blocker, OJ-R9188, in allergic dermatitis

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2009-01-29

OAAI

Ikegami-Kuzuhara, A; Yoshinaka, T; Ohmoto, H; Inoue, Y; Saito, T

Biosignatures in Ancient Rocks: A Summary of Discussions at a Field Workshop on Biosignatures in Ancient Rocks

ASTROBIOLOGY

IF2.6

2008-10-01

PREAI

Ohmoto, Hiroshi; Runnegar, Bruce; Kump, Lee R.; Fogel, Marilyn L.; Kamber, Balz; Anbar, Ariel D.; Knauth, Paul L.; Lowe, Donald R.; Sumner, Dawn Y.; Watanabe, Yumiko

Ab initio calculations for equilibrium fractionations in multiple sulfur isotope systems

CHEMICAL GEOLOGY

IF3.6

2008-04-01

PREAI

Otake, Tsubasa; Lasaga, Antonio C.; Ohmoto, Hiroshi

Biogeochemical cycling of iron in the Archean-Paleoproterozoic Earth: Constraints from iron isotope variations in sedimentary rocks from the Kaapvaal and Pilbara Cratons

CHEMICAL GEOLOGY

IF3.6

2005-05-01

158

PREAI

Yamaguchi, KE; Johnson, CM; Beard, BL; Ohmoto, H

Geochemistry and mineralogy of the 2.45 Ga Pronto paleosols, Ontario, Canada

CHEMICAL GEOLOGY

IF3.6

2005-01-01

PREAI

Nedachi, Y; Nedachi, M; Bennett, G; Ohmoto, H

Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2004-12-01

PREAI

Kitasato, Y; Hoshino, T; Okamoto, M; Kato, S; Koda, Y; Nagata, N; Kinoshita, M; Koga, H; Yoon, DY; Asao, H; Ohmoto, H; Koga, T; Rikimaru, T; Aizawa, H

Kinetics of sulfur isotope exchange between aqueous sulfide and thiosulfate involving intra- and intermolecular reactions at hydrothermal conditions

CHEMICAL GEOLOGY

IF3.6

2004-11-01

PREAI

Chu, X; Ohmoto, H; Cole, DR

The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells

GASTROENTEROLOGY

IF25.1

2004-08-01

OAAI

Tanida, S; Joh, T; Itoh, K; Kataoka, H; Sasaki, M; Ohara, H; Nakazawa, T; Nomura, T; Kinugasa, Y; Ohmoto, H; Ishiguro, H; Yoshino, K; Higashiyama, S; Itoh, M

The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2004-03-01

OAAI

Nakano, N; Higashiyama, S; Ohmoto, H; Ishiguro, H; Taniguchi, N; Wada, Y

Synthesis and structure-activity relationships of 5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-based hydroxamic acids as HB-EGF shedding inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2003-02-01

PREAI

Yoshiizumi, K; Yamamoto, M; Miyasaka, T; Ito, Y; Kumihara, H; Sawa, M; Kiyoi, T; Yamamoto, T; Nakajima, F; Hirayama, R; Kondo, H; Ishibushi, E; Ohmoto, H; Inoue, Y; Yoshino, K

Dissolution of iron hydroxides by marine bacterial siderophore

CHEMICAL GEOLOGY

IF3.6

2002-03-01

PREAI

Yoshida, T; Hayashi, K; Ohmoto, H

New type of metalloproteinase inhibitor: Design and synthesis of new phosphonamide-based hydroxamic acids

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2002-01-15

106

PREAI

Sawa, M; Kiyoi, T; Kurokawa, K; Kumihara, H; Yamamoto, M; Miyasaka, T; Ito, Y; Hirayama, R; Inoue, T; Kirii, Y; Nishiwaki, E; Ohmoto, H; Maeda, Y; Ishibushi, E; Inoue, Y; Yoshino, K; Kondo, H

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy 通过拮抗hb-egf的ADAM12加工抑制心脏肥大: 金属蛋白酶抑制剂作为新疗法

NATURE MEDICINE

IF50

2002-01-01

695

PREAI

Asakura, M; Kitakaze, M; Takashima, S; Liao, Y; Ishikura, F; Yoshinaka, T; Ohmoto, H; Node, K; Yoshino, K; Ishiguro, H; Asanuma, H; Sanada, S; Matsumura, Y; Takeda, H; Beppu, S; Tada, M; Hori, M; Higashiyama, S

Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing

JOURNAL OF CELL BIOLOGY

IF6.4

2000-10-16

283

OAAI

Tokumaru, S; Higashiyama, S; Endo, T; Nakagawa, T; Miyagawa, J; Yamamori, K; Hanakawa, Y; Ohmoto, H; Yoshino, K; Shirakata, Y; Matsuzawa, Y; Hashimoto, K; Taniguchi, N

研究方向