Kah‐Leong Lim - Publications, H-index & Citations

Kah‐Leong Lim

nanyang technological university

63H指数

211论文数

3.0W被引数

收录论文 117

发表时间

Potential Protection Against Parkinson’s Disease by Ergothioneine—Nature’s Multifactorial Neuroprotectant 辅酶抗帕金森病潜力：谷胱甘肽硫转移酶——自然界的多因素神经保护剂

Antioxidants

IF6.6

2026-04-21

OAAI

Teddy J. W. Tng; Irwin K. Cheah; Barry Halliwell; Kah-Leong Lim

Glycerol 3-phosphate acyltransferase exacerbates α-synuclein-induced toxicity by increasing lipid peroxidation 甘油3-磷酸酰基转移酶通过增加脂质过氧化作用加剧 α-突触核蛋白诱导的毒性

Nature Communications

IF15.7

2026-01-19

OAAI

Mengda Ren; Grace G. Y. Lim; Willcyn Tang; Kah-Leong Lim

De novo developing polarity-sensitive NIR probe for lipid droplets and serum based diagnosis of Parkinson’s disease 开发新型脂滴极性敏感近红外探针，用于帕金森病的血清脂滴诊断

Sensors and Actuators B: Chemical

IF0

2025-12-01

PREAI

Sufang Ma; Leyan Li; Bolong Ma; Qi Gao; Yubing Kang; Wenli Cui; Jianfei Liu; Yixin Zhang; Qiang Yu; Zexuan Hong; Yanli Li; Junhong Guo; Kahleong Lim; Chengwu Zhang

APOE4-APP interactions exert early influences on cerebrovascular structure and function: implications for Alzheimer’s disease APOE4-APP相互作用对脑血管结构和功能产生早期影响：对阿尔茨海默病的意义

Frontiers in Neuroscience

IF3.2

2025-10-24

OAAI

Lanboling Guo†; Jessica R. Gaunt†; Calvin Chee Hoe Cheah; Albert I. Chen; Stephanie Claudine; Gavin S. Dawe; Eyleen Lay Keow Goh; Sok-Hong Kho; Pawan Kumar; Grace G. Y. Lim; Kah Leong Lim; Yun-An Lim; Takaomi C. Saido; Takashi Saito; Hiroki Sasaguri; Judy C. G. Sng; Yee Jie Yeap; Alaric K. K. Yip; Norliyana Zainolabidin; Toh Hean Ch’ng‡; George J. Augustine‡

Ergothioneine Treatment Ameliorates the Pathological Phenotypes of Parkinson's Disease Models 鹅肌肽治疗改善了帕金森病模型的病理表型

Journal of Neurochemistry

IF4

2025-07-22

OAAI

Teddy J. W. Tng; Damien M. K. Leow; Geraldine Goh; Ziyin Wang; Yanmei Liu; Richard M. Y. Tang; Kate C. L. Lai; Adeline H. Basil; Huey Ching Choong; Wilson W. B. Goh; Irwin K. Cheah; Wei-Yi Ong; Barry Halliwell; Kah-Leong Lim

Environmental Factors Exacerbate Parkinsonian Phenotypes in an Asian-Specific Knock-In LRRK2 Risk Variant in Mice 环境因素加剧了亚洲特异性的LRRK2风险变异 Knock-In 小鼠中的帕金森样表型

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IF4.9

2025-04-10

OAAI

Bichler, Zoe; Vanan, Sarivin; Zhang, Zhiwei; Dong, Qianying (Sally); Lee, Jolene Wei Ling; Zhang, Chengwu; Hang, Liting; Jiang, Mei; Padmanabhan, Parasuraman; Saw, Wuan Ting; Zhou, Zhidong; Gulyas, Balazs; Lim, Kah Leong; Zeng, Li; Tan, Eng King

Double-locked probe for NIRF/PA imaging mitochondrial H2O2 and viscosity in Parkinson's disease 用于NIRF/PA成像的双锁探针在帕金森氏病中的线粒体H2O2和粘度

SENSORS AND ACTUATORS B-CHEMICAL

IF7.7

2025-03-01

PREAI

Guo, Lixia; Li, Xiaowan; Xie, Shangyu; Su, Baizhi; Yang, Na; Wang, Bin; Ma, Sufang; Li, Lihong; Yan, Lili; Zhang, Boye; Liu, Wen; Lim, Kahleong; Liu, Yang; Diao, Haipeng; Zhang, Chengwu

Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation

AGING CELL

IF7.1

2025-01-05

OAAI

Kalailingam, Pazhanichamy; Ngan, SoFong Cam; Iyappan, Ranjith; Nehchiri, Afra; Mohd-Kahliab, Khalilatul-Hanisah; Lee, Benjamin Sian Teck; Sharma, Bhargy; Machan, Radek; Bo, Sint Thida; Chambers, Emma S.; Fajardo, Val A.; Macpherson, Rebecca E. K.; Liu, Jian; Klentrou, Panagiota; Tsiani, Evangelia Litsa; Lim, Kah Leong; Su, I. Hsin; Gao, Yong-Gui; Richar, A. Mark; Kalaria, Raj N.; Chen, Christopher P.; Balion, Cynthia; de Kleijn, Dominique; McCarthy, Neil E.; Sze, Siu Kwan

Role of lipid droplets in neurodegenerative diseases: From pathogenesis to therapeutics 脂滴在神经退行性疾病中的作用: 从发病机理到治疗学

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

IF7.9

2024-10-01

OAAI

Kang, Yubing; Yeap, Yee Jie; Yang, Jing; Ma, Sufang; Lim, Kah Leong; Zhang, Qin; Lu, Li; Zhang, Chengwu

Synaptic Vesicle Glycoprotein 2C: a role in Parkinson's disease 突触囊泡糖蛋白2C: 在帕金森氏病中的作用

FRONTIERS IN CELLULAR NEUROSCIENCE

IF4

2024-09-05

OAAI

Chang, Chu Hua; Lim, Kah Leong; Foo, Jia Nee

Novel genes involved in vascular dysfunction of the middle temporal gyrus in Alzheimer's disease: transcriptomics combined with machine learning analysis

NEURAL REGENERATION RESEARCH

IF6.7

2024-07-29

OAAI

Wang, Meiling; He, Aojie; Kang, Yubing; Wang, Zhaojun; He, Yahui; Lim, Kahleong; Zhang, Chengwu; Lu, Li

Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation

CELL DEATH & DISEASE

IF9.6

2024-05-21

OAAI

Cui, Wenli; Yang, Jing; Tu, Chuanyun; Zhang, Ziting; Zhao, Huifang; Qiao, Yan; Li, Yanqiu; Yang, Wulin; Lim, Kah-Leong; Ma, Quanhong; Zhang, Chengwu; Lu, Li

Seipin Deficiency Leads to Energy Dyshomeostasis via Inducing Hypothalamic Neuroinflammation and Aberrant Expression of Neuropeptides

NEUROMOLECULAR MEDICINE

IF3.9

2024-05-01

PREAI

Cui, Wenli; Chen, Hong; Lei, Lingfeng; Wang, Wenru; Lim, Kah-Leong; Zhang, Chengwu; Lu, Li

Visualization of accessible cholesterol in cellular membranes using a GRAM domain-based biosensor

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-03-01

OAAI

Koh, Dylan; Naito, Tomoki; Na, Minyoung; Yeap, Yee Jie; Rozario, Pritisha; Zhong, Franklin Lei; Lim, Kah-Leong; Yasunori, Saheki

Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation

EMBO MOLECULAR MEDICINE

IF8.3

2023-11-16

OAAI

Kalailingam, Pazhanichamy; Mohd-Kahliab, Khalilatul-Hanisah; Ngan, SoFong Cam; Iyappan, Ranjith; Melekh, Evelin; Lu, Tian; Zien, Gan Wei; Sharma, Bhargy; Guo, Tiannan; Macneil, Adam J.; Macpherson, Rebecca E. K.; Tsiani, Evangelia Litsa; O'Leary, Deborah D.; Lim, Kah Leong; Su, I. Hsin; Gao, Yong-Gui; Richards, A. Mark; Kalaria, Raj N.; Chen, Christopher P.; Mccarthy, Neil E.; Sze, Siu Kwan

Visualization of accessible cholesterol using a GRAM domain-based biosensor

NATURE COMMUNICATIONS

IF15.7

2023-10-25

OAAI

Koh, Dylan Hong Zheng; Naito, Tomoki; Na, Minyoung; Yeap, Yee Jie; Rozario, Pritisha; Zhong, Franklin L.; Lim, Kah-Leong; Saheki, Yasunori

Adipose transplantation improves olfactory function and neurogenesis via PKCa-involved lipid metabolism in Seipin Knockout mice

STEM CELL RESEARCH & THERAPY

IF7.3

2023-09-07

OAAI

Yang, Jing; Yang, Na; Zhao, Huifang; Qiao, Yan; Li, Yanqiu; Wang, Chunfang; Lim, Kah-Leong; Zhang, Chengwu; Yang, Wulin; Lu, Li

Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration 小胶质细胞中的溶酶体酸化功能障碍: 神经炎症和神经变性的新兴致病机制

JOURNAL OF NEUROINFLAMMATION

IF10.1

2023-08-05

OAAI

Quick, Joseph D.; Silva, Cristian; Wong, Jia Hui; Lim, Kah Leong; Reynolds, Richard; Barron, Anna M.; Zeng, Jialiu; Lo, Chih Hung

Single- cell transcriptomics reveals maturation of transplanted stem cell-derived retinal pigment epithelial cells toward native state 单细胞转录组学揭示了移植的干细胞衍生的视网膜色素上皮细胞向天然状态的成熟

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-06-20

OAAI

Parikh, Bhav Harshad; Blakeley, Paul; Regha, Kakkad; Liu, Zengping; Yang, Binxia; Bhargava, Mayuri; Wong, Daniel Soo Lin; Tan, Queenie Shu Woon; Wong, Claudine See Wei; Wang, Hao Fei; Al-Mubaarak, Abdurrahmaan; Chou, Chai; Cheung, Chui Ming Gemmy; Lim, Kah Leong; Barathi, Veluchamy Amutha; Hunziker, Walter; Lingam, Gopal; Hu, Tim Xiaoming; Su, Xinyi

Endothelial Damage Arising From High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IF7.4

2023-03-01

OAAI

Vinaiphat, Arada; Pazhanchamy, Kalailingam; JebaMercy, Gnanasekaran; Ngan, SoFong Cam; Leow, Melvin Khee-Shing; Ho, Hee Hwa; Gao, Yong-Gui; Lim, Kah Leong; Richards, A. Mark; de Kleijn, Dominique P. V.; Chen, Christopher P.; Kalaria, Raj N.; Liu, Jian; O'Leary, Deborah D.; McCarthy, Neil E.; Sze, Siu Kwan

研究方向