Jeffrey D. Rothstein - Publications, H-index & Citations

Jeffrey D. Rothstein

johns hopkins university

108H指数

345论文数

5.4W被引数

收录论文 129

发表时间

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion 星形胶质细胞MCT1表达对与泛在性MCT1耗竭相关的轴突退行性表型无贡献

Glia

IF5.1

2025-12-02

OAAI

Philips, Thomas; Thompson, Emily G.; Spead, Olivia; Vijayakumar, Balaji G.; Kent, Erica R.; Miller, Sean J.; Nwokeleme, Treasure; Vidensky, Svetlana; Farah, Mohamed Hassan; Rothstein, Jeffrey D.

Biobank-scale genetic characterization of Alzheimer’s disease and related dementias across diverse ancestries 生物银行规模下不同祖先来源的阿尔茨海默病及相关痴呆症的遗传表征

Nature Communications

IF15.7

2025-08-14

OAAI

Marzieh Khani; Fulya Akçimen; Spencer M. Grant; Suleyman Can Akerman; Paul Suhwan Lee; Faraz Faghri; Hampton Leonard; Jonggeol Jeffrey Kim; Mary B. Makarious; Mathew J. Koretsky; Jeffrey D. Rothstein; Cornelis Blauwendraat; Mike A. Nalls; Andrew Singleton; Sara Bandres-Ciga

Corrigendum to “Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data”勘误：Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data

Molecular & Cellular Proteomics

IF5.5

2025-08-07

PREAI

Dušica Vidović; Behrouz Shamsaei; Stephan C. Schürer; Phillip Kogan; Szymon Chojnacki; Michal Kouril; Mario Medvedovic; Wen Niu; Evren U. Azeloglu; Marc R. Birtwistle; Yibang Chen; Tong Chen; Jens Hansen; Bin Hu; Ravi Iyengar; Gomathi Jayaraman; Hong Li; Tong Liu; Eric A. Sobie; Yuguang Xiong; Matthew J. Berberich; Gary Bradshaw; Mirra Chung; Robert A. Everley; Ben Gaudio; Marc Hafner; Marian Kalocsay; Caitlin E. Mills; Maulik K. Nariya; Peter K. Sorger; Kartik Subramanian; Chiara Victor; Maria Banuelos; Victoria Dardov; Ronald Holewinski; Danica-Mae Manalo; Berhan Mandefro; Andrea D. Matlock; Loren Ornelas; Dhruv Sareen; Clive N. Svendsen; Vineet Vaibhav; Jennifer E. Van Eyk; Vidya Venkatraman; Steve Finkbiener; Ernest Fraenkel; Jeffrey Rothstein; Leslie Thompson; Jacob Asiedu; Steven A. Carr; Karen E. Christianson; Desiree Davison; Deborah O. Dele-Oni; Katherine C. DeRuff; Shawn B. Egri; Alvaro Sebastian Vaca Jacome; Jacob D. Jaffe; Daniel Lam; Lev Litichevskiy; Xiaodong Lu; James Mullahoo; Adam Officer; Malvina Papanastasiou; Ryan Peckner; Caidin Toder; Joel Blanchard; Michael Bula; Tak Ko; Li-Huei Tsai; Jennie Z. Young; Vagisha Sharma; Jarek Meller; Michael J. MacCoss

Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function 散发性肌萎缩侧索硬化症诱导多能干细胞来源的神经元揭示了TDP-43功能丧失的特征

Nature Communications

IF15.7

2025-08-02

OAAI

Jeffrey D. Rothstein; Olivia Keeley; Caroline Warlick; Timothy M. Miller; Cindy V. Ly; Jonathan D. Glass; Alyssa N. Coyne

The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging 全球神经变性蛋白质组学联盟: 常见神经退行性疾病和衰老的生物标志物和药物靶点发现

Nature Medicine

IF50

2025-07-15

OAAI

Farhad Imam; Rowan Saloner; Jacob W. Vogel; Varsha Krish; Gamal Abdel-Azim; Muhammad Ali; Lijun An; Federica Anastasi; David Bennett; Alexa Pichet Binette; Adam L. Boxer; Martin Bringmann; Jeffrey M. Burns; Carlos Cruchaga; Jeff L. Dage; Amelia Farinas; Luigi Ferrucci; Caitlin A. Finney; Mark Frasier; Oskar Hansson; Timothy J. Hohman; Erik C. B. Johnson; Mika Kivimaki; Roxanna Korologou-Linden; Agustin Ruiz Laza; Allan I. Levey; Inga Liepelt-Scarfone; Lina Lu; Niklas Mattsson-Carlgren; Lefkos T. Middleton; Kwangsik Nho; Hamilton Se-Hwee Oh; Ronald C. Petersen; Eric M. Reiman; Oliver Robinson; Jeffrey D. Rothstein; Andrew J. Saykin; Artur Shvetcov; Chad Slawson; Bart Smets; Marc Suárez-Calvet; Betty M. Tijms; Maarten Timmers; Fernando Vieira; Natalia Vilor-Tejedor; Pieter Jelle Visser; Keenan A. Walker; Laura M. Winchester; Tony Wyss-Coray; Chengran Yang; Niranjan Bose; Simon Lovestone

Efficacy and Safety of Once Daily Dosing vs. Approved On/Off Dosing of Edaravone Oral Suspension Up to 48 Weeks in Patients With Amyotrophic Lateral Sclerosis (Study MT-1186-A02)埃拉瓦酮口服混悬剂每日一次给药与批准的开关式给药在肌萎缩侧索硬化症患者中的疗效与安全性比较（48周，研究MT-1186-A02）

Muscle & Nerve

IF3.1

2025-06-06

OAAI

Jeffrey Rothstein; Angela Genge; Shari De Silva; Lorne Zinman; Marvin Chum; Adriano Chio; Gen Sobue; Masashi Aoki; Hiide Yoshino; Manabu Doyu; Daniel Selness

Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling

NEUROCHEMICAL RESEARCH

IF3.8

2025-01-09

OAAI

Martinez-Lozada, Zila; Guillem, Alain M.; Song, Isabella; Gonzalez, Michael V.; Takano, Hajime; Parikh, Esha; Rothstein, Jeffrey D.; Putt, Mary E.; Robinson, Michael B.

A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model 在AAV-C9ORF72 (G4C2)66小鼠模型中对TDP-43，聚GP，细胞病理学和行为的稳健评估

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2024-12-26

OAAI

Thompson, Emily G.; Spead, Olivia; Akerman, Suleyman C.; Curcio, Carrie; Zaepfel, Benjamin L.; Kent, Erica R.; Philips, Thomas; Vijayakumar, Balaji G.; Zacco, Anna; Zhou, Weibo; Nagappan, Guhan; Rothstein, Jeffrey D.

Apilimod dimesylate in C9orf72 amyotrophic lateral sclerosis: a randomized phase 2a clinical trial

BRAIN

IF11.7

2024-04-12

PREAI

Babu, Suma; Nicholson, Katharine A.; Rothstein, Jeffrey D.; Swenson, Andrea; Sampognaro, Paul J.; Pant, Pravin; Macklin, Eric A.; Spruill, Susan; Paganoni, Sabrina; Gendron, Tania F.; Prudencio, Mercedes; Petrucelli, Leonard; Nix, Darrell; Landrette, Sean; Nkrumah, Esther; Fandrick, Keith; Edwards, Joan; Young, Peter R.

G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons

ACTA NEUROPATHOLOGICA

IF9.3

2023-11-29

OAAI

Rothstein, Jeffrey D.; Baskerville, Victoria; Rapuri, Sampath; Mehlhop, Emma; Jafar-Nejad, Paymaan; Rigo, Frank; Bennett, Frank; Mizielinska, Sarah; Isaacs, Adrian; Coyne, Alyssa N.

Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects

NEURON

IF15

2023-04-01

OAAI

Workman, Michael J.; Lim, Ryan G.; Wu, Jie; Frank, Aaron; Ornelas, Loren; Panther, Lindsay; Galvez, Erick; Perez, Daniel; Meepe, Imara; Lei, Susan; Valencia, Viviana; Gomez, Emilda; Liu, Chunyan; Moran, Ruby; Pinedo, Louis; Tsitkov, Stanislav; Ho, Ritchie; Kaye, Julia A.; Thompson, Terri; Rothstein, Jeffrey D.; Finkbeiner, Steven; Fraenkel, Ernest; Sareen, Dhruv; Thompson, Leslie M.; Svendsen, Clive N.

Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2022-09-14

OAAI

Gao, Junli; Mewborne, Quinlan T.; Girdhar, Amandeep; Sheth, Udit; Coyne, Alyssa N.; Punathil, Ritika; Kang, Bong Gu; Dasovich, Morgan; Veire, Austin; Hernandez, Mariely DeJesus; Liu, Shuaichen; Shi, Zheng; Dafinca, Ruxandra; Fouquerel, Elise; Talbot, Kevin; Kam, Tae-In; Zhang, Yong-Jie; Dickson, Dennis; Petrucelli, Leonard; Van Blitterswijk, Marka; Guo, Lin; Dawson, Ted M.; Dawson, Valina L.; Leung, Anthony K. L.; Lloyd, Thomas E.; Gendron, Tania F.; Rothstein, Jeffrey D.; Zhang, Ke

Nuclear Pore Dysfunction in Neurodegeneration

NEUROTHERAPEUTICS

IF6.9

2022-07-01

PREAI

Spead, Olivia; Zaepfel, Benjamin L.; Rothstein, Jeffrey D.

The Evolving Landscape of Motor Neuron Disease Therapeutics

NEUROTHERAPEUTICS

IF6.9

2022-07-01

OAAI

Maragakis, Nicholas J.; Rothstein, Jeffrey D.

Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

CELL REPORTS

IF6.9

2022-07-01

OAAI

Duan, Lauren; Zaepfel, Benjamin L.; Aksenova, Vasilisa; Dasso, Mary; Rothstein, Jeffrey D.; Kalab, Petr; Hayes, Lindsey R.

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform 使用人工智能生物靶标发现平台PandaOmics鉴定肌萎缩侧索硬化的治疗靶标

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2022-06-28

OAAI

Pun, Frank W.; Liu, Bonnie Hei Man; Long, Xi; Leung, Hoi Wing; Leung, Geoffrey Ho Duen; Mewborne, Quinlan T.; Gao, Junli; Shneyderman, Anastasia; Ozerov, Ivan V.; Wang, Ju; Ren, Feng; Aliper, Alexander; Bischof, Evelyne; Izumchenko, Evgeny; Guan, Xiaoming; Zhang, Ke; Lu, Bai; Rothstein, Jeffrey D.; Cudkowicz, Merit E.; Zhavoronkov, Alex

Nuclear pore complexes - a doorway to neural injury in neurodegeneration

NATURE REVIEWS NEUROLOGY

IF33.1

2022-04-29

OAAI

Coyne, Alyssa N.; Rothstein, Jeffrey D.

A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

IF3.9

2022-01-10

OAAI

Katz, Jonathan S.; Rothstein, Jeffrey D.; Cudkowicz, Merit E.; Genge, Angela; Oskarsson, Bjorn; Hains, Avis B.; Chen, Chen; Galanter, Joshua; Burgess, Braydon L.; Cho, William; Kerchner, Geoffrey A.; Yeh, Felix L.; Ghosh, Arundhati Sengupta; Cheeti, Sravanthi; Brooks, Logan; Honigberg, Lee; Couch, Jessica A.; Rothenberg, Michael E.; Brunstein, Flavia; Sharma, Khema R.; van den Berg, Leonard; Berry, James D.; Glass, Jonathan D.

Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2021-11-01

OAAI

Jha, Mithilesh Kumar; Passero, Joseph, V; Rawat, Atul; Ament, Xanthe Heifetz; Yang, Fang; Vidensky, Svetlana; Collins, Samuel L.; Horton, Maureen R.; Hoke, Ahmet; Rutter, Guy A.; Latremoliere, Alban; Rothstein, Jeffrey D.; Morrison, Brett M.

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models 在体外和体内ALS模型中使用小分子减少的c9ALS/FTD r(G4C2) 重复扩增的核糖核酸酶募集

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2021-10-27

OAAI

Bush, Jessica A.; Aikawa, Haruo; Fuerst, Rita; Li, Yue; Ursu, Andrei; Meyer, Samantha M.; Benhamou, Raphael, I; Chen, Jonathan L.; Khan, Tanya; Wagner-Griffin, Sarah; Van Meter, Montina J.; Tong, Yuquan; Olafson, Hailey; McKee, Kendra K.; Childs-Disney, Jessica L.; Gendron, Tania F.; Zhang, Yongjie; Coyne, Alyssa N.; Wang, Eric T.; Yildirim, Ilyas; Wang, Kye Won; Petrucelli, Leonard; Rothstein, Jeffrey D.; Disney, Matthew D.

研究方向