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J

Jean-Pascal Machiels

centre leon berard
H指数:39
被引数:5,694

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荣誉奖项

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Integration of radiation therapy with systemic treatments in head and neck cancer: expert opinion and roadmap to consensus

头颈癌中放疗与全身治疗的整合：专家意见与共识路线图

Radiotherapy and Oncology
IF5.3
2026-07-010
PRE
Becherini, Carlotta; Banini, Marco; Blanchard, Pierre; Brana, Irene; Chua, Melvin L. K.; Eriksen, Jesper Grau; Huang, Shao Hui; Gregoire, Vincent; Licitra, Lisa; Locati, Laura Deborah; Ma, Brigette; Machiels, Jean-Pascal; Saintigny, Pierre; Tinhofer, Ingeborg; Livi, Lorenzo; Bossi, Paolo; Harrington, Kevin J.; Bonomo, Pierluigi
An international placebo-controlled randomized multicenter trial of nimorazole with accelerated chemo-radiotherapy for locally advanced HPV-negative squamous cell carcinoma of the head and neck (HNSCC)

一项国际性、安慰剂对照、随机、多中心临床试验，评估尼莫唑联合加速放化疗治疗局部晚期HPV阴性头颈部鳞状细胞癌（HNSCC）的效果。

Radiotherapy and Oncology
IF5.3
2025-10-230
PRE
Vincent Grégoire; Yungan Tao; Johannes Kaanders; Jean-Pascal Machiels; Noémie Vulquin; Sandra Nuyts; Patricia Doornaert; Jan Alsner; Jens Overgaard
A phase II study of monalizumab and durvalumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: results of the I2 cohort of the EORTC-HNCG-1559 trial (UPSTREAM)

一项关于monalizumab和durvalumab在复发性/转移性头颈鳞状细胞癌患者中的II期研究：EORTC-HNCG-1559试验（UPSTREAM）中I2组的成果

ESMO OPEN
IF8.3
2025-05-010
OAAI
Galot, R.; Le Tourneau, C.; Licitra, L.; Guigay, J.; Kong, A.; Tinhofer, I.; Even, C.; Daste, A.; Henry, S.; Borel, C.; Abdeddaim, C.; Seront, E.; Prevost, J. B.; Rutten, A.; Saada-Bouzid, E.; Rolland, F.; Bonomo, P.; Rasschaert, M.; Dirix, L.; Olungu, C.; Tsechilidou, K.; Govaerts, A. S.; Fortpied, C.; Joaquim, A.; Machiels, J. P.
PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma

PPARα介导的脂质代谢重编程支持头颈部鳞状细胞癌中抗EGFR疗法的耐药性。

NATURE COMMUNICATIONS
IF15.7
2025-02-010
OA
van den Bossche, Valentin; Vignau, Julie; Vigneron, Engy; Rizzi, Isabella; Zaryouh, Hannah; Wouters, An; Ambroise, Jerome; Van Laere, Steven; Beyaert, Simon; Helaers, Raphael; van Marcke, Cedric; Mignion, Lionel; Lepicard, Elise Y.; Jordan, Benedicte F.; Guilbaud, Celine; Lowyck, Olivier; Dahou, Hajar; Mendola, Antonella; Desgres, Manon; Aubert, Leo; Gerin, Isabelle; Bommer, Guido T.; Boidot, Romain; Vermonden, Perrine; Warnant, Aurelien; Larondelle, Yvan; Machiels, Jean-Pascal; Feron, Olivier; Schmitz, Sandra
Tumour-agnostic plasma assay for circulating tumour DNA predicts outcome in recurrent and/or metastatic squamous cell carcinoma of the head and neck treated with a PD-1 inhibitor

循环肿瘤DNA的肿瘤不可知血浆测定可预测用PD-1抑制剂治疗的头颈部复发和/或转移性鳞状细胞癌的结果

EUROPEAN JOURNAL OF CANCER
IF7.1
2023-12-010
PRE
Honore, Natasha; van der Elst, Athenais; Dietz, Anna; van Marcke, Cedric; Helaers, Raphael; Mendola, Antonella; Dahou, Hajar; Marbaix, Etienne; Poncin, Renaud; Seront, Emanuel; Schmitz, Sandra; Limaye, Nisha; Galot, Rachel; Machiels, Jean-Pascal
Preclinical and emerging Phase 1 study data indicates that novel deuterated MET kinase inhibitor DO-2 mitigates the side effects seen with current approved MET kinase inhibitors: Preventing deleterious ′de-hinging′ to improve tolerability
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Perera, Timothy P. S.; Mevellec, Laurence; Prenen, Hans; Dekeyser, Bernd; Robbrecht, Debbie; Bins, Sander; Sikkema, Barend; de Bruijn, Peter; Machiels, Jean-Pascal; Galot, Rachel; Briol, Damien; Knight, Richard; Loryan, Irena; Hu, Yang; Wastelin, Florence; Verweij, Jaap
Initial results from first-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in biomarker-selected solid tumors
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-018
PRE
Rodon, Jordi; Yamamoto, Noboru; Doi, Toshihiko; Ghiringhelli, Francois; Goebeler, Maria-Elisabeth; Fujuwara, Yutaka; Villalona-Calero, Miguel; Penel, Nicolas; Patnaik, Amita; Machiels, Jean-Pascal; Addeo, Alfredo; Abbruzzese, James; Postel-Vinay, Sophie; Rottey, Sylvie; Liu, Chunxu; Chuang, Chen-Hua; Kormany, William; Hughes, Paul; Keyvanjah, Kiana; O'Neil, Bert
Trial in progress: First-in-human phase I dose-escalation study of a novel Bicycle toxin conjugate (BT5528) targeting EphA2 in patients with advanced solid tumors
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Fontana, Elisa; Bashir, Babar; Wang, Judy S.; Aljumaily, Raid; Machiels, Jean-Pascal; Vieito, Maria; Falchook, Gerald; Carter, Louise; de Speville, Bernard Doger; Greystoke, Alastair; Kim, Sang Wun; Kotecki, Nuria; Spira, Alexander I.; Candilejo, Irene Moreno; Basu, Bristi; Prenen, Hans; Bessudo, Alberto; Nagasaka, Misako; Ahnert, Jordi Rodon; Park, Joo-Hwan; Teo, Min-Yuen; Rotow, Julia; Liu, Jie; De Rienzo, Assunta; Li, Mengyao; Domingo, Adriana; Orr, Hanna; Bennett, Gavin; Sharma, Rajiv; McKean, Meredith
Safety and anti-tumor activity of a novel Treg depleter RG6292, as a single agent and in combination with atezolizumab in patients with solid tumors
CANCER RESEARCH
IF16.6
2023-04-142
PRE
Gambardella, Valentina; Ong, Michael; Ruiz, Maria Esperanza Rodriguez; Machiels, Jean-Pascal; de Sanmamed, Miguel Fernandez; Tabernero, Josep Maria; Spreafico, Anna; Renouf, Daniel J.; Luen, Stephen J.; Galot, Rachel; Uribe, Bernard Doger de Speville; Aller, Emiliano Calvo; Naing, Aung; Curdt, Samira; Rossmann, Eva; Tanos, Tamara; Smart, Kevin; Amann, Maria; Xie, Yuying; Schnetzler, Gabriel; Boetsch, Christophe; Karanikas, Vaios; Kolben, Theresa; Xu, Linxinyu; Rohrberg, Kristoffer S.
Pharmacokinetic/pharmacodynami c (PK/PD) relationships of the novel Treg depleter RG6292 in Phase Ia and Ib studies in patients with solid tumors
CANCER RESEARCH
IF16.6
2023-04-142
PRE
Tanos, Tamara; Smart, Kevin; Gambardella, Valentina; Rohrberg, Kristoffer; Ong, Michael; Ruiz, Maria Esperanza Rodriguez; Machiels, Jean-Pascal; Sanmamed, Miguel Fernandez; Tabernero, Josep; Spreafico, Anna; Renouf, Daniel; Luen, Stephen; Galot, Rachel; Doger, Bernard; Calvo, Emiliano; Naing, Aung; Curdt, Samira; Staedler, Nicolas; Flores, Mike; Alcaide, Enrique Gomez; Ooi, Chiahuey; Hettich, Michael; Dziadek, Sebastian; Xie, Yuying; Schnetzler, Gabriel; Kolben, Theresa; Xu, Linxinyu; Karanikas, Vaios; Boetsch, Christophe
CYAD-01, an autologous NKG2D-based CART-cell therapy, in relapsed or refractory acute myeloid leukaemia and myelodysplastic syndromes or multiple myeloma (THINK) : haematological cohorts of the dose escalation segment of a phase 1 trial

CYAD-01，自体NKG2D-based CART-细胞疗法治疗复发或难治性急性髓性白血病和骨髓增生异常综合征或多发性骨髓瘤 (THINK): 1期试验剂量递增段的血液学队列

LANCET HAEMATOLOGY
IF17.7
2023-03-0148
PRE
Sallman, David A.; Kerre, Tessa; Havelange, Violaine; Poire, Xavier; Lewalle, Philippe; Wang, Eunice S.; Brayer, Jason B.; Davila, Marco L.; Moors, Ine; Machiels, Jean-Pascal; Awada, Ahmad; Alcantar-Orozco, Erik M.; Borissova, Rossitza; Braun, Nathalie; Dheur, Marie-Sophie; Gilham, David E.; Lonez, Caroline; Lehmann, Frederic F.; Flament, Anne

研究方向

暂未获取到该数据
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Sylvie Rottey
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R
Rachel Galot
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L
Lisa Licitra
H 指数:86论文数:920被引数:4.0万
C
Cédric van Marcke
H 指数:17论文数:80被引数:868
R
Raphaël Helaers
H 指数:21论文数:76被引数:2,163
A
Ahmad Awada
H 指数:75论文数:1,009被引数:2.5万
M
Marc Van den Eynde
H 指数:29论文数:198被引数:6,417
B
Barbara Burtness
H 指数:74论文数:734被引数:3.8万
M
Martine Berlière
H 指数:26论文数:157被引数:3,029
J
Jean-Luc Canon
H 指数:21论文数:99被引数:2,014