未登录 分享 收藏
分享 收藏
Design, Synthesis, and Biological Evaluation of the First Novel Macrocycle-Based FGFR Inhibitors That Overcome Clinically Acquired Resistance Xiang, Shuang; Chen, Xiaojuan; Lin, Jieying; Lin, Xiaojing; Lin, Qianmeng; Song, Xiaojuan; Yan, Ling; Peng, Haoran; Tu, Zhengchao; Patterson, Adam V.; Smaill, Jeff B.; Tu, Yalin; Chen, Yongheng; Lu, Xiaoyun 分享 收藏
The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia Toscan, Cara E.; McCalmont, Hannah; Ashoorzadeh, Amir; Lin, Xiaojing; Fu, Zhe; Doculara, Louise; Kosasih, Hansen J.; Cadiz, Roxanne; Zhou, Anthony; Williams, Sarah; Evans, Kathryn; Khalili, Faezeh; Cai, Ruilin; Yeats, Kristy L.; Gifford, Andrew J.; Pickford, Russell; Mayoh, Chelsea; Xie, Jinhan; Henderson, Michelle J.; Trahair, Toby N.; Patterson, Adam V.; Smaill, Jeff B.; de Bock, Charles E.; Lock, Richard B. 分享 收藏
分享 收藏
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity Yang, Fang; Lin, Qianmeng; Song, Xiaojuan; Huang, Huisi; Chen, Xiaojuan; Tan, Jianwen; Li, Yun; Zhou, Yang; Tu, Zhengchao; Du, Hongli; Zhang, Zhi-min; Ortega, Raquel; Lin, Xiaojing; Patterson, Adam V.; Smaill, Jeff B.; Chen, Yongheng; Lu, Xiaoyun 分享 收藏
分享 收藏
分享 收藏
分享 收藏
Design, Synthesis, and Biological Evaluation of 5-Formyl- pyrrolo[3,2-b]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors Yang, Fang; Chen, Xiaojuan; Song, Xiaojuan; Ortega, Raquel; Lin, Xiaojing; Deng, Wuqing; Guo, Jing; Tu, Zhengchao; Patterson, Adam V.; Smaill, Jeff B.; Chen, Yongheng; Lu, Xiaoyun 分享 收藏
Discovery of Isoform-Selective Akt3 Degraders Overcoming Osimertinib-Induced Resistance in Non-Small Cell Lung Cancer Cells Xu, Fang; Zhang, Xin; Chen, Zhipeng; He, Sheng; Guo, Jing; Yu, Lei; Wang, Yongjin; Hou, Caiyun; AI-furas, Hawaa; Zheng, Zongyao; Smaill, Jeff B.; Patterson, Adam V.; Zhang, Zhi-Min; Chen, Liang; Ren, Xiaomei; Ding, Ke 分享 收藏
Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4 Shao, Min; Chen, Xiaojuan; Yang, Fang; Song, Xiaojuan; Zhou, Yang; Lin, Qianmeng; Fu, Ying; Ortega, Raquel; Lin, Xiaojing; Tu, Zhengchao; Patterson, Adam, V; Smaill, Jeff B.; Chen, Yongheng; Lu, Xiaoyun 分享 收藏
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications Ashoorzadeh, Amir; Mowday, Alexandra M.; Guise, Christopher P.; Silva, Shevan; Bull, Matthew R.; Abbattista, Maria R.; Copp, Janine N.; Williams, Elsie M.; Ackerley, David F.; Patterson, Adam, V; Smaill, Jeff B. 分享 收藏
分享 收藏
Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit Singleton, Dean C.; Mowday, Alexandra M.; Guise, Chris P.; Syddall, Sophie P.; Bai, Sally Y.; Li, Dan; Ashoorzadeh, Amir; Smaill, Jeff B.; Wilson, William R.; Patterson, Adam, V 分享 收藏
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3 Abbattista, Maria R.; Ashoorzadeh, Amir; Guise, Christopher P.; Mowday, Alexandra M.; Mittra, Rituparna; Silva, Shevan; Hicks, Kevin O.; Bull, Matthew R.; Jackson-Patel, Victoria; Lin, Xiaojing; Prosser, Gareth A.; Lambie, Neil K.; Dachs, Gabi U.; Ackerley, David F.; Smaill, Jeff B.; Patterson, Adam V. 分享 收藏
Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506 van der Wiel, Alexander M. A.; Jackson-Patel, Victoria; Niemans, Raymon; Yaromina, Ala; Liu, Emily; Marcus, Damienne; Mowday, Alexandra M.; Lieuwes, Natasja G.; Biemans, Rianne; Lin, Xiaojing; Fu, Zhe; Kumara, Sisira; Jochems, Arthur; Ashoorzadeh, Amir; Anderson, Robert F.; Hicks, Kevin O.; Bull, Matthew R.; Abbattista, Maria R.; Guise, Christopher P.; Deschoemaeker, Sofie; Thiolloy, Sophie; Heyerick, Arne; Solivio, Morwena J.; Balbo, Silvia; Smaill, Jeff B.; Theys, Jan; Dubois, Ludwig J.; Patterson, Adam, V; Lambin, Philippe 分享 收藏
Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents Omran, Ziad; Guise, Chris P.; Chen, Linwei; Rauch, Cyril; Abdalla, Ashraf N.; Abdullah, Omeima; Sindi, Ikhlas A.; Fischer, Peter M.; Smaill, Jeff B.; Patterson, Adam V.; Liu, Yuxiu; Wang, Qingmin 分享 收藏
分享 收藏
Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors 基于2-氨基嘧啶的FGFR4抑制剂设计中共价弹头的研究 Deng, Wuqing; Chen, Xiaojuan; Jiang, Kaili; Song, Xiaojuan; Huang, Minhao; Tu, Zheng-Chao; Zhang, Zhang; Lin, Xiaojing; Ortega, Raquel; Patterson, Adam, V; Smaill, Jeff B.; Ding, Ke; Chen, Suming; Chen, Yongheng; Lu, Xiaoyun 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
