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Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia Bell, Hayden L.; Blair, Helen J.; Gosling, Samantha J. Jepson; Galler, Martin; Astley, Daniel; Moorman, Anthony V.; Heidenreich, Olaf; Veal, Gareth J.; van Delft, Frederik W.; Lunec, John; Irving, Julie A. E. 分享 收藏
Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index Willmore, Elaine; Ahn, Maria; Kyle, Suzanne; Zhao, Yan; Thomas, Huw; Rankin, Kenneth S.; Bevan, Luke; Fazal, Lynsey; Hearn, Keisha; Wilsher, Nicola; Kucia-Tran, Justyna; Ferrari, Nicola; Wallis, Nicola; Thompson, Neil; Lyons, John; Miller, Duncan; Cano, Celine; Noble, Martin E.; Hardcastle, Ian R.; Howard, Steven; Chessari, Gianni; Lunec, John; Newell, David R.; Wedge, Steve R. 分享 收藏
Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile Ahn, Maria; Bevan, Luke; Buck, Ildiko; Cano, Celine; Castro, Juan; Cons, Ben; Endicott, Jane; Fazal, Lynsey; Ferrari, Nicola; Hardcastle, Ian; Hearn, Keisha; Holvey, Rhian; Howard, Steven; Johnson, Chris; Jennings, Claire; Kucia-Tran, Justyna; Kyle, Suzanne; Lunec, John; Lyons, John; Miller, Duncan; Rees, David; Noble, Martin; Newell, David R.; Reeks, Judith; Saini, Harpreet; Denis, Jeffrey St.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil; Vinkovic, Mladen; Ward, George; Wallis, Nicola; Walton, Hugh; Wedge, Stephen; Williams, Pamela; Willmore, Elaine; Wilshire, Nicola; Zhao, Yan; Chessari, Gianni 分享 收藏
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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (vol 14, 5019, 2023) Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su; Healy, Alan R.; Popova, Gergana; Fernandez, Andres Pastor; Mollick, Tanzina; Darekar, Suhas; Sedimbi, Saikiran K.; Nekulova, Marta; Sachweh, Marijke C. C.; Campbell, Johanna; Higgins, Maureen; Tuck, Chloe; Popa, Mihaela; Safont, Mireia Mayoral; Gelebart, Pascal; Fandalyuk, Zinayida; Thompson, Alastair M.; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Faernegardh, Katarina; Yngve, Ulrika; Saleh, Aljona; Haraldsson, Martin; D'Hollander, Agathe C. A.; Franco, Marcela; Zhao, Yan; Hakansson, Maria; Walse, Bjoern; Larsson, Karin; Peat, Emma M.; Pelechano, Vicent; Lunec, John; Vojtesek, Borivoj; Carmena, Mar; Earnshaw, William C.; McCarthy, Anna R.; Westwood, Nicholas J.; Arsenian-Henriksson, Marie; Lane, David P.; Bhatia, Ravi; McCormack, Emmet; Lain, Sonia 分享 收藏
Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation Zadran, Bassier; Sudhindar, Praveen Dhondurao; Wainwright, Daniel; Bury, Yvonne; Luli, Saimir; Howarth, Rachel; McCain, Misti Vanette; Watson, Robyn; Huet, Hannah; Palinkas, Fanni; Palmini, Rolando Berlinguer; Casement, John; Mann, Derek A.; Oakley, Fiona; Lunec, John; Reeves, Helen; Faulkner, Geoffrey J.; Shukla, Ruchi 分享 收藏
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Key features of the environment promoting liver cancer in the absence of cirrhosis 在没有肝硬化的情况下促进肝癌的环境的主要特征 Zaki, Marco Youssef William; Mahdi, Ahmed Khairallah; Patman, Gillian Lucinda; Whitehead, Anna; Mauricio, Joao Pais; McCain, Misti Vanette; Televantou, Despina; Abou-Beih, Sameh; Ramon-Gil, Erik; Watson, Robyn; Cox, Charlotte; Leslie, Jack; Wilson, Caroline; Govaere, Olivier; Lunec, John; Mann, Derek Austin; Nakjang, Sirintra; Oakley, Fiona; Shukla, Ruchi; Anstee, Quentin Mark; Tiniakos, Dina; Reeves, Helen Louise 分享 收藏
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction Chessari, Gianni; Hardcastle, Ian R.; Ahn, Jong Sook; Anil, Burcu; Anscombe, Elizabeth; Bawn, Ruth H.; Bevan, Luke D.; Blackburn, Timothy J.; Buck, Ildiko; Cano, Celine; Carbain, Benoit; Castro, Juan; Cons, Ben; Cully, Sarah J.; Endicott, Jane A.; Fazal, Lynsey; Golding, Bernard T.; Griffin, Roger J.; Haggerty, Karen; Harnor, Suzannah J.; Hearn, Keisha; Hobson, Stephen; Holvey, Rhian S.; Howard, Steven; Jennings, Claire E.; Johnson, Christopher N.; Lunec, John; Miller, Duncan C.; Newell, David R.; Noble, Martin E. M.; Reeks, Judith; Revill, Charlotte H.; Riedinger, Christiane; St Denis, Jeffrey D.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil T.; Vinkovic, Mladen; Wedge, Stephen R.; Williams, Pamela A.; Wilsher, Nicola E.; Zhang, Bian; Zhao, Yan 分享 收藏
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Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells Ciardullo, Carmela; Aptullahoglu, Erhan; Woodhouse, Laura; Lin, Wei-Yu; Wallis, Jonathan P.; Marr, Helen; Marshall, Scott; Bown, Nick; Willmore, Elaine; Lunec, John 分享 收藏
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Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma Chen, Lindi; Pastorino, Fabio; Berry, Philip; Bonner, Jennifer; Kirk, Calum; Wood, Katrina M.; Thomas, Huw D.; Zhao, Yan; Daga, Antonio; Veal, Gareth J.; Lunec, John; Newell, David R.; Ponzoni, Mirco; Tweddle, Deborah A. 分享 收藏
The anti-proliferative and pro-apoptotic effect of MDM2-p53 antagonists evaluated in human tumor cells lines and chronic lymphocytic leukemia patient samples Willmore, Elaine; Zhao, Yan; Ciardullo, Carmela; Woodhouse, Laura; Thomas, Huw D.; Ahn, Maria; Fazal, Lynsey; Noble, Martin E.; Hardcastle, Ian; Howard, Steven; Chessari, Gianni; Lunec, John; Wedge, Steve 分享 收藏
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