Einar M. Sigurdsson

New York University

H指数:49

被引数:1.5万

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Autophagosome-targeting single-domain antibody clears tau in patient-derived neurons and improves motor function in tauopathy mice

自噬体靶向单域抗体清除患者源性神经元中的tau蛋白并改善tau病小鼠的运动功能

Science Translational Medicine

IF14.6

2026-04-150

PRE

Corrigendum to “Formaldehyde induces and promotes Alzheimer's disease pathologies in a 3D human neural cell culture model” [Food Chem. Toxicol. (2025 Dec) 206 115777]

勘误：“Formaldehyde induces and promotes Alzheimer's disease pathologies in a 3D human neural cell culture model” [Food Chem. Toxicol. (2025 Dec) 206 115777]

Food and Chemical Toxicology

IF3.5

2025-10-310

PRE

Formaldehyde induces and promotes Alzheimer’s disease pathologies in a 3D human neural cell culture model

甲醛在三维人神经细胞培养模型中诱导并促进了阿尔茨海默病的病理变化。

Food and Chemical Toxicology

IF3.5

2025-10-010

PRE

Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice

清除截断的tau蛋白可恢复神经元功能并防止tau病小鼠的小胶质细胞活化

Cell Reports

IF6.9

2025-09-160

PREAI

Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2024-10-185

PRE

Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy

ALZHEIMERS & DEMENTIA

IF11.1

2024-10-050

OAAI

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

CELL DEATH & DISEASE

IF9.6

2024-07-300

OAAI

Single-domain antibody-based protein degrader for synucleinopathies

用于突触核蛋白病的基于单域抗体的蛋白质降解剂

MOLECULAR NEURODEGENERATION

IF17.5

2024-05-310

OAAI

Tau-targeting therapies for Alzheimer disease: current status and future directions

NATURE REVIEWS NEUROLOGY

IF33.1

2023-10-2456

PRE

Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology

SCIENCE ADVANCES

IF12.5

2023-05-1215

OAAI

Amyloid-β targeting immunisation in aged non-human primate (Microcebus murinus)

BRAIN BEHAVIOR AND IMMUNITY

IF7.6

2023-03-013

OAAI

Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity

EBIOMEDICINE

IF10.8

2022-10-0116

OAAI

Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

IF6

2022-06-0115

OAAI

Current Status of Clinical Trials on Tau Immunotherapies

DRUGS

IF14.4

2021-06-0860

OAAI

Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

澳大利亚阿尔茨海默病研究进展: 悉尼阿尔茨海默病协会国际会议卫星研讨会

ALZHEIMERS & DEMENTIA

IF11.1

2021-05-315

OAAI

Sexton, Claire E.; Anstey, Kaarin J.; Baldacci, Filippo; Barnum, C. J.; Barron, Anna M.; Blennow, Kaj; Brodaty, Henry; Burnham, Samantha; Elahi, Fanny M.; Gotz, Jurgen; Jeon, Yun-Hee; Koronyo-Hamaoui, Maya; Landau, Susan M.; Lautenschlager, Nicola T.; Laws, Simon M.; Lipnicki, Darren M.; Lu, Hanzhang; Masters, Colin L.; Moyle, Wendy; Nakamura, Akinori; Pasinetti, Giulio Maria; Rao, Naren; Rowe, Christopher; Sachdev, Perminder S.; Schofield, Peter R.; Sigurdsson, Einar M.; Smith, Kate; Srikanth, Velandai; Szoeke, Cassandra; Tansey, Malu G.; Whitmer, Rachel; Wilcock, Donna; Wong, Tien Y.; Bain, Lisa J.; Carrillo, Maria C.

Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice

NEUROBIOLOGY OF DISEASE

IF5.6

2021-01-019

OAAI

Response: Commentary: Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2020-07-020

OAAI

Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models

NEUROBIOLOGY OF DISEASE