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The first-in-class PRX3 inhibitor RSO-021 modulates the composition of malignant pleural effusions by eliciting immunomodulation and decreasing epithelial to mesenchymal protein expression 第一类PRX3抑制剂RSO-021通过引发免疫调节并降低上皮-间质蛋白表达，来调节恶性胸腔积液的组成。 Messier, Terri; Cech, Bradley; Dzialo, Joanna; Gibson, Victoria; Poile, Charlotte; Nakas, Apostolos; Kutywayo, Kudzayi; Bzura, Aleksandra; Rogel, Jan; Naumov, George; Landry, Christopher; Fennell, Dean; Cunniff, Brian 分享 收藏
Peroxiredoxin 3 (PRX3) - a new target for the treatment of aggressive cancers Gibson, V.; Dzialo, J.; Messier, T.; Baitei, E.; Poile, C.; Bzura, A.; Kutywayo, K.; Nakas, A.; Naumov, G.; Fennell, D.; Cunniff, B. 分享 收藏
A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma Zhang, Min; Bzura, Aleksandra; Baitei, Essa Y.; Zhou, Zisen; Spicer, Jake B.; Poile, Charlotte; Rogel, Jan; Branson, Amy; King, Amy; Barber, Shaun; Kamata, Tamihiro; Dzialo, Joanna; Harber, James; Greystoke, Alastair; Nusrat, Nada; Faulkner, Daniel; Sun, Qianqian; Nolan, Luke; Hahne, Jens C.; Scotland, Molly; Walter, Harriet; Darlison, Liz; Morgan, Bruno; Bajaj, Amrita; Brookes, Cassandra; Hollox, Edward J.; Lubawska, Dominika; Jama, Maymun; Griffiths, Gareth; Nakas, Apostolos; Kutywayo, Kudzayi; Luo, Jin-Li; Klampatsa, Astero; Cooper, Andrea; Halder, Koirobi; Wells-Jordan, Peter; Zhou, Huiyu; Dudbridge, Frank; Thomas, Anne; Richards, Catherine Jane; Pritchard, Catrin; Yang, Hongji; Barer, Michael; Fennell, Dean A. 分享 收藏
SLC7A11 modulates sensitivity to the first-in-class mitochondrial peroxiredoxin 3 inhibitor thiostrepton (RSO-021) via a ferroptosis independent pathway Messier, Terri; Gibson, Victoria; Bzura, Aleksandra; Dzialo, Joanna; Poile, Charlotte; Stead, Stephanie; Saaman, Alexis; Naumov, George N.; Fennell, Dean A.; Cunniff, Brian 分享 收藏
First-in-class peroxiredoxin 3 (PRX3) inhibitor RSO-021 triggers mesenchymal-to-epithelial transition in mesothelioma Messier, Terri; Gibson, Victoria; Seward, David J.; Baitei, Essa Y.; Jordan, Peter Wells; Poile, Charlotte; Dzialo, Joanna; Bzura, Aleksandra; Kutywayo, Kudzayi; Nakas, Apostolos; Naumov, George N.; Fennell, Dean A.; Cunniff, Brian 分享 收藏
ASTX295 engages p53-mediated apoptosis and an inflammatory response in patient derived mesothelioma explants Fennell, Dean Anthony; Dzialo, Joanna; Rogel, Jan; Faulkner, Daniel; Nusrat, Nada; Bzura, Aleksandra; Kutywayo, Kudzayi; Wells-Jordan, Peter; Poile, Charlotte; Biondo, Andrea; Sims, Martin; Nakas, Apostolos; Luo, Jin-Li; Zhang, Min; Ahn, Maria 分享 收藏
RSO-021, a first-in-class covalent inhibitor of mitochondrial PRX3: From bench to bedside Fennell, Dean A.; Dulloo, Sean; Szlosarek, Peter; Thistlethwaite, Fiona; Lord, Simon; Rahman, Najib M.; Cunniff, Brian; Dzialo, Joanna; Poile, Charlotte; Panchal, Rakesh; Duncan, Jarrett; Graham, Pip; Bexon, Alice; Naumov, George N.; Spicer, James 分享 收藏
Gene fusions during the early evolution of mesothelioma correlate with impaired DNA repair and Hippo pathways Jama, Maymun; Zhang, Min; Poile, Charlotte; Nakas, Apostolos; Sharkey, Annabel; Dzialo, Joanna; Dawson, Alan; Kutywayo, Kudazyi; Fennell, Dean A.; Hollox, Edward J. 分享 收藏
BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms Singh, Anita; Busacca, Sara; Gaba, Aarti; Sheaff, Michael; Poile, Charlotte; Nakas, Apostolos; Dzialo, Joanna; Bzura, Aleksandra; Dawson, Alan G. G.; Fennell, Dean A. A.; Fry, Andrew M. M. 分享 收藏
First-in-human dose-escalation and expansion study (MITOPE) to evaluate mitochondrial PRX3 inhibition by RSO-021 in patients with mesothelioma and other advanced solid tumors Dulloo, S.; Fennell, D. A.; Szlosarek, P. W.; Thistlethwaite, F.; Lord, S.; Rahman, N. M.; Greystoke, A.; Cunniff, B.; Dzialo, J.; Poile, C.; Panchal, R.; Duncan, J.; Graham, P.; Bexon, A. S.; Naumov, G.; Spicer, J. 分享 收藏
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment (vol 12, 1751, 2021) Zhang, Min; Luo, Jin-Li; Sun, Qianqian; Harber, James; Dawson, Alan G.; Nakas, Apostolos; Busacca, Sara; Sharkey, Annabel J.; Waller, David; Sheaff, Michael T.; Richards, Cathy; Wells-Jordan, Peter; Gaba, Aarti; Poile, Charlotte; Baitei, Essa Y.; Bzura, Aleksandra; Dzialo, Joanna; Jama, Maymun; Le Quesne, John; Bajaj, Amrita; Martinson, Luke; Shaw, Jacqui A.; Pritchard, Catrin; Kamata, Tamihiro; Kuse, Nathaniel; Brannan, Lee; De Philip Zhang, Pan; Yang, Hongji; Griffiths, Gareth; Wilson, Gareth; Swanton, Charles; Dudbridge, Frank; Hollox, Edward J.; Fennell, Dean A. 分享 收藏
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment Zhang, Min; Luo, Jin-Li; Sun, Qianqian; Harber, James; Dawson, Alan G.; Nakas, Apostolos; Busacca, Sara; Sharkey, Annabel J.; Waller, David; Sheaff, Michael T.; Richards, Cathy; Wells-Jordan, Peter; Gaba, Aarti; Poile, Charlotte; Baitei, Essa Y.; Bzura, Aleksandra; Dzialo, Joanna; Jama, Maymun; Le Quesne, John; Bajaj, Amrita; Martison, Luke; Shaw, Jacqui A.; Pritchard, Catrin; Kamata, Tamihiro; Kuse, Nathaniel; Brannan, Lee; Zhang, Pan De Philip; Yang, Hongji; Griffiths, Gareth; Wilson, Gareth; Swanton, Charles; Dudbridge, Frank; Hollox, Edward J. 分享 收藏
BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma Busacca, Sara; O'Regan, Laura; Singh, Anita; Sharkey, Annabel J.; Dawson, Alan G.; Dzialo, Joanna; Parsons, Aimee; Kumar, Neelam; Schunselaar, Laurel M.; Guppy, Naomi; Nakas, Apostolos; Sheaff, Michael; Mansfield, Aaron S.; Janes, Sam M.; Baas, Paul; Fry, Andrew M.; Fennell, Dean A. 分享 收藏
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