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M

Makoto Higuchi

Institute for Quantum Medical Science

73H指数
695论文数
2.1W被引数
收录论文 224
发表时间
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Distinct recombinant tau fibril conformations induce divergent propagation and neurodegenerative phenotypes in a model mouse不同重组tau原纤维构象诱导模型小鼠中不同的传播和神经退行性表型
errActa Neuropathologica Communications
IF5.7
err2026-09-10
err0
errOAAI
errRin Yanai; Shingo Tamai; Gen Matsumoto; Takeharu Minamihisamatsu; Shoko Uchida; Zhiwei Yao; Hiroshi Mizuma; Ming-Rong Zhang; Makoto Higuchi; Masafumi Shimojo; Motomasa Tanaka; Naruhiko Sahara
err分享
err收藏
Spatiotemporal Tau Accumulation and its Clinical Impact on Progressive Supranuclear Palsy: Longitudinal Florzolotau (18F) Positron Emission Tomography空间-时间Tau蛋白积累及其对进行性核上性麻痹的临床影响：纵向氟[18F]正电子发射断层扫描
errMovement Disorders
IF7.6
err2026-09-05
err0
errOAAI
errYoshikazu Chishiki MD, MEng; Kenji Tagai MD, PhD; Yuko Kataoka MD, PhD; Ryoji Goto MD; Kenta Osawa MD; Asaka Oyama MSc; Hideki Matsumoto DDS, PhD; Masanori Ichihashi MD; Yuki Momota PhD; Tetsuji Kamada PhD; Chie Seki PhD; Kiwamu Matsuoka MD, PhD; Kosei Hirata MD, PhD; Shin Kurose MD; Sho Moriguchi MD, PhD; Yuki Komatsu MD; Hideo Kato MD; Yasuharu Yamamoto MD, PhD; Yoshikazu Nakano MD, PhD; Shigeki Hirano MD, PhD; Hitoshi Shinotoh MD, PhD; Hitoshi Shimada MD, PhD; Tokahiko Tokuda MD, PhD; Kazunori Kawamura PhD; Ming-Rong Zhang PhD; Keisuke Takahata MD, PhD; Makoto Higuchi MD, PhD; Hironobu Endo MD, PhD
err分享
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High prevalence of tau pathologies in late-onset psychosis: A PET study晚发性精神病中tau病理的高患病率：一项PET研究
errMolecular Psychiatry
IF10.1
err2026-08-03
err0
errOAAI
errManabu Kubota; Shin Kurose; Kenji Tagai; Yuki Momota; Masanori Ichihashi; Hironobu Endo; Chie Seki; Sho Moriguchi; Yasuharu Yamamoto; Yuko Kataoka; Ryoji Goto; Takehiro Tamura; Hiroki Shiwaku; Kiwamu Matsuoka; Hisaomi Suzuki; Mitsumoto Onaya; Takahiko Tokuda; Hiroyuki Uchida; Hidehiko Takahashi; Kazunori Kawamura; Ming-Rong Zhang; Makoto Higuchi; Keisuke Takahata
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err收藏
Radiosynthesis and quality control testing of two 18F-labeled radiopharmaceuticals for α-synuclein imaging in clinical investigations18F标记的两种放射性药物用于α-突触核蛋白成像的临床研究中的放射性合成与质量控制测试
errEJNMMI Radiopharmacy and Chemistry
IF3.3
err2026-07-23
err0
errOAAI
errHiroki Hashimoto; Takayuki Ohkubo; Kazunori Kawamura; Tomoya Fujishiro; Daisuke Arashi; Tatsuto Sato; Takeru Seki; Masatoshi Muto; Kaito Tsukagoe; Masanao Ogawa; Yusuke Kurihara; Nobuki Nengaki; Wakana Mori; Masayuki Fujinaga; Makoto Higuchi; Ming-Rong Zhang
err分享
err收藏
Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy基于tau蛋白积累的原发性进行性核上性麻痹认知症状的远程网络
errScience Advances
IF12.5
err2026-07-10
err0
errOAAI
errYuki Hori; Hironobu Endo; Kenji Tagai; Yuko Kataoka; Ryoji Goto; Shin Kurose; Yuki Momota; Naomi Kokubo; Chie Seki; Sho Moriguchi; Hitoshi Shimada; Hitoshi Shinotoh; Takahiko Tokuda; Keisuke Takahata; Takafumi Minamimoto; Makoto Higuchi; Toshiyuki Hirabayashi
err分享
err收藏
Design optimization using GATE Monte Carlo simulations for a sub-0.5 mm resolution PET scanner with 3-layer DOI detectors
errphysics in medicine & biology
IF0
err2026-02-02
err0
PREAI
errHan Gyu Kang; Hideaki Tashima; Makoto Higuchi; Taiga Yamaya
err分享
err收藏
Sub-0.5 mm Resolution PET Scanner With 3-Layer DOI Detectors for Rodent Neuroimaging
errIEEE Transactions on Medical Imaging
IF9.8
err2025-10-31
err0
PREAI
errHan Gyu Kang; Hideaki Tashima; Hidekatsu Wakizaka; Makoto Higuchi; Taiga Yamaya
err分享
err收藏
Longitudinal assessment of DREADD expression and efficacy in the monkey brain
errELIFE
IF0
err2025-10-22
err1
PREAI
errNagai, Yuji; Hori, Yukiko; Inoue, Ken-ichi; Hirabayashi, Toshiyuki; Mimura, Koki; Oyama, Kei; Miyakawa, Naohisa; Hori, Yuki; Iwaoki, Haruhiko; Kumata, Katsushi; Zhang, Ming-Rong; Takada, Masahiko; Higuchi, Makoto; Minamimoto, Takafumi
err分享
err收藏
Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-10-01
err0
PREAI
errYamasaki, Tomoteru; Ohyabu, Norio; Wakabayashi, Takeshi; Ibanez, Ignacio; Iwanaga, Kouichi; Yamamoto, Satoshi; Hattori, Masahiko; Sugita, Taku; Terada, Michiko; Onishi, Tomohiro; Sato, Sho; Kosugi, Yohei; Takano, Akihiro; Mcquade, Paul; Maru, Takamitsu; Inui, Naomi; Fujinaga, Masayuki; Mori, Wakana; Nagai, Yuji; Seki, Chie; Uchida, Shoko; Minamimoto, Takafumi; Higuchi, Makoto; Fushimi, Makoto; Zhang, Ming-Rong
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A longitudinal PET study on changes in brain norepinephrine transporter availability following duloxetine treatment in major depressive disorder一项关于度洛西汀治疗在重度抑郁症中脑去甲肾上腺素转运体可利用性变化的长时程正电子发射断层扫描研究
errINTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
IF3.7
err2025-10-01
err0
errOAAI
errMoriguchi, Sho; Takahata, Keisuke; Takano, Harumasa; Endo, Hironobu; Tagai, Kenji; Kitamura, Soichiro; Uchida, Hiroyuki; Mimura, Masaru; Kubota, Manabu; Zhang, Ming-Rong; Higuchi, Makoto
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Longitudinal imaging evaluation of the inflammatory role of purinergic A 2 A receptors during subacute and chronic ischemic stroke亚急性及慢性缺血性卒中中嘌呤能A2A受体炎症作用的纵向影像学评估
errJournal of Cerebral Blood Flow & Metabolism
IF0
err2025-09-08
err0
errOAAI
errMaider Garbizu; Naroa Mocha-Muñoz; Esther Rubio-López; Laura Palacios; Laura Aguado; María Ardaya; Ana Joya; Unai Alduntzin; Sandra Plaza-García; Daniel Padro; Vanessa Gómez-Vallejo; Unai Cossío; Makoto Higuchi; Pedro Ramos-Cabrer; José Luis Zugaza; Jordi Llop; Abraham Martín
err分享
err收藏
Quantification of monoamine oxidase B expression with 11C-SL25.1188 for imaging reactive astrocytes in patients with Alzheimer’s disease使用11C-SL25.1188对阿尔茨海默病患者中反应性星形胶质细胞中单胺氧化酶B的表达进行定量
errEuropean Journal of Nuclear Medicine and Molecular Imaging
IF7.6
err2025-09-06
err0
errOAAI
errKiwamu Matsuoka; Yuhei Takado; Yasuyuki Kimura; Akihiko Kitamura; Hitomi Kitamura; Mayuka Kanda; Michihiro Takada; Maiko Ono; Harutsugu Tatebe; Hironobu Endo; Shin Kurose; Keisuke Takahata; Yoko Ikoma; Masanori Ichihashi; Masaki Oya; Kosei Hirata; Hideki Matsumoto; Asumi Orihara; Naomi Kokubo; Yuko Kataoka; Hong Zhang; Kenji Tagai; Chie Seki; Hitoshi Shinotoh; Tatsuya Kikuchi; Masanori Ichise; Hiroshi Shimizu; Akiyoshi Kakita; Kazunori Kawamura; Ming-Rong Zhang; Hitoshi Shimada; Kenji Nagao; Takahiko Tokuda; Makoto Higuchi
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Development of a submillimeter resolution PET scanner with compact geometry for hybrid multi-photon/PET imaging开发一种紧凑几何结构、亚毫米分辨率PET扫描仪，用于混合多光子/PET成像
errphysics in medicine and biology
IF0
err2025-08-21
err0
PREAI
errHan Gyu Kang; Hiroyuki Takuwa; Hideaki Tashima; Hidekatsu Wakizaka; Makoto Higuchi; Taiga Yamaya
err分享
err收藏
Advances in PET imaging of protein aggregates associated with neurodegenerative disease神经退行性疾病相关蛋白聚集体的PET显像研究进展
errNature Reviews Neurology
IF33.1
err2025-08-11
err0
PREAI
errMakoto Higuchi; Kenji Tagai; Keisuke Takahata; Hironobu Endo
err分享
err收藏
IN VIVO ASSESSMENTS OF TAU PATHOLOGIES IN PATIENTS WITH LATE-ONSET PSYCHOSIS: A PET STUDY
errINTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
IF3.7
err2025-08-01
err0
errOAAI
errKubota, M.; Kurose, S.; Tagai, K.; Momota, Y.; Ichihashi, M.; Endo, H.; Seki, C.; Yamamoto, Y.; Matsuoka, K.; Suzuki, H.; Onaya, M.; Tokuda, T.; Uchida, H.; Tahakashi, H.; Kawamura, K.; Zhang, M-r; Higuchi, M.; Takahata, K.
err分享
err收藏
Concurrent Alzheimer's disease pathologies in Lewy body diseases affect cognition and glucose metabolism in the posterior cingulate gyrus: A multimodal PET study中村 K.; 田井 K.; 真藤 H.; 平野 S.; 北村 S.; 远藤 H.; 高桥 K.; 高道 Y.; 张 M.-R.; 川村 K.; 等. 路易体疾病中并存的阿尔茨海默病病理影响后扣带回的认知和葡萄糖代谢：一项多模态PET研究。阿尔茨海默病杂志. 2025, 106, 1074–1086. [Google Scholar] [CrossRef]
errJournal of Alzheimer’s Disease
IF3.1
err2025-06-20
err0
PREAI
errKosei Nakamura; Kenji Tagai; Hitoshi Shinotoh; Shigeki Hirano; Soichiro Kitamura; Hironobu Endo; Keisuke Takahata; Yuhei Takado; Ming-Rong Zhang; Kazunori Kawamura; Osamu Onodera; Makoto Higuchi; Hitoshi Shimada
err分享
err收藏
iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-TauiPSC 筛选确定了 CACNA2D2 作为 FTLD-Tau 的潜在治疗靶点
errEUROPEAN JOURNAL OF CELL BIOLOGY
IF4.3
err2025-06-01
err0
errOAAI
errImamura, Keiko; Nagahashi, Ayako; Okusa, Aya; Sakasai, Tomoki; Tsukita, Kayoko; Kutoku, Yumiko; Ohsawa, Yutaka; Sunada, Yoshihide; Sahara, Naruhiko; Kanaan, Nicholas M.; Higuchi, Makoto; Mori, Kohji; Ikeda, Manabu; Inoue, Haruhisa
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err收藏
Diffusion Tensor Image Analysis Along the Perivascular Space in Former Professional Athletes with Repetitive Mild Traumatic Brain Injury History血管周围空间中的扩散张量图像分析：针对有重复性轻度创伤性脑损伤史的前职业运动员
errAcademic Radiology
IF3.9
err2025-05-03
err0
errOAAI
errMari Miyata; Koji Kamagata; Yuya Saito; Wataru Uchida; Kaito Takabayashi; Sho Moriguchi; Yuki Momota; Masanori Ichihashi; Shin Kurose; Hironobu Endo; Kenji Tagai; Yuko Kataoka; Masaru Mimura; Shigeki Aoki; Makoto Higuchi; Keisuke Takahata
err分享
err收藏
Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, 18F-SPAL-T-06 and 18F-C05-05
errSCIENTIFIC REPORTS
IF3.9
err2025-03-13
err0
errOAAI
errGoto, Ryoji; Matsuoka, Kiwamu; Kimura, Yasuyuki; Kataoka, Yuko; Oya, Masaki; Hirata, Kosei; Tagai, Kenji; Takahata, Keisuke; Seki, Chie; Kawamura, Kazunori; Zhang, Ming-Rong; Higuchi, Makoto; Endo, Hironobu
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err收藏
A neuroimaging dataset during sequential color qualia similarity judgments with and without reports在有无报告的情况下，进行顺序颜色 quale 相似性判断的神经成像数据集
errSCIENTIFIC DATA
IF6.9
err2025-03-06
err0
errOAAI
errHirao, Takahiro; Miyamae, Mitsuhiro; Matsuyoshi, Daisuke; Inoue, Ryuto; Takado, Yuhei; Obata, Takayuki; Higuchi, Makoto; Tsuchiya, Naotsugu; Yamada, Makiko
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研究方向

暂无研究方向
合作学者
合作期刊
J
John Q. Trojanowski
H 指数: 255 · 论文数: 1.8K
D
Dennis W. Dickson
H 指数: 218 · 论文数: 2.3K
R
Ronald C. Petersen
H 指数: 205 · 论文数: 2.0K
V
Virginia M.‐Y. Lee
H 指数: 200 · 论文数: 920
F
Frank J. Gonzalez
H 指数: 191 · 论文数: 1.7K
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