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D

David Macías

University of Cambridge
H指数:26
被引数:3,064

个人简介

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荣誉奖项

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Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

肺癌和卵巢癌对铂类化疗的治疗耐药性是由可靶向的tgf β 衰老分泌蛋白驱动的

Nature Aging
IF19.4
2026-02-030
OAAI
Estela González-Gualda; Marika A. V. Reinius; David Macias; Samir Morsli; Jianfeng Ge; Ioana Olan; José Ezequiel Martín; Hui-Ling Ou; Muhamad Hartono; María Pilar Puerto-Camacho; Mary Denholm; Rosalind Kieran; Reuben Hoffmann; Mark Dane; Dimitris Veroutis; Guillermo Medrano; Francisca Mulero; Mercedes Jimenez-Linan; Ljiljana Fruk; Carla P. Martins; Mariano Barbacid; Vassilis Gorgoulis; James E. Korkola; Doris M. Rassl; Gary J. Doherty; Robert C. Rintoul; Masashi Narita; James D. Brenton; Daniel Muñoz-Espín
Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality
NATURE METABOLISM
IF20.8
2024-07-243
PRE
Mora-Romero, Bella; Capelo-Carrasco, Nicolas; Perez-Moreno, Juan J.; Alvarez-Vergara, Maria I.; Trujillo-Estrada, Laura; Romero-Molina, Carmen; Martinez-Marquez, Emilio; Morano-Catalan, Noelia; Vizuete, Marisa; Lopez-Barneo, Jose; Nieto-Gonzalez, Jose L.; Garcia-Junco-Clemente, Pablo; Vitorica, Javier; Gutierrez, Antonia; Macias, David; Rosales-Nieves, Alicia E.; Pascual, Alberto
A tumor-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Gonzalez-Gualda, Estela; Macias, David; Morsli, Samir; Martin, Jose Ezequiel; Ou, Hui-Ling; Denholm, Mary; Olan, Ioana; Hoffmann, Reuben; Dane, Mark; Veroutis, Dimitris; Medrano, Guillermo; Mulero, Francisca; Martins, Carla P.; Barbacid, Mariano; Gorgoulis, Vassilis; Korkola, James E.; Rassl, Doris M.; Doherty, Gary J.; Rintoul, Robert C.; Narita, Masashi; Munoz-Espin, Daniel
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

Navitoclax的半乳糖缀合是增加衰老特异性和降低血小板毒性的有效策略

AGING CELL
IF7.1
2020-03-31159
OAAI
Gonzalez-Gualda, Estela; Paez-Ribes, Marta; Lozano-Torres, Beatriz; Macias, David; Wilson, Joseph R., III; Gonzalez-Lopez, Cristina; Ou, Hui-Ling; Miron-Barroso, Sofia; Zhang, Zhenguang; Lerida-Viso, Araceli; Blandez, Juan F.; Bernardos, Andrea; Sancenon, Felix; Rovira, Miguel; Fruk, Ljiljana; Martins, Carla P.; Serrano, Manuel; Doherty, Gary J.; Martinez-Manez, Ramon; Munoz-Espin, Daniel
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
CELL STEM CELL
IF20.4
2019-09-01214
OAAI
Ho, Ya-Hsuan; del Toro, Raquel; Rivera-Torres, Jose; Rak, Justyna; Korn, Claudia; Garcia-Garcia, Andres; Macias, David; Gonzalez-Gomez, Cristina; del Monte, Alberto; Wittner, Monika; Waller, Amie K.; Foster, Holly R.; Lopez-Otin, Carlos; Johnson, Randall S.; Nerlov, Claus; Ghevaert, Cedric; Vainchenker, William; Louache, Fawzia; Andres, Vicente; Mendez-Ferrer, Simon

研究方向

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R
Randall S. Johnson
H 指数:124论文数:593被引数:6.6万
A
Andrew S. Cowburn
H 指数:32论文数:86被引数:4,667
D
Daniel Muñoz‐Espín
H 指数:21论文数:68被引数:7,479
M
Mary Denholm
H 指数:7论文数:34被引数:167
B
Bernardino Clavo
H 指数:23论文数:125被引数:1,589
J
José López‐Barneo
H 指数:64论文数:250被引数:1.4万
E
Estela González‐Gualda
H 指数:10论文数:18被引数:1,835
F
Francisco Robaina
H 指数:17论文数:67被引数:895
G
Gary J. Doherty
H 指数:29论文数:103被引数:7,080
S
Samir Morsli
H 指数:6论文数:15被引数:380