未登录

P

Philipp Holliger

MRC Laboratory of Molecular Biology

H指数:46

被引数:9,997

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences

无模板DNA聚合酶活性的分析与控制：用于指导千碱基规模DNA序列的合成

Nature Communications

IF15.7

2026-02-260

OAAI

A small polymerase ribozyme that can synthesize itself and its complementary strand

一种能够合成自身及其互补链的小型聚合酶核酶

IF45.8

2026-02-120

PRE

Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis

二聚中间体在RNA催化滚动圆合成中的作用

NUCLEIC ACIDS RESEARCH

IF13.1

2025-06-240

OAAI

Trinucleotide substrates under pH-freeze-thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme

在pH冻融循环条件下，三核苷酸底物使核酶聚合酶能够进行开放式的指数级RNA复制

NATURE CHEMISTRY

IF20.2

2025-05-280

OA

Structural insights into a DNA polymerase reading the xeno nucleic acid HNA

读取异种核酸HNA的DNA聚合酶的结构见解

NUCLEIC ACIDS RESEARCH

IF13.1

2024-12-030

OAAI

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-01-117

OAAI

Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening

NATURE BIOMEDICAL ENGINEERING

IF26.6

2023-10-0913

OAAI

Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif

HNA适体的表征表明非规范的G-四链体基序

NUCLEIC ACIDS RESEARCH

IF13.1

2023-07-133

OAAI

Emergence of ATP- and GTP-Binding Aptamers from Single RNA Sequences by Error-Prone Replication and Selection

CHEMSYSTEMSCHEM

IF3.1

2023-07-021

OA

A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA

两个残基的新生链空间门控制2 ′-O-甲基-和2 ′-O-(2-甲氧基乙基)-RNA的合成

NATURE CHEMISTRY

IF20.2

2022-10-1327

OA

A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing

NATURE CHEMISTRY

IF20.2

2022-09-0536

OAAI

On gene silencing by the X10-23 DNAzyme

NATURE CHEMISTRY

IF20.2

2022-07-1813

PRE

Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion

NATURE COMMUNICATIONS

IF15.7

2022-06-0312

OAAI

New chemistries and enzymes for synthetic genetics

CURRENT OPINION IN BIOTECHNOLOGY

IF7

2022-04-0126

PRE

Rolling circle RNA synthesis catalyzed by RNA

IF0

2022-02-0225

OA

Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues

RSC CHEMICAL BIOLOGY

IF3.1

2022-01-0111

OAAI

Introduction to the themed collection on XNA xeno-nucleic acids

RSC CHEMICAL BIOLOGY

IF3.1

2022-01-012

OAAI

Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity

NATURE CHEMISTRY

IF20.2

2020-07-2050

OAAI

Selection of 2′-Deoxy-2′-Fluoroarabino Nucleic Acid (FANA) Aptamers That Bind HIV-1 Integrase with Picomolar Affinity

ACS CHEMICAL BIOLOGY

IF3.8

2019-09-2752

OAAI

Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics

超越DNA和RNA: 合成遗传学的扩展工具箱

cold spring harbor perspectives in medicine

IF8.4

2019-06-0337

OAAI