Merlin Crossley - Publications, H-index & Citations

Merlin Crossley

university of new south wales sydney

61H指数

195论文数

1.2W被引数

收录论文 98

发表时间

Precision targeting of fetal hemoglobin repressors 胎儿血红蛋白抑制物的精确靶向

Blood

IF23.1

2026-08-01

PREAI

Crossley, Merlin

WDR5 serves in co-activation and influences genome targeting of KLF3 WDR5参与协同激活并影响KLF3的基因组靶向定位。

NUCLEIC ACIDS RESEARCH

IF13.1

2025-10-14

OAAI

Yang, Lu; Shah, Manan; Chavalit, Tanit; Spek, Annalise M.; Lim, Wooi F.; Zhong, Ling; Safari, Vala Nejad; Haddad, Mahdi; Vu, Thu H.; Mackay, Joel P.; Raftery, Mark J.; Wilkins, Marc R.; Mathews, Jacqueline M.; Quinlan, Kate G. R.; Crossley, Merlin

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing 通过表观基因组编辑去除启动子CpG甲基化逆转HBG沉默

Nature Communications

IF15.7

2025-07-27

OAAI

Henry W. Bell; Ruopeng Feng; Manan Shah; Yu Yao; James Douglas; Phillip A. Doerfler; Thiyagaraj Mayuranathan; Michael F. O’Dea; Yichao Li; Yong-Dong Wang; Jingjing Zhang; Joel P. Mackay; Yong Cheng; Kate G. R. Quinlan; Mitchell J. Weiss; Merlin Crossley

Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression

MOLECULAR THERAPY

IF12

2024-03-01

OAAI

Rajendiran, Vignesh; Devaraju, Nivedhitha; Haddad, Mahdi; Ravi, Nithin Sam; Panigrahi, Lokesh; Paul, Joshua; Gopalakrishnan, Chandrasekar; Wyman, Stacia; Ariudainambi, Keerthiga; Mahalingam, Gokulnath; Periyasami, Yogapriya; Prasad, Kirti; George, Anila; Sukumaran, Dhiyaneshwaran; Gopinathan, Sandhiya; Pai, Aswin Anand; Nakamura, Yukio; Balasubramanian, Poonkuzhali; Ramalingam, Rajasekaran; Thangavel, Saravanabhavan; Velayudhan, Shaji R.; Corn, Jacob E.; Mackay, Joel P.; Marepally, Srujan; Srivastava, Alok; Crossley, Merlin; Mohankumar, Kumarasamypet M.

miR-365-3p mediates BCL11A and SOX6 erythroid-specific coregulation: A new player in HbF activation

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2023-12-01

OAAI

Simbula, Michela; Manchinu, Maria Francesca; Mingoia, Maura; Pala, Mauro; Asunis, Isadora; Caria, Cristian Antonio; Perseu, Lucia; Shah, Manan; Crossley, Merlin; Moi, Paolo; Ristaldi, Maria Serafina

HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription (vol 54, 1417, 2022)

NATURE GENETICS

IF31.8

2023-07-31

OAAI

Huang, Peng; Peslak, Scott A.; Ren, Ren; Khandros, Eugene; Qin, Kunhua; Keller, Cheryl A.; Giardine, Belinda; Bell, Henry W.; Lan, Xianjiang; Sharma, Malini; Horton, John R.; Abdulmalik, Osheiza; Chou, Stella T. T.; Shi, Junwei; Crossley, Merlin; Hardison, Ross C.; Cheng, Xiaodong; Blobel, Gerd A.

Potent and uniform fetal hemoglobin induction via base editing

NATURE GENETICS

IF31.8

2023-07-03

OAAI

Mayuranathan, Thiyagaraj; Newby, Gregory A.; Feng, Ruopeng; Yao, Yu; Mayberry, Kalin D.; Lazzarotto, Cicera R.; Li, Yichao; Levine, Rachel M.; Nimmagadda, Nikitha; Dempsey, Erin; Kang, Guolian; Porter, Shaina N.; Doerfler, Phillip A.; Zhang, Jingjing; Jang, Yoonjeong; Chen, Jingjing; Bell, Henry W.; Crossley, Merlin; Bhoopalan, Senthil Velan; Sharma, Akshay; Tisdale, John F.; Pruett-Miller, Shondra M.; Cheng, Yong; Tsai, Shengdar Q.; Liu, David R.; Weiss, Mitchell J.; Yen, Jonathan S.

Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins ZNF217和其他锌指蛋白在C端结合蛋白表面沟的特异性识别

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Quinlan, Kate G. R.; Nardini, Marco; Verger, Alexis; Francescato, Pierangelo; Yaswen, Paul; Corda, Daniela; Bolognesi, Martino; Crossley, Merlin

Erythroid Kruppel-like factor directly activates the basic Kruppel-like factor gene in erythroid cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Funnell, Alister P. W.; Maloney, Christopher A.; Thompson, Lucinda J.; Keys, Janelle; Tallack, Michael; Perkins, Andrew C.; Crossley, Merlin

Role for SUMO modification in facilitating transcriptional repression by BKLF

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Perdomo, J; Verger, A; Turner, J; Crossley, M

Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

190

OAAI

Sue, Nancy; Jack, Briony H. A.; Eaton, Sally A.; Pearson, Richard C. M.; Funnell, Alister P. W.; Turner, Jeremy; Czolij, Robert; Denyer, Gareth; Bao, Shisan; Molero-Navajas, Juan Carlos; Perkins, Andrew; Fujiwara, Yuko; Orkin, Stuart H.; Bell-Anderson, Kim; Crossley, Merlin

Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding (vol 23, pg 3427, 2003)

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Eisbacher, M; Holmes, ML; Newton, A; Hogg, PJ; Khachigian, LM; Crossley, M; Chong, BH

Mechanisms directing the nuclear localization of the CtBP family proteins

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Verger, Alexis; Quinlan, Kate G. R.; Crofts, Linda A.; Spano, Stefania; Corda, Daniela; Kable, Eleanor P. W.; Braet, Filip; Crossley, Merlin

Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression C末端结合蛋白PXDLS基序结合裂隙在蛋白质相互作用和转录抑制中的作用

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Quinlan, Kate G. R.; Verger, Alexis; Kwok, Alister; Lee, Stella H. Y.; Perdomo, Jose; Nardini, Marco; Bolognesi, Martino; Crossley, Merlin

Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

126

OAAI

Eisbacher, M; Holmes, ML; Newton, A; Hogg, PJ; Khachigian, LM; Crossley, M; Chong, BH

The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Funnell, Alister P. W.; Norton, Laura J.; Mak, Ka Sin; Burdach, Jon; Artuz, Crisbel M.; Twine, Natalie A.; Wilkins, Marc R.; Power, Carl A.; Hung, Tzong-Tyng; Perdomo, Jose; Koh, Philip; Bell-Anderson, Kim S.; Orkin, Stuart H.; Fraser, Stuart T.; Perkins, Andrew C.; Pearson, Richard C. M.; Crossley, Merlin

Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing KLF3/BKLF和KLF8缺陷小鼠的产生揭示了遗传相互作用以及这些因素在胚胎珠蛋白基因沉默中的作用

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Funnell, Alister P. W.; Mak, Ka Sin; Twine, Natalie A.; Pelka, Gregory J.; Norton, Laura J.; Radziewic, Tania; Power, Melinda; Wilkins, Marc R.; Bell-Anderson, Kim S.; Fraser, Stuart T.; Perkins, Andrew C.; Tam, Patrick P.; Pearson, Richard C. M.; Crossley, Merlin

KLF3 Regulates Muscle-Specific Gene Expression and Synergizes with Serum Response Factor on KLF Binding Sites

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Himeda, Charis L.; Ranish, Jeffrey A.; Pearson, Richard C. M.; Crossley, Merlin; Hauschka, Stephen D.

Effective therapies for sickle cell disease: are we there yet?镰状细胞病的有效疗法: 我们到了吗？

TRENDS IN GENETICS

IF16.3

2022-12-01

OAAI

Crossley, Merlin; Christakopoulos, Georgios E.; Weiss, Mitchell J.

HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription

NATURE GENETICS

IF31.8

2022-08-08

OAAI

Huang, Peng; Peslak, Scott A.; Ren, Ren; Khandros, Eugene; Qin, Kunhua; Keller, Cheryl A.; Giardine, Belinda; Bell, Henry W.; Lan, Xianjiang; Sharma, Malini; Horton, John R.; Abdulmalik, Osheiza; Chou, Stella T.; Shi, Junwei; Crossley, Merlin; Hardison, Ross C.; Cheng, Xiaodong; Blobel, Gerd A.

研究方向