.png){kind=icon}
返回
A class of anti-inflammatory lipids decrease with aging in the central nervous system
.png){kind=icon}
OA
AI
DOI：10.1038/s41589-022-01165-6.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Lipids contribute to the structure, development, and function of healthy brains. Dysregulated lipid metabolism is linked to aging and diseased brains. However, our understanding of lipid metabolism in aging brains remains limited. Here we examined the brain lipidome of mice across their lifespan using untargeted lipidomics. Co-expression network analysis highlighted a progressive decrease in 3-sulfogalactosyl diacylglycerols (SGDGs) and SGDG pathway members, including the potential degradation products lyso-SGDGs. SGDGs show an age-related decline specifically in the central nervous system and are associated with myelination. We also found that an SGDG dramatically suppresses LPS-induced gene expression and release of pro-inflammatory cytokines from macrophages and microglia by acting on the NF-kappa B pathway. The detection of SGDGs in human and macaque brains establishes their evolutionary conservation. This work enhances interest in SGDGs regarding their roles in aging and inflammatory diseases and highlights the complexity of the brain lipidome and potential biological functions in aging.
Keyword:
RAT-BRAIN
NEURODEGENERATIVE DISEASE
IN-VIVO
INFLAMMATION
MYELIN
BIOSYNTHESIS
METABOLISM
EXPRESSION
PATHWAYS
MOUSE
期刊
IF:
13.7
论文数:
4.8K
被引数:
3.3W
机构
引用论文
LipidBlast in silico tandem mass spectrometry database for lipid identification.png)
NATURE METHODS
OAAI
NATURE METHODSIF32.1
OAAI分享收藏More Ulam for Your Brain: A Review on the Potential Role of Ulam in Protecting Against Cognitive Decline为您的大脑提供更多的Ulam: Ulam在预防认知能力下降方面的潜在作用OAAI
OAAI分享收藏分享收藏分享收藏分享收藏分享收藏
查看更多内容