A framework for designing delivery systems

Wilson Poon

doi:10.1038/s41565-020-0759-5

2020-09-07

369

PRE

DOI：10.1038/s41565-020-0759-5

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摘要

En 中文

The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing and treating patients. Nanomaterials are promising vehicles to transport agents that include drugs, contrast agents, immunotherapies and gene editors. They can be engineered to have different physical and chemical properties that influence their interactions with their biological environments and delivery destinations. In this Review Article, we discuss nanoparticle delivery systems and how the biology of disease should inform their design. We propose developing a framework for building optimal delivery systems that uses nanoparticle-biological interaction data and computational analyses to guide future nanomaterial designs and delivery strategies. This Review proposes a framework for designing delivery systems to target diseased tissues based on the biology of the target, the journey and computational algorithms.

Keyword:

EXTRACELLULAR-MATRIX

PROTEIN CORONA

GLOMERULAR-FILTRATION

GOLD NANOPARTICLES

SURFACE-CHEMISTRY

DENDRITIC CELLS

CELLULAR UPTAKE

DRUG-DELIVERY

BLOOD-VESSELS

PARTICLE-SIZE

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Nature Nanotechnology

IF:

34.9

论文数:

4.8K

被引数:

8.1W

机构

university of toronto

学者数:

14.8W

论文数: 12.0W

被引数: 165

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